PDE12 Gene
protein-coding GIFtS: 46
GCID: GC03P057541
|
|
phosphodiesterase 12
| |
Aliases
for PDE12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Phosphodiesterase 121 2 | | 2',5'-Phosphodiesterase 122 | | 2'-PDE1 2 3 | | 2'-Phosphodiesterase1 | | 2-PDE2 3 | | EC 3.1.4.-3 | | DKFZp667B12181 | | EC 3.1.48 |
Export aliases for PDE12 gene to outside databasesPrevious GC identifers: GC03P057520 GC03P057521 |
Summaries
for PDE12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates,triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negativeregulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced byinterferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thuscounteracting the antiviral pathway probably by inhibiting the 2-5A system
|
Genomic Views
for PDE12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PDE12 gene promoter:
USF1 AML1a USF-1 Nkx2-2 Zic1 STAT3 POU6F1 (c2) LCR-F1 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PDE12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p14.3 Ensembl cytogenetic band: 3p14.3 HGNC cytogenetic band: 3p14.3PDE12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P057541: view genomic region
(about GC identifiers)
Start:
|
57,541,981 bp from pter |
End:
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57,547,768 bp from pter |
Size:
|
5,788 bases |
Orientation:
|
plus strand |
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Proteins
for PDE12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7 (See
protein sequence)Recommended Name: 2',5'-phosphodiesterase 12 Size: 609 amino acids; 67352 Da
Secondary accessions: B4DTU8 Q8IYU3 Q8NDU2 Q8TE78Alternative splicing: 2 isoforms: Q6L8Q7-1 Q6L8Q7-2 Explore the universe of human proteins at neXtProt for PDE12: NX_Q6L8Q7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6L8Q7
4/5 DME Specific Peptides for PDE12 (Q6L8Q7) (see all 5)
PDE12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_808881.3
ENSEMBL proteins: ENSP00000420626 ENSP00000309142
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
PDE12 for ontologies About GeneDecksing
PDE12 Antibody Products:
Assay Products for PDE12: |
Protein
Domains /
Families
for PDE12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PDE12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6L8Q7ProtoNet protein and cluster: Q6L8Q7 UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7Similarity: Belongs to the CCR4/nocturin family |
Function
for PDE12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates,triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negativeregulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced byinterferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thuscounteracting the antiviral pathway probably by inhibiting the 2-5A systemEnzyme Numbers (IUBMB): EC 3.1.4.-1 EC 3.1.42
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PDE12 (NM_177966) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDE12 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PDE12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE12 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- |
PDE12 for ontologies About GeneDecksing
|
Pathways & Interactions
for PDE12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDE12
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/7 Interacting proteins for PDE12 (Q6L8Q73 ENSP000003091424) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds
for PDE12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PDE12
Search CenterWatch for drugs/clinical trials and news about PDE12
|
Transcripts
for PDE12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PDE12 gene: NM_177966.5 Unigene Cluster for PDE12: Phosphodiesterase 12 Hs.572993 [show with all ESTs]Unigene Representative Sequence: NM_1779662 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487257(uc003div.3) ENST00000311180(uc003diw.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PDE12 (NM_177966) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDE12 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PDE12 |
Additional cDNA sequence: AB115695.1 AK001526.1 AK300374.1 AL831824.1 BX647169.1 U79276.1 6 DOTS entries: DT.97783470 DT.212755 DT.212754 DT.97775889 DT.102836853 DT.100775105 24/125 AceView cDNA sequences (see all 125): BC034978 BM713922 BQ229223 BM715149 AA885134 CB161864 AI761667 AI382811 AA565476 AA971515 AI925395 BM691775 AI369813 AI436695 AB115695 BM676538 NM_177966 BU738755 AI432398 AL831824 AA937775 AI434620 BM665856 BU728653
GeneLoc Exon Structure
|
Expression
for PDE12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PDE12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTTTGCT
About this image
See PDE12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDE12
SOURCE GeneReport for Unigene cluster: Hs.572993
UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for PDE12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDE12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDE12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE12 |
Orthologs
for PDE12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PDE12 gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PDE121 |
phosphodiesterase 12 |
72.44(n)
72.2(a) |
|
416005 XM_003641977.1 XP_003642025.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PDE126 |
-- |
62(a) |
1 ↔ 1 |
2(163284371-163290104) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.256792 |
Xenopus laevis transcribed sequence with weak similarity more |
72.86(n) |
|
CA971246.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BI429084.12 |
-- |
75(n) |
|
325182 BI429084.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG317591 |
CG31759 |
44.86(n)
36.78(a) |
|
326158 NM_165001.2 NP_723736.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
R17.26 |
Protein R17.2 |
20(a) |
1 ↔ 1 |
III(10839913-10844836) |
ENSEMBL Gene Tree for PDE12 (if available)
TreeFam Gene Tree for PDE12 (if available) |
Paralogs
for PDE12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PDE12 gene
- ANGEL12 CCRN4L2 CNOT6L2 ANGEL22 CNOT62
PDE12 for paralogs About GeneDecksing
|
Genomic Variants
for PDE12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PDE12 (57541981 - 57547768 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDE12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDE12 |
|
Disorders
/ Diseases
for PDE12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PDE12 for disorders About GeneDecksing
1  disease for PDE12: About MalaCardstoxic shock syndrome
1 disease from the University of Copenhagen DISEASES database for PDE12:Pharyngitis Human Genome Epidemiology (HuGE) Navigator: PDE12 (1 document)
Export disorders for PDE12 gene to outside databases
|
Publications
for PDE12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PDE12 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with PDE12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of 2'-phosphodiesterase, which plays a role in the 2- 5A system regulated by interferon. (PubMed id 15231837)1, 2, 3 Kubota K.... Iijima Y. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Human 2'-phosphodiesterase localizes to the mitochond rial matrix with a putative function in mitochondrial RNA turnover. (PubMed id 21245038)1 Poulsen J.B....KjA (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- PDE12 removes mitochondrial RNA poly(A) tails and con trols translation in human mitochondria. (PubMed id 21666256)1 Rorbach J....Minczuk M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for PDE12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PDE12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PDE12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PDE12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PDE12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PDE12 gene:
Search GeneIP for patents involving PDE12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PDE12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PDE12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDE12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDE12 | | | OriGene Protein Over-expression Lysate for PDE12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PDE12 | | OriGene 3'-UTR Clone for PDE12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDE12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDE12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PDE12 | | OriGene Custom Protein Services for PDE12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDE12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDE12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE12 |
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| | | | Search Tocris compounds for PDE12 |
| |  |  |  |  | | | | |
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 | | | PDE12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE12 |
|  |  |  | | | | ThermoFisher Antibodies for PDE12 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PDE12 |
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