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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDE4B Gene

protein-coding   GIFtS: 70
GCID: GC01P066339

Phosphodiesterase 4B, CAMP-Specific

(Previous names: phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog...)
(Previous symbol: DPDE4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphodiesterase 4B, CAMP-Specific1 2     PDE4B52
DPDE41 2 3 5     PDEIVB2
Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog,
Drosophila)1 2
     CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4B2
PDE322 3     CAMP-Specific Phosphodiesterase-4 B Isoform2
EC 3.1.4.173 8     Dunce-Like Phosphodiesterase E42
Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog
Phosphodiesterase E4)1
     EC 3.1.48
Phosphodiesterase E4 Dunce Homolog (Drosophila)1     

External Ids:    HGNC: 87811   Entrez Gene: 51422   Ensembl: ENSG000001845887   OMIM: 6001275   UniProtKB: Q073433   

Export aliases for PDE4B gene to outside databases

Previous GC identifers: GC01P065729 GC01P065615 GC01P065628 GC01P065970 GC01P064366


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE4B Gene:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE)
family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular
responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide
phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in
signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this
protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice
variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for PDE4B Gene: 
PDE4B (phosphodiesterase 4B, cAMP-specific) is a protein-coding gene. Diseases associated with PDE4B include schizophrenia, and tardive dyskinesia, and among its related super-pathways are G-protein mediated events and Signaling by GPCR. GO annotations related to this gene include 3',5'-cyclic-AMP phosphodiesterase activity and metal ion binding. An important paralog of this gene is PDE3A.

UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from
antidepressants to antiasthmatic and anti-inflammatory agents

summary for PDE4B Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDE4B gene promoter:
         Sox5   C/EBPbeta   Lmo2   FOXL1   AREB6   SRY   FOXO4   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDE4B promoter sequence
   Search SABiosciences Chromatin IP Primers for PDE4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31

PDE4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE4B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P066339:  view genomic region     (about GC identifiers)

Start:
66,258,193 bp from pter      End:
66,840,262 bp from pter
Size:
582,070 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343 (See protein sequence)
Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4B  
Size: 736 amino acids; 83343 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions
Sequence caution: Sequence=AAA35643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/33 PDB 3D structures from and Proteopedia for PDE4B (see all 33):
1F0J (3D)        1JP1 (3D)        1JP2 (3D)        1RO6 (3D)        1RO9 (3D)        1ROR (3D)    
Secondary accessions: O15443 Q13945 Q5TEK4 Q5TEK5 Q5TEK6
Alternative splicing: 3 isoforms:  Q07343-1   Q07343-2   Q07343-3   

Explore the universe of human proteins at neXtProt for PDE4B: NX_Q07343

Explore proteomics data for PDE4B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07343

  • 4/32 DME Specific Peptides for PDE4B (Q07343) (see all 32)
     SVLENHH  IDMVLAT  SVSEMAS  QSTHVLL 

    PDE4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDE4B Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001032416.1  NP_001032417.1  NP_001032418.1  NP_002591.2  

    ENSEMBL proteins: 
     ENSP00000332116   ENSP00000342637   ENSP00000392947   ENSP00000397548   ENSP00000432400  
     ENSP00000431909   ENSP00000360084   ENSP00000437249   ENSP00000436104   ENSP00000432592  
     ENSP00000360088  
    Reactome Protein details: Q07343
    Human Recombinant Protein Products for PDE4B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for PDE4B
    OriGene Purified Proteins for PDE4B
    OriGene Protein Over-expression Lysate for PDE4B
    OriGene MassSpec for PDE4B 
    OriGene Custom Protein Services for PDE4B
    GenScript Custom Purified and Recombinant Proteins Services for PDE4B
    Novus Biologicals PDE4B Protein
    Novus Biologicals PDE4B Lysates
    Sino Biological Recombinant Protein for PDE4B
    Sino Biological Cell Lysate for PDE4B 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE4B 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005891colocalizes with voltage-gated calcium channel complex ISS--
    GO:0030018Z disc ISS--

    PDE4B for ontologies           About GeneDecksing



    PDE4B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDE4B
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    Novus Biologicals PDE4B Antibodies
    Abcam antibodies for PDE4B
    Cloud-Clone Corp. Antibodies for PDE4B 
    ThermoFisher Antibodies for PDE4B
    LSBio Antibodies in human, mouse, rat for PDE4B 

    Assay Products for PDE4B: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PDE4B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDE4B 
    Cloud-Clone Corp. CLIAs for PDE4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE4B 
    Phosphodiesterases, 3',5'-cyclic nucleotide

    4 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q07343

    ProtoNet protein and cluster: Q07343

    UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily


    PDE4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE4B_HUMAN, Q07343
    Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological
    processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from
    antidepressants to antiasthmatic and anti-inflammatory agents
    Catalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
    Enzyme regulation: Inhibited by rolipram

         Genatlas biochemistry entry for PDE4B:
    cAMP specific nucleotide phosphodiesterase class IV,B,with homology to Drosophila dunce gene,involved in signal
    transduction

         Enzyme Numbers (IUBMB): EC 3.1.4.171 2 EC 3.1.42

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ISS--
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity IGI8413254
    GO:0030552cAMP binding IGI8413254
    GO:0044325ion channel binding ISS--
         
    PDE4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDE4B:
     Increased cell number in S and 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pde4b):
     cardiovascular system  cellular  immune system  mortality/aging  nervous system 

    PDE4B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pde4btm1Mct for PDE4B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDE4B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDE4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDE4B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDE4B 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE4B
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE4B (see all 34):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-4328 hsa-miR-199a-3p hsa-miR-4272 hsa-miR-374a hsa-miR-449a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPDE4B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for PDE4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PDE4B (NM_002600)
    Sino Biological Human cDNA Clone for PDE4B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4B
    Sirion Biotech Customized lentivirus for stable overexpression of PDE4B 
                         Customized lentivirus expression plasmids for stable overexpression of PDE4B 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDE4B About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    Opioid Signalling0.55
    DARPP-32 events0.30
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Sweet Taste Signaling
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    4Circadian entrainment
    Morphine addiction0.53
    5Signal transduction cAMP signaling
    G Protein Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDE4B
        Cellular Effects of Sildenafil
    Sperm Motility

    2 BioSystems Pathways for PDE4B
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways


    5/6        Reactome Pathways for PDE4B (see all 6)
        GPCR downstream signaling
    DARPP-32 events
    Signal Transduction
    Signaling by GPCR
    G alpha (s) signalling events

    1 PharmGKB Pathway for PDE4B
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for PDE4B):
        Purine metabolism
    Morphine addiction

    UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
    Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1


    PDE4B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDE4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for PDE4B (Q073433 ENSP000003321164) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    ADCY10ENSP000003568254STRING: ENSP00000356825
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001780neutrophil homeostasis ISS--
    GO:0006198cAMP catabolic process IGI8413254
    GO:0007165signal transduction ----
    GO:0030593neutrophil chemotaxis ISS--
    GO:0032729positive regulation of interferon-gamma production IMP17404263

    PDE4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDE4B for compounds           About GeneDecksing

    EMD Millipore small molecules for PDE4B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PDE4B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    7 HMDB Compounds for PDE4B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    CaffeineHycomine (see all 15)58-08-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/26 DrugBank Compounds for PDE4B (see all 26)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (S)-Rolipram-- --targetinhibitor17139284 11752352 17016423 10592235
    DyphyllineDihydroxypropyl Theophylline (see all 8)479-18-5targetinhibitor7925603 17139284 225216 17016423
    Iloprost-- 78919-13-8targetinducer11551870 12952271 12441759 2461561
    PapaverineChlorhydrate de Papaverine (see all 8)61-25-6targetinhibitor17139284 17016423 12646997 19231363
    Theobromine-- 83-67-0targetinhibitor17514358 18568240 11692087 15095008
    (R)-Mesopram-- --target--17139284 17016423 10592235
    (R)-Rolipram-- --targetinhibitor17139284 11752352 17016423
    1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester-- --target--17139284 17016423 10592235
    3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester-- --target--17139284 17016423 10592235
    4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone-- 61413-54-5target--17139284 17016423 10592235

    2 IUPHAR Ligands for PDE4B (PDE4B)    About this table 
    LigandTypeActionAffinityPubmed IDs
    rolipram
    InhibitorInhibition99177268
    Ro201724
    InhibitorInhibition6.49177268

    4 Novoseek inferred chemical compound relationships for PDE4B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rolipram 87.2 9 7559525 (2), 11839681 (2), 17481393 (1), 15003452 (1) (see all 6)
    cilomilast 83.6 1 15576036 (1)
    cyclic amp 53.7 9 15331441 (4), 19369227 (2)
    forskolin 40.2 2 9003416 (2)

    Search CenterWatch for drugs/clinical trials and news about PDE4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDE4B gene (4 alternative transcripts): 
    NM_001037339.1  NM_001037340.1  NM_001037341.1  NM_002600.3  

    Unigene Cluster for PDE4B:

    Phosphodiesterase 4B, cAMP-specific
    Hs.198072  [show with all ESTs]
    Unigene Representative Sequence: NM_001037341
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000329654(uc001dcn.3 uc001dco.3) ENST00000341517 ENST00000423207(uc009war.3 uc001dcp.3)
    ENST00000531358 ENST00000532040 ENST00000526666 ENST00000412480 ENST00000371048
    ENST00000490695 ENST00000491340 ENST00000528771 ENST00000371045(uc001dcq.3 uc009was.3)
    ENST00000531025 ENST00000526197 ENST00000480109 ENST00000534463 ENST00000524999
    ENST00000483863
    miRNA
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    hsa-miR-21* hsa-miR-323-3p hsa-miR-4328 hsa-miR-199a-3p hsa-miR-4272 hsa-miR-374a hsa-miR-449a hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPDE4B 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE4B
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    OriGene clones in human, mouse for PDE4B (see all 27)
    OriGene ORF clones in mouse, rat for PDE4B
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    GenScript: all cDNA clones in your preferred vector (see all 4): PDE4B (NM_002600)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4B
    Sirion Biotech Customized lentivirus for stable overexpression of PDE4B 
                         Customized lentivirus expression plasmids for stable overexpression of PDE4B 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE4B
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE4B

    Additional mRNA sequence: 

    AB209081.1 AK289969.1 AK290006.1 AK290206.1 AK294441.1 BC036108.1 BC046161.1 BC071607.1 
    BC101480.1 BC105040.1 CR749667.1 EF595686.1 L12685.1 L12686.1 L20966.1 M97515.1 
    U85048.1 

    23 DOTS entries:

    DT.100741919  DT.100741918  DT.121644658  DT.40259510  DT.442607  DT.100804857  DT.121331236  DT.95371539 
    DT.92037235  DT.121331177  DT.92025734  DT.100691054  DT.121331222  DT.121331184  DT.121331223  DT.121331224 
    DT.121331225  DT.121331230  DT.121331245  DT.97825163  DT.99955375  DT.40118505  DT.91986363 

    24/144 AceView cDNA sequences (see all 144):

    AA805258 BM760114 AU118147 U85048 AA206316 AI684715 BM759232 AL133915 
    AW086078 AW571513 AA453293 CD721828 BU170024 BP344045 AA769288 BF957513 
    AA582841 BX951946 CR749667 AI830034 AK000989 BU616750 BF934703 AL601446 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4B (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:              -     -     -     -     -                                         -     -           -     -                                               -   
    SP2:                                -     -                                         -     -           -     -                                               -   
    SP3:                                                                                                  -     -                                               -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                        -                                                   

    ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
    SP1:              -                           
    SP2:              -                           
    SP3:              -                           
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for PDE4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDE4B expression in normal human tissues (normalized intensities)      PDE4B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PDE4B Expression
    About this image


    PDE4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             Fetal Neuronal Stem Cells (NSC)   
             ganglion/cranial   
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             T Helper Cells Thymus
             CD19+ B Cells   
             mouse/organ system/cardiovascular system   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Mature Cardiac Fibroblasts Myocardium
             heart/ventricle   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Lymphatic Endothelial Cells (HLEC)   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See PDE4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDE4B

    SOURCE GeneReport for Unigene cluster: Hs.198072

    UniProtKB/Swiss-Prot: PDE4B_HUMAN, Q07343
    Tissue specificity: Expressed in brain, heart, lung and skeletal muscle

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PDE4B gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde4b1 , 5 phosphodiesterase 4B, cAMP specific1, 5 89.74(n)1
    96.81(a)1
      4 (46.99 cM)5
    185781  NM_019840.21  NP_062814.21 
     1020875435 
    chicken
    (Gallus gallus)
    Aves PDE4B1 phosphodiesterase 4B, cAMP-specific 79.12(n)
    91.03(a)
      424700  NM_001031291.1  NP_001026462.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDE4B6
    phosphodiesterase 4B, cAMP-specific
    91(a)
    1 ↔ 1
    GL343410.1(505548-591291)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.18532 Xenopus laevis transcribed sequence with strong similarity more 81.08(n)    BG371004.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pde4ba1 phosphodiesterase 4B, cAMP-specific a 72.89(n)
    82.74(a)
      565706  XM_703863.5  XP_708955.2 


    ENSEMBL Gene Tree for PDE4B (if available)
    TreeFam Gene Tree for PDE4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDE4B gene
    PDE3A2  PDE4D2  PDE8B2  PDE4C2  PDE7B2  PDE1B2  PDE1A2  PDE9A2  
    PDE1C2  PDE7A2  PDE8A2  PDE3B2  PDE4A2  
    9 SIMAP similar genes for PDE4B using alignment to 6 protein entries:     PDE4B_HUMAN (see all proteins):
    PDE4B5    HSPDE4D    PDE4D    PDE4A    PDE4DN2    PDE4C
    PDE7B    PDE1B    PDE7A

    PDE4B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/10807 SNPs in PDE4B are shown (see all 10807)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342046111,2
    C--64445765(+) AGATG-/T/TA  
            
    AACTT
    2 -- int10--------
    rs789829351,2
    C--64445765(+) AGATGC/TAAACT 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1480943971,2
    C--64445765(+) AGATG-/TAAACTT 2 -- int10--------
    rs774359701,2
    C--64445766(+) GATGTG/AAACTT 2 -- int11Minor allele frequency- A:0.00CSA 1
    rs676454101,2
    C--64457156(+) AAATA-/TGTGTGT 2 -- int10--------
    rs1116880861,2
    C--64539400(+) GTGGT-/TATAC 
    CCAGTGGA
    TATAT
    2 -- int11Minor allele frequency- TATACCCAGTGGA:0.00CSA 2
    rs344825811,2
    C--64539404(+) TTATACCCAGTG 
    GATATA
    /-
    TCTGG
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs50085001,2
    C--64539412(+) AGTGGA/TTATAT 2 -- int10--------
    rs105884651,2
    C--64540035(+) TTTTT-/T/TT  
            
    CATAA
    2 -- int11NA 2
    rs557063831,2
    C,F--64549636(+) GGACAT/ATGAAG 2 -- int12Minor allele frequency- A:0.50NA 4

    HapMap Linkage Disequilibrium report for PDE4B (66258193 - 66508193 bp, first 250kb of PDE4B)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for PDE4B (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672085CNV Deletion23128226
    esv2749351CNV Deletion23290073
    esv2449251CNV Deletion19546169
    esv2673068CNV Deletion23128226
    esv2584680CNV Deletion19546169
    esv2676257CNV Deletion23128226
    esv2671160CNV Deletion23128226
    esv2749329CNV Deletion23290073
    esv1957663CNV Deletion18987734
    esv2668868CNV Deletion23128226


    Human Gene Mutation Database (HGMD): PDE4B
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600127    OMIM disorders: --

    19 diseases for PDE4B:    About MalaCards
    schizophrenia    tardive dyskinesia    bipolar disorder    panic disorder
    major depressive disorder    hiv type 1    diffuse large b-cell lymphoma    b-cell lymphomas
    liver disease    osteosarcoma    chronic lymphocytic leukemia    multiple sclerosis
    alcoholism    melanoma    leukemia    prostate cancer
    endotheliitis    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PDE4B:
    Schizophrenia

    PDE4B for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PDE4B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    schizophrenia 60.2 28 17417055 (5), 18394866 (5), 17823207 (2), 19350560 (2) (see all 10)
    bipolar disorder 55.6 7 19350560 (2), 17417055 (2), 18394866 (2), 18785206 (1)
    psychiatric disorder 32.3 2 17417055 (1), 16293762 (1)
    asthma 0 1 18348140 (1)

    Genetic Association Database (GAD): PDE4B
    Human Genome Epidemiology (HuGE) Navigator: PDE4B (19 documents)

    Export disorders for PDE4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDE4B gene, integrated from 9 sources (see all 137):
    (articles sorted by number of sources associating them with PDE4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (PubMed id 18785206)1, 4, 9 Numata S....Ohmori T. (2008)
    2. PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (PubMed id 18394866)1, 4, 9 Fatemi S.H....Menniti F.S. (2008)
    3. Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. (PubMed id 18329668)1, 4, 9 Numata S....Ohmori T. (2008)
    4. The PDE4B gene confers sex-specific protection agains t schizophrenia. (PubMed id 17417055)1, 4, 9 Pickard B.S....Muir W.J. (2007)
    5. Association study of PDE4B gene variants in scandinavian schizophrenia and bipolar disorder multicenter case-control samples. (PubMed id 19350560)1, 4, 9 KAohler A.K. and OtnA (2009)
    6. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. (PubMed id 9371714)1, 2, 9 Huston E.... Houslay M.D. (1997)
    7. Genetic association and post-mortem brain mRNA analys is of DISC1 and related genes in schizophrenia. (PubMed id 19632097)1, 4, 9 Rastogi A....Wong A.H. (2009)
    8. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    9. Phosphodiesterase 4B genetic variants are not associa ted with antipsychotic-induced tardive dyskinesia. (PubMed id 20436352)1, 4 Souza R.P....Wong A.H. (2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5142 HGNC: 8781 AceView: PDE4B Ensembl:ENSG00000184588 euGenes: HUgn5142
    ECgene: PDE4B Kegg: 5142 H-InvDB: PDE4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDE4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDE4B gene:
    Search GeneIP for patents involving PDE4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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