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PDE2A Gene

protein-coding   GIFtS: 69
GCID: GC11M072287

Phosphodiesterase 2A, CGMP-Stimulated

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phosphodiesterase 2A, CGMP-Stimulated1 2     PED2A42
Cyclic GMP-Stimulated Phosphodiesterase2 3     CGMP-Dependent 3',5'-Cyclic Phosphodiesterase2
CGS-PDE2 3     CGMP-Stimulated Phosphodiesterase 12
cGSPDE2 3     CGMP-Stimulated Phosphodiesterase 42
EC 3.1.4.173 8     EC 3.1.48
PDE2A12     

External Ids:    HGNC: 87771   Entrez Gene: 51382   Ensembl: ENSG000001866427   OMIM: 6026585   UniProtKB: O004083   
ORGUL members:         

Export aliases for PDE2A gene to outside databases

Previous GC identifers: GC11M074619 GC11M073826 GC11M072509 GC11M072013 GC11M071964 GC11M068580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PDE2A Gene:
PDE2A (phosphodiesterase 2A, cGMP-stimulated) is a protein-coding gene. GO annotations related to this gene include calcium channel activity and protein homodimerization activity. An important paralog of this gene is PDE11A.

UniProtKB/Swiss-Prot: PDE2A_HUMAN, O00408
Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP,
which are key regulators of many important physiological processes

summary for PDE2A Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDE2A gene promoter:
         Nkx3-1   E2F-3a   E2F-4   E2F-5   NRSF form 1   E2F-2   NRSF form 2   Egr-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDE2A promoter sequence
   Search Chromatin IP Primers for PDE2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.1-q14.1

PDE2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE2A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M072287:  view genomic region     (about GC identifiers)

Start:
72,287,185 bp from pter      End:
72,385,635 bp from pter
Size:
98,451 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PDE2A_HUMAN, O00408 (See protein sequence)
Recommended Name: cGMP-dependent 3',5'-cyclic phosphodiesterase  
Size: 941 amino acids; 105717 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions (By similarity)
Subunit: Homodimer
Miscellaneous: cGMP binds at an allosteric activator site (By similarity)
Selected PDB 3D structures from and Proteopedia for PDE2A (see all 7):
1Z1L (3D)        3IBJ (3D)        3ITM (3D)        3ITU (3D)        4HTX (3D)        4HTZ (3D)    
Secondary accessions: E9PGI1 Q5J793
Alternative splicing: 4 isoforms:  O00408-1   O00408-2   O00408-3   O00408-4   (Soluble form)

Explore the universe of human proteins at neXtProt for PDE2A: NX_O00408

Explore proteomics data for PDE2A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDE2A (O00408) (see all 5)
     HDLDHRG  ERHHFAQ  ISCMCHDL  SVMERHHF 


    See PDE2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137311.1  NP_001139681.1  NP_001230713.1  NP_002590.1  

    ENSEMBL proteins: 
     ENSP00000334910   ENSP00000365633   ENSP00000445443   ENSP00000442256   ENSP00000410310  
     ENSP00000446399   ENSP00000388997   ENSP00000392457   ENSP00000440834   ENSP00000439077  
     ENSP00000441322   ENSP00000438559   ENSP00000438008   ENSP00000442797   ENSP00000438868  
     ENSP00000439683   ENSP00000443737   ENSP00000439302   ENSP00000443232   ENSP00000438295  
     ENSP00000445750   ENSP00000411657  
    Reactome Protein details: O00408

    PDE2A Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for PDE2A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PDE2A
    GenScript Custom Purified and Recombinant Proteins Services for PDE2A
    Novus Biologicals PDE2A Protein
    Novus Biologicals PDE2A Lysate
    Sino Biological Recombinant Protein for PDE2A
    Sino Biological Cell Lysate for PDE2A
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE2A

     
    Search eBioscience for Proteins for PDE2A 

     
    antibodies-online proteins for PDE2A (3 products) 

     
    antibodies-online peptides for PDE2A

    PDE2A Antibody Products:

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    Abcam antibodies for PDE2A
    Cloud-Clone Corp. Antibodies for PDE2A
    ThermoFisher Antibodies for PDE2A
    antibodies-online antibodies for PDE2A (51 products) 

    PDE2A Assay Products:

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    Cloud-Clone Corp. ELISAs for PDE2A
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    antibodies-online kits for PDE2A (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE2A
    Phosphodiesterases, 3',5'-cyclic nucleotide

    5 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR003018 GAF
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry O00408

    ProtoNet protein and cluster: O00408

    1 Blocks protein domain: IPB003018 GAF domain

    UniProtKB/Swiss-Prot: PDE2A_HUMAN, O00408
    Domain: GAF 1 functions as a dimerization domain, whereas GAF 2 binds cGMP, which causes activation of the
    catalytic activity of the enzyme (By similarity)
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily
    Similarity: Contains 2 GAF domains


    Find genes that share domains with PDE2A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE2A_HUMAN, O00408
    Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP,
    which are key regulators of many important physiological processes
    Catalytic activity: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate

         Enzyme Numbers (IUBMB): EC 3.1.4.171 2 EC 3.1.42

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004112cyclic-nucleotide phosphodiesterase activity IDA15938621
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:0004118cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA17329248
    GO:0005262calcium channel activity TAS10375378
         
    Find genes that share ontologies with PDE2A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDE2A:
     Decreased POU5F1-GFP protein e 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Pde2a):
     mortality/aging 

    Find genes that share phenotypes with PDE2A           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PDE2A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDE2A:
    hsa-mir-192-5p (MIRT004169), hsa-mir-335-5p (MIRT017522)

    Block miRNA regulation of human, mouse, rat PDE2A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDE2A (see all 16):
    hsa-miR-379 hsa-miR-3910 hsa-miR-4283 hsa-miR-520d-5p hsa-miR-200c* hsa-miR-3201 hsa-miR-550a* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPDE2A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDE2A
    Predesigned siRNA for gene silencing in human, mouse, rat PDE2A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDE2A

    Clone
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    OriGene clones in human, mouse for PDE2A (see all 19)
    OriGene ORF clones in mouse, rat for PDE2A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PDE2A (NM_002599)
    Sino Biological Human cDNA Clone for PDE2A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE2A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PDE2A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE2A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDE2A_HUMAN, O00408: Cell membrane; Lipid-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    plasma membrane5
    endoplasmic reticulum4
    golgi apparatus4
    mitochondrion4
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10375378
    GO:0005737cytoplasm IDA10375378
    GO:0005759mitochondrial matrix ISS--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005794Golgi apparatus ISS--

    Find genes that share ontologies with PDE2A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDE2A About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    5CREB Pathway
    Activation of PKC through GPCR0.63


    Find genes that share SuperPaths with PDE2A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PDE2A (see all 10)
        Activation of PKA through GPCR
    PKA Signaling
    Sweet Taste Signaling
    Relaxin Pathway
    Activation of PKC through GPCR


    2 Reactome Pathways for PDE2A
        cGMP effects
    G alpha (s) signalling events


    2 Kegg Pathways  (Kegg details for PDE2A):
        Purine metabolism
    Morphine addiction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDE2A
    Interactions:

        Search GeneGlobe Interaction Network for PDE2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDE2A (O004081, 3 ENSP000003349104) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIPO001701, 3, ENSP000002791464EBI-1785967,EBI-704197 I2D: score=1 STRING: ENSP00000279146
    ADCY10ENSP000003568254STRING: ENSP00000356825
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY3ENSP000002606004STRING: ENSP00000260600
    ADCY7ENSP000002542354STRING: ENSP00000254235
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17329248
    GO:0006198cAMP catabolic process IMP19252089
    GO:0006626protein targeting to mitochondrion ISS--
    GO:0007165signal transduction ----
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with PDE2A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PDE2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    6 HMDB Compounds for PDE2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    SildenafilCaverta (see all 4)139755-83-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for PDE2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cyclic Guanosine Monophosphate-- 7665-99-8target--17139284 17016423 10592235
    3-ISOBUTYL-1-METHYLXANTHINE-- --target--10592235
    Tofisopam-- 22345-47-7targetinhibitor20967473

    3 IUPHAR Ligands for PDE2A (PDE2A)    About this table
    LigandTypeActionAffinityPubmed IDs
    BAY607550
    InhibitorInhibition8.3 - 8.815555642
    EHNA
    InhibitorInhibition5.38730511
    cGMP
    ActivatorActivation5.3--

    Selected Novoseek inferred chemical compound relationships for PDE2A gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cgmp 90.5 153 7623766 (4), 17704206 (4), 7658441 (3), 1335252 (3) (see all 96)
    zaprinast 86.3 8 8789382 (1), 1336365 (1), 8075860 (1), 1327377 (1) (see all 8)
    3',5'-cyclic nucleotide 80.3 1 1321624 (1)
    8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate 79.2 1 8294911 (1)
    exisulind 77.8 5 12392815 (1), 12642683 (1), 15534096 (1)
    8-bromo cgmp 75.6 4 8789382 (1), 16920709 (1), 19168131 (1), 8864545 (1)
    ibmx 72.6 3 1742017 (1), 19049345 (1)
    erythro-9-(2 hydroxy 3-nonyl)adenine 69.9 3 8519602 (2), 7623766 (1)
    cyclic amp 68.3 11 2164476 (2), 1742017 (1), 1710526 (1), 1695013 (1) (see all 8)
    cicletanine 65.9 1 10694190 (1)



    Find genes that share compounds with PDE2A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDE2A gene (4 alternative transcripts): 
    NM_001143839.3  NM_001146209.2  NM_001243784.1  NM_002599.4  

    Unigene Cluster for PDE2A:

    Phosphodiesterase 2A, cGMP-stimulated
    Hs.503163  [show with all ESTs]
    Unigene Representative Sequence: NM_002599
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000334456(uc001oso.3 uc010rra.2 uc010rrc.2 uc010rrd.2)
    ENST00000376450(uc001osn.3) ENST00000539367 ENST00000544570 ENST00000418754
    ENST00000540345 ENST00000536918 ENST00000420501 ENST00000544239 ENST00000441209
    ENST00000542223 ENST00000475807 ENST00000538299 ENST00000536308 ENST00000543750
    ENST00000543575 ENST00000490749 ENST00000541998
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    Selected qRT-PCR Assays for microRNAs that regulate PDE2A (see all 16):
    hsa-miR-379 hsa-miR-3910 hsa-miR-4283 hsa-miR-520d-5p hsa-miR-200c* hsa-miR-3201 hsa-miR-550a* hsa-miR-124
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE2A
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDE2A
      QuantiTect SYBR Green Assays in human, mouse, rat PDE2A
      QuantiFast Probe-based Assays in human, mouse, rat PDE2A

    Additional mRNA sequence: 

    AK131525.1 AK295676.1 AK312434.1 AY495087.1 AY495088.1 AY495089.1 BC040974.1 U67733.1 

    15 DOTS entries:

    DT.100024786  DT.91887082  DT.120748129  DT.446378  DT.100024783  DT.120748108  DT.120748117  DT.120748115 
    DT.100784287  DT.100784285  DT.120748106  DT.100024784  DT.120748150  DT.65288358  DT.91934727 

    Selected AceView cDNA sequences (see all 155):

    BU149270 BM919799 BM450793 AL119545 BF792178 BI253707 AL555496 CB155735 
    BI259167 BI255184 CB152659 BI259477 AK092278 CB153104 AL119813 CB152204 
    CR617254 CB153510 AX747449 CR624524 T33251 BF971103 U67733 BI757204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDE2A (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22a ·
    SP1:              -                 -                       -                                                                       -                       -   
    SP2:                                -                       -                                                                       -                       -   
    SP3:              -                 -     -     -     -     -     -     -     -     -     -     -                                   -                       -   
    SP4:                                                                                                                                                        -   
    SP5:                                -     -     -                                                                                                               

    ExUns: 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b
    SP1:                          -           -                                             
    SP2:                          -                                                         
    SP3:                          -           -                                             
    SP4:                          -                                                         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for PDE2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PDE2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATAAATC
    PDE2A Expression
    About this image


    PDE2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Spleen (Hematopoietic System)
    PDE2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503163

    UniProtKB/Swiss-Prot: PDE2A_HUMAN, O00408
    Tissue specificity: Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney
    and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PDE2A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde2a1 , 5 phosphodiesterase 2A, cGMP-stimulated1, 5 88.57(n)1
    93.54(a)1
      7 (54.57 cM)5
    2077281  NM_001143848.21  NP_001137320.11 
     1014216915 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.132892 Xenopus laevis transcribed sequence with moderate similarity more 75.96(n)    BJ067538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii PDE2A (2 of 2)6
    PDE2A (1 of 2)6
    phosphodiesterase 2A, cGMP-stimulated
    80(a)
    80(a)
    1 ↔ many
    1 ↔ many
    15(47102844-47117723) ENSDARG00000091508
    15(47086070-47092960) ENSDARG00000079064
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0083041 AgaP_AGAP008304 57.92(n)
    51.02(a)
      1277681  XM_317162.4  XP_317162.4 
    worm
    (Caenorhabditis elegans)
    Secernentea R08D7.63 Cyclic GMP phosphodiesterase 37(a)   III(9047383-9054333)   --


    ENSEMBL Gene Tree for PDE2A (if available)
    TreeFam Gene Tree for PDE2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDE2A gene
    PDE11A2  PDE6A2  PDE3A2  PDE6B2  PDE6C2  PDE5A2  PDE10A2  PDE3B2  
    8 SIMAP similar genes for PDE2A using alignment to 22 protein entries:     PDE2A_HUMAN (see all proteins):
    PDE6B    PDE5A    PDE6A    PDE4D    PDE9A    PDE11A
    PDE10A    PDE4

    Find genes that share paralogs with PDE2A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDE2A (see all 2129)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1434970191,2
    Cuntested172319732(+) CAGGGC/TCTCCT 8 T A mis11Minor allele frequency- T:0.00NA 3812
    rs4435101,2
    C,F,A--72286705(+) TCAGGC/GGTGCA 4 -- int112Minor allele frequency- G:0.26EA NA WA CSA 396
    rs1854381581,2
    --72286716(+) CCTTCA/GGCAGG 4 -- int10--------
    rs1468699711,2
    --72286917(+) TTTTCC/TTCTAT 4 -- int10--------
    rs1905447611,2
    --72286967(+) CATGGC/TCAGGC 4 -- int10--------
    rs1127175471,2
    C--72287053(+) AGAAGA/GGGGGC 4 -- int10--------
    rs1809926701,2
    --72287070(+) CCAAGG/TGTGGA 4 -- int10--------
    rs1504456421,2
    --72287145(+) CCCACC/GCCAAG 4 -- int10--------
    rs786380301,2
    C,F--72287156(+) CACAAA/CGTCTG 4 -- int11Minor allele frequency- C:0.04WA 118
    rs12991611,2
    C,F,H--72287350(+) GAAACA/C/GGAGAA 8 -- ut31 ese3 trp322MN NA NS EA WA CSA 1249

    HapMap Linkage Disequilibrium report for PDE2A (72287185 - 72385635 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PDE2A (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664373CNV Deletion23128226
    esv2325810CNV Deletion18987734
    esv1200915CNV Insertion17803354
    esv268579CNV Insertion20981092
    nsv509429CNV Insertion20534489
    esv1004730CNV Insertion20482838
    esv269430CNV Insertion20981092
    esv274169CNV Insertion20981092
    esv1163550CNV Insertion17803354
    esv25409CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602658    OMIM disorders: --


    Find genes that share disorders with PDE2A           About GenesLikeMe

    4 Novoseek inferred disease relationships for PDE2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinitis pigmentosa 55.9 2 1683837 (1), 9990021 (1)
    retinal degeneration 36.5 1 9811932 (1)
    colon cancer 0 1 12392815 (1)
    tumors 0 2 17704206 (2)

    Genetic Association Database (GAD): PDE2A
    Human Genome Epidemiology (HuGE) Navigator: PDE2A (4 documents)

    Export disorders for PDE2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDE2A gene, integrated from 10 sources (see all 150):
    (articles sorted by number of sources associating them with PDE2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human cDNAs encoding a cGMP- stimulated 3',5'-cyclic nucleotide phosphodiesterase. (PubMed id 9210593)1, 2, 3, 9 Rosman G.J....Loughney K. (Gene 1997)
    2. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. (PubMed id 15938621)1, 2, 9 Iffland A.... Ellenberger T. (Biochemistry 2005)
    3. Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. (PubMed id 19828435)1, 2, 9 Pandit J.... Menniti F.S. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (Nat. Genet. 2012)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells. (PubMed id 10375378)1, 9 Sadhu K....Wolda S.L. (J. Histochem. Cytochem. 1999)
    7. Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3. (PubMed id 17704206)1, 9 Surapisitchat J....Beavo J.A. (Circ. Res. 2007)
    8. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. (PubMed id 19689430)1, 9 Matthiesen K. and Nielsen J. (Biochem. J. 2009)
    9. Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression. (PubMed id 14687666)1, 9 Bender A.T....Beavo J.A. (Cell. Signal. 2004)
    10. Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans. (PubMed id 19252089)1, 9 Adderley S.P....Sprague R.S. (Am. J. Physiol. Heart Circ. Physiol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5138 HGNC: 8777 AceView: PDE2A Ensembl:ENSG00000186642 euGenes: HUgn5138
    ECgene: PDE2A Kegg: 5138 H-InvDB: PDE2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PDE2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDE2A gene:
    Search GeneIP for patents involving PDE2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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