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Aliases for PDE1A Gene

Aliases for PDE1A Gene

  • Phosphodiesterase 1A, Calmodulin-Dependent 2 3
  • 61 KDa Cam-PDE 3 4
  • EC 3.1.4.17 4 63
  • Cam-PDE 1A 3 4
  • HCAM-1 3 4
  • Calcium/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 3
  • CAM-PDE-1A 3
  • EC 3.1.4 63
  • HSPDE1A 3
  • HCAM1 3

External Ids for PDE1A Gene

Previous GeneCards Identifiers for PDE1A Gene

  • GC02M181214
  • GC02M181690
  • GC02M182971
  • GC02M183209
  • GC02M182832
  • GC02M182715
  • GC02M174863

Summaries for PDE1A Gene

Entrez Gene Summary for PDE1A Gene

  • Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

GeneCards Summary for PDE1A Gene

PDE1A (Phosphodiesterase 1A, Calmodulin-Dependent) is a Protein Coding gene. Among its related pathways are Immune System and DAG and IP3 signaling. GO annotations related to this gene include calmodulin binding and cGMP binding. An important paralog of this gene is PDE7A.

UniProtKB/Swiss-Prot for PDE1A Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP

Tocris Summary for PDE1A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE1A Gene

Genomics for PDE1A Gene

Regulatory Elements for PDE1A Gene

Genomic Location for PDE1A Gene

Chromosome:
2
Start:
182,140,035 bp from pter
End:
182,523,192 bp from pter
Size:
383,158 bases
Orientation:
Minus strand

Genomic View for PDE1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE1A Gene

Proteins for PDE1A Gene

  • Protein details for PDE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54750-PDE1A_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A
    Protein Accession:
    P54750
    Secondary Accessions:
    • D3DPG5
    • Q86VZ0
    • Q9C0K8
    • Q9C0K9
    • Q9C0L0
    • Q9C0L1
    • Q9C0L2
    • Q9C0L3
    • Q9C0L4
    • Q9UFX3

    Protein attributes for PDE1A Gene

    Size:
    535 amino acids
    Molecular mass:
    61252 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PDE1A Gene

    Alternative splice isoforms for PDE1A Gene

neXtProt entry for PDE1A Gene

Proteomics data for PDE1A Gene at MOPED

Post-translational modifications for PDE1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for PDE1A Gene

Gene Families for PDE1A Gene

Protein Domains for PDE1A Gene

Graphical View of Domain Structure for InterPro Entry

P54750

UniProtKB/Swiss-Prot:

PDE1A_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
genes like me logo Genes that share domains with PDE1A: view

Function for PDE1A Gene

Molecular function for PDE1A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+)
UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP

Enzyme Numbers (IUBMB) for PDE1A Gene

Gene Ontology (GO) - Molecular Function for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity --
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS 8557689
GO:0005516 calmodulin binding IEA --
GO:0008081 phosphoric diester hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE1A: view
genes like me logo Genes that share phenotypes with PDE1A: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PDE1A Gene

Localization for PDE1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE1A Gene COMPARTMENTS Subcellular localization image for PDE1A gene
Compartment Confidence
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDE1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE1A Gene

Pathways & Interactions for PDE1A Gene

SuperPathways for PDE1A Gene

genes like me logo Genes that share pathways with PDE1A: view

Interacting Proteins for PDE1A Gene

Selected Interacting proteins: P54750-PDE1A_HUMAN for PDE1A Gene via I2D

Gene Ontology (GO) - Biological Process for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS --
GO:0007596 blood coagulation TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PDE1A: view

No data available for SIGNOR curated interactions for PDE1A Gene

Drugs & Compounds for PDE1A Gene

(18) Drugs for PDE1A Gene - From: HMDB, NovoSeek, DrugBank, IUPHAR, DGIdb, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bepridil Approved, Withdrawn Pharma Pore Blocker, Target, inhibitor 0
Felodipine Approved, Investigational Pharma Potentiation, Activator, Target, inhibitor 21
Nicardipine Approved Pharma Antagonist, Target, inhibitor 28
Caffeine Approved Nutra Activator, Target, inhibitor, competitive 317
Dipyridamole Approved Pharma Inhibition, Inhibitor Adenosine transport inhibitor 75

(6) Additional Compounds for PDE1A Gene - From: HMDB, Tocris, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MY-5445
78351-75-4
Ro 20-1724
29925-17-5
3,5-cyclic nucleotide
genes like me logo Genes that share compounds with PDE1A: view

Transcripts for PDE1A Gene

mRNA/cDNA for PDE1A Gene

(9) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDE1A Gene

Phosphodiesterase 1A, calmodulin-dependent:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE1A Gene

No ASD Table

Relevant External Links for PDE1A Gene

GeneLoc Exon Structure for
PDE1A
ECgene alternative splicing isoforms for
PDE1A

Expression for PDE1A Gene

mRNA expression in normal human tissues for PDE1A Gene

mRNA differential expression in normal tissues according to GTEx for PDE1A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for PDE1A Gene

This gene is overexpressed in Frontal cortex (27.7), Brain (15.1), Fetal Brain (10.9), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDE1A Gene



SOURCE GeneReport for Unigene cluster for PDE1A Gene Hs.191046

mRNA Expression by UniProt/SwissProt for PDE1A Gene

P54750-PDE1A_HUMAN
Tissue specificity: Several tissues, including brain, kidney, testes and heart
genes like me logo Genes that share expression patterns with PDE1A: view

Protein tissue co-expression partners for PDE1A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PDE1A Gene

Orthologs for PDE1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE1A 36
  • 100 (a)
OneToOne
PDE1A 35
  • 99.76 (n)
  • 99.82 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PDE1A 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde1a 36
  • 93 (a)
OneToOne
Pde1a 16
Pde1a 35
  • 88.34 (n)
  • 93 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE1A 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE1A 36
  • 95 (a)
OneToOne
PDE1A 35
  • 92.11 (n)
  • 94.28 (a)
cow
(Bos Taurus)
Mammalia PDE1A 36
  • 94 (a)
OneToOne
PDE1A 35
  • 91.95 (n)
  • 92.67 (a)
rat
(Rattus norvegicus)
Mammalia Pde1a 35
  • 88.72 (n)
  • 93.16 (a)
chicken
(Gallus gallus)
Aves PDE1A 36
  • 80 (a)
OneToOne
PDE1A 35
  • 78.37 (n)
  • 79.96 (a)
lizard
(Anolis carolinensis)
Reptilia PDE1A 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde1a 35
  • 74.79 (n)
  • 78.12 (a)
zebrafish
(Danio rerio)
Actinopterygii pde1a 36
  • 65 (a)
OneToOne
pde1a 35
  • 69.5 (n)
  • 76.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pde1c 36
  • 21 (a)
OneToMany
Pde1c 35
  • 55.16 (n)
  • 55.95 (a)
CG14940 37
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008967 35
  • 56.69 (n)
  • 58.49 (a)
worm
(Caenorhabditis elegans)
Secernentea pde-1 36
  • 37 (a)
OneToMany
T04D3.3 37
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for PDE1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE1A Gene

ENSEMBL:
Gene Tree for PDE1A (if available)
TreeFam:
Gene Tree for PDE1A (if available)

Paralogs for PDE1A Gene

Paralogs for PDE1A Gene

genes like me logo Genes that share paralogs with PDE1A: view

Variants for PDE1A Gene

Sequence variations from dbSNP and Humsavar for PDE1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1484 -- 182,142,771(+) ACTCG(G/T)CTGGC utr-variant-3-prime
rs1999 -- 182,142,523(+) ATCCC(A/C)CCTGT utr-variant-3-prime
rs167284 -- 182,275,602(-) gaact(A/G)aatac intron-variant
rs300881 -- 182,270,554(-) attac(A/G)tttta intron-variant
rs300882 -- 182,270,408(-) ATGTA(A/G)CGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE1A Gene

Variant ID Type Subtype PubMed ID
nsv875477 CNV Loss 21882294
nsv3064 CNV Insertion 18451855
esv2673668 CNV Deletion 23128226
esv2677830 CNV Deletion 23128226
esv2721209 CNV Deletion 23290073
esv2433646 CNV Deletion 19546169
esv2343576 CNV Deletion 18987734
esv2675520 CNV Deletion 23128226
esv27621 CNV Loss 19812545
esv1007075 CNV Deletion 20482838
dgv479n27 CNV Gain 19166990
nsv834481 CNV Gain 17160897
esv2465768 CNV Deletion 19546169
esv2721210 CNV Deletion 23290073
nsv516110 CNV Loss 19592680
esv2479479 CNV Deletion 19546169
esv2241730 CNV Deletion 18987734
esv2874 CNV Deletion 18987735
esv2721211 CNV Deletion 23290073
esv7845 CNV Loss 19470904
nsv215323 CNV Loss 16902084
esv2721212 CNV Deletion 23290073
esv2279238 CNV Deletion 18987734
esv2721213 CNV Deletion 23290073
dgv682n67 CNV Gain 20364138
nsv821840 CNV Gain 20364138
esv2721214 CNV Deletion 23290073

Variation tolerance for PDE1A Gene

Residual Variation Intolerance Score: 14.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE1A Gene

HapMap Linkage Disequilibrium report
PDE1A
Human Gene Mutation Database (HGMD)
PDE1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE1A Gene

Disorders for PDE1A Gene

Relevant External Links for PDE1A

Genetic Association Database (GAD)
PDE1A
Human Genome Epidemiology (HuGE) Navigator
PDE1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE1A
genes like me logo Genes that share disorders with PDE1A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDE1A Gene

Publications for PDE1A Gene

  1. Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization. (PMID: 11342109) Michibata H. … Omori K. (Biochim. Biophys. Acta 2001) 2 23 67
  2. Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. (PMID: 8557689) Loughney K. … Ferguson K. (J. Biol. Chem. 1996) 2 23 67
  3. Association of PDE11A global haplotype with major depression and antidepressant drug response. (PMID: 19557111) Luo H.R. … Wong M.L. (Neuropsychiatr Dis Treat 2009) 23 67
  4. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. (PMID: 19689430) Matthiesen K. … Nielsen J. (Biochem. J. 2009) 23 67
  5. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. (PMID: 19797176) Miller C.L. … Yan C. (Circ. Res. 2009) 23 67

Products for PDE1A Gene

Sources for PDE1A Gene

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