Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDE4B Gene

Aliases for PDE4B Gene

  • Phosphodiesterase 4B 2 3 5
  • Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila) 2 3
  • DPDE4 3 4
  • Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4) 2
  • Phosphodiesterase E4 Dunce Homolog (Drosophila) 2
  • CAMP-Specific 3,5-Cyclic Phosphodiesterase 4B 2
  • Phosphodiesterase 4B, CAMP-Specific 2
  • Dunce-Like Phosphodiesterase E4 3
  • EC 3.1.4.17 63
  • EC 3.1.4.53 4
  • EC 3.1.4 63
  • PDEIVB 3
  • PDE32 4

External Ids for PDE4B Gene

Previous HGNC Symbols for PDE4B Gene

  • DPDE4

Previous GeneCards Identifiers for PDE4B Gene

  • GC01P066339
  • GC01P065729
  • GC01P065615
  • GC01P065628
  • GC01P065970
  • GC01P064366

Summaries for PDE4B Gene

Entrez Gene Summary for PDE4B Gene

  • This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for PDE4B Gene

PDE4B (Phosphodiesterase 4B) is a Protein Coding gene. Diseases associated with PDE4B include ocular hypotension and acrodysostosis. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. GO annotations related to this gene include ion channel binding and cAMP binding. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE4B Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Tocris Summary for PDE4B Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE4B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4B Gene

Genomics for PDE4B Gene

Regulatory Elements for PDE4B Gene

Promoters for PDE4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDE4B on UCSC Golden Path with GeneCards custom track

Genomic Location for PDE4B Gene

Chromosome:
1
Start:
65,792,510 bp from pter
End:
66,374,579 bp from pter
Size:
582,070 bases
Orientation:
Plus strand

Genomic View for PDE4B Gene

Genes around PDE4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4B Gene

Proteins for PDE4B Gene

  • Protein details for PDE4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07343-PDE4B_HUMAN
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 4B
    Protein Accession:
    Q07343
    Secondary Accessions:
    • A5YW33
    • O15443
    • Q13945
    • Q5TEK4
    • Q5TEK5
    • Q5TEK6

    Protein attributes for PDE4B Gene

    Size:
    736 amino acids
    Molecular mass:
    83343 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA35643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE4B Gene

    Alternative splice isoforms for PDE4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE4B Gene

Proteomics data for PDE4B Gene at MOPED

Post-translational modifications for PDE4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDE4B (PDE4B)

Domains & Families for PDE4B Gene

Gene Families for PDE4B Gene

Protein Domains for PDE4B Gene

Graphical View of Domain Structure for InterPro Entry

Q07343

UniProtKB/Swiss-Prot:

PDE4B_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4B: view

Function for PDE4B Gene

Molecular function for PDE4B Gene

GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,B,with homology to Drosophila dunce gene,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Enzyme Numbers (IUBMB) for PDE4B Gene

genes like me logo Genes that share phenotypes with PDE4B: view

Animal Models for PDE4B Gene

MGI Knock Outs for PDE4B:

Animal Model Products

miRNA for PDE4B Gene

miRTarBase miRNAs that target PDE4B

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE4B Gene

Localization for PDE4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE4B Gene COMPARTMENTS Subcellular localization image for PDE4B gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PDE4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE4B Gene

Pathways & Interactions for PDE4B Gene

genes like me logo Genes that share pathways with PDE4B: view

UniProtKB/Swiss-Prot Q07343-PDE4B_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.

Gene Ontology (GO) - Biological Process for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IGI 8413254
GO:0032729 positive regulation of interferon-gamma production IMP 17404263
GO:0071222 cellular response to lipopolysaccharide ISS --
GO:1901898 negative regulation of relaxation of cardiac muscle ISS --
genes like me logo Genes that share ontologies with PDE4B: view

No data available for SIGNOR curated interactions for PDE4B Gene

Drugs & Compounds for PDE4B Gene

(50) Drugs for PDE4B Gene - From: HMDB, DGIdb, DrugBank, Novoseek, ApexBio, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amrinone Approved Pharma inhibitor, Target 0
Dyphylline Approved Pharma inhibitor, Target 0
Enprofylline Approved Pharma inhibitor, Target 0
Ibudilast Approved, Investigational Pharma inhibitor, Target 11
Papaverine Approved Pharma inhibitor, Target 12

(6) Additional Compounds for PDE4B Gene - From: HMDB, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ro201724
Inhibition, Inhibitor
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MMPX
78033-08-6
MY-5445
78351-75-4

(5) Tocris Compounds for PDE4B Gene

Compound Action Cas Number
Dipyridamole Adenosine transport inhibitor 58-32-2
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
MMPX PDE1 inhibitor 78033-08-6
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5

(3) ApexBio Compounds for PDE4B Gene

Compound Action Cas Number
Apremilast (CC-10004) PDE4 inhibitor 608141-41-9
Cilomilast Potent PDE4 inhibitor 153259-65-5
Doxofylline 69975-86-6
genes like me logo Genes that share compounds with PDE4B: view

Transcripts for PDE4B Gene

Unigene Clusters for PDE4B Gene

Phosphodiesterase 4B, cAMP-specific:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10: - - - - - - - - - -

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PDE4B Gene

GeneLoc Exon Structure for
PDE4B
ECgene alternative splicing isoforms for
PDE4B

Expression for PDE4B Gene

mRNA expression in normal human tissues for PDE4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDE4B Gene

This gene is overexpressed in Fetal Brain (50.8) and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE4B Gene



SOURCE GeneReport for Unigene cluster for PDE4B Gene Hs.198072

mRNA Expression by UniProt/SwissProt for PDE4B Gene

Q07343-PDE4B_HUMAN
Tissue specificity: Expressed in brain, heart, lung and skeletal muscle.
genes like me logo Genes that share expression patterns with PDE4B: view

Protein tissue co-expression partners for PDE4B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PDE4B Gene

Orthologs for PDE4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE4B 35
  • 92.14 (n)
  • 97.23 (a)
PDE4B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE4B 35
  • 92.33 (n)
  • 96.95 (a)
PDE4B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde4b 35
  • 89.74 (n)
  • 96.81 (a)
Pde4b 16
Pde4b 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE4B 35
  • 99.49 (n)
  • 99.45 (a)
PDE4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde4b 35
  • 89 (n)
  • 96.39 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE4B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE4B 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE4B 35
  • 79.12 (n)
  • 91.03 (a)
PDE4B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE4B 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde4c 35
  • 71.23 (n)
  • 77.83 (a)
Str.13756 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1853 35
zebrafish
(Danio rerio)
Actinopterygii pde4ba 35
  • 73.74 (n)
  • 83.76 (a)
PDE4B (3 of 3) 36
  • 78 (a)
OneToMany
pde4ba 36
  • 75 (a)
OneToMany
pde4bb 36
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dnc 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea R153.1a 37
  • 58 (a)
R153.1b 37
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3388 35
Species with no ortholog for PDE4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE4B Gene

ENSEMBL:
Gene Tree for PDE4B (if available)
TreeFam:
Gene Tree for PDE4B (if available)

Paralogs for PDE4B Gene

Paralogs for PDE4B Gene

(8) SIMAP similar genes for PDE4B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PDE4B: view

Variants for PDE4B Gene

Sequence variations from dbSNP and Humsavar for PDE4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2227297 - 66,372,574(+) ATTTC(A/C/T)GCAGC reference, missense
rs4004 -- 66,111,919(+) TACCA(G/T)GTTCT intron-variant
rs477308 -- 66,223,323(-) TTGTT(A/G)TGGTG intron-variant
rs478690 -- 66,203,253(+) taacc(C/T)gacct intron-variant
rs479464 -- 66,203,304(+) ctttg(G/T)tgaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE4B Gene

Variant ID Type Subtype PubMed ID
dgv3n17 CNV Loss 16327808
nsv437216 CNV Loss 16327808
esv2584680 CNV Deletion 19546169
esv2749318 CNV Deletion 23290073
esv1957663 CNV Deletion 18987734
esv4724 CNV Deletion 18987735
esv2673068 CNV Deletion 23128226
esv2449251 CNV Deletion 19546169
nsv160460 CNV Loss 16902084
nsv870457 CNV Loss 21882294
esv2671160 CNV Deletion 23128226
esv2672085 CNV Deletion 23128226
esv270349 CNV Insertion 20981092
esv25256 CNV Loss 19812545
esv271003 CNV Insertion 20981092
nsv506931 CNV Insertion 20534489
esv2668868 CNV Deletion 23128226
esv2749329 CNV Deletion 23290073
esv2676257 CNV Deletion 23128226
esv2749340 CNV Deletion 23290073
esv2749351 CNV Deletion 23290073
nsv1199 CNV Insertion 18451855
nsv461716 CNV Gain 19166990
nsv159464 CNV Loss 16902084
nsv159040 CNV Loss 16902084
nsv871500 CNV Loss 21882294

Variation tolerance for PDE4B Gene

Residual Variation Intolerance Score: 7.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE4B Gene

HapMap Linkage Disequilibrium report
PDE4B
Human Gene Mutation Database (HGMD)
PDE4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4B Gene

Disorders for PDE4B Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDE4B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ocular hypotension
  • hypotony of eye
acrodysostosis
  • acrodysplasia
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search PDE4B in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE4B

Genetic Association Database (GAD)
PDE4B
Human Genome Epidemiology (HuGE) Navigator
PDE4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE4B
genes like me logo Genes that share disorders with PDE4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4B Gene

Publications for PDE4B Gene

  1. Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (PMID: 18785206) Numata S. … Ohmori T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 48 67
  2. Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples. (PMID: 19350560) KAohler A.K. … Djurovic S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23
  3. The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D. (PMID: 20347962) Mori F. … Mengod G. (J. Chem. Neuroanat. 2010) 3 23
  4. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. (PMID: 19632097) Rastogi A. … Wong A.H. (Schizophr. Res. 2009) 3 23
  5. The measurement of cyclic nucleotide phosphodiesterase 4 activities via the quantification of inorganic phosphate with malachite green. (PMID: 19231363) Zhu S. … Liao F. (Anal. Chim. Acta 2009) 25 26

Products for PDE4B Gene

Sources for PDE4B Gene

Back to Top

Content