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Aliases for PDE4B Gene

Aliases for PDE4B Gene

  • Phosphodiesterase 4B, CAMP-Specific 2 3
  • DPDE4 3 4 6
  • Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila) 2 3
  • Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4) 2
  • Phosphodiesterase E4 Dunce Homolog (Drosophila) 2
  • CAMP-Specific 3,5-Cyclic Phosphodiesterase 4B 3
  • Dunce-Like Phosphodiesterase E4 3
  • EC 3.1.4.17 63
  • EC 3.1.4.53 4
  • EC 3.1.4 63
  • PDEIVB 3
  • PDE32 4

External Ids for PDE4B Gene

Previous HGNC Symbols for PDE4B Gene

  • DPDE4

Previous GeneCards Identifiers for PDE4B Gene

  • GC01P066339
  • GC01P065729
  • GC01P065615
  • GC01P065628
  • GC01P065970
  • GC01P064366

Summaries for PDE4B Gene

Entrez Gene Summary for PDE4B Gene

  • This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for PDE4B Gene

PDE4B (Phosphodiesterase 4B, CAMP-Specific) is a Protein Coding gene. Diseases associated with PDE4B include schizophrenia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include ion channel binding and 3,5-cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE4B Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Tocris Summary for PDE4B Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE4B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4B Gene

Genomics for PDE4B Gene

Regulatory Elements for PDE4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDE4B Gene

Start:
65,792,510 bp from pter
End:
66,374,579 bp from pter
Size:
582,070 bases
Orientation:
Plus strand

Genomic View for PDE4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4B Gene

Proteins for PDE4B Gene

  • Protein details for PDE4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07343-PDE4B_HUMAN
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 4B
    Protein Accession:
    Q07343
    Secondary Accessions:
    • A5YW33
    • O15443
    • Q13945
    • Q5TEK4
    • Q5TEK5
    • Q5TEK6

    Protein attributes for PDE4B Gene

    Size:
    736 amino acids
    Molecular mass:
    83343 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE4B Gene

    Alternative splice isoforms for PDE4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE4B Gene

Proteomics data for PDE4B Gene at MOPED

Post-translational modifications for PDE4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDE4B (PDE4B)

Domains for PDE4B Gene

Gene Families for PDE4B Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Protein Domains for PDE4B Gene

Graphical View of Domain Structure for InterPro Entry

Q07343

UniProtKB/Swiss-Prot:

PDE4B_HUMAN :
  • Q07343
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4B: view

Function for PDE4B Gene

Molecular function for PDE4B Gene

GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,B,with homology to Drosophila dunce gene,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Enzyme Numbers (IUBMB) for PDE4B Gene

Gene Ontology (GO) - Molecular Function for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity ISS --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IGI 8413254
GO:0030552 cAMP binding IGI 8413254
GO:0044325 ion channel binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE4B: view
genes like me logo Genes that share phenotypes with PDE4B: view

Animal Models for PDE4B Gene

MGI Knock Outs for PDE4B:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE4B

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PDE4B Gene

Localization for PDE4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE4B Gene COMPARTMENTS Subcellular localization image for PDE4B gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005891 colocalizes_with voltage-gated calcium channel complex ISS --
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with PDE4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE4B Gene

Pathways for PDE4B Gene

genes like me logo Genes that share pathways with PDE4B: view

Pathways by source for PDE4B Gene

UniProtKB/Swiss-Prot Q07343-PDE4B_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1

Gene Ontology (GO) - Biological Process for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001780 neutrophil homeostasis ISS --
GO:0006198 cAMP catabolic process IGI 8413254
GO:0007165 signal transduction --
GO:0030593 neutrophil chemotaxis ISS --
GO:0032729 positive regulation of interferon-gamma production IMP 17404263
genes like me logo Genes that share ontologies with PDE4B: view

Compounds for PDE4B Gene

(5) Tocris Compounds for PDE4B Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(3) ApexBio Compounds for PDE4B Gene

Compound Action Cas Number
Apremilast (CC-10004) PDE4 inhibitor [608141-41-9]
Cilomilast Potent PDE4 inhibitor [153259-65-5]
Doxofylline [69975-86-6]

(7) HMDB Compounds for PDE4B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Caffeine
  • Hycomine
58-08-2
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5

(2) IUPHAR Ligand for PDE4B Gene

Ligand Type Action Affinity Pubmed IDs
rolipram Inhibitor Inhibition 7.2
Ro201724 Inhibitor Inhibition 6.2

(4) Novoseek inferred chemical compound relationships for PDE4B Gene

Compound -log(P) Hits PubMed IDs
rolipram 87.2 8
cilomilast 83.6 1
cyclic amp 53.7 6
forskolin 40.2 2
genes like me logo Genes that share compounds with PDE4B: view

Transcripts for PDE4B Gene

Unigene Clusters for PDE4B Gene

Phosphodiesterase 4B, cAMP-specific:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE4B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10: - - - - - - - - - -

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE4B Gene

GeneLoc Exon Structure for
PDE4B
ECgene alternative splicing isoforms for
PDE4B

Expression for PDE4B Gene

mRNA expression in normal human tissues for PDE4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PDE4B Gene

This gene is overexpressed in Fetal Brain (50.8) and Heart (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE4B Gene

SOURCE GeneReport for Unigene cluster for PDE4B Gene Hs.198072

mRNA Expression by UniProt/SwissProt for PDE4B Gene

Q07343-PDE4B_HUMAN
Tissue specificity: Expressed in brain, heart, lung and skeletal muscle
genes like me logo Genes that share expressions with PDE4B: view

Expression partners for PDE4B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PDE4B Gene

Orthologs for PDE4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE4B 35
  • 92.14 (n)
  • 97.23 (a)
PDE4B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE4B 35
  • 92.33 (n)
  • 96.95 (a)
PDE4B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde4b 35
  • 89.74 (n)
  • 96.81 (a)
Pde4b 16
Pde4b 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE4B 35
  • 99.49 (n)
  • 99.45 (a)
PDE4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde4b 35
  • 89 (n)
  • 96.39 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE4B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE4B 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE4B 35
  • 79.12 (n)
  • 91.03 (a)
PDE4B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE4B 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde4c 35
  • 71.23 (n)
  • 77.83 (a)
Str.13756 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1853 35
zebrafish
(Danio rerio)
Actinopterygii pde4ba 35
  • 73.74 (n)
  • 83.76 (a)
PDE4B (3 of 3) 36
  • 78 (a)
OneToMany
pde4ba 36
  • 75 (a)
OneToMany
pde4bb 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dnc 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea R153.1a 37
  • 58 (a)
R153.1b 37
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3388 35
Species with no ortholog for PDE4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE4B Gene

ENSEMBL:
Gene Tree for PDE4B (if available)
TreeFam:
Gene Tree for PDE4B (if available)

Paralogs for PDE4B Gene

Paralogs for PDE4B Gene

Selected SIMAP similar genes for PDE4B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PDE4B: view

Variants for PDE4B Gene

Sequence variations from dbSNP and Humsavar for PDE4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4004 -- 66,111,919(+) TACCA(G/T)GTTCT intron-variant
rs471257 -- 66,191,995(+) CTACA(A/G)TTCAA intron-variant
rs472952 -- 66,335,081(-) GATCA(C/T)GATAA intron-variant
rs474358 -- 66,199,938(+) tgaat(A/G)gtatt intron-variant
rs475826 -- 66,341,861(-) TCTGG(C/T)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE4B Gene

Variant ID Type Subtype PubMed ID
dgv3n17 CNV Loss 16327808
nsv437216 CNV Loss 16327808
esv2584680 CNV Deletion 19546169
esv2749318 CNV Deletion 23290073
esv1957663 CNV Deletion 18987734
esv4724 CNV Deletion 18987735
esv2673068 CNV Deletion 23128226
esv2449251 CNV Deletion 19546169
nsv160460 CNV Loss 16902084
nsv870457 CNV Loss 21882294
esv2671160 CNV Deletion 23128226
esv2672085 CNV Deletion 23128226
esv270349 CNV Insertion 20981092
esv25256 CNV Loss 19812545
esv271003 CNV Insertion 20981092
nsv506931 CNV Insertion 20534489
esv2668868 CNV Deletion 23128226
esv2749329 CNV Deletion 23290073
esv2676257 CNV Deletion 23128226
esv2749340 CNV Deletion 23290073
esv2749351 CNV Deletion 23290073
nsv1199 CNV Insertion 18451855
nsv461716 CNV Gain 19166990
nsv159464 CNV Loss 16902084
nsv159040 CNV Loss 16902084
nsv871500 CNV Loss 21882294

Relevant External Links for PDE4B Gene

HapMap Linkage Disequilibrium report
PDE4B
Human Gene Mutation Database (HGMD)
PDE4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4B Gene

Disorders for PDE4B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PDE4B Gene in MalaCards »

(1) Diseases for PDE4B Gene including...

(1) University of Copenhagen DISEASES for PDE4B Gene

(4) Novoseek inferred disease relationships for PDE4B Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 60.2 22
bipolar disorder 55.6 7
psychiatric disorder 32.3 2
asthma 0 1

Relevant External Links for PDE4B

Genetic Association Database (GAD)
PDE4B
Human Genome Epidemiology (HuGE) Navigator
PDE4B
genes like me logo Genes that share disorders with PDE4B: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PDE4B Gene

Publications for PDE4B Gene

  1. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. (PMID: 9371714) Huston E. … Houslay M.D. (Biochem. J. 1997) 3 4 23
  2. Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. (PMID: 15003452) Xu R.X. … Nolte R.T. (J. Mol. Biol. 2004) 3 4 23
  3. Structural basis for the activity of drugs that inhibit phosphodiesterases. (PMID: 15576036) Card G.L. … Zhang K.Y.J. (Structure 2004) 3 4 23
  4. PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6). (PMID: 17519386) Cheung Y.F. … Castle J.C. (J. Pharmacol. Exp. Ther. 2007) 3 4 23
  5. Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. (PMID: 17727341) Wang H. … Ke H. (Biochem. J. 2007) 3 4 23

Products for PDE4B Gene

Sources for PDE4B Gene

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