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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDE4B Gene

protein-coding   GIFtS: 67
GCID: GC01P066339

phosphodiesterase 4B, cAMP-specific

(Previous names: phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog...)
(Previous symbol: DPDE4)
 Explore 19 diseases affiliated with
PDE4B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDE4B    

Aliases
for PDE4B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phosphodiesterase 4B, CAMP-Specific1 2     PDE4B52
DPDE41 2 3 5     PDEIVB2
Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog,
Drosophila)1 2
     CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4B2
PDE322 3     CAMP-Specific Phosphodiesterase-4 B Isoform2
EC 3.1.4.173 8     Dunce-Like Phosphodiesterase E42
Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog
Phosphodiesterase E4)1
     EC 3.1.48

External Ids:    HGNC: 87811   Entrez Gene: 51422   Ensembl: ENSG000001845887   OMIM: 6001275   UniProtKB: Q073433   

Export aliases for PDE4B gene to outside databases

Previous GC identifers: GC01P065729 GC01P065615 GC01P065628 GC01P065970 GC01P064366


Summaries
for PDE4B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDE4B:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to
extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs)
regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene
encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with
schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms,
have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May
be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to
antiasthmatic and anti-inflammatory agents

summary for PDE4B:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE4B


Genomic Views
for PDE4B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDE4B gene promoter:
         Sox5   C/EBPbeta   Lmo2   FOXL1   AREB6   SRY   FOXO4   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDE4B promoter sequence
   Search SABiosciences Chromatin IP Primers for PDE4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31

PDE4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE4B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P066339:  view genomic region     (about GC identifiers)

Start:
 66,258,193 bp from pter      End:
 66,840,262 bp from pter
Size:
 582,070 bases      Orientation:
 plus strand

Proteins
for PDE4B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343 (See protein sequence)
Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B  
Size: 736 amino acids; 83343 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions
Sequence caution: Sequence=AAA35643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/32 PDB 3D structures from and Proteopedia for PDE4B (see all 32):
1F0J (3D)        1JP1 (3D)        1JP2 (3D)        1RO6 (3D)        1RO9 (3D)        1ROR (3D)    
Secondary accessions: O15443 Q13945 Q5TEK4 Q5TEK5 Q5TEK6
Alternative splicing: 3 isoforms:  Q07343-1   Q07343-2   Q07343-3   

Explore the universe of human proteins at neXtProt for PDE4B: NX_Q07343

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q07343

    • 4/32 DME Specific Peptides for PDE4B (Q07343) (see all 32)
     SVLENHH  IDMVLAT  SVSEMAS  QSTHVLL 

    PDE4B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001032416.1  NP_001032417.1  NP_001032418.1  NP_002591.2  

    ENSEMBL proteins: 
     ENSP00000332116   ENSP00000342637   ENSP00000392947   ENSP00000397548   ENSP00000432400  
     ENSP00000431909   ENSP00000360084   ENSP00000437249   ENSP00000436104   ENSP00000432592  
     ENSP00000360088  
    Reactome Protein details: Q07343
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for PDE4B
    OriGene Purified Proteins (see all 2): PDE4B
    OriGene Protein Over-expression Lysate (see all 3): PDE4B
    OriGene Custom Protein Services for PDE4B 
    GenScript Custom Purified and Recombinant Proteins Services for PDE4B
    Novus Biologicals PDE4B Protein
    Novus Biologicals PDE4B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PDE4B

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005626insoluble fraction ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--


    PDE4B for ontologies           About GeneDecksing



    PDE4B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDE4B
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 8): PDE4B
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    Novus Biologicals PDE4B Antibodies
    Search for Antibodies for PDE4B at Abcam  
    Uscn Antibodies for PDE4B
    ThermoFisher Antibodies for PDE4B

    Assay Products for PDE4B: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDE4B
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PDE4B

    Protein Domains /
    Families
    for PDE4B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDE4B for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR002073 PDEase_catalytic_dom
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q07343

    ProtoNet protein and cluster: Q07343

    UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily


    Function
    for PDE4B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
    Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May
    be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to
    antiasthmatic and anti-inflammatory agents
    Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
    Enzyme regulation: Inhibited by rolipram

         Genatlas biochemistry entry for PDE4B:
    cAMP specific nucleotide phosphodiesterase class IV,B,with homology to Drosophila dunce gene,involved in signal
    transduction

    Enzyme Numbers (IUBMB): EC 3.1.4.171 2 EC 3.1.42

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE4B
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE4B (see all 34):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-4328 hsa-miR-199a-3p hsa-miR-4272 hsa-miR-374a hsa-miR-449a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: PDE4B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE4B (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE4B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PDE4B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4B (see all 10)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4B (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PDE4B (NM_002600)
    Sino Biological Human cDNA Clone for PDE4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4B 

    Cell Line
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    Search LifeMap BioReagents cell lines for PDE4B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4B

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity IEA--
    GO:0046872metal ion binding IEA--


    PDE4B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PDE4B:
     Increased cell number in S and 

    Animal Models:
         Mouse knock-out Pde4btm1Mct for PDE4B
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pde4b):
     cardiovascular system  cellular  immune system  mortality/aging  nervous system 

    PDE4B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDE4B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Opioid Signalling
    		Opioid Signalling1.00
    		DARPP-32 events0.30
    		Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Sweet Taste Signaling
    		Cellular Effects of Sildenafil0.46
    		Sperm Motility0.36
    4G Protein Signaling Pathways
    		G Protein Signaling Pathways1.00
    5Purine metabolism
    		Purine metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDE4B
        Cellular Effects of Sildenafil
    Sperm Motility

    2 BioSystems Pathways for PDE4B 
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways

    5/6        Reactome Pathways for PDE4B (see all 6)
        GPCR downstream signaling
    DARPP-32 events
    Signal Transduction
    Signaling by GPCR
    G alpha (s) signalling events

    1 PharmGKB Pathway for PDE4B
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    1         Kegg Pathway  (Kegg details for PDE4B):
        Purine metabolism

    UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
    Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1


    PDE4B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDE4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for PDE4B (Q073433 ENSP000003321164) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    ADCY10ENSP000003568254STRING: ENSP00000356825
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis IEA--
    GO:0006198cAMP catabolic process IEA--
    GO:0007165signal transduction IEA--
    GO:0030593neutrophil chemotaxis IEA--
    GO:0035690cellular response to drug IEA--


    PDE4B for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDE4B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDE4B for compounds           About GeneDecksing

    EMD Millipore small molecules for PDE4B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDE4B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RS 25344 hydrochloridePotent PDE4 inhibitor[152814-89-6]
    RolipramPDE4 inhibitor[61413-54-5]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    MesopramOrally active PDE4 inhibitor[189940-24-7]
    CDP 840 hydrochloridePotent and selective PDE4 inhibitor[162542-90-7]

    7 HMDB Compounds for PDE4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    CaffeineHycomine (see all 15)58-08-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/25 DrugBank Compounds for PDE4B (see all 25)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (S)-Rolipram-- --targetinhibitor17139284 11752352 17016423 10592235
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetinhibitor7925603 17139284 225216 17016423
    Iloprost-- 78919-13-8targetinducer11551870 12952271 12441759 2461561
    PapaverineChlorhydrate de Papaverine (see all 8)61-25-6targetinhibitor17139284 17016423 12646997 19231363
    Theobromine-- 83-67-0targetinhibitor17514358 18568240 11692087 15095008
    (R)-Mesopram-- --target--17139284 17016423 10592235
    (R)-Rolipram-- --targetinhibitor17139284 11752352 17016423
    1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester-- --target--17139284 17016423 10592235
    3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester-- --target--17139284 17016423 10592235
    4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone-- 61413-54-5target--17139284 17016423 10592235

    4 Novoseek chemical compound relationships for PDE4B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rolipram 87.2 9 7559525 (2), 11839681 (2), 17481393 (1), 15003452 (1) (see all 6)
    cilomilast 83.6 1 15576036 (1)
    cyclic amp 53.7 9 15331441 (4), 19369227 (2)
    forskolin 40.2 2 9003416 (2)

    Search CenterWatch for drugs/clinical trials and news about PDE4B 

    Transcripts
    for PDE4B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDE4B gene (4 alternative transcripts): 
    NM_001037339.1  NM_001037340.1  NM_001037341.1  NM_002600.3  

    Unigene Cluster for PDE4B:

    Phosphodiesterase 4B, cAMP-specific
    Hs.198072  [show with all ESTs]
    Unigene Representative Sequence: NM_001037341
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000329654(uc001dcn.3 uc001dco.3) ENST00000341517 ENST00000423207(uc009war.3 uc001dcp.3)
    ENST00000531358 ENST00000532040 ENST00000526666 ENST00000412480 ENST00000371048
    ENST00000490695 ENST00000491340 ENST00000528771 ENST00000371045(uc001dcq.3 uc009was.3)
    ENST00000531025 ENST00000526197 ENST00000480109 ENST00000534463 ENST00000524999
    ENST00000483863

    miRNA
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    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE4B (see all 34):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-4328 hsa-miR-199a-3p hsa-miR-4272 hsa-miR-374a hsa-miR-449a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: PDE4B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE4B (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE4B
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PDE4B (NM_002600)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4B 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE4B
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE4B

    Additional cDNA sequence: 

    AB209081.1 AK289969.1 AK290006.1 AK290206.1 AK294441.1 BC036108.1 BC046161.1 BC071607.1 
    BC101480.1 BC105040.1 CR749667.1 EF595686.1 L12685.1 L12686.1 L20966.1 M97515.1 
    U85048.1 

    23 DOTS entries:

    DT.100741919  DT.100741918  DT.121644658  DT.40259510  DT.442607  DT.100804857  DT.121331236  DT.95371539 
    DT.92037235  DT.121331177  DT.92025734  DT.100691054  DT.121331222  DT.121331184  DT.121331223  DT.121331224 
    DT.121331225  DT.121331230  DT.121331245  DT.97825163  DT.99955375  DT.40118505  DT.91986363 

    24/144 AceView cDNA sequences (see all 144):

    AA453293 BU616750 AW086078 AW571513 AK000989 AU118147 AA805258 BM760114 
    AI830034 U85048 AA206316 AL133915 AI684715 BM759232 BF934703 CD721828 
    AA582841 BX951946 CR749667 BP344045 BF957513 BU170024 AA769288 BM759398 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:              -     -     -     -     -                                         -     -           -     -                                               -   
    SP2:                                -     -                                         -     -           -     -                                               -   
    SP3:                                                                                                  -     -                                               -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                        -                                                   

    ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
    SP1:              -                           
    SP2:              -                           
    SP3:              -                           
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for PDE4B

    Expression
    for PDE4B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDE4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PDE4B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePerivenous HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium

    See PDE4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDE4B

    SOURCE GeneReport for Unigene cluster: Hs.198072

    UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
    Tissue specificity: Expressed in brain, heart, lung and skeletal muscle

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    Orthologs
    for PDE4B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PDE4B gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PDE4B1 phosphodiesterase 4B, cAMP-specific 79.12(n)
    91.03(a)    		   424700  NM_001031291.1  NP_001026462.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PDE4B6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 GL343410.1(507458-588224)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.18532 Xenopus laevis transcribed sequence with strong similarity more 81.08(n)    BG371004.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pde4ba1 phosphodiesterase 4B, cAMP-specific a 72.89(n)
    82.74(a)    		   565706  XM_703863.5  XP_708955.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dnc3 behavior cAMP-specific phosphodiesterase 61(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea R153.1b3   -- 58(a)
    (best of 2)    		   II(7627989-7649880)   --


    ENSEMBL Gene Tree for PDE4B (if available)
    TreeFam Gene Tree for PDE4B (if available) 

    Paralogs
    for PDE4B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDE4B gene
    PDE4D2  PDE8B2  PDE3A2  PDE4C2  PDE1B2  PDE1A2  PDE7B2  PDE9A2  
    PDE1C2  PDE7A2  PDE8A2  PDE4A2  PDE3B2  
    9 SIMAP similar genes for PDE4B using alignment to 6 protein entries:     PDE4B_HUMAN (see all proteins):
    PDE4B5    HSPDE4D    PDE4D    PDE4A    PDE4DN2    PDE4C
    PDE7B    PDE1B    PDE7A

    PDE4B for paralogs           About GeneDecksing



    Genomic Variants
    for PDE4B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9301 NCBI SNPs in PDE4B are shown (see all 9301)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs360360471,2
    		C--64365006(+) ACTTTCT/-GATAC 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1147978201,2
    		C,F,--64365100(+) AGAAGC/TGCTTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1114766251,2
    		--64365248(+) AATCCG/ATATAT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs772460531,2
    		F,--64365873(+) AATAGT/CAGGTT 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1160053531,2
    		C,F,--64365939(+) AGATGG/AGATTT 2 -- us2k11Minor allele frequency- A:0.04WA 118
    rs726850191,2
    		--64366044(+) GTCTCA/GGGCTT 2 -- us2k10--------
    rs740853461,2
    		C,--64366261(+) CTTCAC/TGCCTA 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs740853471,2
    		C,--64366648(+) AGGAGT/ACCAGA 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs127577671,2
    		C--64366954(+) TCGGTC/ATCTGG 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs729313531,2
    		C,F,--64367575(+) TCCCCC/AACCCC 2 -- int1 us2k11Minor allele frequency- A:0.11EA 120

    HapMap Linkage Disequilibrium report for PDE4B (66258193 - 66508193 bp, first 250kb of PDE4B)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for PDE4B
         3 CNVs: 63964 5499 1004
         5 Indels: 43035 11401 44608 11402 97380
    Human Gene Mutation Database (HGMD): PDE4B

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    Disorders / Diseases
    for PDE4B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDE4B for disorders           About GeneDecksing

    OMIM gene information: 600127    OMIM disorders: --

    19 diseases for PDE4B:    About MalaCards
    diffuse large b-cell lymphoma    schizophrenia    bipolar affective disorder    b-cell lymphomas
    tardive dyskinesia    major depressive disorder    bipolar disorder    panic disorder
    chronic lymphocytic leukemia    lymphocytic leukemia    multiple sclerosis    liver disease
    leukemia    osteosarcoma    melanoma    malaria
    neuronitis    alcoholism    hiv type 1

    1 disease from the University of Copenhagen DISEASES database for PDE4B:
    Schizophrenia

    4 Novoseek disease relationships for PDE4B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 60.2 28 17417055 (5), 18394866 (5), 17823207 (2), 19350560 (2) (see all 10)
    bipolar disorder 55.6 7 19350560 (2), 17417055 (2), 18394866 (2), 18785206 (1)
    psychiatric disorder 32.3 2 17417055 (1), 16293762 (1)
    asthma 0 1 18348140 (1)

    Human Genome Epidemiology (HuGE) Navigator: PDE4B (19 documents)

    Export disorders for PDE4B gene to outside databases

    Publications
    for PDE4B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDE4B gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with PDE4B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. (PubMed id 9371714)1, 2, 9 Huston E.... Houslay M.D. (1997)
    2. PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. (PubMed id 17088426)1, 7 Terrin A....Zaccolo M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. (PubMed id 8413254)1, 2 Bolger G.... Ferguson K. (1993)
    5. A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA. (PubMed id 8384210)1, 2 McLaughlin M.M.... Livi G.P. (1993)
    6. The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family. (PubMed id 8392015)1, 2 Obernolte R....Shelton E.R. (1993)
    7. Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (PubMed id 18785206)1, 9 Numata S....Ohmori T. (2008)
    8. PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (PubMed id 18394866)1, 9 Fatemi S.H....Menniti F.S. (2008)
    9. Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. (PubMed id 18329668)1, 9 Numata S....Ohmori T. (2008)
    10. DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. (PubMed id 16293762)1, 9 Millar J.K....Porteous D.J. (2005)

    External Searches for PDE4B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDE4B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5142 HGNC: 8781 AceView: PDE4B Ensembl:ENSG00000184588 euGenes: HUgn5142
    ECgene: PDE4B Kegg: 5142 H-InvDB: PDE4B

    Other Databases showing PDE4B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDE4B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDE4B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PDE4B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDE4B gene:
    Search GeneIP for patents involving PDE4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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