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Aliases for PDE4B Gene

Aliases for PDE4B Gene

  • Phosphodiesterase 4B 2 3 5
  • Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila) 2 3
  • CAMP-Specific 3,5-Cyclic Phosphodiesterase 4B 2 3
  • DPDE4 3 4
  • Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4) 2
  • Phosphodiesterase E4 Dunce Homolog (Drosophila) 2
  • Phosphodiesterase 4B, CAMP-Specific 2
  • Dunce-Like Phosphodiesterase E4 3
  • EC 61
  • EC 4
  • EC 3.1.4 61
  • PDEIVB 3
  • PDE32 4

External Ids for PDE4B Gene

Previous HGNC Symbols for PDE4B Gene

  • DPDE4

Previous GeneCards Identifiers for PDE4B Gene

  • GC01P066339
  • GC01P065729
  • GC01P065615
  • GC01P065628
  • GC01P065970
  • GC01P064366

Summaries for PDE4B Gene

Entrez Gene Summary for PDE4B Gene

  • This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for PDE4B Gene

PDE4B (Phosphodiesterase 4B) is a Protein Coding gene. Diseases associated with PDE4B include Ocular Hypotension and Acrodysostosis. Among its related pathways are GABAergic synapse and Sweet Taste Signaling. GO annotations related to this gene include ion channel binding and cAMP binding. An important paralog of this gene is PDE4D.

UniProtKB/Swiss-Prot for PDE4B Gene

  • Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Tocris Summary for PDE4B Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE4B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4B Gene

Genomics for PDE4B Gene

Regulatory Elements for PDE4B Gene

Enhancers for PDE4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G066315 1.6 FANTOM5 Ensembl ENCODE dbSUPER 32.3 +524.3 524274 2.4 SRF ZNF362 TAF1 MAX RAD21 GABPA YY1 ZNF507 FOXA1 JUND PDE4B GC01P066323 GC01M066254
GH01G066327 1.2 FANTOM5 Ensembl dbSUPER 18.9 +535.3 535282 0.4 MTA2 JUNB BMI1 DPF2 EP300 JUND IKZF1 RELB IKZF2 SPI1 PDE4B GC01P066323 GC01P066373
GH01G066329 1.6 FANTOM5 ENCODE dbSUPER 13 +541.6 541627 9.3 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 YY1 GATA2 ELK1 ZNF143 ZNF207 PDE4B SLC35D1 GC01P066323 GC01P066373
GH01G066339 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +555.1 555065 17.0 HDGF PKNOX1 ZNF133 SIN3A FEZF1 YY1 ETS1 GATA2 CBX5 ZNF143 PDE4B GC01P066323 GC01P066373
GH01G066393 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +603.1 603099 4.0 PKNOX1 TBL1XR1 BMI1 GATA2 RELB ETV6 IKZF2 CREM CBFB JUNB PDE4B GC01P066373 LOC105378776
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDE4B on UCSC Golden Path with GeneCards custom track

Promoters for PDE4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008010 390 201 CTCF MAZ SUZ12 JUNB ZNF398 EP300 GLIS2 HDAC2 PRDM10 ZBTB26

Genomic Location for PDE4B Gene

65,792,510 bp from pter
66,374,579 bp from pter
582,070 bases
Plus strand

Genomic View for PDE4B Gene

Genes around PDE4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4B Gene

Proteins for PDE4B Gene

  • Protein details for PDE4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cAMP-specific 3,5-cyclic phosphodiesterase 4B
    Protein Accession:
    Secondary Accessions:
    • A5YW33
    • O15443
    • Q13945
    • Q5TEK4
    • Q5TEK5
    • Q5TEK6

    Protein attributes for PDE4B Gene

    736 amino acids
    Molecular mass:
    83343 Da
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    • Sequence=AAA35643.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE4B Gene

    Alternative splice isoforms for PDE4B Gene


neXtProt entry for PDE4B Gene

Selected DME Specific Peptides for PDE4B Gene


Post-translational modifications for PDE4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PDE4B Gene

Gene Families for PDE4B Gene

Protein Domains for PDE4B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
genes like me logo Genes that share domains with PDE4B: view

Function for PDE4B Gene

Molecular function for PDE4B Gene

GENATLAS Biochemistry:
cAMP specific nucleotide phosphodiesterase class IV,B,with homology to Drosophila dunce gene,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-cyclic phosphate + H(2)O = adenosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by rolipram.
UniProtKB/Swiss-Prot Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Enzyme Numbers (IUBMB) for PDE4B Gene

Gene Ontology (GO) - Molecular Function for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity IEA --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0030552 cAMP binding IGI 8413254
genes like me logo Genes that share ontologies with PDE4B: view
genes like me logo Genes that share phenotypes with PDE4B: view

Animal Models for PDE4B Gene

MGI Knock Outs for PDE4B:

Animal Model Products

CRISPR Products

miRNA for PDE4B Gene

miRTarBase miRNAs that target PDE4B

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE4B Gene

Localization for PDE4B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE4B gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000930 gamma-tubulin complex IEA --
GO:0005813 centrosome IEA --
GO:0005829 cytosol TAS --
GO:0005891 colocalizes_with voltage-gated calcium channel complex ISS --
GO:0008021 synaptic vesicle IEA --
genes like me logo Genes that share ontologies with PDE4B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE4B Gene

Pathways & Interactions for PDE4B Gene

genes like me logo Genes that share pathways with PDE4B: view

Pathways by source for PDE4B Gene

UniProtKB/Swiss-Prot Q07343-PDE4B_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.

Gene Ontology (GO) - Biological Process for PDE4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001780 neutrophil homeostasis ISS --
GO:0006198 cAMP catabolic process IGI 8413254
GO:0007165 signal transduction IEA --
GO:0030593 neutrophil chemotaxis ISS --
GO:0032729 positive regulation of interferon-gamma production IMP 17404263
genes like me logo Genes that share ontologies with PDE4B: view

No data available for SIGNOR curated interactions for PDE4B Gene

Drugs & Compounds for PDE4B Gene

(58) Drugs for PDE4B Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Roflumilast Approved Pharma inhibitor, Target PDE-4 inhibitor 0
Amrinone Approved Pharma inhibitor, Target 0
Dyphylline Approved Pharma inhibitor, Target 0
Enprofylline Approved Pharma inhibitor, Target 0
Ibudilast Approved, Investigational Pharma inhibitor, Target 11

(2) Additional Compounds for PDE4B Gene - From: Tocris and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inhibition, Inhibitor
Antagonist 28822-58-4

(5) Tocris Compounds for PDE4B Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) 85416-75-7
IBMX PDE inhibitor (non-selective) 28822-58-4
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
Rolipram PDE4 inhibitor 61413-54-5
Sildenafil citrate Orally active, potent PDE5 inhibitor 171599-83-0

(13) ApexBio Compounds for PDE4B Gene

Compound Action Cas Number
(R)-(-)-Rolipram 85416-75-7
AN-2728 PDE4 inhibitor,anti-inflammatory compound 906673-24-3
Apremilast (CC-10004) PDE4 inhibitor 608141-41-9
CDP 840 hydrochloride PDE4 inhibitor,potent and selective 162542-90-7
Cilomilast Potent PDE4 inhibitor 153259-65-5
Doxofylline 69975-86-6
GSK256066 PDE4-inhibitor,selective and highly potent 801312-28-7
GSK256066 2,2,2-trifluoroacetic acid PDE4 inhibitor 1415560-64-3
Irsogladine PDE4 inhibitor 57381-26-7
Oglemilast Potent PDE4 inhibitor 778576-62-8
Roflumilast PDE-4 inhibitor 162401-32-3
Rolipram PDE4-inhibitor and an anti-inflammatory agent 61413-54-5
S- (+)-Rolipram CAMP-specific PDE4 inhibitor 85416-73-5
genes like me logo Genes that share compounds with PDE4B: view

Drug Products

Transcripts for PDE4B Gene

Unigene Clusters for PDE4B Gene

Phosphodiesterase 4B, cAMP-specific:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP5: -
SP6: -
SP7: -
SP10: - - - - - - - - - -

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21a · 21b · 21c
SP1: -
SP2: -
SP3: -

Relevant External Links for PDE4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDE4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDE4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDE4B Gene

This gene is overexpressed in Fetal Brain (50.8) and Heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDE4B Gene

Protein tissue co-expression partners for PDE4B Gene

NURSA nuclear receptor signaling pathways regulating expression of PDE4B Gene:


SOURCE GeneReport for Unigene cluster for PDE4B Gene:


mRNA Expression by UniProt/SwissProt for PDE4B Gene:

Tissue specificity: Expressed in brain, heart, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for PDE4B Gene

  • Nervous system(5)
  • Muscle(2.4)
  • Lung(2)
genes like me logo Genes that share expression patterns with PDE4B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE4B Gene

Orthologs for PDE4B Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDE4B 34 35
  • 99.49 (n)
(Monodelphis domestica)
Mammalia PDE4B 35
  • 93 (a)
(Canis familiaris)
Mammalia PDE4B 34 35
  • 92.33 (n)
(Bos Taurus)
Mammalia PDE4B 34 35
  • 92.14 (n)
(Ornithorhynchus anatinus)
Mammalia PDE4B 35
  • 90 (a)
(Mus musculus)
Mammalia Pde4b 34 16 35
  • 89.74 (n)
(Rattus norvegicus)
Mammalia Pde4b 34
  • 89 (n)
(Gallus gallus)
Aves PDE4B 34 35
  • 79.12 (n)
(Anolis carolinensis)
Reptilia PDE4B 35
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pde4c 34
  • 71.23 (n)
Str.13756 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1853 34
(Danio rerio)
Actinopterygii pde4bb 35
  • 79 (a)
PDE4B (3 of 3) 35
  • 78 (a)
pde4ba 34 35
  • 73.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta dnc 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea R153.1a 36
  • 58 (a)
R153.1b 36
  • 58 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3388 34
Species where no ortholog for PDE4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE4B Gene

Gene Tree for PDE4B (if available)
Gene Tree for PDE4B (if available)

Paralogs for PDE4B Gene

Paralogs for PDE4B Gene

(8) SIMAP similar genes for PDE4B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PDE4B: view

Variants for PDE4B Gene

Sequence variations from dbSNP and Humsavar for PDE4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000378 -- 65,873,721(+) TTGTC(G/T)AAGAC intron-variant
rs1000001548 -- 65,963,264(+) TAGTG(C/T)GTTTG intron-variant
rs1000012620 -- 65,820,708(+) ATCTA(C/G)AAAGT intron-variant
rs1000012782 -- 66,094,265(+) GACTG(C/T)GCTTC intron-variant
rs1000014008 -- 66,015,294(+) CCTAG(C/G)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE4B Gene

Variant ID Type Subtype PubMed ID
dgv3n17 CNV loss 16327808
dgv97n106 CNV deletion 24896259
esv1957663 CNV deletion 18987734
esv2449251 CNV deletion 19546169
esv25256 CNV loss 19812545
esv2584680 CNV deletion 19546169
esv2668868 CNV deletion 23128226
esv2671160 CNV deletion 23128226
esv2672085 CNV deletion 23128226
esv2673068 CNV deletion 23128226
esv2676257 CNV deletion 23128226
esv2749318 CNV deletion 23290073
esv2749329 CNV deletion 23290073
esv2749340 CNV deletion 23290073
esv2749351 CNV deletion 23290073
esv2762148 CNV gain 21179565
esv2764244 CNV loss 21179565
esv3306072 CNV mobile element insertion 20981092
esv3365990 CNV insertion 20981092
esv3402340 CNV insertion 20981092
esv3563349 CNV deletion 23714750
esv3563371 CNV deletion 23714750
esv3586289 CNV loss 21293372
esv3586291 CNV loss 21293372
esv3586292 CNV loss 21293372
esv3586293 CNV loss 21293372
esv3586294 CNV loss 21293372
esv4724 CNV loss 18987735
nsv1014111 CNV loss 25217958
nsv1122357 CNV deletion 24896259
nsv1127004 CNV deletion 24896259
nsv1133862 CNV deletion 24896259
nsv1145349 CNV deletion 24896259
nsv1199 CNV insertion 18451855
nsv159040 CNV deletion 16902084
nsv159464 CNV deletion 16902084
nsv160460 CNV deletion 16902084
nsv437216 CNV loss 16327808
nsv461716 CNV gain 19166990
nsv475416 CNV novel sequence insertion 20440878
nsv506931 OTHER sequence alteration 20534489
nsv546440 CNV gain 21841781
nsv998127 CNV loss 25217958

Variation tolerance for PDE4B Gene

Residual Variation Intolerance Score: 7.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE4B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4B Gene

Disorders for PDE4B Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDE4B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ocular hypotension
  • hypotony of eye
  • acrodysplasia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search PDE4B in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE4B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PDE4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE4B Gene

Publications for PDE4B Gene

  1. Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples. (PMID: 19350560) KAohler A.K. … Djurovic S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  2. Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (PMID: 18785206) Numata S. … Ohmori T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 22 46 64
  3. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. (PMID: 19632097) Rastogi A. … Wong A.H. (Schizophr. Res. 2009) 3 22 46 64
  4. Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population. (PMID: 18329668) Numata S. … Ohmori T. (J Psychiatr Res 2008) 3 22 46 64
  5. PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. (PMID: 18394866) Fatemi S.H. … Menniti F.S. (Schizophr. Res. 2008) 3 22 46 64

Products for PDE4B Gene

Sources for PDE4B Gene

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