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PDE4C Gene

protein-coding   GIFtS: 66
GCID: GC19M018318

Phosphodiesterase 4C, CAMP-Specific

(Previous names: phosphodiesterase 4C, cAMP-specific (dunce (Drosophila)-homolog...)
(Previous symbol: DPDE1)
  Search for PDE4C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphodiesterase 4C, CAMP-Specific1 2     Phosphodiesterase 4C, CAMP-Specific (Phosphodiesterase E1 Dunce Homolog,
Drosophila)2
DPDE11 2 3 5     Phosphodiesterase E1 Dunce Homolog2
PDE212 3     EC 3.1.4.533
Phosphodiesterase 4C, CAMP-Specific (Dunce (Drosophila)-Homolog
Phosphodiesterase E1)1
     EC 3.1.48
Phosphodiesterase E1 Dunce Homolog (Drosophila)1     EC 3.1.4.178
CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4C2     

External Ids:    HGNC: 87821   Entrez Gene: 51432   Ensembl: ENSG000001056507   OMIM: 6001285   UniProtKB: Q084933   

Export aliases for PDE4C gene to outside databases

Previous GC identifers: GC19M018814 GC19M018678 GC19M018165 GC19M018181 GC19M017882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDE4C Gene:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4
subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of
cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein
plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene.(provided by RefSeq, Jul 2011)

GeneCards Summary for PDE4C Gene:
PDE4C (phosphodiesterase 4C, cAMP-specific) is a protein-coding gene. GO annotations related to this gene include 3',5'-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE4D.

UniProtKB/Swiss-Prot: PDE4C_HUMAN, Q08493
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes

summary for PDE4C Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE4C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDE4C gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE4C promoter sequence
   Search Chromatin IP Primers for PDE4C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE4C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

PDE4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE4C gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018318:  view genomic region     (about GC identifiers)

Start:
18,318,771 bp from pter      End:
18,366,229 bp from pter
Size:
47,459 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDE4C_HUMAN, Q08493 (See protein sequence)
Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C  
Size: 712 amino acids; 79902 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions
Subunit: Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2 (By similarity)
2 PDB 3D structures from and Proteopedia for PDE4C:
1LXU (3D)        2QYM (3D)    
Secondary accessions: B3KTC4 Q9UN44 Q9UN45 Q9UN46 Q9UPJ6
Alternative splicing: 7 isoforms:  Q08493-1   Q08493-2   Q08493-3   Q08493-4   Q08493-5   Q08493-6   Q08493-7   

Explore the universe of human proteins at neXtProt for PDE4C: NX_Q08493

Explore proteomics data for PDE4C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDE4C (Q08493) (see all 28)
     NREWYQS  PIRIQQR  SVLENHH  IDMVLAT 


    See PDE4C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000914.2  NP_001092288.1  NP_001092289.1  

    ENSEMBL proteins: 
     ENSP00000347689   ENSP00000469696   ENSP00000402091   ENSP00000262805   ENSP00000470210  
     ENSP00000473713   ENSP00000474591   ENSP00000476923   ENSP00000473937   ENSP00000474849  
     ENSP00000476961   ENSP00000472034   ENSP00000439470  
    Reactome Protein details: Q08493

    PDE4C Human Recombinant Protein Products:

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    Novus Biologicals PDE4C Protein
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    Cloud-Clone Corp. Proteins for PDE4C

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE4C
    Phosphodiesterases, 3',5'-cyclic nucleotide

    4 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q08493

    ProtoNet protein and cluster: Q08493

    UniProtKB/Swiss-Prot: PDE4C_HUMAN, Q08493
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily


    Find genes that share domains with PDE4C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE4C_HUMAN, Q08493
    Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
    Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
    Enzyme regulation: Inhibited by rolipram

         Genatlas biochemistry entry for PDE4C:
    cAMP specific nucleotide phosphodiesterase class IV,C,with homology to Drosophila dunce gene,involved in signal
    transduction

         Enzyme Numbers (IUBMB): EC 3.1.4.172 EC 3.1.4.531 EC 3.1.42

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity TAS9349724
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PDE4C           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PDE4C:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin  Increased S DNA content 
     Increased cell size  Increased gamma-H2AX phosphory 

    Animal Models:
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    1 qRT-PCR Assays for microRNA that regulate PDE4C:
    hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidPDE4C 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): PDE4C (NM_000923)
    Sino Biological Human cDNA Clone for PDE4C
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDE4C_HUMAN, Q08493: Cell projection, cilium (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005829cytosol TAS--
    GO:0072372primary cilium ISS--

    Find genes that share ontologies with PDE4C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDE4C About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    3Ca-dependent events
    Opioid Signalling0.54
    4Circadian entrainment
    Morphine addiction0.53
    5G Protein Signaling Pathways
    G Protein Signaling Pathways0.44


    Find genes that share SuperPaths with PDE4C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PDE4C
        Cellular Effects of Sildenafil
    Sperm Motility

    1 BioSystems Pathway for PDE4C
        G Protein Signaling Pathways


    2 Reactome Pathways for PDE4C
        DARPP-32 events
    G alpha (s) signalling events

    1 PharmGKB Pathway for PDE4C
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for PDE4C):
        Purine metabolism
    Morphine addiction

    UniProtKB/Swiss-Prot: PDE4C_HUMAN, Q08493
    Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDE4C
    Interactions:

        Search GeneGlobe Interaction Network for PDE4C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDE4C (ENSP000003476894) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY10ENSP000003568254STRING: ENSP00000356825
    ADCY3ENSP000002606004STRING: ENSP00000260600
    ADCY9ENSP000002940164STRING: ENSP00000294016
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNASENSP000003601414STRING: ENSP00000360141
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006198cAMP catabolic process IEA--
    GO:0007165signal transduction IEA--

    Find genes that share ontologies with PDE4C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PDE4C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    5 HMDB Compounds for PDE4C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    6 DrugBank Compounds for PDE4C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetinhibitor7925603 17139284 225216 17016423
    Iloprost-- 78919-13-8targetinducer11551870 12952271 12441759 2461561
    KetotifenKetotifen Fumarate (see all 5)34580-14-8targetinhibitor1702263 16313925
    Ibudilast2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine (see all 18)50847-11-5targetinhibitor16313925
    Piclamilast-- 144035-83-6target--15765929
    Roflumilast-- 162401-32-3targetinhibitor17726343

    2 IUPHAR Ligands for PDE4C (PDE4C)    About this table
    LigandTypeActionAffinityPubmed IDs
    rolipram
    InhibitorInhibition6.59177268
    Ro201724
    InhibitorInhibition5.49177268

    2 Novoseek inferred chemical compound relationships for PDE4C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rolipram 85.6 1 7559525 (1)
    forskolin 52.9 2 9003416 (2)



    Find genes that share compounds with PDE4C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDE4C gene (3 alternative transcripts): 
    NM_000923.4  NM_001098818.2  NM_001098819.2  

    Unigene Cluster for PDE4C:

    Phosphodiesterase 4C, cAMP-specific
    Hs.132584  [show with all ESTs]
    Unigene Representative Sequence: NM_000923
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355502(uc010ebl.3 uc010xqc.2 uc002nik.4 uc002nil.4 uc002nim.1)
    ENST00000594617 ENST00000447275(uc010ebk.3) ENST00000597360 ENST00000262805(uc002nig.4 uc002nih.4 uc002nii.4 uc002nif.4 uc010ebm.1)
    ENST00000594465 ENST00000599188 ENST00000598111 ENST00000597297 ENST00000595343
    ENST00000593594 ENST00000597573 ENST00000610023 ENST00000599754 ENST00000596647
    ENST00000600667 ENST00000539010
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate PDE4C:
    hsa-miR-759
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    Additional mRNA sequence: 

    AK295050.1 AK300888.1 AK300983.1 AY429555.1 AY429556.1 AY429557.1 AY429558.1 BC109067.1 
    BC109068.2 L20968.1 NR_040546.1 U66346.1 U66348.1 U66349.1 U88712.1 U88713.1 
    Z46632.1 

    9 DOTS entries:

    DT.86847663  DT.92420785  DT.402412  DT.99946719  DT.97837785  DT.86847662  DT.121452176  DT.75163496 
    DT.95295349 

    Selected AceView cDNA sequences (see all 47):

    AY429557 U66347 AW006350 AK095384 U66349 AY429555 BF110229 U66346 
    AY429556 BM700968 AY429558 BF850213 AW296578 L20968 CD609809 BF512057 
    BE670986 U88712 AA551067 BF447869 U88713 BF512058 BF111241 AA620403 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDE4C (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
    SP1:                          -                       -     -     -                                         -                             -                     
    SP2:                                                        -     -                                         -                             -                     
    SP3:                                                                                                        -                             -                     
    SP4:                                                  -     -     -                                                                                             
    SP5:                                                                                                  -     -                             -                     

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PDE4C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDE4C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTCCTGC
    PDE4C Expression
    About this image


    PDE4C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
    PDE4C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE4C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132584

    UniProtKB/Swiss-Prot: PDE4C_HUMAN, Q08493
    Tissue specificity: Expressed in various tissues but not in cells of the immune system

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PDE4C gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde4c1 , 5 phosphodiesterase 4C, cAMP specific1, 5 80.66(n)1
    81.9(a)1
      8 (34.15 cM)5
    1103851  NM_201607.21  NP_963901.11 
     707237205 
    zebrafish
    (Danio rerio)
    Actinopterygii pde4cb6
    pde4ca6
    phosphodiesterase 4C, cAMP-specific a
    66(a)
    62(a)
    1 ↔ many
    1 ↔ many
    11(6767964-6876042) ENSDARG00000002411
    2(24550615-24636238) ENSDARG00000013221


    ENSEMBL Gene Tree for PDE4C (if available)
    TreeFam Gene Tree for PDE4C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDE4C gene
    PDE4D2  PDE8B2  PDE4B2  PDE7B2  PDE1B2  PDE1A2  PDE9A2  PDE1C2  
    PDE7A2  PDE8A2  PDE4A2  
    16 SIMAP similar genes for PDE4C using alignment to 16 protein entries:     PDE4C_HUMAN (see all proteins):
    PDE4    HSPDE4D    PDE4D    PDE4DN2    PDE4B    PDE4A
    PDE1A    PDE1C    PDE8B    DKFZp686L23131    PDE8A    PDE1B
    PDE7B    PDE7A    PDE7B variant protein    PDE9A

    Find genes that share paralogs with PDE4C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDE4C (see all 950)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs747034301,2
    C--18318406(+) ATGAA-/T/TTT 
            
    TTTTT
    7 -- ds5001 cds10--------
    rs1135008051,2
    C--18318595(+) ACGGGA/G/TTTTCA 4 -- ds50011CSA 2
    rs1855910781,2
    --18318623(+) CTCGAA/TCTCCT 4 -- ds50010--------
    rs1456766131,2
    --18318744(+) GGGAAA/GTAAGT 4 -- ds50010--------
    rs1162629911,2
    C,F--18318943(+) AGTTCG/ATGAAC 4 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.01WA 118
    rs1454365921,2
    --18319268(+) AGGATA/GCCACC 4 -- ut31 nc-transcript-variant0--------
    rs1892067831,2
    C--18319342(+) GGGGGA/TGCCGC 4 -- ut31 nc-transcript-variant0--------
    rs1114758161,2
    F--18319535(+) GGGAGG/ATCACA 4 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.50CSA 4
    rs1815858381,2
    --18319649(+) AGGGGC/TCTCCC 4 -- ut31 nc-transcript-variant0--------
    rs1841925131,2
    --18319679(+) AGGCAC/GTTTCA 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for PDE4C (18318771 - 18366229 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDE4C (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3778n71CNV Loss21882294
    nsv911264CNV Loss21882294
    nsv911256CNV Loss21882294
    dgv3773n71CNV Loss21882294
    nsv911260CNV Loss21882294
    nsv833775CNV Loss17160897
    nsv470131CNV Loss18288195
    dgv3779n71CNV Loss21882294
    dgv3780n71CNV Loss21882294
    dgv3774n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): PDE4C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDE4C
    DNA2.0 Custom Variant and Variant Library Synthesis for PDE4C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600128    OMIM disorders: --


    Find genes that share disorders with PDE4C           About GenesLikeMe

    Genetic Association Database (GAD): PDE4C
    Human Genome Epidemiology (HuGE) Navigator: PDE4C (4 documents)

    Export disorders for PDE4C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDE4C gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with PDE4C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. (PubMed id 10574328)1, 2 Sullivan M.... Houslay M.D. (Cell. Signal. 1999)
    5. Molecular cloning and functional expression in yeast of a human cAMP- specific phosphodiesterase subtype (PDE IV-C). (PubMed id 7843419)1, 2 Engels P.... Luebbert H. (FEBS Lett. 1995)
    6. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. (PubMed id 8413254)1, 2 Bolger G.... Ferguson K. (Mol. Cell. Biol. 1993)
    7. Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis. (PubMed id 9349724)1, 9 Obernolte R.... Shelton E.R. (Biochim. Biophys. Acta 1997)
    8. Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain. (PubMed id 11207431)1, 9 PAcrez-Torres S....Mengod G. (J. Chem. Neuroanat. 2000)
    9. Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. (PubMed id 8009369)1, 9 Milatovich A....Francke U. (Somat. Cell Mol. Genet. 1994)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5143 HGNC: 8782 AceView: PDE4C Ensembl:ENSG00000105650 euGenes: HUgn5143
    ECgene: PDE4C Kegg: 5143 H-InvDB: PDE4C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDE4C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDE4C gene:
    Search GeneIP for patents involving PDE4C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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