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Aliases for PDE12 Gene

Aliases for PDE12 Gene

  • Phosphodiesterase 12 2 3
  • Mitochondrial Deadenylase 3 4
  • 2-Phosphodiesterase 2 3
  • 2-PDE 3 4
  • 2,5-Phosphodiesterase 12 3
  • EC 3.1.13.4 4
  • EC 3.1.4.- 4
  • EC 3.1.4 63

External Ids for PDE12 Gene

Previous GeneCards Identifiers for PDE12 Gene

  • GC03P057520
  • GC03P057521
  • GC03P057541

Summaries for PDE12 Gene

GeneCards Summary for PDE12 Gene

PDE12 (Phosphodiesterase 12) is a Protein Coding gene. Diseases associated with PDE12 include pharyngitis. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is CNOT6.

UniProtKB/Swiss-Prot for PDE12 Gene

  • Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3,5-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE12 Gene

Genomics for PDE12 Gene

Regulatory Elements for PDE12 Gene

Genomic Location for PDE12 Gene

Start:
57,556,254 bp from pter
End:
57,566,844 bp from pter
Size:
10,591 bases
Orientation:
Plus strand

Genomic View for PDE12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE12 Gene

Proteins for PDE12 Gene

  • Protein details for PDE12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8Q7-PDE12_HUMAN
    Recommended name:
    2,5-phosphodiesterase 12
    Protein Accession:
    Q6L8Q7
    Secondary Accessions:
    • B4DTU8
    • Q8IYU3
    • Q8NDU2
    • Q8TE78

    Protein attributes for PDE12 Gene

    Size:
    609 amino acids
    Molecular mass:
    67352 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PDE12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE12 Gene

Proteomics data for PDE12 Gene at MOPED

Selected DME Specific Peptides for PDE12 Gene

Post-translational modifications for PDE12 Gene

  • Ubiquitination at Lys61, Lys84, Lys97, and Lys427
  • Modification sites at PhosphoSitePlus

Other Protein References for PDE12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PDE12 Gene

Protein Domains for PDE12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDE12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L8Q7

UniProtKB/Swiss-Prot:

PDE12_HUMAN :
  • Q6L8Q7
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with PDE12: view

No data available for Gene Families for PDE12 Gene

Function for PDE12 Gene

Molecular function for PDE12 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 8.0 for 2-5 oligoadenylate exonuclease activity. {ECO:0000269 PubMed:22285541};
UniProtKB/Swiss-Prot CatalyticActivity: Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function: Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3,5-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Enzyme Numbers (IUBMB) for PDE12 Gene

Gene Ontology (GO) - Molecular Function for PDE12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004535 poly(A)-specific ribonuclease activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE12: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PDE12 Gene

Localization for PDE12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE12 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE12 Gene COMPARTMENTS Subcellular localization image for PDE12 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PDE12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PDE12: view

Pathways for PDE12 Gene

SuperPathways for PDE12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDE12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with PDE12: view

No data available for Pathways by source for PDE12 Gene

Transcripts for PDE12 Gene

mRNA/cDNA for PDE12 Gene

Unigene Clusters for PDE12 Gene

Phosphodiesterase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE12 Gene

No ASD Table

Relevant External Links for PDE12 Gene

GeneLoc Exon Structure for
PDE12
ECgene alternative splicing isoforms for
PDE12

Expression for PDE12 Gene

mRNA expression in normal human tissues for PDE12 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE12 Gene

SOURCE GeneReport for Unigene cluster for PDE12 Gene Hs.572993

mRNA Expression by UniProt/SwissProt for PDE12 Gene

Q6L8Q7-PDE12_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with PDE12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PDE12 Gene

Orthologs for PDE12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDE12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE12 35
  • 99.34 (n)
  • 99.18 (a)
PDE12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE12 35
  • 88.45 (n)
  • 91.63 (a)
PDE12 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE12 35
  • 88.12 (n)
  • 92.45 (a)
PDE12 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde12 35
  • 86.57 (n)
  • 88.49 (a)
Pde12 16
Pde12 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE12 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE12 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde12 35
  • 86.47 (n)
  • 90.41 (a)
chicken
(Gallus gallus)
Aves PDE12 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE12 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25679 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2468 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
pde12 35
  • 57.74 (n)
  • 59.02 (a)
pde12 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009079 35
  • 48.29 (n)
  • 40.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31759 35
  • 45.26 (n)
  • 36.53 (a)
CG31759 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pde-12 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 13 (a)
OneToMany
NGL3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9594 36
  • 40 (a)
OneToOne
Species with no ortholog for PDE12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE12 Gene

ENSEMBL:
Gene Tree for PDE12 (if available)
TreeFam:
Gene Tree for PDE12 (if available)

Paralogs for PDE12 Gene

Paralogs for PDE12 Gene

genes like me logo Genes that share paralogs with PDE12: view

Variants for PDE12 Gene

Sequence variations from dbSNP and Humsavar for PDE12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1979074 -- 57,560,471(-) GCGCA(C/T)GCCTG utr-variant-3-prime
rs2241988 - 57,556,446(-) AGCCC(A/G)GCTCA reference, missense
rs2278755 -- 57,557,887(-) GCAGT(A/G)TGGCA intron-variant
rs3172345 -- 57,561,688(+) GATTT(C/T)CCCCA utr-variant-3-prime
rs3732546 -- 57,559,427(+) CACGC(C/T)TAAAG intron-variant

Relevant External Links for PDE12 Gene

HapMap Linkage Disequilibrium report
PDE12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PDE12 Gene

Disorders for PDE12 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PDE12 Gene including...

Search for PDE12 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PDE12 Gene

Relevant External Links for PDE12

Genetic Association Database (GAD)
PDE12
Human Genome Epidemiology (HuGE) Navigator
PDE12
genes like me logo Genes that share disorders with PDE12: view

No data available for UniProtKB/Swiss-Prot for PDE12 Gene

Publications for PDE12 Gene

  1. Identification of 2'-phosphodiesterase, which plays a role in the 2- 5A system regulated by interferon. (PMID: 15231837) Kubota K. … Iijima Y. (J. Biol. Chem. 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. (PMID: 21666256) Rorbach J. … Minczuk M. (Nucleic Acids Res. 2011) 3 4
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for PDE12 Gene

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