Aliases for PDE12 Gene
External Ids for PDE12 Gene
Previous GeneCards Identifiers for PDE12 Gene
GeneCards Summary for PDE12 Gene
PDE12 (Phosphodiesterase 12) is a Protein Coding gene. Diseases associated with PDE12 include Kabuki Syndrome 1 and Microphthalmia With Limb Anomalies. GO annotations related to this gene include poly(A)-specific ribonuclease activity. An important paralog of this gene is CNOT6.
UniProtKB/Swiss-Prot for PDE12 Gene
Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3,5-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.