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PDE3A Gene

protein-coding   GIFtS: 68
GCID: GC12P020422

Phosphodiesterase 3A, CGMP-Inhibited

  Search for PDE3A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphodiesterase 3A, CGMP-Inhibited1 2     CGI-PDE-A2
Cyclic GMP-Inhibited Phosphodiesterase A2 3     CAMP Phosphodiesterase, Myocardial CGMP-Inhibited2
CGI-PDE A2 3     CGMP-Inhibited 3',5'-Cyclic Phosphodiesterase A2
EC 3.1.4.173 8     EC 3.1.48
CGI-PDE2     

External Ids:    HGNC: 87781   Entrez Gene: 51392   Ensembl: ENSG000001725727   OMIM: 1238055   UniProtKB: Q144323   

Export aliases for PDE3A gene to outside databases

Previous GC identifers: GC12P020791 GC12P020523 GC12P020413 GC12P020294


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDE3A Gene:
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE
enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the
amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet
aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle
contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart
failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Sep 2011)

GeneCards Summary for PDE3A Gene:
PDE3A (phosphodiesterase 3A, cGMP-inhibited) is a protein-coding gene. GO annotations related to this gene include cGMP-inhibited cyclic-nucleotide phosphodiesterase activity and cAMP binding. An important paralog of this gene is PDE11A.

UniProtKB/Swiss-Prot: PDE3A_HUMAN, Q14432
Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP,
which are key regulators of many important physiological processes (By similarity)

summary for PDE3A Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDE3A gene promoter:
         STAT5B   Pax-5   CUTL1   Evi-1   POU2F1   POU2F1a   POU2F1b   POU2F1c   AP-2alpha   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE3A promoter sequence
   Search Chromatin IP Primers for PDE3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12.2

PDE3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE3A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P020422:  view genomic region     (about GC identifiers)

Start:
20,522,179 bp from pter      End:
20,837,315 bp from pter
Size:
315,137 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDE3A_HUMAN, Q14432 (See protein sequence)
Recommended Name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A  
Size: 1141 amino acids; 124979 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions (By similarity)
1 PDB 3D structure from and Proteopedia for PDE3A:
1LRC (3D)    
Secondary accessions: O60865 Q13348 Q17RD1

Explore the universe of human proteins at neXtProt for PDE3A: NX_Q14432

Explore proteomics data for PDE3A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDE3A (Q14432) (see all 6)
     EFYEQGD  SVLENHH  LDHVEFK  TSATGLPT 


    See PDE3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000912.3  NP_001231612.1  

    ENSEMBL proteins: 
     ENSP00000351957  
    Reactome Protein details: Q14432

    PDE3A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PDE3A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PDE3A
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    Novus Biologicals PDE3A Protein
    Novus Biologicals PDE3A Lysate
    Sino Biological Recombinant Protein for PDE3A
    Sino Biological Cell Lysate for PDE3A
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE3A

     
    Search eBioscience for Proteins for PDE3A 

    PDE3A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for PDE3A
    Cloud-Clone Corp. Antibodies for PDE3A
    ThermoFisher Antibodies for PDE3A
    LSBio Antibodies in human, mouse, rat for PDE3A

    PDE3A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDE3A
    Cloud-Clone Corp. CLIAs for PDE3A
    Search eBioscience for ELISAs for PDE3A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE3A
    Phosphodiesterases, 3',5'-cyclic nucleotide

    3 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR023174 PDEase_CS
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q14432

    ProtoNet protein and cluster: Q14432

    1 Blocks protein domain: IPB001917 Aminotransferase

    UniProtKB/Swiss-Prot: PDE3A_HUMAN, Q14432
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily


    Find genes that share domains with PDE3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE3A_HUMAN, Q14432
    Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP,
    which are key regulators of many important physiological processes (By similarity)
    Catalytic activity: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate
    Enzyme regulation: Inhibited by cGMP

         Genatlas biochemistry entry for PDE3A:
    cAMP,cGMP inhibited nucleotide phosphodiesterase 3A homolog,involved in fat metabolism

         Enzyme Numbers (IUBMB): EC 3.1.4.171 2 EC 3.1.42

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity IEA--
    GO:0004119cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA--
    GO:0030552cAMP binding IEA--
         
    Find genes that share ontologies with PDE3A           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PDE3A:
     Increased homologous recombina  Increased viability after born  Synthetic lethal with Ras  Synthetic lethal with paclitax 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pde3a):
     normal  reproductive system 

    Find genes that share phenotypes with PDE3A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pde3atm1Vman for PDE3A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDE3A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDE3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDE3A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDE3A

    miRNA
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    miRTarBase miRNAs that target PDE3A:
    hsa-mir-128-3p (MIRT022078), hsa-mir-155-5p (MIRT001528)

    Block miRNA regulation of human, mouse, rat PDE3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDE3A (see all 16):
    hsa-miR-362-3p hsa-miR-3607-3p hsa-miR-27a hsa-miR-128 hsa-miR-139-5p hsa-miR-3681* hsa-miR-218 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmidPDE3A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PDE3A
    Predesigned siRNA for gene silencing in human, mouse, rat PDE3A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: PDE3A (NM_000921)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE3A

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDE3A_HUMAN, Q14432: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PDE3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDE3A About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    5CREB Pathway
    Activation of PKC through GPCR0.63


    Find genes that share SuperPaths with PDE3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PDE3A (see all 10)
        Activation of PKA through GPCR
    PKA Signaling
    Sweet Taste Signaling
    Relaxin Pathway
    Activation of PKC through GPCR

    2 GeneGo (Thomson Reuters) Pathways for PDE3A
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction PKA signaling


    2 Reactome Pathways for PDE3A
        cGMP effects
    G alpha (s) signalling events

    1 PharmGKB Pathway for PDE3A
        Proton Pump Inhibitor Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for PDE3A):
        Purine metabolism
    Insulin signaling pathway
    Progesterone-mediated oocyte maturation
    Morphine addiction

        Pathway & Disease-focused RT2 Profiler PCR Array including PDE3A: 
              Hypertension in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PDE3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDE3A (Q144322, 3 ENSP000003519574) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3295899 I2D: score=1 STRING: ENSP00000309503
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY10ENSP000003568254STRING: ENSP00000356825
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001556oocyte maturation IEA--
    GO:0006198cAMP catabolic process IMP19252089
    GO:0006629lipid metabolic process TAS8921398
    GO:0007165signal transduction ----
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with PDE3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PDE3A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    6 HMDB Compounds for PDE3A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Theophylline1,3-Dimethylxanthine (see all 96)58-55-9--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected DrugBank Compounds for PDE3A (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Milrinone-- 78415-72-2targetinhibitor10511123 12181427 10859452 12652111 12135876 11752352
    CilostazolCilostazole (see all 2)73963-72-1targetinhibitor12180353 19218671 16472148 11752352 18282775
    AmrinoneAmrinona [inn-spanish] (see all 4)60719-84-8targetinhibitor12076859 19901885 18468627 11752352
    AnagrelideAnagrelide HCL (see all 3)68475-42-3targetinhibitor17139284 11752352 17016423 2846839
    OxtriphyllineCholine theophyllinate (see all 2)4499-40-5targetinhibitor15237094 12887610 16651698
    TheophyllineDimethylxanthine (see all 6)58-55-9targetinhibitor15237094 12887610 16651698
    AminophyllineAminophyllin (see all 4)317-34-0targetinhibitor11939921 11752352
    Enoximone-- 77671-31-9targetinhibitor16987374 17714066
    Ibudilast2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine (see all 18)50847-11-5targetinhibitor21036126
    Levosimendan-- 141505-33-1targetinhibitor16116344

    3 IUPHAR Ligands for PDE3A (PDE3A)    About this table
    LigandTypeActionAffinityPubmed IDs
    cilostamide
    InhibitorInhibition7.510644042
    milrinone
    InhibitorInhibition6.310644042
    cGMP
    InhibitorInhibition6.3--

    Selected Novoseek inferred chemical compound relationships for PDE3A gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    8-((4-bromo-2,3-dioxobutyl)thio)-adenosine 3',5'-cyclic monophosphate 93.1 2 11955000 (1), 11863434 (1)
    cilostamide 91.5 8 8395509 (1), 8812137 (1), 19332778 (1), 1313303 (1) (see all 6)
    milrinone 85.4 11 7860763 (2), 1324870 (2), 8812137 (1), 1652182 (1) (see all 7)
    cgmp 77 55 11468344 (4), 8713077 (3), 17704206 (3), 18394675 (3) (see all 18)
    cilostazol 67.2 5 15354266 (1), 14645013 (1), 20136824 (1), 10644042 (1)
    amrinone 64.7 3 1324870 (2), 10644042 (1)
    forskolin 55.5 5 9031467 (2), 11832336 (1), 16153182 (1)
    cyclic amp 47.8 1 17392505 (5), 18467075 (1)
    isoproterenol 41.3 9 15867171 (3), 11832336 (1), 16186489 (1)
    adenylate 31.4 2 15354266 (1), 9031467 (1), 17392505 (1)



    Find genes that share compounds with PDE3A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDE3A gene (2 alternative transcripts): 
    NM_000921.4  NM_001244683.1  

    Unigene Cluster for PDE3A:

    Phosphodiesterase 3A, cGMP-inhibited
    Hs.386791  [show with all ESTs]
    Unigene Representative Sequence: NM_000921
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359062(uc001reh.2 uc021qwa.1) ENST00000542675 ENST00000544307

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PDE3A (see all 16):
    hsa-miR-362-3p hsa-miR-3607-3p hsa-miR-27a hsa-miR-128 hsa-miR-139-5p hsa-miR-3681* hsa-miR-218 hsa-miR-329
    SwitchGear 3'UTR luciferase reporter plasmidPDE3A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PDE3A
    Clone
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    OriGene ORF clones in mouse, rat for PDE3A
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    GenScript: all cDNA clones in your preferred vector: PDE3A (NM_000921)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE3A
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PDE3A
      QuantiFast Probe-based Assays in human, mouse, rat PDE3A

    Additional mRNA sequence: 

    AJ005036.1 AK308317.1 BC117369.1 BC117371.1 M91667.2 U36798.1 

    2 DOTS entries:

    DT.109816  DT.121120039 

    Selected AceView cDNA sequences (see all 84):

    BM726612 AI628567 BF593925 AI961922 CK300107 AI597722 BQ187047 BF435350 
    BU632064 BX501734 AI624266 AL707984 AL600910 CA430169 CB985950 BX093899 
    BQ005500 BF438453 BM930781 AW072688 AA313509 AW008123 BQ005307 AI687304 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PDE3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTGCATA
    PDE3A Expression
    About this image


    PDE3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     NULL (Uncategorized)
             DKK1-induced cells
    PDE3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.386791
        Pathway & Disease-focused RT2 Profiler PCR Array including PDE3A: 
              Hypertension in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PDE3A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde3a1 , 5 phosphodiesterase 3A, cGMP inhibited1, 5 83.58(n)1
    84.32(a)1
      6 (71.87 cM)5
    546111  NM_018779.11  NP_061249.11 
     1412492695 
    chicken
    (Gallus gallus)
    Aves PDE3A1 phosphodiesterase 3A, cGMP-inhibited 76.34(n)
    81.92(a)
      418185  XM_416416.4  XP_416416.4 
    lizard
    (Anolis carolinensis)
    Reptilia PDE3A6
    phosphodiesterase 3A, cGMP-inhibited
    78(a)
    1 ↔ 1
    5(8490071-8565571)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851299.12   -- 76.02(n)    BX851299.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.111812 Transcribed sequence with weak similarity to protein more 75.74(n)    BG307206.1 


    ENSEMBL Gene Tree for PDE3A (if available)
    TreeFam Gene Tree for PDE3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDE3A gene
    PDE11A2  PDE6A2  PDE6B2  PDE6C2  PDE2A2  PDE5A2  PDE10A2  PDE3B2  
    3 SIMAP similar genes for PDE3A using alignment to 1 protein entry:     PDE3A_HUMAN:
    PDE4    PDE3B    PDE8A

    Find genes that share paralogs with PDE3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDE3A (see all 6697)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714368201,2
    C--20311011(+) ATATAA/TAAATA 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1857212271,2
    --20311041(+) ATATAA/TAAATA 1 -- int10--------
    rs1901992451,2
    --20311061(+) ATATAA/TAAATA 1 -- int10--------
    rs347001201,2
    C,F--20323164(+) TTCACTT/-TTTTT 1 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs755181651,2
    --20336380(+) TTTTTC/TCCTAT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs340076811,2
    C--20336525(+) TTATA-/ATAC  
            
    TACAT
    1 -- int10--------
    rs105945861,2
    C--20336801(+) TTTCT-/CAGTGTT 1 -- int11Minor allele frequency- CA:0.00CSA 2
    rs339595431,2
    C--20367955(+) ATGTT-/AATATA 1 -- int10--------
    rs348486151,2
    C--20373616(+) TTTTT-/T/T   
      TTTTTT
    GAGAT
    1 -- int10--------
    rs1929157241,2
    --20388576(+) AAATAC/TACTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDE3A (20522179 - 20772179 bp, first 250kb of PDE3A)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDE3A (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2218919CNV Deletion18987734
    esv2668063CNV Deletion23128226
    esv1015874CNV Deletion17803354
    esv2663850CNV Deletion23128226
    esv2745621CNV Deletion23290073
    esv2674271CNV Deletion23128226
    esv1692681CNV Insertion17803354
    esv1326828CNV Insertion17803354
    nsv634CNV Insertion18451855
    nsv469158CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123805    OMIM disorders: --


    Find genes that share disorders with PDE3A           About GenesLikeMe

    3 Novoseek inferred disease relationships for PDE3A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 33 2 8695850 (1), 9031467 (1)
    erectile dysfunction 15.5 3 10421499 (2), 10859452 (1)
    heart failure 4.43 3 15867171 (2), 17332439 (1)

    Genetic Association Database (GAD): PDE3A
    Human Genome Epidemiology (HuGE) Navigator: PDE3A (5 documents)

    Export disorders for PDE3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDE3A gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with PDE3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase. (PubMed id 1315035)1, 2, 3, 9 Meacci E.... Manganiello V. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase. (PubMed id 8155697)1, 2, 9 Degerman E.... Manganiello V. (Biochim. Biophys. Acta 1994)
    3. Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum. (PubMed id 10421499)1, 2, 9 Kuthe A....Maegert H.-J. (Chem. Biol. Interact. 1999)
    4. Human platelet cGI-PDE: expression in yeast and localization of the catalytic domain by deletion mutagenesis. (PubMed id 8695850)1, 2, 9 Cheung P.P....Colman R.W. (Blood 1996)
    5. Cardiac type cGMP-inhibited phosphodiesterase (PDE3A) gene structure: similarity and difference to adipocyte type PDE3B gene. (PubMed id 10679291)1, 3, 9 Kasuya J....Fujita-Yamaguchi Y. (Biochem. Biophys. Res. Commun. 2000)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)1, 4 Marroni F....Pramstaller P.P. (Circ Cardiovasc Genet 2009)
    8. Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. (PubMed id 19478329)1, 4 Aston K.I. and Carrell D.T. (J. Androl. 2009)
    9. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (JAMA 2009)
    10. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5139 HGNC: 8778 AceView: PDE3A Ensembl:ENSG00000172572 euGenes: HUgn5139
    ECgene: PDE3A Kegg: 5139 H-InvDB: PDE3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDE3A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/PDE3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDE3A gene:
    Search GeneIP for patents involving PDE3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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