Aliases for PDE4D Gene
- Phosphodiesterase 4D, CAMP-Specific 2 3
- DPDE3 3 4 6
- ACRDYS2 3 6
- STRK1 3 6
- PDE43 3 4
- Phosphodiesterase 4D, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E3) 2
- Phosphodiesterase 4D, CAMP-Specific (Phosphodiesterase E3 Dunce Homolog, Drosophila) 3
- Phosphodiesterase E3 Dunce Homolog (Drosophila) 2
External Ids for PDE4D Gene
Previous HGNC Symbols for PDE4D Gene
Previous GeneCards Identifiers for PDE4D Gene
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
GeneCards Summary for PDE4D Gene
PDE4D (Phosphodiesterase 4D, CAMP-Specific) is a Protein Coding gene. Diseases associated with PDE4D include acrodysostosis 2, with or without hormone resistance and acrodysostosis with multiple hormone resistance. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include enzyme binding and ion channel binding. An important paralog of this gene is PDE7A.
UniProtKB/Swiss-Prot for PDE4D Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.