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Aliases for PDE4C Gene

Aliases for PDE4C Gene

  • Phosphodiesterase 4C 2 3 5
  • DPDE1 3 4
  • PDE21 3 4
  • Phosphodiesterase 4C, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E1) 2
  • Phosphodiesterase 4C, CAMP-Specific (Phosphodiesterase E1 Dunce Homolog, Drosophila) 3
  • Phosphodiesterase E1 Dunce Homolog (Drosophila) 2
  • Phosphodiesterase 4C, CAMP-Specific 2
  • Phosphodiesterase E1 Dunce Homolog 3
  • EC 63
  • EC 4
  • EC 3.1.4 63

External Ids for PDE4C Gene

Previous HGNC Symbols for PDE4C Gene

  • DPDE1

Previous GeneCards Identifiers for PDE4C Gene

  • GC19M018814
  • GC19M018678
  • GC19M018165
  • GC19M018318
  • GC19M017882

Summaries for PDE4C Gene

Entrez Gene Summary for PDE4C Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE4C Gene

PDE4C (Phosphodiesterase 4C) is a Protein Coding gene. Diseases associated with PDE4C include Ocular Hypotension. Among its related pathways are cAMP signaling pathway and DAG and IP3 signaling. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE4C Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Tocris Summary for PDE4C Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE4C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4C Gene

Genomics for PDE4C Gene

Regulatory Elements for PDE4C Gene

Enhancers for PDE4C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDE4C on UCSC Golden Path with GeneCards custom track

Genomic Location for PDE4C Gene

18,207,961 bp from pter
18,255,419 bp from pter
47,459 bases
Minus strand

Genomic View for PDE4C Gene

Genes around PDE4C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE4C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4C Gene

Proteins for PDE4C Gene

  • Protein details for PDE4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 4C
    Protein Accession:
    Secondary Accessions:
    • B3KTC4
    • Q9UN44
    • Q9UN45
    • Q9UN46
    • Q9UPJ6

    Protein attributes for PDE4C Gene

    712 amino acids
    Molecular mass:
    79902 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

    Three dimensional structures from OCA and Proteopedia for PDE4C Gene

    Alternative splice isoforms for PDE4C Gene

neXtProt entry for PDE4C Gene

Proteomics data for PDE4C Gene at MOPED

Post-translational modifications for PDE4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PDE4C Gene

Gene Families for PDE4C Gene

Protein Domains for PDE4C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4C: view

Function for PDE4C Gene

Molecular function for PDE4C Gene

GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,C,with homology to Drosophila dunce gene,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Enzyme Numbers (IUBMB) for PDE4C Gene

Gene Ontology (GO) - Molecular Function for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with PDE4C: view
genes like me logo Genes that share phenotypes with PDE4C: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE4C

miRNA for PDE4C Gene

miRTarBase miRNAs that target PDE4C

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDE4C Gene

Localization for PDE4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE4C Gene

Cell projection, cilium.

Subcellular locations from

Jensen Localization Image for PDE4C Gene COMPARTMENTS Subcellular localization image for PDE4C gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for PDE4C Gene

Pathways & Interactions for PDE4C Gene

genes like me logo Genes that share pathways with PDE4C: view

Pathways by source for PDE4C Gene

UniProtKB/Swiss-Prot Q08493-PDE4C_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.

SIGNOR curated interactions for PDE4C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PDE4C: view

Drugs & Compounds for PDE4C Gene

(21) Drugs for PDE4C Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dyphylline Approved Pharma inhibitor, Target 0
Ibudilast Approved, Investigational Pharma inhibitor, Target 11
Iloprost Approved, Investigational Pharma Full agonist, Agonist, Target, inducer Others, Prostacyclin (PGI2) analog 77
Ketotifen Approved Pharma Target, inhibitor 21
Roflumilast Approved Pharma Target, inhibitor PDE-4 inhibitor 0

(6) Additional Compounds for PDE4C Gene - From: HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inhibition, Inhibitor
  • Dihydrogen oxide
  • Steam
Etazolate hydrochloride

(5) Tocris Compounds for PDE4C Gene

Compound Action Cas Number
Dipyridamole Adenosine transport inhibitor 58-32-2
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
MMPX PDE1 inhibitor 78033-08-6
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5

(3) ApexBio Compounds for PDE4C Gene

Compound Action Cas Number
Apremilast (CC-10004) PDE4 inhibitor 608141-41-9
Cilomilast Potent PDE4 inhibitor 153259-65-5
Doxofylline 69975-86-6
genes like me logo Genes that share compounds with PDE4C: view

Transcripts for PDE4C Gene

Unigene Clusters for PDE4C Gene

Phosphodiesterase 4C, cAMP-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP8: -
SP10: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23

Relevant External Links for PDE4C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDE4C Gene

mRNA expression in normal human tissues for PDE4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDE4C Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDE4C Gene

SOURCE GeneReport for Unigene cluster for PDE4C Gene Hs.132584

mRNA Expression by UniProt/SwissProt for PDE4C Gene

Tissue specificity: Expressed in various tissues but not in cells of the immune system.
genes like me logo Genes that share expression patterns with PDE4C: view

Protein tissue co-expression partners for PDE4C Gene

Primer Products

No data available for mRNA differential expression in normal tissues for PDE4C Gene

Orthologs for PDE4C Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PDE4C 35
  • 86.04 (n)
  • 88.01 (a)
PDE4C 36
  • 80 (a)
(Canis familiaris)
Mammalia PDE4C 35
  • 87.21 (n)
  • 89.65 (a)
PDE4C 36
  • 80 (a)
(Mus musculus)
Mammalia Pde4c 35
  • 80.66 (n)
  • 81.9 (a)
Pde4c 16
Pde4c 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Pde4c 35
  • 81.29 (n)
  • 83.68 (a)
(Monodelphis domestica)
Mammalia PDE4C 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
(Pan troglodytes)
Mammalia PDE4C 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3555 35
(Danio rerio)
Actinopterygii pde4ca 36
  • 62 (a)
pde4cb 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta dnc 37
  • 58 (a)
(Caenorhabditis elegans)
Secernentea R153.1a 37
  • 55 (a)
R153.1b 37
  • 53 (a)
Species with no ortholog for PDE4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PDE4C Gene

Gene Tree for PDE4C (if available)
Gene Tree for PDE4C (if available)

Paralogs for PDE4C Gene

Paralogs for PDE4C Gene

genes like me logo Genes that share paralogs with PDE4C: view

Variants for PDE4C Gene

Sequence variations from dbSNP and Humsavar for PDE4C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2229228 - 18,218,974(-) GAACC(A/G)GCCCC nc-transcript-variant, reference, missense
rs10413646 - 18,222,174(+) TGGGC(A/G)AGAGT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs34503849 - 18,219,334(+) TGATC(C/T)GGGAC nc-transcript-variant, reference, missense
rs11879710 - 18,218,975(+) GGGCC(A/G)GTTCC nc-transcript-variant, reference, missense
rs7259012 -- 18,210,463(+) AAGAC(A/G)GGGAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PDE4C Gene

Variant ID Type Subtype PubMed ID
dgv3773n71 CNV Loss 21882294
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv911256 CNV Loss 21882294
nsv911260 CNV Loss 21882294
nsv911263 CNV Gain 21882294
nsv911264 CNV Loss 21882294
nsv470131 CNV Loss 18288195
dgv3778n71 CNV Loss 21882294
dgv3779n71 CNV Loss 21882294
dgv3780n71 CNV Loss 21882294

Variation tolerance for PDE4C Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE4C Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4C Gene

Disorders for PDE4C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE4C Gene - From: GeneCards

Disorder Aliases PubMed IDs
ocular hypotension
  • hypotony of eye
- elite association - COSMIC cancer census association via MalaCards
Search PDE4C in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE4C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PDE4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4C Gene

Publications for PDE4C Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Preferential inhibition of human phosphodiesterase 4 by ibudilast. (PMID: 16313925) Huang Z. … Noguchi K. (Life Sci. 2006) 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Zardaverine and aerosolised iloprost in a model of acute respiratory failure. (PMID: 12952271) Schermuly R.T. … Walmrath D. (Eur. Respir. J. 2003) 25 26

Products for PDE4C Gene

Sources for PDE4C Gene