Aliases for PDE4A Gene
External Ids for PDE4A Gene
Previous HGNC Symbols for PDE4A Gene
Previous GeneCards Identifiers for PDE4A Gene
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PDE4A Gene
PDE4A (Phosphodiesterase 4A, CAMP-Specific) is a Protein Coding gene. Diseases associated with PDE4A include rubinstein-taybi syndrome and asthma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include cAMP binding and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE7A.
UniProtKB/Swiss-Prot for PDE4A Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.