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Aliases for PDE1B Gene

Aliases for PDE1B Gene

  • Phosphodiesterase 1B, Calmodulin-Dependent 2 3
  • PDE1B1 3 4 6
  • 63 KDa Cam-PDE 3 4
  • EC 3.1.4.17 4 63
  • Cam-PDE 1B 3 4
  • PDES1B 3 4
  • Presumed 63kDa Form Of The Type 1 Cyclic Nucleotide Phosphodiesterase Family Known As PDE1B 3
  • Calcium/Calmodulin-Dependent 3,5-Cyclic Nucleotide Phosphodiesterase 1B 3
  • Calcium/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 3
  • Calmodulin-Stimulated Phosphodiesterase PDE1B1 3
  • EC 3.1.4 63
  • PDES1B, 6

External Ids for PDE1B Gene

Previous HGNC Symbols for PDE1B Gene

  • PDES1B

Previous GeneCards Identifiers for PDE1B Gene

  • GC12P055070
  • GC12P054660
  • GC12P053229
  • GC12P054943
  • GC12P051981

Summaries for PDE1B Gene

Entrez Gene Summary for PDE1B Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for PDE1B Gene

PDE1B (Phosphodiesterase 1B, Calmodulin-Dependent) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include calmodulin binding and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE1B Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.

Tocris Summary for PDE1B Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE1B Gene

Genomics for PDE1B Gene

Regulatory Elements for PDE1B Gene

Genomic Location for PDE1B Gene

Start:
54,549,350 bp from pter
End:
54,579,239 bp from pter
Size:
29,890 bases
Orientation:
Plus strand

Genomic View for PDE1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE1B Gene

Proteins for PDE1B Gene

  • Protein details for PDE1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01064-PDE1B_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1B
    Protein Accession:
    Q01064
    Secondary Accessions:
    • Q92825
    • Q96KP3

    Protein attributes for PDE1B Gene

    Size:
    536 amino acids
    Molecular mass:
    61380 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PDE1B Gene

    Alternative splice isoforms for PDE1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE1B Gene

Proteomics data for PDE1B Gene at MOPED

Post-translational modifications for PDE1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE1B Gene

Antibody Products

Domains for PDE1B Gene

Gene Families for PDE1B Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Protein Domains for PDE1B Gene

Graphical View of Domain Structure for InterPro Entry

Q01064

UniProtKB/Swiss-Prot:

PDE1B_HUMAN :
  • Q01064
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
genes like me logo Genes that share domains with PDE1B: view

Function for PDE1B Gene

Molecular function for PDE1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+)
UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.

Enzyme Numbers (IUBMB) for PDE1B Gene

Gene Ontology (GO) - Molecular Function for PDE1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004112 cyclic-nucleotide phosphodiesterase activity --
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity IEA --
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS 9419816
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with PDE1B: view
genes like me logo Genes that share phenotypes with PDE1B: view

Animal Models for PDE1B Gene

MGI Knock Outs for PDE1B:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE1B

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PDE1B Gene

Localization for PDE1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE1B Gene COMPARTMENTS Subcellular localization image for PDE1B gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for PDE1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PDE1B: view

Pathways for PDE1B Gene

genes like me logo Genes that share pathways with PDE1B: view

Gene Ontology (GO) - Biological Process for PDE1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001505 regulation of neurotransmitter levels IEA --
GO:0001975 response to amphetamine IEA --
GO:0006198 cAMP catabolic process IDA 14687666
GO:0006915 apoptotic process TAS 8855339
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with PDE1B: view

Compounds for PDE1B Gene

(5) Tocris Compounds for PDE1B Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(2) ApexBio Compounds for PDE1B Gene

Compound Action Cas Number
Cilostazol PDE3 inhibitor [73963-72-1]
Sildenafil Citrate Treat erectile dysfunction and PAH [171599-83-0]

(5) HMDB Compounds for PDE1B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Water
  • Dihydrogen oxide
7732-18-5

(4) Drugbank Compounds for PDE1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Bepridil
64706-54-3 target inhibitor
Felodipine
  • Dl-Felodipine
72509-76-3 target inhibitor
Nicardipine
  • Nicardipine HCl
55985-32-5 target inhibitor
S,S-(2-Hydroxyethyl)Thiocysteine
target

(2) IUPHAR Ligand for PDE1B Gene

Ligand Type Action Affinity Pubmed IDs
SCH51866 Inhibitor Inhibition 7.2
calmodulin Activator Activation
genes like me logo Genes that share compounds with PDE1B: view

Transcripts for PDE1B Gene

Unigene Clusters for PDE1B Gene

Phosphodiesterase 1B, calmodulin-dependent:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE1B Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6:
SP7: - - -
SP8: - - - - - - - - -

Relevant External Links for PDE1B Gene

GeneLoc Exon Structure for
PDE1B
ECgene alternative splicing isoforms for
PDE1B

Expression for PDE1B Gene

mRNA expression in normal human tissues for PDE1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE1B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (10.8), Brain - Caudate (basal ganglia) (9.0), and Brain - Nucleus accumbens (basal ganglia) (8.0).

Protein differential expression in normal tissues for PDE1B Gene

This gene is overexpressed in Urine (46.6) and Frontal cortex (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE1B Gene

SOURCE GeneReport for Unigene cluster for PDE1B Gene Hs.530871

genes like me logo Genes that share expressions with PDE1B: view

Expression partners for PDE1B Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PDE1B Gene

Orthologs for PDE1B Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE1B 35
  • 91.76 (n)
  • 96.44 (a)
PDE1B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE1B 35
  • 88.91 (n)
  • 95.51 (a)
PDE1B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde1b 35
  • 90.78 (n)
  • 96.07 (a)
Pde1b 16
Pde1b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE1B 35
  • 99.5 (n)
  • 99.44 (a)
PDE1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde1b 35
  • 90.65 (n)
  • 96.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PDE1B 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC777528 35
  • 80.76 (n)
  • 85.37 (a)
PDE1B 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE1B 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde1b 35
  • 74.55 (n)
  • 83.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14940 37
  • 53 (a)
Pde1c 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T04D3.3 37
  • 54 (a)
pde-1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for PDE1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PDE1B Gene

ENSEMBL:
Gene Tree for PDE1B (if available)
TreeFam:
Gene Tree for PDE1B (if available)

Paralogs for PDE1B Gene

Paralogs for PDE1B Gene

Selected SIMAP similar genes for PDE1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PDE1B: view

Variants for PDE1B Gene

Sequence variations from dbSNP and Humsavar for PDE1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs884510 -- 54,578,515(-) TCACT(A/G)TATCA utr-variant-3-prime
rs1022232 -- 54,551,281(+) GAGAG(G/T)CGTTA intron-variant
rs1144995 -- 54,566,153(-) ACTTA(C/T)GAATT intron-variant
rs1153136 -- 54,568,742(+) AGTGA(A/G)CCAAG intron-variant
rs1153137 -- 54,569,978(+) TACAG(A/G)CGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE1B Gene

Variant ID Type Subtype PubMed ID
nsv832421 CNV Gain 17160897

Relevant External Links for PDE1B Gene

HapMap Linkage Disequilibrium report
PDE1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE1B Gene

Disorders for PDE1B Gene

Relevant External Links for PDE1B

Genetic Association Database (GAD)
PDE1B
Human Genome Epidemiology (HuGE) Navigator
PDE1B

No disorders were found for PDE1B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PDE1B Gene

Publications for PDE1B Gene

  1. Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. (PMID: 9419816) Yu J. … Gelinas R. (Cell. Signal. 1997) 2 3 4 23
  2. Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. (PMID: 8855339) Jiang X. … Epstein P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 23
  3. Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. (PMID: 11747989) Fidock M.D. … Lanfear J. (Cell. Signal. 2002) 3 4 23
  4. Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression. (PMID: 14687666) Bender A.T. … Beavo J.A. (Cell. Signal. 2004) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PDE1B Gene

Sources for PDE1B Gene

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