Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PDE4DIP Gene

protein-coding GIFtS: 55
GCID: GC01M144836

phosphodiesterase 4D interacting protein

(Previous name: cardiomyopathy associated 2 )
(Previous symbol: CMYA2)

Explore 10 diseases affiliated with
PDE4DIP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphodiesterase 4D Interacting Protein¹ ²		Cardiomyopathy-Associated Protein 2² ³
CMYA2¹ ² ³		Phosphodiesterase 4D-Interacting Protein² ³
MMGL¹ ² ³		Cardiomyopathy Associated 2¹
KIAA0454¹ ³		Myomegalin¹
KIAA0477¹ ³

External Ids:	HGNC: 15580¹	Entrez Gene: 9659²	Ensembl: ENSG00000178104⁷	OMIM: 608117⁵	UniProtKB: Q5VU43³

Export aliases for PDE4DIP gene to outside databases

Previous GC identifers: GC01P144477 GC01M141455 GC01M142582 GC01M142604 GC01M142606 GC01M142189 GC01M143563 GC01M144833 GC01M119142

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE4DIP:

The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell.

Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Function: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes

(By similarity)

Gene Wiki entry for PDE4DIP (Myomegalin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167185.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDE4DIP gene promoter:
SRF Max1 NF-1 NF-1/L Bach2 SRF (504 AA) SREBP-1b C/EBPalpha AREB6 Zic1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): PDE4DIP promoter sequence

Search SABiosciences Chromatin IP Primers for PDE4DIP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE4DIP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q12 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

PDE4DIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE4DIP gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M144836: view genomic region (about GC identifiers)

Start:	144,836,157 bp from pter	End:	145,076,186 bp from pter
Size:	240,030 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43 (See protein sequence)

Recommended Name: Myomegalin

Size: 2346 amino acids; 265080 Da

Subunit: Interacts with PDE4D (By similarity)

Subcellular location: Golgi apparatus (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm.

Nucleus

Developmental stage: Expressed in fetal heart

Sequence caution: Sequence=AAH04860.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=BAA32299.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAA32322.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD91152.1;

Type=Frameshift; Positions=1507; Sequence=CAH18128.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

Secondary accessions: A2RU15 O75042 O75065 Q2YDC1 Q5VU42 Q5VU44 Q5VU45 Q5VU46 Q5VU47 Q5VU48 Q5VU49

Q68DU2 Q6AZ93 Q6PK88 Q86T40 Q86TB2 Q8N3W0 Q8TAY9 Q9HCP2 Q9HCP3 Q9HCP4 Q9HCP5

Alternative splicing: 11 isoforms: Q5VU43-1 Q5VU43-2 Q5VU43-3 Q5VU43-4 Q5VU43-6 Q5VU43-7 Q5VU43-8 Q5VU43-9

Q5VU43-10 Q5VU43-11 Q5VU43-12 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDE4DIP: NX_Q5VU43

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5VU43

PDE4DIP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (9 alternative transcripts):

NP_001002810.1 NP_001002811.1 NP_001002812.1 NP_001182189.1 NP_001182190.1 NP_001185761.1 NP_001185763.2 NP_055459.4

NP_071754.3

ENSEMBL proteins:

ENSP00000327209 ENSP00000358360 ENSP00000358363 ENSP00000435654 ENSP00000358366

ENSP00000436694 ENSP00000432498 ENSP00000431450 ENSP00000431596 ENSP00000358357

ENSP00000358355 ENSP00000316434 ENSP00000433392 ENSP00000436791 ENSP00000436751

ENSP00000431138 ENSP00000435920 ENSP00000358353 ENSP00000358354 ENSP00000431777

ENSP00000435483 ENSP00000437202 ENSP00000433819 ENSP00000435616 ENSP00000432251

ENSP00000435743 ENSP00000432562 ENSP00000432732 ENSP00000358351

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): PDE4DIP OriGene Custom Protein Services for PDE4DIP
	GenScript Custom Purified and Recombinant Proteins Services for PDE4DIP
	Novus Biologicals PDE4DIP Protein Novus Biologicals PDE4DIP Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PDE4DIP

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11374908
GO:0005737	cytoplasm	IDA	11374908
GO:0005794	Golgi apparatus	ISS	11134006
GO:0005813	centrosome	ISS	11134006
GO:0030016	myofibril	ISS	11134006

PDE4DIP for ontologies About GeneDecksing

PDE4DIP Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for PDE4DIP
	GenScript Custom Superior Antibodies Services for PDE4DIP
	Novus Biologicals PDE4DIP Antibodies
	Search for Antibodies for PDE4DIP at Abcam
	Uscn Antibodies for PDE4DIP
	Search ThermoFisher Antibodies for PDE4DIP

Assay Products for PDE4DIP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PDE4DIP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PDE4DIP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDE4DIP for domains About GeneDecksing

2 InterPro domains/families:

IPR010630 NBPF_dom

IPR012943 Spindle_assoc

Graphical View of Domain Structure for InterPro Entry Q5VU43

ProtoNet protein and cluster: Q5VU43

2 Blocks protein families:

IPB001854 Ribosomal protein L29

IPB012943 Spindle associated

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Similarity: Contains 1 NBPF domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Function: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes

(By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 5): PDE4DIP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE4DIP
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE4DIP (see all 18):
		hsa-miR-345 hsa-miR-148b* hsa-miR-362-3p hsa-miR-513c hsa-miR-371-5p hsa-miR-218 hsa-miR-339-5p hsa-miR-373*

		SwitchGear 3'UTR luciferase reporter plasmids (see all 3): PDE4DIP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE4DIP (see all 6) OriGene siRNA: PDE4DIP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE4DIP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PDE4DIP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4DIP (see all 14) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4DIP (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): PDE4DIP (NM_001195260)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE4DIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4DIP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PDE4DIP
		Search LifeMap BioReagents cell lines for PDE4DIP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4DIP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17923693
GO:0019899	enzyme binding	ISS	11134006

PDE4DIP for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PDE4DIP:

Synthetic lethal with Ras

Synthetic lethal with imatinib

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PDE4DIP

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/32 Interacting proteins for PDE4DIP (Q5VU43^{2, 3} ENSP00000358360⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GFI1B	Q5VTD9²^,³, ENSP00000344782⁴	MINT-2867137 I2D: score=2 STRING: ENSP00000344782
NEK2	P51955²^,³, ENSP00000355966⁴	MINT-8263731 I2D: score=2 STRING: ENSP00000355966
SMN1	Q16637²^,³	MINT-8271377 I2D: score=2
SMN2	Q16637²^,³	MINT-8271377 I2D: score=2
CDKN1A	P38936²^,³	MINT-8252105 I2D: score=2

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0043623	cellular protein complex assembly	ISS	11134006

PDE4DIP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PDE4DIP

1 HMDB Compound for PDE4DIP About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--

Search CenterWatch for drugs/clinical trials and news about PDE4DIP / MYOME

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PDE4DIP gene (9 alternative transcripts):

NM_001002810.3 NM_001002811.1 NM_001002812.1 NM_001195260.1 NM_001195261.1 NM_001198832.1 NM_001198834.2 NM_014644.4

NM_022359.5

Unigene Clusters for PDE4DIP:

Phosphodiesterase 4D interacting protein

Hs.584841 [show with all ESTs], Hs.613082 [show with all ESTs], Hs.657490 [show with all ESTs], Hs.731111 [show with all ESTs]

Unigene Representative Sequences: AL080213, AB042555, AK124487, NM_014644

18/63 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 63):

ENST00000469668 ENST00000531417 ENST00000528060 ENST00000525630 ENST00000460027

ENST00000524688 ENST00000313382(uc001eln.4 uc001elx.4) ENST00000524974(uc001elv.4)

ENST00000369354 ENST00000369356(uc001elk.2 uc001elw.4 uc021ouh.1)

ENST00000530740 ENST00000369359 ENST00000464924 ENST00000530062 ENST00000526182

ENST00000533768 ENST00000534367 ENST00000530130

miRNA Products:		OriGene 3'-UTR Clone (see all 5): PDE4DIP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE4DIP
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE4DIP (see all 18):
		hsa-miR-345 hsa-miR-148b* hsa-miR-362-3p hsa-miR-513c hsa-miR-371-5p hsa-miR-218 hsa-miR-339-5p hsa-miR-373*

		SwitchGear 3'UTR luciferase reporter plasmids (see all 3): PDE4DIP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE4DIP (see all 6) OriGene siRNA: PDE4DIP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE4DIP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4DIP (see all 14) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4DIP (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): PDE4DIP (NM_001195260)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE4DIP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4DIP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDE4DIP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PDE4DIP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE4DIP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE4DIP

Additional cDNA sequence:

AB007923.2 AB007946.1 AB042557.1 AF086451.1 AK000835.1 AK001619.1 AK021585.1 AK024906.1

AL831815.2 AL832024.2 AL832085.1 AL833273.1 BC004860.2 BC025406.1 BC078660.1 BC132717.1

BC152439.1 BX647660.1 CR749273.1 XR_159152.1 XR_171192.1

24/79 DOTS entries (see all 79):

DT.100880361 DT.452896 DT.448155 DT.91665329 DT.91983083 DT.97818813 DT.99950187 DT.100880359

DT.95159277 DT.100030547 DT.97819830 DT.100880366 DT.100030544 DT.100009110 DT.101971490 DT.101973646

DT.121435992 DT.121460398 DT.100030545 DT.100880360 DT.107988 DT.91781552 DT.95159276 DT.121435399

24/400 AceView cDNA sequences (see all 400):

BQ674922 AI821140 CD107052 AB007923 BG109671 AA434604 CA418528 BQ719934

BC078660 BG624068 CB143956 BI754116 NM_014644 AA489265 CR612016 AA603761

Z40798 CR593177 CB115636 AI123091 CB155787 BQ948265 BM468062 CF552528

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4DIP (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^
SP1:													-				-		-		-		-										-		-				-
SP2:																																	-		-				-
SP3:																																	-		-				-
SP4:																																	-		-				-
SP5:																																	-		-				-

ExUns:	19	^	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33a	·	33b	·	33c	^	34	^	35a	·	35b	^	36	^	37	^	38	^
SP1:																									-		-		-		-				-		-		-						-
SP2:																									-		-		-		-				-		-		-
SP3:																									-		-		-		-				-		-		-
SP4:																									-		-		-		-
SP5:																									-		-		-		-

ExUns:	39	^	40	^	41	^	42	^	43	^	44	^	45	^	46	^	47a	·	47b	^	48	^	49a	·	49b	^	50a	·	50b	^	51	^	52	^	53	^	54	^	55a	·	55b
SP1:									-										-				-
SP2:																			-				-																-
SP3:																			-				-
SP4:
SP5:

ECgene alternative splicing isoforms for PDE4DIP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PDE4DIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAGTGG

About this image

PDE4DIP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Zeugopod Epiphyseal End

Chondrocytes

Bone, Cartilage

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

See PDE4DIP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDE4DIP

SOURCE GeneReport for Unigene clusters: Hs.584841 Hs.613082 Hs.657490 Hs.731111

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Tissue specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta

SABiosciences Custom PCR Arrays for PDE4DIP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDE4DIP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat PDE4DIP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE4DIP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE4DIP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4DIP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDE4DIP gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC425735¹	myomegalin-like	59.1(n) 51.84(a)		425735 XM_423459.3 XP_423459.3
lizard (Anolis carolinensis)	Reptilia	PDE4DIP⁶	--	46(a)	1 ↔ 1	4(73629942-73738594)
zebrafish (Danio rerio)	Actinopterygii	LOC100534920¹	myomegalin-like	49.97(n) 39.5(a)		100534920 XM_003200729.1 XP_003200777.1
worm (Caenorhabditis elegans)	Secernentea	tag-241⁶	--	8(a)	possible ortholog	X(11826025-11836077)
rice (Oryza sativa)	Liliopsida	--	nuclear-pore anchor, putative, expressed	9(a)	possible ortholog	2(31003292-31017324)

ENSEMBL Gene Tree for PDE4DIP (if available)
TreeFam Gene Tree for PDE4DIP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PDE4DIP gene

CDK5RAP2²

4 SIMAP similar genes for PDE4DIP using alignment to 26 protein entries: MYOME_HUMAN (see all proteins):

PFN1 CDK5RAP2 PFN2 DKFZp686M1993

PDE4DIP for paralogs About GeneDecksing

5/22 Pseudogenes.org Pseudogenes for PDE4DIP (see all 22)
PGOHUM00000243915 PGOHUM00000243918 PGOHUM00000243927 PGOHUM00000244171 PGOHUM00000251076

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201246900^1,2	C	other	145015987(+)	`GGCCTC/TGATCT`	9	Q R	mis¹ int¹		0	--	--	--	--
rs76199660^1,2	C,F	other	145075775(+)	`GTAAGA/G/TCGTGT`	7	T P S	mis¹ int¹		2		NA EU	5067
rs937705^1,2	C,F	--	144850978(-)	`ATTTTG/AAAATA`	3	--	ds500¹ int¹		3		NA CSA	10
rs66517132^1,2	C,	--	144851072(+)	`ACACT-/GTTTTT`	3	--	int¹ ds500¹		0	--	--	--	--
rs201783427^1,2		--	144851072(+)	`CACTG-/TTTTTT`	3	--	ds500¹ int¹		0	--	--	--	--
rs11421548^1,2	C	--	144851073(+)	`TTTTT-/TAAACT`	3	--	ds500¹ int¹		0	--	--	--	--
rs600646^1,2	F,A,H,	--	144851114(-)	`CCCAGG/ATGATT`	3	--	int¹ ds500¹		4		NS EA CSA	297
rs149229002^1,2		--	144851174(+)	`TCCTGC/GGATTG`	3	--	int¹ ds500¹		0	--	--	--	--
rs200189293^1,2		--	144851188(+)	`CCAGG-/AGGT AGGTA`	3	--	ds500¹ int¹		0	--	--	--	--
rs1698588^1,2	C	--	144851316(-)	`GAACTC/GTAACT`	3	--	ds500¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PDE4DIP (144836157 - 145076186 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 38 variations for PDE4DIP
15/27 CNVs (see all 27): 6780 34695 31652 39008 0685 69888 0387 34696 58332 23199 60883 3310 97496 2324 69883
11 Indels: 59955 44445 97497 59954 63036 60884 59956 44443 39655 44444 39654

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDE4DIP

DNA2.0 Custom Variant and Variant Library Synthesis for PDE4DIP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PDE4DIP for disorders About GeneDecksing

OMIM gene information: 608117 OMIM disorders: --

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD)

associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein

10 diseases for PDE4DIP: About MalaCards

myeloproliferative disorder eosinophilia cardiomyopathy esophageal squamous cell carcinoma

squamous cell carcinoma usher syndrome esophagitis ataxia

carcinoma schizophrenia

Human Genome Epidemiology (HuGE) Navigator: PDE4DIP (1 document)

Export disorders for PDE4DIP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PDE4DIP gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with PDE4DIP)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2, 3} Seki N.... Ohara O. (1997)
Isolation of novel heart-specific genes using the BodyMap database. (PubMed id 11374908)^{1, 2, 9} Soejima H.... Mukai T. (2001)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. (PubMed id 11134006)^{1, 3} Verde I....Conti M. (2001)
Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. (PubMed id 17143517)^{1, 9} Shimada H....Hiwasa T. (2007)
Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. (PubMed id 17923693)^{1, 9} Faul C....Mundel P. (2007)
Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. (PubMed id 12907457)^{2, 9} Wilkinson K.... Aguiar R.C.T. (2003)
Identification of novel germline polymorphisms governi ng capecitabine sensitivity. (PubMed id 22864933)¹ O'Donnell P.H....Dolan M.E. (2012)
Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)¹ Wong K.A....O'Bryan J.P. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9659	HGNC: 15580	AceView: PDE4DIP	Ensembl:ENSG00000178104	euGenes: HUgn9659
ECgene: PDE4DIP	H-InvDB: PDE4DIP

(According to HUGE)
About This Section

HUGE: KIAA0477 KIAA0454

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PDE4DIP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PDE4DIP	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PDE4DIP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PDE4DIP gene:
Search GeneIP for patents involving PDE4DIP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE4DIP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDE4DIP
	OriGene Protein Over-expression Lysate for PDE4DIP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for PDE4DIP		OriGene 3'-UTR Clone for PDE4DIP
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4DIP		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4DIP
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for PDE4DIP		OriGene Custom Protein Services for PDE4DIP
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDE4DIP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDE4DIP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE4DIP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE4DIP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE4DIP
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE4DIP

	GenScript Custom Purified and Recombinant Proteins Services for PDE4DIP		GenScript cDNA clones with any tag delivered in your preferred vector for PDE4DIP
	GenScript Custom Assay Services for PDE4DIP		GenScript Custom Superior Antibodies Services for PDE4DIP
	GenScript Custom overexpressing Cell Line Services for PDE4DIP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in PDE4DIP promoter
	Search Chromatin IP Primers for PDE4DIP
	RT² qPCR Primer Assay in human, mouse, rat PDE4DIP
	GNC Network for PDE4DIP
	SABiosciences Custom PCR Arrays for PDE4DIP

Search Tocris compounds for PDE4DIP

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	PDE4DIP antibodies
	PDE4DIP proteins
	PDE4DIP lysates

	Search for Antibodies for PDE4DIP at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for PDE4DIP
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

PDE4DIP Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for PDE4DIP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4DIP

	SwitchGear 3'UTR luciferase reporter plasmids for PDE4DIP
	SwitchGear Promoter luciferase reporter plasmids for PDE4DIP

Search ThermoFisher Antibodies for PDE4DIP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4DIP

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PDE4DIP gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

PDE4DIP Gene

phosphodiesterase 4D interacting protein

Aliases
for PDE4DIP gene

Summaries
for PDE4DIP gene

Genomic Views
for PDE4DIP gene

Proteins
for PDE4DIP gene

Protein Domains /
Families
for PDE4DIP gene

Function
for PDE4DIP gene

Pathways & Interactions
for PDE4DIP gene

Drugs & Compounds
for PDE4DIP gene

Transcripts
for PDE4DIP gene

Expression
for PDE4DIP gene

Orthologs
for PDE4DIP gene

Paralogs
for PDE4DIP gene

Genomic Variants
for PDE4DIP gene

Disorders / Diseases
for PDE4DIP gene

Publications
for PDE4DIP gene

External Searches for PDE4DIP gene

Genome Databases showing PDE4DIP gene

Other Databases showing PDE4DIP gene

Specialized Databases showing PDE4DIP gene

Intellectual Property
for PDE4DIP gene

Products
for PDE4DIP gene

View Random Gene

Advanced Search

Export list of displayed genes

PDE4DIP Gene

phosphodiesterase 4D interacting protein

Aliasesfor PDE4DIP gene

Summariesfor PDE4DIP gene

Genomic Viewsfor PDE4DIP gene

Proteinsfor PDE4DIP gene

Protein Domains /Familiesfor PDE4DIP gene

Functionfor PDE4DIP gene

Pathways & Interactionsfor PDE4DIP gene

Drugs & Compoundsfor PDE4DIP gene

Transcriptsfor PDE4DIP gene

Expression for PDE4DIP gene

Orthologsfor PDE4DIP gene

Paralogsfor PDE4DIP gene

Genomic Variantsfor PDE4DIP gene

Disorders / Diseasesfor PDE4DIP gene

Publicationsfor PDE4DIP gene

External Searches for PDE4DIP gene

Genome Databases showing PDE4DIP gene

Other Databases showing PDE4DIP gene

Specialized Databases showing PDE4DIP gene

Intellectual Propertyfor PDE4DIP gene

Productsfor PDE4DIP gene

View Random Gene

Aliases
for PDE4DIP gene

Summaries
for PDE4DIP gene

Genomic Views
for PDE4DIP gene

Proteins
for PDE4DIP gene

Protein Domains /
Families
for PDE4DIP gene

Function
for PDE4DIP gene

Pathways & Interactions
for PDE4DIP gene

Drugs & Compounds
for PDE4DIP gene

Transcripts
for PDE4DIP gene

Expression
for PDE4DIP gene

Orthologs
for PDE4DIP gene

Paralogs
for PDE4DIP gene

Genomic Variants
for PDE4DIP gene

Disorders / Diseases
for PDE4DIP gene

Publications
for PDE4DIP gene

Intellectual Property
for PDE4DIP gene

Products
for PDE4DIP gene