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Aliases for PDE1C Gene

Aliases for PDE1C Gene

  • Phosphodiesterase 1C, Calmodulin-Dependent 70kDa 2 3
  • EC 3.1.4.17 4 63
  • Cam-PDE 1C 3 4
  • HCam-3 3 4
  • Human 3,5 Cyclic Nucleotide Phosphodiesterase (HSPDE1C1A) 3
  • Phosphodiesterase 1C, Calmodulin-Dependent (70kD) 2
  • EC 3.1.4 63
  • Hcam3 3

External Ids for PDE1C Gene

Previous GeneCards Identifiers for PDE1C Gene

  • GC07M031435
  • GC07M031534
  • GC07M031759

Summaries for PDE1C Gene

Entrez Gene Summary for PDE1C Gene

  • Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).[supplied by OMIM, Oct 2009]

GeneCards Summary for PDE1C Gene

PDE1C (Phosphodiesterase 1C, Calmodulin-Dependent 70kDa) is a Protein Coding gene. Diseases associated with PDE1C include tracheal disease. Among its related pathways are Immune System and DAG and IP3 signaling. GO annotations related to this gene include calmodulin binding and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE1C Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP

Gene Wiki entry for PDE1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE1C Gene

Genomics for PDE1C Gene

Regulatory Elements for PDE1C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDE1C Gene

Chromosome:
7
Start:
31,616,777 bp from pter
End:
32,299,404 bp from pter
Size:
682,628 bases
Orientation:
Minus strand

Genomic View for PDE1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE1C Gene

Proteins for PDE1C Gene

  • Protein details for PDE1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14123-PDE1C_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1C
    Protein Accession:
    Q14123
    Secondary Accessions:
    • B3KPC6
    • E9PE92
    • Q14124
    • Q8NB10

    Protein attributes for PDE1C Gene

    Size:
    709 amino acids
    Molecular mass:
    80760 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PDE1C Gene

    Alternative splice isoforms for PDE1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE1C Gene

Proteomics data for PDE1C Gene at MOPED

Post-translational modifications for PDE1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for PDE1C Gene

Gene Families for PDE1C Gene

Protein Domains for PDE1C Gene

Suggested Antigen Peptide Sequences for PDE1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14123

UniProtKB/Swiss-Prot:

PDE1C_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
genes like me logo Genes that share domains with PDE1C: view

Function for PDE1C Gene

Molecular function for PDE1C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+)
UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP

Enzyme Numbers (IUBMB) for PDE1C Gene

Gene Ontology (GO) - Molecular Function for PDE1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS 8557689
GO:0005516 calmodulin binding IEA --
GO:0008081 phosphoric diester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE1C: view

Phenotypes for PDE1C Gene

MGI mutant phenotypes for PDE1C:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PDE1C: view

Animal Models for PDE1C Gene

MGI Knock Outs for PDE1C:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE1C

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for PDE1C Gene

Localization for PDE1C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE1C Gene COMPARTMENTS Subcellular localization image for PDE1C gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PDE1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005929 cilium --
genes like me logo Genes that share ontologies with PDE1C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE1C Gene

Pathways & Interactions for PDE1C Gene

genes like me logo Genes that share pathways with PDE1C: view

Interacting Proteins for PDE1C Gene

Gene Ontology (GO) - Biological Process for PDE1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS --
GO:0007608 sensory perception of smell --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PDE1C: view

No data available for SIGNOR curated interactions for PDE1C Gene

Drugs & Compounds for PDE1C Gene

(9) Drugs for PDE1C Gene - From: HMDB, NovoSeek, DrugBank, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Caffeine Approved Nutra Activator, Target, inhibitor, competitive 317
Adenosine monophosphate Approved Nutra 0
cyclic amp Experimental Pharma 0
Cyclic GMP Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0

(3) Additional Compounds for PDE1C Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
2,3-Cyclic nucleotide
3,5-cyclic nucleotide
genes like me logo Genes that share compounds with PDE1C: view

Transcripts for PDE1C Gene

Unigene Clusters for PDE1C Gene

Phosphodiesterase 1C, calmodulin-dependent 70kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE1C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE1C Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - - - - - - - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

ExUns: 23 ^ 24 ^ 25
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for PDE1C Gene

GeneLoc Exon Structure for
PDE1C
ECgene alternative splicing isoforms for
PDE1C

Expression for PDE1C Gene

mRNA expression in normal human tissues for PDE1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE1C Gene

This gene is overexpressed in Heart - Left Ventricle (x7.7).

Protein differential expression in normal tissues from HIPED for PDE1C Gene

This gene is overexpressed in Bone (38.1) and Frontal cortex (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE1C Gene



SOURCE GeneReport for Unigene cluster for PDE1C Gene Hs.728862

mRNA Expression by UniProt/SwissProt for PDE1C Gene

Q14123-PDE1C_HUMAN
Tissue specificity: Expressed in several tissues, including brain and heart
genes like me logo Genes that share expression patterns with PDE1C: view

Protein tissue co-expression partners for PDE1C Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PDE1C Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE1C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE1C 35
  • 91.24 (n)
  • 95.58 (a)
PDE1C 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE1C 35
  • 91.55 (n)
  • 95.83 (a)
PDE1C 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde1c 35
  • 88.17 (n)
  • 94.76 (a)
Pde1c 16
Pde1c 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE1C 35
  • 99.44 (n)
  • 99.61 (a)
PDE1C 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde1c 35
  • 88.54 (n)
  • 94.53 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE1C 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE1C 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE1C 35
  • 75.62 (n)
  • 77.71 (a)
PDE1C 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE1C 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde1c 35
  • 71.02 (n)
  • 73.24 (a)
Str.17555 35
zebrafish
(Danio rerio)
Actinopterygii PDE1C (1 of 2) 36
  • 81 (a)
OneToMany
PDE1C (2 of 2) 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14940 37
  • 57 (a)
Pde1c 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T04D3.3 37
  • 55 (a)
pde-1 35
  • 54.51 (n)
  • 50.39 (a)
pde-1 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for PDE1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE1C Gene

ENSEMBL:
Gene Tree for PDE1C (if available)
TreeFam:
Gene Tree for PDE1C (if available)

Paralogs for PDE1C Gene

Paralogs for PDE1C Gene

(8) SIMAP similar genes for PDE1C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PDE1C: view

Variants for PDE1C Gene

Sequence variations from dbSNP and Humsavar for PDE1C Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs27332 -- 31,661,423(+) ATTGG(G/T)AATAT intron-variant
rs27333 -- 31,663,911(+) tcaaa(C/T)ataat intron-variant
rs30554 -- 32,016,352(+) gtggg(A/G)gcttg intron-variant
rs30555 -- 32,018,165(+) acaag(C/T)gttgg intron-variant
rs30556 -- 32,018,179(+) ttatg(C/T)tgaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE1C Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
dgv7244n71 CNV Gain 21882294
nsv887914 CNV Gain 21882294
esv271942 CNV Insertion 20981092
nsv887916 CNV Loss 21882294
esv33248 CNV Gain 17666407
nsv887917 CNV Gain 21882294
esv6756 CNV Gain 19470904
nsv824052 CNV Loss 20364138
esv2734209 CNV Deletion 23290073
esv2428975 CNV Insertion 19546169
esv1399325 CNV Insertion 17803354
nsv464420 CNV Loss 19166990
nsv887918 CNV Gain 21882294
nsv824053 CNV Loss 20364138
esv2734210 CNV Deletion 23290073
esv2677609 CNV Deletion 23128226
nsv527840 CNV Loss 19592680
nsv887919 CNV Gain 21882294
esv2225343 CNV Deletion 18987734
esv2105969 CNV Deletion 18987734
esv3414 CNV Deletion 18987735
esv2665337 CNV Deletion 23128226
esv2734211 CNV Deletion 23290073
esv6080 CNV Loss 19470904
nsv887920 CNV Loss 21882294
nsv464421 CNV Gain 19166990
nsv523567 CNV Gain 19592680
esv2752156 CNV Gain 17911159
esv2670779 CNV Deletion 23128226
nsv824055 CNV Loss 20364138
nsv528955 CNV Loss 19592680
nsv5688 CNV Insertion 18451855
nsv887921 CNV Gain 21882294
esv2513864 CNV Deletion 19546169
esv2271605 CNV Deletion 18987734
esv2734212 CNV Deletion 23290073
esv2678586 CNV Deletion 23128226
esv2608247 CNV Deletion 19546169
esv2734213 CNV Deletion 23290073
nsv5689 CNV Insertion 18451855
esv2734214 CNV Deletion 23290073
esv1014975 CNV Deletion 17803354
esv2734215 CNV Deletion 23290073

Variation tolerance for PDE1C Gene

Residual Variation Intolerance Score: 49.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE1C Gene

HapMap Linkage Disequilibrium report
PDE1C
Human Gene Mutation Database (HGMD)
PDE1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE1C Gene

Disorders for PDE1C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE1C Gene - From: DISEASES

Disorder Aliases PubMed IDs
tracheal disease
  • disorder of trachea
- elite association
Search PDE1C in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE1C

Genetic Association Database (GAD)
PDE1C
Human Genome Epidemiology (HuGE) Navigator
PDE1C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE1C
genes like me logo Genes that share disorders with PDE1C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE1C Gene

Publications for PDE1C Gene

  1. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. (PMID: 19797176) Miller C.L. … Yan C. (Circ. Res. 2009) 23 67
  2. Characterization of phosphodiesterase 1 in human malignant melanoma cell lines. (PMID: 19414353) Shimizu K. … Tagawa T. (Anticancer Res. 2009) 23 67
  3. Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells. (PMID: 19741056) Ortiz-Capisano M.C. … Beierwaltes W.H. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 23 67
  4. Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway. (PMID: 19232106) Sato Y. … Nishida M. (BMC Syst Biol 2009) 23 67
  5. Gene expression and protein localization of calmodulin-dependent phosphodiesterase during ontogenesis of chick retina. (PMID: 18041092) Deplano S. … Bisti S. (J. Neurosci. Res. 2008) 23 67

Products for PDE1C Gene

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