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Aliases for PDE2A Gene

Aliases for PDE2A Gene

  • Phosphodiesterase 2A, CGMP-Stimulated 2 3
  • Cyclic GMP-Stimulated Phosphodiesterase 3 4
  • EC 3.1.4.17 4 64
  • CGS-PDE 3 4
  • CGSPDE 3 4
  • CGMP-Dependent 3,5-Cyclic Phosphodiesterase 3
  • CGMP-Stimulated Phosphodiesterase 1 3
  • CGMP-Stimulated Phosphodiesterase 4 3
  • EC 3.1.4 64
  • PDE2A1 3
  • PED2A4 3

External Ids for PDE2A Gene

Summaries for PDE2A Gene

GeneCards Summary for PDE2A Gene

PDE2A (Phosphodiesterase 2A, CGMP-Stimulated) is a Protein Coding gene. Diseases associated with PDE2A include retinitis pigmentosa. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include protein homodimerization activity and calcium channel activity. An important paralog of this gene is PDE6A.

UniProtKB/Swiss-Prot for PDE2A Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes

  • Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration

Tocris Summary for PDE2A Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3 cyclic phosphate bonds in adenosine and/or guanine 3,5 cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE2A Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE2A Gene

Genomics for PDE2A Gene

Genomic Location for PDE2A Gene

Start:
72,576,140 bp from pter
End:
72,674,591 bp from pter
Size:
98,452 bases
Orientation:
Minus strand

Genomic View for PDE2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE2A Gene

Regulatory Elements for PDE2A Gene

Proteins for PDE2A Gene

  • Protein details for PDE2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00408-PDE2A_HUMAN
    Recommended name:
    cGMP-dependent 3,5-cyclic phosphodiesterase
    Protein Accession:
    O00408
    Secondary Accessions:
    • B2R646
    • B3KRV5
    • E9PGI1
    • F6W5Z0
    • Q5J791
    • Q5J792
    • Q5J793
    • Q6ZMR1

    Protein attributes for PDE2A Gene

    Size:
    941 amino acids
    Molecular mass:
    105717 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • cGMP binds at an allosteric activator site.
    SequenceCaution:
    • Sequence=AAS75515.1; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE2A Gene

    Alternative splice isoforms for PDE2A Gene

neXtProt entry for PDE2A Gene

Proteomics data for PDE2A Gene at MOPED

Selected DME Specific Peptides for PDE2A Gene

Post-translational modifications for PDE2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PDE2A Gene

Gene Families for PDE2A Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Protein Domains for PDE2A Gene

UniProtKB/Swiss-Prot:

PDE2A_HUMAN
Domain:
  • GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.:
    • O00408
  • Contains 2 GAF domains.:
    • O00408
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.:
    • O00408
genes like me logo Genes that share domains with PDE2A: view

Function for PDE2A Gene

Molecular function for PDE2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate
UniProtKB/Swiss-Prot Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes
UniProtKB/Swiss-Prot Function: Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration

Enzyme Numbers (IUBMB) for PDE2A Gene

Gene Ontology (GO) - Molecular Function for PDE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004112 cyclic-nucleotide phosphodiesterase activity IDA 15938621
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA 17329248
GO:0005262 calcium channel activity TAS 10375378
GO:0005515 protein binding IPI 17329248
genes like me logo Genes that share ontologies with PDE2A: view

Phenotypes for PDE2A Gene

MGI mutant phenotypes for PDE2A:
inferred from 2 alleles
GenomeRNAi human phenotypes for PDE2A:
genes like me logo Genes that share phenotypes with PDE2A: view

miRNA for PDE2A Gene

miRTarBase miRNAs that target PDE2A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PDE2A Gene

Localization for PDE2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE2A Gene

Isoform PDE2A3: Cell membrane; Lipid-anchor.
Isoform PDE2A2: Mitochondrion matrix.
Isoform PDE2A1: Cytoplasm.
Isoform 5: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE2A Gene COMPARTMENTS Subcellular localization image for PDE2A gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
mitochondrion 4
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PDE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10375378
GO:0005737 cytoplasm IDA 10375378
GO:0005759 mitochondrial matrix ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005794 Golgi apparatus ISS --
genes like me logo Genes that share ontologies with PDE2A: view

Pathways for PDE2A Gene

genes like me logo Genes that share pathways with PDE2A: view

Gene Ontology (GO) - Biological Process for PDE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17329248
GO:0006198 cAMP catabolic process IMP 19252089
GO:0006626 protein targeting to mitochondrion ISS --
GO:0007165 signal transduction --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with PDE2A: view

Compounds for PDE2A Gene

(5) Tocris Compounds for PDE2A Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(6) HMDB Compounds for PDE2A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Sildenafil
  • Caverta
139755-83-2

(3) Drugbank Compounds for PDE2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-ISOBUTYL-1-METHYLXANTHINE
target
Cyclic Guanosine Monophosphate
7665-99-8 target
Tofisopam
22345-47-7 target inhibitor

(3) IUPHAR Ligand for PDE2A Gene

Ligand Type Action Affinity Pubmed IDs
BAY607550 Inhibitor Inhibition 8.8
EHNA Inhibitor Inhibition 5.3
cGMP Activator Activation

(29) Novoseek inferred chemical compound relationships for PDE2A Gene

Compound -log(P) Hits PubMed IDs
cgmp 90.5 115
zaprinast 86.3 8
3,5-cyclic nucleotide 80.3 1
8-(4-chlorophenylthio)guanosine-3-5-cyclic monophosphate 79.2 1
exisulind 77.8 3
genes like me logo Genes that share compounds with PDE2A: view

Transcripts for PDE2A Gene

Unigene Clusters for PDE2A Gene

Phosphodiesterase 2A, cGMP-stimulated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE2A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9: -

Relevant External Links for PDE2A Gene

GeneLoc Exon Structure for
PDE2A
ECgene alternative splicing isoforms for
PDE2A

Expression for PDE2A Gene

mRNA expression in normal human tissues for PDE2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE2A Gene

This gene is overexpressed in Spleen (5.1) and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE2A Gene

SOURCE GeneReport for Unigene cluster for PDE2A Gene Hs.503163

mRNA Expression by UniProt/SwissProt for PDE2A Gene

O00408-PDE2A_HUMAN
Tissue specificity: Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas
genes like me logo Genes that share expressions with PDE2A: view

Orthologs for PDE2A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE2A 36
  • 99.67 (n)
  • 99.67 (a)
PDE2A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE2A 36
  • 91.59 (n)
  • 95.76 (a)
PDE2A 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE2A 36
  • 90.29 (n)
  • 93.74 (a)
PDE2A 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde2a 36
  • 88.57 (n)
  • 93.54 (a)
Pde2a 16
Pde2a 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE2A 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE2A 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde2a 36
  • 88.17 (n)
  • 92.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13289 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pde2a 36
  • 72.51 (n)
  • 75.83 (a)
zebrafish
(Danio rerio)
Actinopterygii PDE2A (1 of 2) 37
  • 80 (a)
OneToMany
PDE2A (2 of 2) 37
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008304 36
  • 57.92 (n)
  • 51.02 (a)
worm
(Caenorhabditis elegans)
Secernentea pde-2 37
  • 27 (a)
OneToOne
R08D7.6 38
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
OneToOne
Species with no ortholog for PDE2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE2A Gene

ENSEMBL:
Gene Tree for PDE2A (if available)
TreeFam:
Gene Tree for PDE2A (if available)

Paralogs for PDE2A Gene

Paralogs for PDE2A Gene

genes like me logo Genes that share paralogs with PDE2A: view

Variants for PDE2A Gene

Sequence variations from dbSNP and Humsavar for PDE2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs90409 -- 72,607,431(+) CCCAG(C/G)CCAGA intron-variant
rs151449 -- 72,635,252(-) TTAGA(G/T)AATAG intron-variant
rs163608 -- 72,650,332(-) GAGTT(C/T)CTTGG intron-variant
rs163692 -- 72,650,269(-) AAGGC(A/G)GATGG intron-variant
rs163693 -- 72,649,743(-) CCCAC(A/G/T)TGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE2A Gene

Variant ID Type Subtype PubMed ID
nsv832207 CNV Loss 17160897
nsv468633 CNV Loss 19166990
nsv523601 CNV Loss 19592680
nsv509429 CNV Insertion 20534489
esv1004730 CNV Insertion 20482838
esv1163550 CNV Insertion 17803354
nsv825991 CNV Gain 20364138
esv268579 CNV Insertion 20981092
esv274169 CNV Insertion 20981092
esv1200915 CNV Insertion 17803354
esv2325810 CNV Deletion 18987734
esv2664373 CNV Deletion 23128226
esv25409 CNV Loss 19812545
esv269430 CNV Insertion 20981092
esv259916 OTHER Complex 20981092

Relevant External Links for PDE2A Gene

HapMap Linkage Disequilibrium report
PDE2A

Disorders for PDE2A Gene

(1) MalaCards Diseases for PDE2A Gene

Search for PDE2A Gene in MalaCards »

(4) Novoseek inferred disease relationships for PDE2A Gene

Disease -log(P) Hits PubMed IDs
retinitis pigmentosa 55.9 2
retinal degeneration 36.5 1
colon cancer 0 1
tumors 0 2

Relevant External Links for PDE2A

Genetic Association Database (GAD)
PDE2A
Human Genome Epidemiology (HuGE) Navigator
PDE2A
genes like me logo Genes that share disorders with PDE2A: view

No data available for UniProtKB/Swiss-Prot for PDE2A Gene

Publications for PDE2A Gene

  1. Isolation and characterization of human cDNAs encoding a cGMP- stimulated 3',5'-cyclic nucleotide phosphodiesterase. (PMID: 9210593) Rosman G.J. … Loughney K. (Gene 1997) 2 3 4 23
  2. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. (PMID: 15938621) Iffland A. … Ellenberger T. (Biochemistry 2005) 3 4 23
  3. Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. (PMID: 19828435) Pandit J. … Menniti F.S. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 23
  4. Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. (PMID: 17704206) Surapisitchat J. … Beavo J.A. (Circ. Res. 2007) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PDE2A Gene

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