Aliases for PDE1C Gene
External Ids for PDE1C Gene
Previous GeneCards Identifiers for PDE1C Gene
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]
GeneCards Summary for PDE1C Gene
PDE1C (Phosphodiesterase 1C, Calmodulin-Dependent 70kDa) is a Protein Coding gene. Diseases associated with PDE1C include tracheal disease. Among its related pathways are Immune System and DAG and IP3 signaling. GO annotations related to this gene include calmodulin binding and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE7A.
UniProtKB/Swiss-Prot for PDE1C Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP