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Aliases for PDE4C Gene

Aliases for PDE4C Gene

  • Phosphodiesterase 4C, CAMP-Specific 2 3
  • DPDE1 3 4
  • PDE21 3 4
  • Phosphodiesterase 4C, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E1) 2
  • Phosphodiesterase 4C, CAMP-Specific (Phosphodiesterase E1 Dunce Homolog, Drosophila) 3
  • Phosphodiesterase E1 Dunce Homolog (Drosophila) 2
  • Phosphodiesterase E1 Dunce Homolog 3
  • EC 3.1.4.17 63
  • EC 3.1.4.53 4
  • EC 3.1.4 63

External Ids for PDE4C Gene

Previous HGNC Symbols for PDE4C Gene

  • DPDE1

Previous GeneCards Identifiers for PDE4C Gene

  • GC19M018814
  • GC19M018678
  • GC19M018165
  • GC19M018318
  • GC19M017882

Summaries for PDE4C Gene

Entrez Gene Summary for PDE4C Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE4C Gene

PDE4C (Phosphodiesterase 4C, CAMP-Specific) is a Protein Coding gene. Diseases associated with PDE4C include ocular hypotension. Among its related pathways are Signaling by GPCR and G Protein Signaling Pathways. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE4C Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Tocris Summary for PDE4C Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE4C Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4C Gene

Genomics for PDE4C Gene

Regulatory Elements for PDE4C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDE4C Gene

Chromosome:
19
Start:
18,207,961 bp from pter
End:
18,255,419 bp from pter
Size:
47,459 bases
Orientation:
Minus strand

Genomic View for PDE4C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE4C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4C Gene

Proteins for PDE4C Gene

  • Protein details for PDE4C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08493-PDE4C_HUMAN
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 4C
    Protein Accession:
    Q08493
    Secondary Accessions:
    • B3KTC4
    • Q9UN44
    • Q9UN45
    • Q9UN46
    • Q9UPJ6

    Protein attributes for PDE4C Gene

    Size:
    712 amino acids
    Molecular mass:
    79902 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.

    Three dimensional structures from OCA and Proteopedia for PDE4C Gene

    Alternative splice isoforms for PDE4C Gene

neXtProt entry for PDE4C Gene

Proteomics data for PDE4C Gene at MOPED

Post-translational modifications for PDE4C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for PDE4C Gene

Gene Families for PDE4C Gene

Protein Domains for PDE4C Gene

Graphical View of Domain Structure for InterPro Entry

Q08493

UniProtKB/Swiss-Prot:

PDE4C_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4C: view

Function for PDE4C Gene

Molecular function for PDE4C Gene

GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,C,with homology to Drosophila dunce gene,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Enzyme Numbers (IUBMB) for PDE4C Gene

Gene Ontology (GO) - Molecular Function for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008081 phosphoric diester hydrolase activity --
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with PDE4C: view
genes like me logo Genes that share phenotypes with PDE4C: view

Animal Model Products

miRNA for PDE4C Gene

miRTarBase miRNAs that target PDE4C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE4C

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PDE4C Gene

Localization for PDE4C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE4C Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE4C Gene COMPARTMENTS Subcellular localization image for PDE4C gene
Compartment Confidence
extracellular 5
cytosol 4

Gene Ontology (GO) - Cellular Components for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005829 cytosol TAS --
GO:0072372 primary cilium ISS --
genes like me logo Genes that share ontologies with PDE4C: view

Pathways & Interactions for PDE4C Gene

genes like me logo Genes that share pathways with PDE4C: view

Pathways by source for PDE4C Gene

UniProtKB/Swiss-Prot Q08493-PDE4C_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1

SIGNOR curated interactions for PDE4C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PDE4C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0008152 metabolic process --
GO:0046676 negative regulation of insulin secretion IEA --
genes like me logo Genes that share ontologies with PDE4C: view

Drugs & Compounds for PDE4C Gene

(22) Drugs for PDE4C Gene - From: HMDB, DrugBank, NovoSeek, ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dyphylline Approved Pharma inhibitor, Target 0
Ibudilast Approved, Investigational Pharma inhibitor, Target 10
Iloprost Approved, Investigational Pharma Full agonist, Agonist, Target, inducer Others, Prostacyclin (PGI2) analog 73
Ketotifen Approved Pharma Target, inhibitor 20
Roflumilast Approved Pharma Target, inhibitor PDE-4 inhibitor 0

(5) Additional Compounds for PDE4C Gene - From: HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ro201724
Inhibition, Inhibitor
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MY-5445
78351-75-4
Ro 20-1724
29925-17-5
genes like me logo Genes that share compounds with PDE4C: view

Transcripts for PDE4C Gene

Unigene Clusters for PDE4C Gene

Phosphodiesterase 4C, cAMP-specific:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE4C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - -
SP7:
SP8: -
SP9:
SP10: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE4C Gene

GeneLoc Exon Structure for
PDE4C
ECgene alternative splicing isoforms for
PDE4C

Expression for PDE4C Gene

mRNA expression in normal human tissues for PDE4C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDE4C Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDE4C Gene



SOURCE GeneReport for Unigene cluster for PDE4C Gene Hs.132584

mRNA Expression by UniProt/SwissProt for PDE4C Gene

Q08493-PDE4C_HUMAN
Tissue specificity: Expressed in various tissues but not in cells of the immune system
genes like me logo Genes that share expression patterns with PDE4C: view

Protein tissue co-expression partners for PDE4C Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PDE4C Gene

Orthologs for PDE4C Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE4C 35
  • 86.04 (n)
  • 88.01 (a)
PDE4C 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE4C 35
  • 87.21 (n)
  • 89.65 (a)
PDE4C 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde4c 35
  • 80.66 (n)
  • 81.9 (a)
Pde4c 16
Pde4c 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde4c 35
  • 81.29 (n)
  • 83.68 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE4C 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PDE4C 36
  • 87 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3555 35
zebrafish
(Danio rerio)
Actinopterygii pde4ca 36
  • 62 (a)
OneToMany
pde4cb 36
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dnc 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea R153.1a 37
  • 55 (a)
R153.1b 37
  • 53 (a)
Species with no ortholog for PDE4C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PDE4C Gene

ENSEMBL:
Gene Tree for PDE4C (if available)
TreeFam:
Gene Tree for PDE4C (if available)

Paralogs for PDE4C Gene

Paralogs for PDE4C Gene

genes like me logo Genes that share paralogs with PDE4C: view

Variants for PDE4C Gene

Sequence variations from dbSNP and Humsavar for PDE4C Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs169237 -- 18,237,060(+) AGAAC(C/T)ACTGG intron-variant
rs172043 -- 18,240,864(+) ATGCA(A/G)CATAG intron-variant
rs271828 -- 18,231,667(+) CAAGG(A/C)CACTC intron-variant
rs271829 -- 18,235,008(+) TTTTT(A/T)AAATA intron-variant, upstream-variant-2KB
rs271830 -- 18,235,393(+) ctcga(A/T)ctcct intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PDE4C Gene

Variant ID Type Subtype PubMed ID
dgv3773n71 CNV Loss 21882294
nsv833775 CNV Loss 17160897
dgv3774n71 CNV Loss 21882294
nsv911256 CNV Loss 21882294
nsv911260 CNV Loss 21882294
nsv911263 CNV Gain 21882294
nsv911264 CNV Loss 21882294
nsv470131 CNV Loss 18288195
dgv3778n71 CNV Loss 21882294
dgv3779n71 CNV Loss 21882294
dgv3780n71 CNV Loss 21882294

Variation tolerance for PDE4C Gene

Residual Variation Intolerance Score: 32.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.27; 85.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE4C Gene

HapMap Linkage Disequilibrium report
PDE4C
Human Gene Mutation Database (HGMD)
PDE4C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4C Gene

Disorders for PDE4C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE4C Gene - From: GeneCards

Disorder Aliases PubMed IDs
ocular hypotension
  • hypotony of eye, unspecified
- elite association
Search PDE4C in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE4C

Genetic Association Database (GAD)
PDE4C
Human Genome Epidemiology (HuGE) Navigator
PDE4C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE4C
genes like me logo Genes that share disorders with PDE4C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4C Gene

Publications for PDE4C Gene

  1. The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D. (PMID: 20347962) Mori F. … Mengod G. (J. Chem. Neuroanat. 2010) 23 67
  2. PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries. (PMID: 18234184) Santos-Silva A.J. … Verde I. (Eur. J. Pharmacol. 2008) 23 67
  3. [Functional expression of adenylyl cyclase and phosphodiesterase in ejaculated human spermatozoa]. (PMID: 16597029) Cai Z.M. … Yu J. (Zhonghua Nan Ke Xue 2006) 23 67
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26

Products for PDE4C Gene

Sources for PDE4C Gene

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