Aliases for PDE2A Gene
External Ids for PDE2A Gene
GeneCards Summary for PDE2A Gene
PDE2A (Phosphodiesterase 2A, CGMP-Stimulated) is a Protein Coding gene. Diseases associated with PDE2A include retinitis pigmentosa. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include protein homodimerization activity and calcium channel activity. An important paralog of this gene is PDE6A.
UniProtKB/Swiss-Prot for PDE2A Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes
Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3 cyclic phosphate bonds in adenosine and/or guanine 3,5 cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.