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PDE1B Gene

protein-coding   GIFtS: 66
GCID: GC12P054943

Phosphodiesterase 1B, Calmodulin-Dependent


(Previous symbol: PDES1B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphodiesterase 1B, Calmodulin-Dependent1 2     Calcium/Calmodulin-Dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B2
PDES1B1 2 3 5     Calcium/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase2
PDE1B12 3 5     Calmodulin-Stimulated Phosphodiesterase PDE1B12
Cam-PDE 1B2 3     Presumed 63kDa Form Of The Type 1 Cyclic Nucleotide Phosphodiesterase
Family Known As PDE1B2
63 KDa Cam-PDE2 3     EC 3.1.48
EC 3.1.4.173 8     

External Ids:    HGNC: 87751   Entrez Gene: 51532   Ensembl: ENSG000001233607   OMIM: 1718915   UniProtKB: Q010643   

Export aliases for PDE1B gene to outside databases

Previous GC identifers: GC12P055070 GC12P054660 GC12P053229 GC12P051981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDE1B Gene:
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1
subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin
complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a
substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively
spliced transcript variants encoding different isoforms have been described for this gene.(provided by RefSeq,
Jul 2011)

GeneCards Summary for PDE1B Gene:
PDE1B (phosphodiesterase 1B, calmodulin-dependent) is a protein-coding gene. GO annotations related to this gene include calmodulin-dependent cyclic-nucleotide phosphodiesterase activity and calmodulin binding. An important paralog of this gene is PDE4D.

UniProtKB/Swiss-Prot: PDE1B_HUMAN, Q01064
Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP,
which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate

summary for PDE1B Gene:
Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the
hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or
cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by
controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8
selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both
cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue
distribution. These enzymes are involved in many signal transduction pathways and their functions include
vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone
secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDE1B gene promoter:
         CRE-BP1   MZF-1   AREB6   SREBP-1a   FOXF2   ATF-2   Pax-2   Pax-2a   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDE1B promoter sequence
   Search Chromatin IP Primers for PDE1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

PDE1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054943:  view genomic region     (about GC identifiers)

Start:
54,943,134 bp from pter      End:
54,973,023 bp from pter
Size:
29,890 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PDE1B_HUMAN, Q01064 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B  
Size: 536 amino acids; 61380 Da
Cofactor: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a
preference for magnesium and/or manganese ions
Subunit: Homodimer (By similarity)
2 PDB 3D structures from and Proteopedia for PDE1B:
1LXR (3D)        1TAZ (3D)    
Secondary accessions: Q92825 Q96KP3
Alternative splicing: 2 isoforms:  Q01064-1   Q01064-2   

Explore the universe of human proteins at neXtProt for PDE1B: NX_Q01064

Explore proteomics data for PDE1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDE1B (Q01064) (see all 19)
     MKTALQQ  HAADVTQ  SVLENHH  VLATDMS 


    See PDE1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000915.1  NP_001159447.1  NP_001275697.1  NP_001275698.1  

    ENSEMBL proteins: 
     ENSP00000243052   ENSP00000447354   ENSP00000442559   ENSP00000448519  
    Reactome Protein details: Q01064

    PDE1B Human Recombinant Protein Products:

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    OriGene Custom Protein Services for PDE1B
    GenScript Custom Purified and Recombinant Proteins Services for PDE1B
    Novus Biologicals PDE1B Protein
    Novus Biologicals PDE1B Lysate
    Sino Biological Recombinant Protein for PDE1B
    Sino Biological Cell Lysate for PDE1B
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE1B

     
    Search eBioscience for Proteins for PDE1B 

     
    antibodies-online proteins for PDE1B (3 products) 

     
    antibodies-online peptides for PDE1B

    PDE1B Antibody Products:

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    antibodies-online antibodies for PDE1B (56 products) 

    PDE1B Assay Products:

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    Cloud-Clone Corp. ELISAs for PDE1B
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    antibodies-online kits for PDE1B (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PDE: Phosphodiesterases

    IUPHAR Guide to PHARMACOLOGY protein family classification: PDE1B
    Phosphodiesterases, 3',5'-cyclic nucleotide

    5 InterPro protein domains:
     IPR002073 PDEase_catalytic_dom
     IPR013706 PDEase_N
     IPR023174 PDEase_CS
     IPR023088 PDEase
     IPR003607 HD/PDEase_dom

    Graphical View of Domain Structure for InterPro Entry Q01064

    ProtoNet protein and cluster: Q01064

    UniProtKB/Swiss-Prot: PDE1B_HUMAN, Q01064
    Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily


    Find genes that share domains with PDE1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE1B_HUMAN, Q01064
    Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP,
    which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate
    Catalytic activity: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate
    Enzyme regulation: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+)

         Enzyme Numbers (IUBMB): EC 3.1.4.171 2 EC 3.1.42

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004112cyclic-nucleotide phosphodiesterase activity ----
    GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity ----
    GO:00041153',5'-cyclic-AMP phosphodiesterase activity IEA--
    GO:0004117calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS9419816
         
    Find genes that share ontologies with PDE1B           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PDE1B:
     Decreased TP53 protein express  Decreased nuclei size in G2M  Increased circadian rhythm amp  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Pde1b):
     behavior/neurological 

    Find genes that share phenotypes with PDE1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pde1btm1Cvv for PDE1B

       genOway: Develop your customized and physiologically relevant rodent model for PDE1B

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PDE1B (see all 56):
    hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-631 hsa-miR-128 hsa-miR-650 hsa-miR-105 hsa-miR-4314 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidPDE1B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PDE1B

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    GenScript: all cDNA clones in your preferred vector (see all 2): PDE1B (NM_000924)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDE1B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDE1B_HUMAN, Q01064: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with PDE1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDE1B About   (see all 16)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.92
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.67
    PLC-gamma1 signalling0.94
    G-protein mediated events0.65
    CaM pathway0.93
    Phospholipase C-mediated cascade0.59
    2Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    3Sweet Taste Signaling
    Sweet Taste Signaling0.72
    Bitter Taste Signaling0.44
    Cellular Effects of Sildenafil0.46
    Sperm Motility0.37
    4Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with PDE1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PDE1B (see all 10)
        Activation of PKA through GPCR
    PKA Signaling
    Sweet Taste Signaling
    Relaxin Pathway
    Activation of PKC through GPCR

    1 BioSystems Pathway for PDE1B
        G Protein Signaling Pathways


    3 Reactome Pathways for PDE1B
        cGMP effects
    Cam-PDE 1 activation
    G alpha (s) signalling events


    3 Kegg Pathways  (Kegg details for PDE1B):
        Purine metabolism
    Calcium signaling pathway
    Morphine addiction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDE1B
    Interactions:

        Search GeneGlobe Interaction Network for PDE1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDE1B (Q010642, 3 ENSP000002430524) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE3AQ050862, 3, ENSP000003810454MINT-8276461 I2D: score=2 STRING: ENSP00000381045
    RHOXF2Q9BQY43I2D: score=1 
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY10ENSP000003568254STRING: ENSP00000356825
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001505regulation of neurotransmitter levels IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006198cAMP catabolic process IDA14687666
    GO:0006915apoptotic process TAS8855339
    GO:0007165signal transduction TAS--

    Find genes that share ontologies with PDE1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PDE1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CilostamidePDE3 inhibitor[68550-75-4]
    RolipramPDE4 inhibitor[61413-54-5]
    IBMXPDE inhibitor (non-selective)[28822-58-4]
    Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]
    (R)-(-)-RolipramPDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905)[85416-75-7]

    5 HMDB Compounds for PDE1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    4 DrugBank Compounds for PDE1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FelodipineDl-Felodipine (see all 4)72509-76-3targetinhibitor9231746 2933041
    Bepridil-- 64706-54-3targetinhibitor2933041
    NicardipineNicardipine HCl (see all 3)55985-32-5targetinhibitor9231746
    S,S-(2-Hydroxyethyl)Thiocysteine-- --target----

    2 IUPHAR Ligands for PDE1B (PDE1B)    About this table
    LigandTypeActionAffinityPubmed IDs
    SCH51866
    InhibitorInhibition7.28961086
    calmodulin
    ActivatorActivation7.2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDE1B gene (4 alternative transcripts): 
    NM_000924.3  NM_001165975.2  NM_001288768.1  NM_001288769.1  

    Unigene Cluster for PDE1B:

    Phosphodiesterase 1B, calmodulin-dependent
    Hs.530871  [show with all ESTs]
    Unigene Representative Sequence: NM_000924
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243052(uc001sgd.2 uc010soz.2 uc010spa.1) ENST00000548855
    ENST00000550285 ENST00000538346 ENST00000394277(uc001sge.3 uc001sgf.3 uc009znq.3)
    ENST00000550620 ENST00000542335 ENST00000552774
    miRNA
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    hsa-miR-3194-5p hsa-miR-330-5p hsa-miR-631 hsa-miR-128 hsa-miR-650 hsa-miR-105 hsa-miR-4314 hsa-miR-890
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      QuantiFast Probe-based Assays in human, mouse, rat PDE1B

    Additional mRNA sequence: 

    AJ401609.1 AK126899.1 AK296422.1 AK302899.1 AK302931.1 BC032226.1 BX538092.1 M94539.1 
    U40584.1 U56976.1 U86078.1 

    6 DOTS entries:

    DT.413414  DT.100747432  DT.100773891  DT.80102043  DT.101980529  DT.86849496 

    Selected AceView cDNA sequences (see all 59):

    BX113721 CA395159 R24757 BC032226 BP342896 NM_000924 CB155259 CA392998 
    BX538092 BX951582 CA397265 CD609814 BM875274 BI488476 AL703102 BP382649 
    R86851 CK823966 AJ401609 U56976 U86078 AA323891 CA308319 AK126899 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDE1B (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:              -     -     -           -                                                           -     -                                 
    SP2:                                      -     -                                                     -     -                                 
    SP3:                                      -                                                           -     -                                 
    SP4:                                      -     -     -     -                                         -     -                                 
    SP5:              -     -     -           -                                                                                                   


    ECgene alternative splicing isoforms for PDE1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PDE1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTCACCC
    PDE1B Expression
    About this image


    PDE1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Adipose (Muscoskeletal System)
             White adipocyte-like cells
    PDE1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530871
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PDE1B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde1b1 , 5 phosphodiesterase 1B, Ca2+-calmodulin dependent1, 5 90.78(n)1
    96.07(a)1
      15 (58.99 cM)5
    185741  NM_008800.21  NP_032826.11 
     1035032985 
    chicken
    (Gallus gallus)
    Aves LOC7775281 calcium/calmodulin-dependent 3',5'-cyclic nucleotide more 80.76(n)
    85.37(a)
      777528  XM_001236973.3  XP_001236974.3 
    lizard
    (Anolis carolinensis)
    Reptilia PDE1B6
    phosphodiesterase 1B, calmodulin-dependent
    72(a)
    1 ↔ 1
    GL343252.1(556056-731572)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pde1b1 phosphodiesterase 1B, calmodulin-dependent 74.55(n)
    83.21(a)
      100036722  NM_001097267.1  NP_001090736.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG149403 calmodulin-dependent cyclic-nucleotide
    phosphodiesterase
    53(a)   33A2   --
    worm
    (Caenorhabditis elegans)
    Secernentea T04D3.33 3',5' cyclic phosphodieterase 54(a)   I(13319143-13326754)   --


    ENSEMBL Gene Tree for PDE1B (if available)
    TreeFam Gene Tree for PDE1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDE1B gene
    PDE4D2  PDE8B2  PDE4B2  PDE4C2  PDE7B2  PDE1A2  PDE9A2  PDE1C2  
    PDE7A2  PDE8A2  PDE4A2  
    11 SIMAP similar genes for PDE1B using alignment to 3 protein entries:     PDE1B_HUMAN (see all proteins):
    DKFZp686L23131    HSPDE1A    PDE1A    PDE1C    PDE4    PDE4A
    PDE4C    PDE4D    PDE4B    PDE8A    PDE8B

    Find genes that share paralogs with PDE1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDE1B (see all 726)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1489284071,2
    C,Funtested154777229(+) CTGTCA/C/TCCCCG 2 S syn11NA 4552
    rs2074729371,2
    Cuntested154802350(+) AAGTTA/GTGTGA 2 -- int10--------
    rs30366341,2
    C--51994316(-) cacac-/ACGCACA 2 -- int10--------
    rs38374631,2
    F--52006415(+) GAGTGA/TGTGTG 2 -- int16Minor allele frequency- T:0.36NA CSA 11
    rs1448979171,2
    C--54774784(+) TCCCAC/TTTATT 1 -- us2k10--------
    rs749934501,2
    --54774855(+) GTGTGC/TGTGTG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs106910391,2
    C--54774886(+) gtgtg-/TG/TGTG/TG
    TGTG
    /TGTGTGTG
    AATTA
    2 -- us2k1 cds11NA 2
    rs1864396271,2
    --54774938(+) GATGTA/GACACT 1 -- us2k10--------
    rs731091361,2
    F--54775035(+) TGGAAA/TCTCCT 1 -- us2k11Minor allele frequency- T:0.06NA 120
    rs1486091521,2
    --54775365(+) TACTTC/GTGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDE1B (54943134 - 54973023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PDE1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832421CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 171891    OMIM disorders: --


    Find genes that share disorders with PDE1B           About GenesLikeMe

    Genetic Association Database (GAD): PDE1B
    Human Genome Epidemiology (HuGE) Navigator: PDE1B (3 documents)

    Export disorders for PDE1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDE1B gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PDE1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells. (PubMed id 8855339)1, 2, 3, 9 Jiang X.... Epstein P.M. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1. (PubMed id 9419816)1, 2, 3, 9 Yu J.... Gelinas R. (Cell. Signal. 1997)
    3. Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants. (PubMed id 11747989)1, 2, 9 Fidock M.D.... Lanfear J. (Cell. Signal. 2002)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase. (PubMed id 1326532)1, 2 Repaske D.R.... Conti M. (J. Biol. Chem. 1992)
    7. Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase. (PubMed id 9003415)1, 9 Spence S.... Houslay M.D. (Biochem. J. 1997)
    8. Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression. (PubMed id 14687666)1, 9 Bender A.T....Beavo J.A. (Cell. Signal. 2004)
    9. Phosphodiesterases in neurodegenerative disorders. (PubMed id 23129425)1 Bollen E. and Prickaerts J. (IUBMB Life 2012)
    10. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5153 HGNC: 8775 AceView: PDE1B Ensembl:ENSG00000123360 euGenes: HUgn5153
    ECgene: PDE1B Kegg: 5153 H-InvDB: PDE1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDE1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDE1B gene:
    Search GeneIP for patents involving PDE1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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