Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDE1A Gene

Aliases for PDE1A Gene

  • Phosphodiesterase 1A 2 3 5
  • Phosphodiesterase 1A, Calmodulin-Dependent 2 3
  • 61 KDa Cam-PDE 3 4
  • EC 3.1.4.17 4 61
  • Cam-PDE 1A 3 4
  • HCAM-1 3 4
  • Calcium/Calmodulin-Dependent 3,5-Cyclic Nucleotide Phosphodiesterase 1A 3
  • Calcium/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 3
  • CAM-PDE-1A 3
  • EC 3.1.4 61
  • HSPDE1A 3
  • HCAM1 3

External Ids for PDE1A Gene

Previous GeneCards Identifiers for PDE1A Gene

  • GC02M181214
  • GC02M181690
  • GC02M182971
  • GC02M183209
  • GC02M182832
  • GC02M182715
  • GC02M174863

Summaries for PDE1A Gene

Entrez Gene Summary for PDE1A Gene

  • Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

GeneCards Summary for PDE1A Gene

PDE1A (Phosphodiesterase 1A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and DAG and IP3 signaling. GO annotations related to this gene include calmodulin binding and cGMP binding. An important paralog of this gene is PDE1C.

UniProtKB/Swiss-Prot for PDE1A Gene

  • Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

Tocris Summary for PDE1A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE1A Gene

Genomics for PDE1A Gene

Regulatory Elements for PDE1A Gene

Enhancers for PDE1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F182143 0.8 Ensembl ENCODE 6 +378.6 378618 1.2 STAT1 ZNF366 THRAP3 CEBPB KDM1A PDE1A GC02M182141 RN7SL267P
GH02F182540 0.4 Ensembl 10.9 -17.1 -17109 0.2 REST PDE1A GC02M182581
GH02F182504 0.5 ENCODE 7.6 +18.1 18144 0.2 CEBPB FOS NR2F2 PDE1A GC02P182516 PIR50077
GH02F182650 0.7 Ensembl 4.9 -127.7 -127735 0.5 CTCF ZNF654 FOXA3 CEBPB TRIM22 CEBPG REST RAD21 FOXK2 SMC3 PDE1A PIR54634 GC02P182636
GH02F182522 0.6 ENCODE 5.3 +0.2 240 0.8 NR3C1 OSR2 POLR2A SMARCA4 SCRT2 PRDM10 PRDM1 TRIM28 PDE1A GC02M182521
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDE1A on UCSC Golden Path with GeneCards custom track

Promoters for PDE1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001830298 192 801 NR3C1 OSR2 POLR2A SMARCA4 SCRT2 PRDM10 PRDM1 TRIM28

Genomic Location for PDE1A Gene

Chromosome:
2
Start:
182,140,035 bp from pter
End:
182,523,192 bp from pter
Size:
383,158 bases
Orientation:
Minus strand

Genomic View for PDE1A Gene

Genes around PDE1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE1A Gene

Proteins for PDE1A Gene

  • Protein details for PDE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54750-PDE1A_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase 1A
    Protein Accession:
    P54750
    Secondary Accessions:
    • D3DPG5
    • Q86VZ0
    • Q9C0K8
    • Q9C0K9
    • Q9C0L0
    • Q9C0L1
    • Q9C0L2
    • Q9C0L3
    • Q9C0L4
    • Q9UFX3

    Protein attributes for PDE1A Gene

    Size:
    535 amino acids
    Molecular mass:
    61252 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PDE1A Gene

    Alternative splice isoforms for PDE1A Gene

neXtProt entry for PDE1A Gene

Selected DME Specific Peptides for PDE1A Gene

P54750:
  • HAADVTQ
  • SVLENHH
  • LYNDRSVLENHH
  • VLSTDMS
  • IHDYEHTG
  • SQIGFIDFIVEPT
  • KYKNPYHN
  • QGDKEAELGLPFSPLCDR
  • TNNFHIQ
  • LMEEFFLQGDKE
  • VYIDETR
  • SIVHAVQAGIFVERM
  • LDTEDEL
  • LVKQLERG
  • LHAADISHP

Post-translational modifications for PDE1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PDE1A Gene

Gene Families for PDE1A Gene

Protein Domains for PDE1A Gene

Graphical View of Domain Structure for InterPro Entry

P54750

UniProtKB/Swiss-Prot:

PDE1A_HUMAN :
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
genes like me logo Genes that share domains with PDE1A: view

Function for PDE1A Gene

Molecular function for PDE1A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).
UniProtKB/Swiss-Prot Function:
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.

Enzyme Numbers (IUBMB) for PDE1A Gene

Gene Ontology (GO) - Molecular Function for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004115 3,5-cyclic-AMP phosphodiesterase activity TAS --
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity TAS 8557689
GO:0005516 calmodulin binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PDE1A: view
genes like me logo Genes that share phenotypes with PDE1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PDE1A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDE1A Gene

Localization for PDE1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE1A gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PDE1A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE1A Gene

Pathways & Interactions for PDE1A Gene

genes like me logo Genes that share pathways with PDE1A: view

Interacting Proteins for PDE1A Gene

Gene Ontology (GO) - Biological Process for PDE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006198 cAMP catabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0034391 regulation of smooth muscle cell apoptotic process IEA --
GO:0046069 cGMP catabolic process IEA --
GO:0048660 regulation of smooth muscle cell proliferation IEA --
genes like me logo Genes that share ontologies with PDE1A: view

No data available for SIGNOR curated interactions for PDE1A Gene

Drugs & Compounds for PDE1A Gene

(23) Drugs for PDE1A Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bepridil Approved, Withdrawn Pharma Pore Blocker, Target, inhibitor 0
Felodipine Approved, Investigational Pharma Potentiation, Activator, Target, inhibitor 22
Nicardipine Approved Pharma Antagonist, Target, inhibitor 30
Caffeine Approved Nutra Antagonist, Target, inhibitor, competitive A1 and A2B antagonist. CNS stimulant 380
Dipyridamole Approved Pharma Inhibition, Inhibitor Adenosine transport inhibitor 80

(3) Additional Compounds for PDE1A Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
IBMX
Antagonist 28822-58-4

(5) Tocris Compounds for PDE1A Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) 85416-75-7
IBMX PDE inhibitor (non-selective) 28822-58-4
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor 40297-09-4
Rolipram PDE4 inhibitor 61413-54-5
Sildenafil citrate Orally active, potent PDE5 inhibitor 171599-83-0

(2) ApexBio Compounds for PDE1A Gene

Compound Action Cas Number
Dipyridamole 58-32-2
Vinpocetine PDE inhibitor 42971-09-5
genes like me logo Genes that share compounds with PDE1A: view

Transcripts for PDE1A Gene

mRNA/cDNA for PDE1A Gene

(18) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PDE1A Gene

Phosphodiesterase 1A, calmodulin-dependent:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE1A Gene

No ASD Table

Relevant External Links for PDE1A Gene

GeneLoc Exon Structure for
PDE1A
ECgene alternative splicing isoforms for
PDE1A

Expression for PDE1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PDE1A Gene

mRNA differential expression in normal tissues according to GTEx for PDE1A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.1).

Protein differential expression in normal tissues from HIPED for PDE1A Gene

This gene is overexpressed in Frontal cortex (27.7), Brain (15.1), Fetal Brain (10.9), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PDE1A Gene



Protein tissue co-expression partners for PDE1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDE1A Gene:

PDE1A

SOURCE GeneReport for Unigene cluster for PDE1A Gene:

Hs.191046

mRNA Expression by UniProt/SwissProt for PDE1A Gene:

P54750-PDE1A_HUMAN
Tissue specificity: Several tissues, including brain, kidney, testes and heart.
genes like me logo Genes that share expression patterns with PDE1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PDE1A Gene

Orthologs for PDE1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE1A 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia PDE1A 34 35
  • 92.11 (n)
cow
(Bos Taurus)
Mammalia PDE1A 34 35
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Pde1a 34
  • 88.72 (n)
mouse
(Mus musculus)
Mammalia Pde1a 34 16 35
  • 88.34 (n)
oppossum
(Monodelphis domestica)
Mammalia PDE1A 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE1A 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE1A 34 35
  • 78.37 (n)
lizard
(Anolis carolinensis)
Reptilia PDE1A 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde1a 34
  • 74.79 (n)
zebrafish
(Danio rerio)
Actinopterygii pde1a 34 35
  • 69.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008967 34
  • 56.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pde1c 34 35
  • 55.16 (n)
CG14940 36
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea T04D3.3 36
  • 54 (a)
pde-1 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
Species where no ortholog for PDE1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE1A Gene

ENSEMBL:
Gene Tree for PDE1A (if available)
TreeFam:
Gene Tree for PDE1A (if available)

Paralogs for PDE1A Gene

Paralogs for PDE1A Gene

genes like me logo Genes that share paralogs with PDE1A: view

Variants for PDE1A Gene

Sequence variations from dbSNP and Humsavar for PDE1A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165500 -- 182,274,353(+) GCATA(C/T)GGAAA intron-variant
rs10169102 -- 182,481,344(+) ACCTC(C/T)CTGTC intron-variant
rs10169895 -- 182,198,161(+) ttata(A/G)agcat intron-variant
rs10170443 -- 182,256,192(+) aactc(A/G)tcatc intron-variant
rs10171703 -- 182,478,375(+) CATTC(C/T)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE1A Gene

Variant ID Type Subtype PubMed ID
nsv954721 CNV deletion 24416366
nsv834481 CNV gain 17160897
nsv821840 CNV gain 20364138
nsv583916 CNV gain 21841781
nsv583913 CNV loss 21841781
nsv516110 CNV loss 19592680
nsv478225 CNV novel sequence insertion 20440878
nsv3064 CNV insertion 18451855
nsv215323 CNV deletion 16902084
nsv1149683 CNV duplication 26484159
nsv1138872 CNV deletion 24896259
nsv1072471 CNV deletion 25765185
nsv1009882 CNV gain 25217958
esv7845 CNV loss 19470904
esv3593565 CNV loss 21293372
esv3593564 CNV loss 21293372
esv3593563 CNV loss 21293372
esv3593561 CNV loss 21293372
esv3593560 CNV loss 21293372
esv3593559 CNV gain 21293372
esv3584219 CNV loss 25503493
esv3584218 CNV loss 25503493
esv3584217 CNV loss 25503493
esv3584216 CNV loss 25503493
esv3560647 CNV deletion 23714750
esv3560646 CNV deletion 23714750
esv3023397 CNV deletion 24192839
esv2874 CNV loss 18987735
esv2762981 CNV loss 21179565
esv27621 CNV loss 19812545
esv2721214 CNV deletion 23290073
esv2721213 CNV deletion 23290073
esv2721212 CNV deletion 23290073
esv2721211 CNV deletion 23290073
esv2721210 CNV deletion 23290073
esv2721209 CNV deletion 23290073
esv2677830 CNV deletion 23128226
esv2675520 CNV deletion 23128226
esv2673668 CNV deletion 23128226
esv2479479 CNV deletion 19546169
esv2465768 CNV deletion 19546169
esv2433646 CNV deletion 19546169
esv2343576 CNV deletion 18987734
esv2279238 CNV deletion 18987734
esv2241730 CNV deletion 18987734
esv1007075 CNV deletion 20482838
dgv7212n54 CNV loss 21841781
dgv682n67 CNV gain 20364138
dgv479n27 CNV gain 19166990
dgv2109n106 CNV deletion 24896259
dgv2108n106 CNV deletion 24896259

Variation tolerance for PDE1A Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE1A Gene

Human Gene Mutation Database (HGMD)
PDE1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDE1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE1A Gene

Disorders for PDE1A Gene

Relevant External Links for PDE1A

Genetic Association Database (GAD)
PDE1A
Human Genome Epidemiology (HuGE) Navigator
PDE1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE1A

No disorders were found for PDE1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDE1A Gene

Publications for PDE1A Gene

  1. Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization. (PMID: 11342109) Michibata H. … Omori K. (Biochim. Biophys. Acta 2001) 2 3 4 22 64
  2. Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. (PMID: 8557689) Loughney K. … Ferguson K. (J. Biol. Chem. 1996) 2 3 4 22 64
  3. Association of PDE11A global haplotype with major depression and antidepressant drug response. (PMID: 19557111) Luo H.R. … Wong M.L. (Neuropsychiatr Dis Treat 2009) 3 22 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for PDE1A Gene

Sources for PDE1A Gene

Content
Loading form....