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PDE12 Gene

protein-coding   GIFtS: 50
GCID: GC03P057541

Phosphodiesterase 12

  See PDE12-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphodiesterase 121 2     2',5'-Phosphodiesterase 122
2'-phosphodiesterase1 2     EC 3.1.13.43
Mitochondrial Deadenylase2 3     EC 3.1.4.-3
2'-PDE2 3     EC 3.1.48
2-PDE2 3     

External Ids:    HGNC: 253861   Entrez Gene: 2016262   Ensembl: ENSG000001748407   UniProtKB: Q6L8Q73   

Export aliases for PDE12 gene to outside databases

Previous GC identifers: GC03P057520 GC03P057521


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PDE12 Gene:
PDE12 (phosphodiesterase 12) is a protein-coding gene. Diseases associated with PDE12 include pharyngitis. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ANGEL1.

UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7
Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated
oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme
degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of
oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways
for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction
of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A
system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDE12 gene promoter:
         USF1   AML1a   USF-1   Nkx2-2   Zic1   STAT3   POU6F1 (c2)   LCR-F1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE12 promoter sequence
   Search Chromatin IP Primers for PDE12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDE12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p14.3

PDE12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE12 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P057541:  view genomic region     (about GC identifiers)

Start:
57,541,981 bp from pter      End:
57,552,571 bp from pter
Size:
10,591 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7 (See protein sequence)
Recommended Name: 2',5'-phosphodiesterase 12 precursor  
Size: 609 amino acids; 67352 Da
Cofactor: Magnesium
Secondary accessions: B4DTU8 Q8IYU3 Q8NDU2 Q8TE78
Alternative splicing: 2 isoforms:  Q6L8Q7-1   Q6L8Q7-2   

Explore the universe of human proteins at neXtProt for PDE12: NX_Q6L8Q7

Explore proteomics data for PDE12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys61, Lys84, Lys97, Lys427
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PDE12 (Q6L8Q7) (see all 5)
     VLQRSSV  AAAKKSRK  SDPLHKELLEKL  LSRIATNALKGHAK 


    See PDE12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_808881.3  
    ENSEMBL proteins: 
     ENSP00000420626   ENSP00000309142  

    PDE12 Human Recombinant Protein Products:

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    Novus Biologicals PDE12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE12

     
    Search eBioscience for Proteins for PDE12 

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    PDE12 Assay Products:

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    Cloud-Clone Corp. ELISAs for PDE12
    Cloud-Clone Corp. CLIAs for PDE12
    Search eBioscience for ELISAs for PDE12 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q6L8Q7

    ProtoNet protein and cluster: Q6L8Q7

    UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7
    Similarity: Belongs to the CCR4/nocturin family


    Find genes that share domains with PDE12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE12_HUMAN, Q6L8Q7
    Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated
    oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme
    degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of
    oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways
    for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction
    of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A
    system
    Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP
    Biophysicochemical properties: pH dependence: Optimum pH is 8.0 for 2'-5' oligoadenylate exonuclease activity;

         Enzyme Numbers (IUBMB): EC 3.1.4.-1 EC 3.1.13.41 EC 3.1.42

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004535poly(A)-specific ribonuclease activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PDE12           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Pde12 (no phenotypes)

    Find genes that share phenotypes with PDE12           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDE12
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDE12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDE12
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    miRNA
    Products:
        
    miRTarBase miRNAs that target PDE12:
    hsa-mir-196b-5p (MIRT042666), hsa-mir-484 (MIRT041882), hsa-mir-877-3p (MIRT037032), hsa-let-7b-5p (MIRT005039), hsa-mir-26b-5p (MIRT029374), hsa-mir-1 (MIRT023732), hsa-mir-155-5p (MIRT020694)

    Block miRNA regulation of human, mouse, rat PDE12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDE12 (see all 36):
    hsa-let-7d hsa-miR-218 hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-186 hsa-miR-3613-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPDE12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDE12
    Predesigned siRNA for gene silencing in human, mouse, rat PDE12

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for PDE12
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    GenScript: all cDNA clones in your preferred vector: PDE12 (NM_177966)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE12
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PDE12

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PDE12 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDE12_HUMAN, Q6L8Q7: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with PDE12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDE12
    Interactions:

        Search GeneGlobe Interaction Network for PDE12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDE12 (Q6L8Q73 ENSP000003091424) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBL4AP114413, ENSP000003586744I2D: score=2 STRING: ENSP00000358674
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ATG101Q9BSB43I2D: score=1 
    NSMAFQ926363I2D: score=1 
    PRKAG1P546193I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--

    Find genes that share ontologies with PDE12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDE12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDE12 gene: 
    NM_177966.5  

    Unigene Cluster for PDE12:

    Phosphodiesterase 12
    Hs.572993  [show with all ESTs]
    Unigene Representative Sequence: NM_177966
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487257(uc003div.3) ENST00000311180(uc003diw.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat PDE12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDE12 (see all 36):
    hsa-let-7d hsa-miR-218 hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-186 hsa-miR-3613-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPDE12 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PDE12
    Predesigned siRNA for gene silencing in human, mouse, rat PDE12
    Clone
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    OriGene ORF clones in mouse, rat for PDE12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDE12 (NM_177966)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE12
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PDE12
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PDE12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDE12
      QuantiTect SYBR Green Assays in human, mouse, rat PDE12
      QuantiFast Probe-based Assays in human, mouse, rat PDE12

    Additional mRNA sequence: 

    AB115695.1 AK001526.1 AK300374.1 AL831824.1 BX647169.1 U79276.1 

    6 DOTS entries:

    DT.97783470  DT.212755  DT.212754  DT.97775889  DT.102836853  DT.100775105 

    Selected AceView cDNA sequences (see all 125):

    AI369813 BC034978 AB115695 BM676538 AA971515 NM_177966 BU738755 AL831824 
    AI382811 AA565476 BM665856 AI925395 AI436695 AI434620 AA937775 BM715149 
    AA885134 BM691775 BU728653 AI761667 AI078399 AI432398 BM713922 CB161864 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDE12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTTTGCT
    PDE12 Expression
    About this image

    PDE12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDE12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.572993

    UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PDE12 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde121 , 5 phosphodiesterase 121, 5 86.57(n)1
    88.49(a)1
      14 (16.09 cM)5
    2119481  NM_178668.31  NP_848783.31 
     266599585 
    chicken
    (Gallus gallus)
    Aves PDE126
    phosphodiesterase 12
    71(a)
    1 ↔ 1
    12(8701129-8705214)
    lizard
    (Anolis carolinensis)
    Reptilia PDE126
    phosphodiesterase 12
    66(a)
    1 ↔ 1
    2(163284371-163290104)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256792 Xenopus laevis transcribed sequence with weak similarity more 72.86(n)    CA971246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI429084.12   -- 75(n)   325182  BI429084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317591 CG31759 45.26(n)
    36.53(a)
      326158  NM_165000.2  NP_723735.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pde-126
    Protein R17.2 (R17.2) mRNA, complete cds
    20(a)
    1 ↔ 1
    III(10840012-10844935) WBGene00011268
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NGL3(YML118W)4 Putative endonuclease, has a domain similar to a magnesium-dependent more   --   13(32334-33851) 854921  NP_013588.1 


    ENSEMBL Gene Tree for PDE12 (if available)
    TreeFam Gene Tree for PDE12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDE12 gene
    ANGEL12  CCRN4L2  ANGEL22  CNOT6L2  CNOT62  

    Find genes that share paralogs with PDE12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDE12 (see all 200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125287601,2
    C,F--57540004(+) GTGAGG/ACTCCA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs668305491,2
    C--57540019(+) AAAAA-/TAAAAA 1 -- us2k10--------
    rs98121391,2
    C,A--57540027(+) aaaaaT/Aaaaaa 1 -- us2k1 tfbs32Minor allele frequency- A:0.25NA WA 4
    rs671165651,2
    C--57540027(+) AAAAA-/TAAAAA 1 -- us2k10--------
    rs1916576011,2
    --57540129(+) GAAAAC/TGAAAA 1 -- us2k10--------
    rs1842554041,2
    --57540186(+) TTAGAA/GGAAAT 1 -- us2k10--------
    rs1400365371,2
    C--57540211(+) TATGGC/GTTAGA 1 -- us2k10--------
    rs1874376351,2
    --57540255(+) CTTATC/GTGCTA 1 -- us2k10--------
    rs1927345431,2
    --57540263(+) CTACTC/GTCCCC 1 -- us2k10--------
    rs1455798001,2
    --57540384(+) GTTGCC/TCAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDE12 (57541981 - 57552571 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PDE12: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDE12
    DNA2.0 Custom Variant and Variant Library Synthesis for PDE12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for PDE12:    
    About MalaCards
    pharyngitis

    1 disease from the University of Copenhagen DISEASES database for PDE12:
    Pharyngitis

    Find genes that share disorders with PDE12           About GenesLikeMe

    Genetic Association Database (GAD): PDE12
    Human Genome Epidemiology (HuGE) Navigator: PDE12 (1 document)

    Export disorders for PDE12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDE12 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PDE12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of 2'-phosphodiesterase, which plays a role in the 2- 5A system regulated by interferon. (PubMed id 15231837)1, 2, 3 Kubota K.... Iijima Y. (J. Biol. Chem. 2004)
    2. Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover. (PubMed id 21245038)1, 2 Poulsen J.B....KjA ( 2011)
    3. PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. (PubMed id 21666256)1, 2 Rorbach J....Minczuk M. (Nucleic Acids Res. 2011)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1. (PubMed id 22285541)2 Poulsen J.B.... Martensen P.M. (Biochimie 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201626 HGNC: 25386 AceView: 2'-PDE Ensembl:ENSG00000174840 euGenes: HUgn201626
    ECgene: PDE12 H-InvDB: PDE12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PDE12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDE12 gene:
    Search GeneIP for patents involving PDE12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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