Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDE4C Gene

Aliases for PDE4C Gene

  • Phosphodiesterase 4C, CAMP-Specific 2 3
  • DPDE1 3 4 6
  • PDE21 3 4
  • Phosphodiesterase 4C, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E1) 2
  • Phosphodiesterase 4C, CAMP-Specific (Phosphodiesterase E1 Dunce Homolog, Drosophila) 3
  • Phosphodiesterase E1 Dunce Homolog (Drosophila) 2
  • CAMP-Specific 3,5-Cyclic Phosphodiesterase 4C 3
  • Phosphodiesterase E1 Dunce Homolog 3
  • EC 3.1.4.17 64
  • EC 3.1.4.53 4
  • EC 3.1.4 64

External Ids for PDE4C Gene

Previous Symbols for PDE4C Gene

  • DPDE1

Summaries for PDE4C Gene

Entrez Gene Summary for PDE4C Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE4C Gene

PDE4C (Phosphodiesterase 4C, CAMP-Specific) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE4C Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Tocris Summary for PDE4C Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3 cyclic phosphate bonds in adenosine and/or guanine 3,5 cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE4C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4C Gene

Genomics for PDE4C Gene

Genomic Location for PDE4C Gene

Start:
18,207,961 bp from pter
End:
18,255,419 bp from pter
Size:
47,459 bases
Orientation:
Minus strand

Genomic View for PDE4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4C Gene

Regulatory Elements for PDE4C Gene

Proteins for PDE4C Gene

  • Protein details for PDE4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08493-PDE4C_HUMAN
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 4C
    Protein Accession:
    Q08493
    Secondary Accessions:
    • B3KTC4
    • Q9UN44
    • Q9UN45
    • Q9UN46
    • Q9UPJ6

    Protein attributes for PDE4C Gene

    Size:
    712 amino acids
    Molecular mass:
    79902 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

    Three dimensional structures from OCA and Proteopedia for PDE4C Gene

    Alternative splice isoforms for PDE4C Gene

neXtProt entry for PDE4C Gene

Proteomics data for PDE4C Gene at MOPED

Post-translational modifications for PDE4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PDE4C Gene

Gene Families for PDE4C Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Protein Domains for PDE4C Gene

UniProtKB/Swiss-Prot:

PDE4C_HUMAN
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.:
    • Q08493
genes like me logo Genes that share domains with PDE4C: view

Function for PDE4C Gene

Molecular function for PDE4C Gene

GENATLAS Biochemistry: cAMP specific nucleotide phosphodiesterase class IV,C,with homology to Drosophila dunce gene,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity: Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by rolipram
UniProtKB/Swiss-Prot Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Enzyme Numbers (IUBMB) for PDE4C Gene

Gene Ontology (GO) - Molecular Function for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS 9349724
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE4C: view
genes like me logo Genes that share phenotypes with PDE4C: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PDE4C Gene

Localization for PDE4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE4C Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE4C Gene COMPARTMENTS Subcellular localization image for PDE4C gene
Compartment Confidence
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005829 cytosol TAS --
GO:0072372 primary cilium ISS --
genes like me logo Genes that share ontologies with PDE4C: view

Pathways for PDE4C Gene

genes like me logo Genes that share pathways with PDE4C: view

Pathways by source for PDE4C Gene

1 PharmGKB pathway for PDE4C Gene
2 KEGG pathways for PDE4C Gene

UniProtKB/Swiss-Prot Q08493-PDE4C_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1

Gene Ontology (GO) - Biological Process for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with PDE4C: view

Compounds for PDE4C Gene

(5) Tocris Compounds for PDE4C Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(5) HMDB Compounds for PDE4C Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Water
  • Dihydrogen oxide
7732-18-5

(6) Drugbank Compounds for PDE4C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Dyphylline
  • Dihydroxypropyl Theophylline
479-18-5 target inhibitor
Ibudilast
  • 2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine
50847-11-5 target inhibitor
Iloprost
78919-13-8 target inducer
Ketotifen
  • Ketotifen Fumarate
34580-14-8 target inhibitor
Piclamilast
144035-83-6 target

(2) IUPHAR Ligand for PDE4C Gene

Ligand Type Action Affinity Pubmed IDs
rolipram Inhibitor Inhibition 7.2
Ro201724 Inhibitor Inhibition 6.2

(2) Novoseek inferred chemical compound relationships for PDE4C Gene

Compound -log(P) Hits PubMed IDs
rolipram 85.6 1
forskolin 52.9 2
genes like me logo Genes that share compounds with PDE4C: view

Transcripts for PDE4C Gene

Unigene Clusters for PDE4C Gene

Phosphodiesterase 4C, cAMP-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7:
SP8: -
SP9:
SP10: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE4C Gene

GeneLoc Exon Structure for
PDE4C
ECgene alternative splicing isoforms for
PDE4C

Expression for PDE4C Gene

mRNA expression in normal human tissues for PDE4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PDE4C Gene

SOURCE GeneReport for Unigene cluster for PDE4C Gene Hs.132584

mRNA Expression by UniProt/SwissProt for PDE4C Gene

Q08493-PDE4C_HUMAN
Tissue specificity: Expressed in various tissues but not in cells of the immune system
genes like me logo Genes that share expressions with PDE4C: view

Orthologs for PDE4C Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE4C 37
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE4C 36
  • 86.04 (n)
  • 88.01 (a)
PDE4C 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE4C 36
  • 87.21 (n)
  • 89.65 (a)
PDE4C 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde4c 36
  • 80.66 (n)
  • 81.9 (a)
Pde4c 16
Pde4c 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE4C 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pde4c 36
  • 81.29 (n)
  • 83.68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3555 36
zebrafish
(Danio rerio)
Actinopterygii pde4ca 37
  • 62 (a)
OneToMany
pde4cb 37
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dnc 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea R153.1a 38
  • 55 (a)
R153.1b 38
  • 53 (a)
Species with no ortholog for PDE4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PDE4C Gene

ENSEMBL:
Gene Tree for PDE4C (if available)
TreeFam:
Gene Tree for PDE4C (if available)

Paralogs for PDE4C Gene

Paralogs for PDE4C Gene

genes like me logo Genes that share paralogs with PDE4C: view

Variants for PDE4C Gene

Sequence variations from dbSNP and Humsavar for PDE4C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs169237 -- 18,237,060(+) AGAAC(C/T)ACTGG intron-variant
rs172043 -- 18,240,864(+) ATGCA(A/G)CATAG intron-variant
rs271828 -- 18,231,667(+) CAAGG(A/C)CACTC intron-variant
rs271829 -- 18,235,008(+) TTTTT(A/T)AAATA intron-variant
rs271830 -- 18,235,393(+) ctcga(A/T)ctcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE4C Gene

Variant ID Type Subtype PubMed ID
dgv3773n71 CNV Loss 21882294
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv911256 CNV Loss 21882294
nsv911260 CNV Loss 21882294
nsv911263 CNV Gain 21882294
nsv911264 CNV Loss 21882294
nsv470131 CNV Loss 18288195
dgv3778n71 CNV Loss 21882294
dgv3779n71 CNV Loss 21882294
dgv3780n71 CNV Loss 21882294

Relevant External Links for PDE4C Gene

HapMap Linkage Disequilibrium report
PDE4C
Human Gene Mutation Database (HGMD)
PDE4C

Disorders for PDE4C Gene

Relevant External Links for PDE4C

Genetic Association Database (GAD)
PDE4C
Human Genome Epidemiology (HuGE) Navigator
PDE4C
genes like me logo Genes that share disorders with PDE4C: view

No data available for UniProtKB/Swiss-Prot for PDE4C Gene

Publications for PDE4C Gene

  1. Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain. (PMID: 11207431) PAcrez-Torres S. … Mengod G. (J. Chem. Neuroanat. 2000) 3 23
  2. Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. (PMID: 8009369) Milatovich A. … Francke U. (Somat. Cell Mol. Genet. 1994) 3 23
  3. Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis. (PMID: 9349724) Obernolte R. … Shelton E.R. (Biochim. Biophys. Acta 1997) 3 23
  4. Molecular cloning and functional expression in yeast of a human cAMP- specific phosphodiesterase subtype (PDE IV-C). (PMID: 7843419) Engels P. … Luebbert H. (FEBS Lett. 1995) 3 4
  5. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. (PMID: 8413254) Bolger G. … Ferguson K. (Mol. Cell. Biol. 1993) 3 4

Products for PDE4C Gene

Sources for PDE4C Gene

Back to Top

Content