Aliases for PDE4A Gene
- Phosphodiesterase 4A 2 3 5
- DPDE2 3 4
- PDE46 3 4
- Phosphodiesterase 4A, CAMP-Specific (Dunce (Drosophila)-Homolog Phosphodiesterase E2) 2
- Phosphodiesterase E2 Dunce Homolog (Drosophila) 2
- Phosphodiesterase E2 Dunce Homolog, Drosophila 3
- CAMP-Specific 3,5-Cyclic Phosphodiesterase 4A 3
- Phosphodiesterase 4A, CAMP-Specific (Dunce 3
External Ids for PDE4A Gene
Previous HGNC Symbols for PDE4A Gene
Previous GeneCards Identifiers for PDE4A Gene
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
GeneCards Summary for PDE4A Gene
PDE4A (Phosphodiesterase 4A) is a Protein Coding gene. Diseases associated with PDE4A include Asthma and Respiratory Failure. Among its related pathways are Signaling by GPCR and Purine metabolism (KEGG). GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-AMP phosphodiesterase activity. An important paralog of this gene is PDE4B.
UniProtKB/Swiss-Prot for PDE4A Gene
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.