Aliases for PDE4B Gene
- Phosphodiesterase 4B, CAMP-Specific 2 3
- DPDE4 3 4 6
- Phosphodiesterase 4B, CAMP-Specific (Phosphodiesterase E4 Dunce Homolog, Drosophila) 2 3
- Phosphodiesterase 4B, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E4) 2
- Phosphodiesterase E4 Dunce Homolog (Drosophila) 2
- CAMP-Specific 3,5-Cyclic Phosphodiesterase 4B 3
- Dunce-Like Phosphodiesterase E4 3
External Ids for PDE4B Gene
Previous HGNC Symbols for PDE4B Gene
Previous GeneCards Identifiers for PDE4B Gene
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
GeneCards Summary for PDE4B Gene
PDE4B (Phosphodiesterase 4B, CAMP-Specific) is a Protein Coding gene. Diseases associated with PDE4B include schizophrenia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include ion channel binding and 3,5-cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE7A.
UniProtKB/Swiss-Prot for PDE4B Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.