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Aliases for PDE3B Gene

Aliases for PDE3B Gene

  • Phosphodiesterase 3B, CGMP-Inhibited 2 3
  • Cyclic GMP-Inhibited Phosphodiesterase B 3 4
  • EC 3.1.4.17 4 63
  • CGI-PDE B 3 4
  • CGIPDE1 3 4
  • CGIP1 3 4
  • Cyclic Nucleotide Phosphodiesterase 3
  • EC 3.1.4 63
  • HcGIP1 3

External Ids for PDE3B Gene

Previous GeneCards Identifiers for PDE3B Gene

  • GC11P015846
  • GC11P015413
  • GC11P014704
  • GC11P014629
  • GC11P014328

Summaries for PDE3B Gene

GeneCards Summary for PDE3B Gene

PDE3B (Phosphodiesterase 3B, CGMP-Inhibited) is a Protein Coding gene. Diseases associated with PDE3B include lipodystrophy, familial partial, 2 and pelizaeus-merzbacher disease. Among its related pathways are Signaling by GPCR and mTOR signalling. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE6A.

UniProtKB/Swiss-Prot for PDE3B Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Tocris Summary for PDE3B Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE3B Gene

Genomics for PDE3B Gene

Regulatory Elements for PDE3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDE3B Gene

Chromosome:
11
Start:
14,643,656 bp from pter
End:
14,872,059 bp from pter
Size:
228,404 bases
Orientation:
Plus strand

Genomic View for PDE3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE3B Gene

Proteins for PDE3B Gene

  • Protein details for PDE3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13370-PDE3B_HUMAN
    Recommended name:
    cGMP-inhibited 3,5-cyclic phosphodiesterase B
    Protein Accession:
    Q13370
    Secondary Accessions:
    • B7ZM37
    • O00639
    • Q14408
    • Q6SEI4

    Protein attributes for PDE3B Gene

    Size:
    1112 amino acids
    Molecular mass:
    124333 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6.

    Three dimensional structures from OCA and Proteopedia for PDE3B Gene

    Alternative splice isoforms for PDE3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE3B Gene

Proteomics data for PDE3B Gene at MOPED

Selected DME Specific Peptides for PDE3B Gene

Post-translational modifications for PDE3B Gene

  • Ubiquitination at Lys 33, Lys 285, Lys 312, Lys 339, Lys 546, Lys 611, and Lys 943
  • Modification sites at PhosphoSitePlus

Other Protein References for PDE3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PDE3B Gene

Gene Families for PDE3B Gene

Protein Domains for PDE3B Gene

Graphical View of Domain Structure for InterPro Entry

Q13370

UniProtKB/Swiss-Prot:

PDE3B_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
genes like me logo Genes that share domains with PDE3B: view

Function for PDE3B Gene

Molecular function for PDE3B Gene

GENATLAS Biochemistry:
cAMP,cGMP inhibited nucleotide phosphodiesterase,123 kDa,class III, beta subunit
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by cGMP
UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Enzyme Numbers (IUBMB) for PDE3B Gene

Gene Ontology (GO) - Molecular Function for PDE3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity TAS 17884339
GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity TAS 8884271
GO:0005515 protein binding IPI 17255105
GO:0008081 phosphoric diester hydrolase activity --
GO:0043422 protein kinase B binding ISS --
genes like me logo Genes that share ontologies with PDE3B: view
genes like me logo Genes that share phenotypes with PDE3B: view

Animal Models for PDE3B Gene

MGI Knock Outs for PDE3B:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE3B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PDE3B Gene

Localization for PDE3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE3B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE3B Gene COMPARTMENTS Subcellular localization image for PDE3B gene
Compartment Confidence
cytosol 4
endoplasmic reticulum 3
golgi apparatus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDE3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 18586889
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PDE3B: view

Pathways & Interactions for PDE3B Gene

genes like me logo Genes that share pathways with PDE3B: view

PCR Array Products

SIGNOR curated interactions for PDE3B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PDE3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006198 cAMP catabolic process IEP 17884339
GO:0007162 negative regulation of cell adhesion IMP 17884339
GO:0007165 signal transduction --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PDE3B: view

Drugs & Compounds for PDE3B Gene

(47) Drugs for PDE3B Gene - From: NovoSeek, HMDB, IUPHAR, DGIdb, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cilostazol Approved Pharma inhibitor PDE3 inhibitor, PDE3A inhibitor. Also adenosine uptake inhibitor 98
Milrinone Approved Pharma Inhibition, Inhibitor, inhibitor PDE-3 inhibitor 26
Caffeine Approved Nutra Activator, Target, inhibitor, competitive 317
Amrinone Approved Pharma inhibitor 0
Adenosine monophosphate Approved Nutra 0

(31) Additional Compounds for PDE3B Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MY-5445
78351-75-4
Ro 20-1724
29925-17-5
2,3-Cyclic nucleotide
genes like me logo Genes that share compounds with PDE3B: view

Transcripts for PDE3B Gene

Unigene Clusters for PDE3B Gene

Phosphodiesterase 3B, cGMP-inhibited:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE3B Gene

No ASD Table

Relevant External Links for PDE3B Gene

GeneLoc Exon Structure for
PDE3B
ECgene alternative splicing isoforms for
PDE3B

Expression for PDE3B Gene

mRNA expression in normal human tissues for PDE3B Gene

mRNA differential expression in normal tissues according to GTEx for PDE3B Gene

This gene is overexpressed in Colon - Sigmoid (x5.6), Adipose - Subcutaneous (x4.9), and Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for PDE3B Gene

This gene is overexpressed in Hair follicle (42.5) and Pancreas (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE3B Gene



SOURCE GeneReport for Unigene cluster for PDE3B Gene Hs.445711

mRNA Expression by UniProt/SwissProt for PDE3B Gene

Q13370-PDE3B_HUMAN
Tissue specificity: Abundant in adipose tissues
genes like me logo Genes that share expression patterns with PDE3B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for PDE3B Gene

Orthologs for PDE3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDE3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE3B 35
  • 88.99 (n)
  • 86.31 (a)
PDE3B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE3B 35
  • 84.58 (n)
  • 82.15 (a)
PDE3B 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde3b 35
  • 85.63 (n)
  • 83.29 (a)
Pde3b 16
Pde3b 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE3B 35
  • 99.21 (n)
  • 99.24 (a)
PDE3B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde3b 35
  • 84.98 (n)
  • 82.3 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE3B 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE3B 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE3B 35
  • 71.36 (n)
  • 67.39 (a)
PDE3B 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE3B 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pde3b 35
  • 64.87 (n)
  • 65.8 (a)
PDE3B 36
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13290 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for PDE3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE3B Gene

ENSEMBL:
Gene Tree for PDE3B (if available)
TreeFam:
Gene Tree for PDE3B (if available)

Paralogs for PDE3B Gene

Paralogs for PDE3B Gene

(3) SIMAP similar genes for PDE3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PDE3B: view

Variants for PDE3B Gene

Sequence variations from dbSNP and Humsavar for PDE3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1011649 -- 14,834,562(+) CAAGC(A/C)TGAGA intron-variant
rs1037378 -- 14,830,944(+) ATATA(A/G)TAGTA intron-variant
rs1037379 -- 14,831,238(+) TTTTA(A/G)GGAAA intron-variant
rs1065539 -- 14,776,330(+) ACAGA(C/T)ACTGG intron-variant
rs1839834 -- 14,807,914(+) AATTA(A/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE3B Gene

Variant ID Type Subtype PubMed ID
nsv517985 CNV Loss 19592680
nsv897005 CNV Loss 21882294
esv1063774 CNV Insertion 17803354
nsv832071 CNV Loss 17160897

Variation tolerance for PDE3B Gene

Residual Variation Intolerance Score: 10.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.21; 52.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE3B Gene

HapMap Linkage Disequilibrium report
PDE3B
Human Gene Mutation Database (HGMD)
PDE3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE3B Gene

Disorders for PDE3B Gene

MalaCards: The human disease database

(2) MalaCards diseases for PDE3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lipodystrophy, familial partial, 2
  • dunnigan syndrome
pelizaeus-merzbacher disease
  • leukodystrophy, sudanophilic
- elite association
Search PDE3B in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE3B

Genetic Association Database (GAD)
PDE3B
Human Genome Epidemiology (HuGE) Navigator
PDE3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE3B
genes like me logo Genes that share disorders with PDE3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE3B Gene

Publications for PDE3B Gene

  1. Cyclic nucleotide phosphodiesterases. (PMID: 11692087) Essayan D.M. (J. Allergy Clin. Immunol. 2001) 23 25 67
  2. Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family. (PMID: 8884271) Miki T. … Manganiello V.C. (Genomics 1996) 2 23 67
  3. Nitric oxide-induced changes in endothelial expression of phosphodiesterases 2, 3, and 5. (PMID: 19751368) Schankin C.J. … Kruuse C. (Headache 2010) 23 67
  4. Cyclic AMP signaling in pancreatic islets. (PMID: 20217503) Furman B. … Pyne N.J. (Adv. Exp. Med. Biol. 2010) 23 67
  5. Protein microarray analysis identifies cyclic nucleotide phosphodiesterase as an interactor of Nogo-A. (PMID: 19508346) Sumiyoshi K. … Satoh J. (Neuropathology 2010) 23 67

Products for PDE3B Gene

Sources for PDE3B Gene

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