Aliases for PDE3B Gene
External Ids for PDE3B Gene
Previous GeneCards Identifiers for PDE3B Gene
GeneCards Summary for PDE3B Gene
PDE3B (Phosphodiesterase 3B) is a Protein Coding gene. Diseases associated with PDE3B include lipodystrophy, familial partial, 2. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE7A.
UniProtKB/Swiss-Prot for PDE3B Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.