Aliases for PDE1C Gene
External Ids for PDE1C Gene
Previous GeneCards Identifiers for PDE1C Gene
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]
GeneCards Summary for PDE1C Gene
PDE1C (Phosphodiesterase 1C) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and CREB Pathway. GO annotations related to this gene include calmodulin binding and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE1A.
UniProtKB/Swiss-Prot for PDE1C Gene
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.