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Aliases for PDE2A Gene

Aliases for PDE2A Gene

  • Phosphodiesterase 2A 2 3 5
  • Cyclic GMP-Stimulated Phosphodiesterase 3 4
  • Phosphodiesterase 2A, CGMP-Stimulated 2 3
  • EC 3.1.4.17 4 63
  • CGS-PDE 3 4
  • CGSPDE 3 4
  • CGMP-Stimulated Phosphodiesterase 1 3
  • CGMP-Stimulated Phosphodiesterase 2 3
  • CGMP-Stimulated Phosphodiesterase 4 3
  • EC 3.1.4 63
  • PDE2A1 3
  • PED2A4 3

External Ids for PDE2A Gene

Previous GeneCards Identifiers for PDE2A Gene

  • GC11M074619
  • GC11M073826
  • GC11M072509
  • GC11M072013
  • GC11M071964
  • GC11M072287
  • GC11M068580

Summaries for PDE2A Gene

GeneCards Summary for PDE2A Gene

PDE2A (Phosphodiesterase 2A) is a Protein Coding gene. Diseases associated with PDE2A include retinitis pigmentosa. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include protein homodimerization activity and calcium channel activity. An important paralog of this gene is PDE6A.

UniProtKB/Swiss-Prot for PDE2A Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

  • Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Tocris Summary for PDE2A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE2A Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE2A Gene

Genomics for PDE2A Gene

Regulatory Elements for PDE2A Gene

Genomic Location for PDE2A Gene

Chromosome:
11
Start:
72,576,140 bp from pter
End:
72,674,591 bp from pter
Size:
98,452 bases
Orientation:
Minus strand

Genomic View for PDE2A Gene

Genes around PDE2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE2A Gene

Proteins for PDE2A Gene

  • Protein details for PDE2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00408-PDE2A_HUMAN
    Recommended name:
    cGMP-dependent 3,5-cyclic phosphodiesterase
    Protein Accession:
    O00408
    Secondary Accessions:
    • B2R646
    • B3KRV5
    • E9PGI1
    • F6W5Z0
    • Q5J791
    • Q5J792
    • Q5J793
    • Q6ZMR1

    Protein attributes for PDE2A Gene

    Size:
    941 amino acids
    Molecular mass:
    105717 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • cGMP binds at an allosteric activator site.
    SequenceCaution:
    • Sequence=AAS75515.1; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE2A Gene

    Alternative splice isoforms for PDE2A Gene

neXtProt entry for PDE2A Gene

Proteomics data for PDE2A Gene at MOPED

Selected DME Specific Peptides for PDE2A Gene

Post-translational modifications for PDE2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PDE2A Gene

Gene Families for PDE2A Gene

Protein Domains for PDE2A Gene

Graphical View of Domain Structure for InterPro Entry

O00408

UniProtKB/Swiss-Prot:

PDE2A_HUMAN :
  • GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
Domain:
  • GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the catalytic activity of the enzyme.
  • Contains 2 GAF domains.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.
genes like me logo Genes that share domains with PDE2A: view

Function for PDE2A Gene

Molecular function for PDE2A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate.
UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
UniProtKB/Swiss-Prot Function:
Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Enzyme Numbers (IUBMB) for PDE2A Gene

Gene Ontology (GO) - Molecular Function for PDE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0042803 protein homodimerization activity IPI 19828435
genes like me logo Genes that share ontologies with PDE2A: view
genes like me logo Genes that share phenotypes with PDE2A: view

Animal Models for PDE2A Gene

MGI Knock Outs for PDE2A:

Animal Model Products

miRNA for PDE2A Gene

miRTarBase miRNAs that target PDE2A

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE2A Gene

Localization for PDE2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE2A Gene

Isoform PDE2A3: Cell membrane; Lipid-anchor.
Isoform PDE2A2: Mitochondrion matrix.
Isoform PDE2A1: Cytoplasm.
Isoform 5: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE2A Gene COMPARTMENTS Subcellular localization image for PDE2A gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PDE2A Gene

Pathways & Interactions for PDE2A Gene

genes like me logo Genes that share pathways with PDE2A: view

Gene Ontology (GO) - Biological Process for PDE2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17329248
GO:0006198 cAMP catabolic process IMP 19252089
GO:0007165 signal transduction IEA --
GO:0008152 metabolic process IDA 17329248
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus IDA 14687666
genes like me logo Genes that share ontologies with PDE2A: view

No data available for SIGNOR curated interactions for PDE2A Gene

Drugs & Compounds for PDE2A Gene

(25) Drugs for PDE2A Gene - From: Novoseek, HMDB, IUPHAR, DGIdb, DrugBank, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dipyridamole Approved Pharma Inhibition, Inhibitor Adenosine transport inhibitor 76
Tofisopam Approved Pharma Target, inhibitor 2
Milrinone Approved Pharma Inhibition, Inhibitor, inhibitor PDE-3 inhibitor 32
sildenafil Approved, Investigational Pharma Inhibition, Inhibitor 0
Caffeine Approved Nutra Antagonist, Target, inhibitor, competitive 339

(18) Additional Compounds for PDE2A Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MMPX
78033-08-6
MY-5445
78351-75-4
Ro 20-1724
29925-17-5
genes like me logo Genes that share compounds with PDE2A: view

Drug Products

Transcripts for PDE2A Gene

Unigene Clusters for PDE2A Gene

Phosphodiesterase 2A, cGMP-stimulated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE2A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - - - - - - - - -
SP4: -
SP5: - - -
SP6:
SP7:
SP8:
SP9:

ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9: -

Relevant External Links for PDE2A Gene

GeneLoc Exon Structure for
PDE2A
ECgene alternative splicing isoforms for
PDE2A

Expression for PDE2A Gene

mRNA expression in normal human tissues for PDE2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE2A Gene

This gene is overexpressed in Spleen (x5.1) and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for PDE2A Gene

This gene is overexpressed in Frontal cortex (24.7), Brain (20.9), and Adrenal (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE2A Gene



SOURCE GeneReport for Unigene cluster for PDE2A Gene Hs.503163

mRNA Expression by UniProt/SwissProt for PDE2A Gene

O00408-PDE2A_HUMAN
Tissue specificity: Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with PDE2A: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PDE2A Gene

Orthologs for PDE2A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE2A 35
  • 99.67 (n)
  • 99.67 (a)
PDE2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE2A 36
  • 94 (a)
OneToOne
PDE2A 35
  • 91.59 (n)
  • 95.76 (a)
dog
(Canis familiaris)
Mammalia PDE2A 35
  • 90.29 (n)
  • 93.74 (a)
PDE2A 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde2a 16
Pde2a 35
  • 88.57 (n)
  • 93.54 (a)
Pde2a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE2A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE2A 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde2a 35
  • 88.17 (n)
  • 92.77 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13289 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pde2a 35
  • 72.51 (n)
  • 75.83 (a)
zebrafish
(Danio rerio)
Actinopterygii PDE2A (1 of 2) 36
  • 80 (a)
OneToMany
PDE2A (2 of 2) 36
  • 80 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008304 35
  • 57.92 (n)
  • 51.02 (a)
worm
(Caenorhabditis elegans)
Secernentea pde-2 36
  • 27 (a)
OneToOne
R08D7.6 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToOne
Species with no ortholog for PDE2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE2A Gene

ENSEMBL:
Gene Tree for PDE2A (if available)
TreeFam:
Gene Tree for PDE2A (if available)

Paralogs for PDE2A Gene

Paralogs for PDE2A Gene

genes like me logo Genes that share paralogs with PDE2A: view

Variants for PDE2A Gene

Sequence variations from dbSNP and Humsavar for PDE2A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs341047 - 72,590,459(-) GTACA(A/C/T)CGACC reference, missense, utr-variant-5-prime
rs151449 -- 72,635,252(-) TTAGA(G/T)AATAG intron-variant
rs180539 -- 72,653,204(-) CAGCA(G/T)GTCCA intron-variant
rs184654 -- 72,653,361(-) TTGCT(A/C/G)TCTGA intron-variant
rs415603 -- 72,654,454(-) CCCGG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE2A Gene

Variant ID Type Subtype PubMed ID
nsv832207 CNV Loss 17160897
nsv468633 CNV Loss 19166990
nsv523601 CNV Loss 19592680
nsv509429 CNV Insertion 20534489
esv1004730 CNV Insertion 20482838
esv1163550 CNV Insertion 17803354
nsv825991 CNV Gain 20364138
esv268579 CNV Insertion 20981092
esv274169 CNV Insertion 20981092
esv1200915 CNV Insertion 17803354
esv2325810 CNV Deletion 18987734
esv2664373 CNV Deletion 23128226
esv25409 CNV Loss 19812545
esv269430 CNV Insertion 20981092
esv259916 OTHER Complex 20981092

Variation tolerance for PDE2A Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE2A Gene

HapMap Linkage Disequilibrium report
PDE2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE2A Gene

Disorders for PDE2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE2A Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search PDE2A in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE2A

Genetic Association Database (GAD)
PDE2A
Human Genome Epidemiology (HuGE) Navigator
PDE2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE2A
genes like me logo Genes that share disorders with PDE2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE2A Gene

Publications for PDE2A Gene

  1. Isolation and characterization of human cDNAs encoding a cGMP- stimulated 3',5'-cyclic nucleotide phosphodiesterase. (PMID: 9210593) Rosman G.J. … Loughney K. (Gene 1997) 2 3 4 23 67
  2. The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. (PMID: 20967473) Rundfeldt C. … WlaA_ P. (J Neural Transm 2010) 25 26
  3. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. (PMID: 19689430) Matthiesen K. … Nielsen J. (Biochem. J. 2009) 3 23
  4. Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans. (PMID: 19252089) Adderley S.P. … Sprague R.S. (Am. J. Physiol. Heart Circ. Physiol. 2009) 3 23
  5. Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. (PMID: 19828435) Pandit J. … Menniti F.S. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for PDE2A Gene

Sources for PDE2A Gene

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