PDE4A Gene
protein-coding GIFtS: 66
GCID: GC19P010527
|
|
phosphodiesterase 4A, cAMP-specific(Previous names: phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog...)
(Previous symbol: DPDE2)
| |
Aliases
for PDE4A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphodiesterase 4A, CAMP-Specific1 2 | | CAMP-Specific 3',5'-Cyclic Phosphodiesterase 4A2 | | DPDE21 2 3 5 | | Phosphodiesterase 4A, CAMP-Specific (Dunce2 | | PDE462 3 | | Phosphodiesterase E2 Dunce Homolog, Drosophila2 | | EC 3.1.4.173 8 | | Phosphodiesterase Isozyme 42 | | Phosphodiesterase 4A, CAMP-Specific (Dunce (Drosophila)-HomologPhosphodiesterase E2)1 | | EC 3.1.48 | | PDE42 | | |
Export aliases for PDE4A gene to outside databasesPrevious GC identifers: GC19P010663 GC19P010376 GC19P010392 GC19P010111 |
Summaries
for PDE4A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PDE4A:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily.This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses toextracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in manyimportant physiological processes. Alternatively spliced transcript variants encoding different isoforms have beendescribed for this gene.(provided by RefSeq, Jul 2011)
UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
 summary
for PDE4A: Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.
Gene Wiki entry for PDE4A
|
Genomic Views
for PDE4A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PDE4A gene promoter:
CREB PPAR-gamma1 AP-1 PPAR-gamma2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for PDE4A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE4A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2PDE4A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P010527: view genomic region
(about GC identifiers)
Start:
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10,527,449 bp from pter |
End:
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10,580,307 bp from pter |
Size:
|
52,859 bases |
Orientation:
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plus strand |
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Proteins
for PDE4A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815 (See
protein sequence)Recommended Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4A Size: 886 amino acids; 98143 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has apreference for magnesium and/or manganese ions
Subunit: Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 andisoform 6 interact with ARRB2
Subcellular location: Isoform 1: Cytoplasm, perinuclear region
Subcellular location: Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane
Subcellular location: Isoform 4: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for associationwith membranes
Subcellular location: Isoform 6: Cytoplasm, perinuclear region
Subcellular location: Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic
3 PDB 3D structures from  and Proteopedia  for PDE4A:2QYK (3D)
3I8V (3D)
3TVX (3D)
Secondary accessions: O75522 O76092 Q16255 Q16691 Q5DM53 Q6PMT2 Q8IVA7 Q8WUQ3 Q9H3H2Alternative splicing: 7 isoforms: P27815-1 P27815-2 P27815-3 P27815-4 P27815-5 P27815-6 P27815-7 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Probably represents a non-functional splice isoform)Explore the universe of human proteins at neXtProt for PDE4A: NX_P27815
Post-translational modifications:
Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 andSer-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 andSer-123 respectively by PKA1
Proteolytically cleaved by caspase-31
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P27815
4/29 DME Specific Peptides for PDE4A (P27815) (see all 29)
PDE4A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001104777.1 NP_001104778.1 NP_001104779.1 NP_001230050.1 NP_006193.1
ENSEMBL proteins: ENSP00000468507 ENSP00000270474 ENSP00000293683 ENSP00000394754 ENSP00000467137 ENSP00000341007 ENSP00000465792 ENSP00000370078 Reactome Protein details: P27815
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
PDE4A for ontologies About GeneDecksing
PDE4A Antibody Products:
Assay Products for PDE4A: |
Protein
Domains /
Families
for PDE4A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PDE4A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P27815ProtoNet protein and cluster: P27815 UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily |
Function
for PDE4A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processesCatalytic activity: Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphateEnzyme regulation: Isoform 1, isoform 2, isoform 6 and isoform 7 are inhibited by rolipram and cilomilast. Isoform 1,isoform 2 and isoform 6 are inhibited by 4-[(3-butoxy-4-methoxyphenyl)-methyl]-2-imidazolidinone (Ro 20-1724),roflumilast and denbufyllineBiophysicochemical properties: Kinetic parameters: KM=4.0 uM for cAMP (isoform 2); KM=3 uM for cAMP (isoform 6); Genatlas biochemistry entry for PDE4A:cAMP specific nucleotide phosphodiesterase class IV,A,with homology to Drosophila dunce gene,involved in signaltransduction
Enzyme Numbers (IUBMB): EC 3.1.4.171 2 EC 3.1.42
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): PDE4A (NM_001111308) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDE4A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4A |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
PDE4A for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for PDE4A: Pde4atm1Mct Pde4atm1.1Hazh
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Pde4a):
PDE4A for phenotypes About GeneDecksing
|
Pathways & Interactions
for PDE4A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Opioid Signalling | | | 2 | G Protein Signaling Pathways | | | 3 | Signaling by GPCR | | | 4 | G-protein signaling_G-Protein alpha-i signaling cascades | | | 5 | Sweet Taste Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for PDE4A
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PDE4A
2  GeneGo (Thomson Reuters) Pathways for PDE4A
1  BioSystems Pathway for PDE4A
5/6 
Reactome Pathways for PDE4A (see all 6)
1  PharmGKB Pathway for PDE4A
1 
Kegg Pathway (Kegg details for PDE4A):
UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815Pathway: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1
PDE4A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDE4A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/64 Interacting proteins for PDE4A (P278152, 3 ENSP000002704744) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
PDE4A for ontologies About GeneDecksing
|
Drugs & Compounds
for PDE4A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PDE4A for compounds About GeneDecksing
Compounds for PDE4A available from Tocris Bioscience About this table
6 HMDB Compounds for PDE4A About this table
10/14 DrugBank Compounds for PDE4A (see all 14) About this table
10/124 Novoseek chemical compound relationships for PDE4A gene (see all 124) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rolipram |
96.8 |
300 |
7559525 (4), 8651945 (4), 9218122 (3), 10640323 (3) (see all 99) |
| roflumilast |
96.1 |
112 |
19843061 (4), 19386793 (3), 16257550 (3), 17573446 (3) (see all 58) |
| cilomilast |
95.7 |
73 |
14561639 (3), 16424413 (3), 14636078 (2), 17155857 (2) (see all 45) |
| piclamilast |
92.3 |
21 |
15339393 (3), 15765929 (2), 9559883 (1), 10193778 (1) (see all 14) |
| cdp 840 |
90.2 |
8 |
9218122 (1), 9163639 (1), 9405253 (1), 11044563 (1) (see all 8) |
| 8-((4-bromo-2,3-dioxobutyl)thio)-adenosine 3',5'-cyclic monophosphate |
87.6 |
2 |
2160272 (1), 11863434 (1) |
| cilostamide |
85.8 |
15 |
1329900 (2), 9105766 (1), 1313303 (1), 9716350 (1) (see all 11) |
| siguazodan |
84.8 |
5 |
9223593 (1), 18788505 (1), 11044563 (1), 15265810 (1) |
| motapizone |
83.4 |
5 |
9154331 (2), 9559883 (1), 11834608 (1), 20082309 (1) |
| zardaverine |
81.3 |
1 |
11044563 (1) |
Search CenterWatch for drugs/clinical trials and news about PDE4A
|
Transcripts
for PDE4A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PDE4A gene (5 alternative transcripts): NM_001111307.1 NM_001111308.1 NM_001111309.1 NM_001243121.1 NM_006202.2 Unigene Cluster for PDE4A: Phosphodiesterase 4A, cAMP-specific Hs.89901 [show with all ESTs]Unigene Representative Sequence: NM_00111130710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592685 ENST00000352831(uc002moj.2) ENST00000293683(uc002mok.2)
ENST00000440014(uc002mol.2) ENST00000591971 ENST00000344979(uc002mom.2 uc002moo.2)
ENST00000589073 ENST00000586275 ENST00000590407 ENST00000380702(uc021uow.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): PDE4A (NM_001111308) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDE4A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4A |
Additional cDNA sequence: AF073745.2 AY266362.1 AY593872.1 AY618547.1 BC019864.1 BC038234.1 L20965.1 M37744.1 S75213.1 U18087.1 U18088.1 U68532.1 U97584.1 9 DOTS entries: DT.208282 DT.75134232 DT.97812911 DT.100691695 DT.91866715 DT.92427218 DT.86844360 DT.121480539 DT.121480536 24/108 AceView cDNA sequences (see all 108): BU169201 BM021079 F31164 AW138155 AF073745 BC019864 NM_006202 BQ052490 BQ672933 F37034 AW296744 BQ711857 S75213 BC038234 BQ446409 BQ928991 BM462182 AY593872 U97584 CR604925 BF116176 BQ961810 BM021314 BQ009232
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4A (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | ^ | 19a | · |
|---|
|
| SP1: | | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | · | 19c | · | 19d |
|---|
|
| SP1: | | | | | | | |
| SP2: | | | | | | | |
| SP3: | | | | | | | |
| SP4: | | | | | | | |
| SP5: | | | | | | |
ECgene alternative splicing isoforms for PDE4A
|
Expression
for PDE4A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PDE4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCACTGTG
About this image
See PDE4A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDE4A
SOURCE GeneReport for Unigene cluster: Hs.89901
UniProtKB/Swiss-Prot: PDE4A_HUMAN, P27815Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenalglands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, aswell as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is alsofound in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 isexpressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in thebrain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level)
SABiosciences Custom PCR Arrays for PDE4A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDE4A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDE4A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE4A | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE4A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4A |
Orthologs
for PDE4A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PDE4A gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
PDE4A6 |
-- |
73(a) |
1 ↔ 1 |
2(28469915-28547520) |
zebrafish
(Danio rerio) |
Actinopterygii |
pde4a1 |
phosphodiesterase 4A, cAMP-specific |
70.71(n)
74.43(a) |
|
572061 XM_695720.4 XP_700812.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dnc3 |
behavior cAMP-specific phosphodiesterase |
60(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
R153.1a3 |
cyclic nucleotide phosphodiesterase |
54(a) |
|
II(7627989-7634156) -- |
ENSEMBL Gene Tree for PDE4A (if available)
TreeFam Gene Tree for PDE4A (if available) |
Paralogs
for PDE4A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PDE4A gene
- PDE4D2 PDE8B2 PDE3A2 PDE4B2 PDE4C2 PDE1B2 PDE1A2 PDE7B2
- PDE9A2 PDE1C2 PDE7A2 PDE8A2 PDE3B2
7 SIMAP similar genes for PDE4A using alignment to 5 protein entries: PDE4A_HUMAN (see all proteins):PDE4B PDE8B HSPDE4D PDE4B5 PDE4D PDE4C
PDE1B
PDE4A for paralogs About GeneDecksing
|
Genomic Variants
for PDE4A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PDE4A (10527449 - 10580307 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDE4A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDE4A |
|
Disorders
/ Diseases
for PDE4A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PDE4A for disorders About GeneDecksing
OMIM gene information: 600126
OMIM disorders: --
20/90  diseases for PDE4A (see all 90): About MalaCardsrubinstein-taybi syndrome spinal cord injury diffuse large b-cell lymphoma b-cell lymphomas
intermittent claudication leydig cell tumor premature ejaculation allergic rhinitis
major depressive disorder inflammatory bowel disease pulmonary eosinophilia chronic obstructive pulmonary disease
eosinophilia cerebrovascular accident pleurisy contact dermatitis
chronic granulomatous disease primary pulmonary hypertension lymphocytic leukemia cystic fibrosis
17 diseases from the University of Copenhagen DISEASES database for PDE4A:Hypertension Premature ejaculation Sexual dysfunction Chronic obstructive pulmonary disease
Asthma Heart disease Priapism Cholera
Intermittent claudication Diabetes mellitus Cerebrovascular accident Dyspepsia
Peyronie's disease Retinitis pigmentosa Atopic dermatitis Hypoactive sexual desire disorder
Hypogonadism 10/62 Novoseek disease relationships for PDE4A gene (see all 62) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pulmonary disease chronic obstructive |
76.4 |
84 |
11964752 (3), 18341675 (2), 19213793 (2), 16267357 (2) (see all 55) |
| chronic obstructive asthma |
65.6 |
9 |
15912967 (1), 16257373 (1), 10419856 (1), 17428447 (1) (see all 7) |
| asthma |
63.6 |
111 |
19135348 (4), 15639300 (3), 11964752 (3), 14636078 (2) (see all 66) |
| inflammation |
48.7 |
39 |
15607122 (2), 16469485 (2), 14580925 (2), 10372831 (2) (see all 29) |
| airways disease |
46.6 |
2 |
16861399 (1), 15765929 (1) |
| dermatitis atopic |
41.5 |
11 |
17355425 (2), 8752839 (2), 9338548 (1), 10419856 (1) (see all 8) |
| necrosis |
38.8 |
32 |
10193778 (2), 19256507 (2), 11996895 (2), 14561639 (1) (see all 21) |
| leydig cell tumor |
33.2 |
1 |
1713581 (1) |
| asthma allergic |
30.6 |
7 |
15665325 (3), 11590377 (2) |
| leukemia lymphocytic chronic |
29.4 |
10 |
12531792 (2), 11839681 (2), 15652238 (2), 17699872 (1) (see all 5) |
Human Genome Epidemiology (HuGE) Navigator: PDE4A (3 documents)
Export disorders for PDE4A gene to outside databases
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Publications
for PDE4A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PDE4A gene, integrated from 9 sources (see all 734):
(articles sorted by number of sources associating them with PDE4A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. (PubMed id 18095939)1, 2, 9 Mackenzie K.F.... Bolger G.B. (2008)
- Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. (PubMed id 8009369)1, 3, 9 Milatovich A....Francke U. (1994)
- Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. (PubMed id 15738310)1, 2 Wallace D.A.... Houslay M.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
- Purification and characterization of the human pde4a catalytic domain (pde4a(330-723)) expressed in sf9 cells. (PubMed id 11566027)1, 2 Lario P.I.... Huang Z. (2001)
- Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10. (PubMed id 11306681)1, 2 Rena G.... Houslay M.D. (2001)
- Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2. (PubMed id 9677330)1, 2 Sullivan M.... Houslay M.D. (1998)
- Molecular cloning of a novel splice variant of human type IVA (PDE- IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19. (PubMed id 7772058)1, 2 Horton Y.M.... Houslay M.D. (1995)
- Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1). (PubMed id 7888306)1, 2 Sullivan M.... Houslay M.D. (1994)
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External Searches for PDE4A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PDE4A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PDE4A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PDE4A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PDE4A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PDE4A gene:
Search GeneIP for patents involving PDE4A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PDE4A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for PDE4A | | OriGene shRNA RFP for PDE4A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE4A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDE4A | | | OriGene Protein Over-expression Lysate for PDE4A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PDE4A | | OriGene 3'-UTR Clone for PDE4A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE4A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PDE4A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE4A |
|  |  |  | | | | ThermoFisher Antibodies for PDE4A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE4A |
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