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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDE12 Gene

protein-coding   GIFtS: 49
GCID: GC03P057541

Phosphodiesterase 12

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphodiesterase 121 2     2',5'-Phosphodiesterase 122
2'-phosphodiesterase1 2     EC 3.1.4.-3
2'-PDE2 3     EC 3.1.48
2-PDE2 3     

External Ids:    HGNC: 253861   Entrez Gene: 2016262   Ensembl: ENSG000001748407   UniProtKB: Q6L8Q73   

Export aliases for PDE12 gene to outside databases

Previous GC identifers: GC03P057520 GC03P057521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PDE12 Gene: 
PDE12 (phosphodiesterase 12) is a protein-coding gene. Diseases associated with PDE12 include toxic shock syndrome. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is ANGEL1.

UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7
Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated
oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme
degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of
oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways
for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction
of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A
system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDE12 gene promoter:
         USF1   AML1a   USF-1   Nkx2-2   Zic1   STAT3   POU6F1 (c2)   LCR-F1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDE12 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDE12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDE12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p14.3

PDE12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE12 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P057541:  view genomic region     (about GC identifiers)

Start:
57,541,981 bp from pter      End:
57,552,571 bp from pter
Size:
10,591 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7 (See protein sequence)
Recommended Name: 2',5'-phosphodiesterase 12  
Size: 609 amino acids; 67352 Da
Secondary accessions: B4DTU8 Q8IYU3 Q8NDU2 Q8TE78
Alternative splicing: 2 isoforms:  Q6L8Q7-1   Q6L8Q7-2   

Explore the universe of human proteins at neXtProt for PDE12: NX_Q6L8Q7

Explore proteomics data for PDE12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6L8Q7

  • 4/5 DME Specific Peptides for PDE12 (Q6L8Q7) (see all 5)
     VLQRSSV  AAAKKSRK  SDPLHKELLEKL  LSRIATNALKGHAK 

    PDE12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDE12 Protein Expression
    REFSEQ proteins: NP_808881.3  
    ENSEMBL proteins: 
     ENSP00000420626   ENSP00000309142  

    Human Recombinant Protein Products for PDE12: 
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    OriGene Protein Over-expression Lysate for PDE12
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for PDE12
    Novus Biologicals PDE12 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDE12 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    PDE12 for ontologies           About GeneDecksing



    PDE12 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for PDE12 
    Cloud-Clone Corp. CLIAs for PDE12


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005135 Endo/exonuclease/phosphatase

    Graphical View of Domain Structure for InterPro Entry Q6L8Q7

    ProtoNet protein and cluster: Q6L8Q7

    UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7
    Similarity: Belongs to the CCR4/nocturin family


    PDE12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDE12_HUMAN, Q6L8Q7
    Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated
    oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme
    degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of
    oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways
    for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction
    of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A
    system

         Enzyme Numbers (IUBMB): EC 3.1.4.-1 EC 3.1.42

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity IEA--
         
    PDE12 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDE12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDE12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDE12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDE12 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDE12:
    hsa-let-7b (MIRT005039)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE12
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE12 (see all 36):
    hsa-let-7d hsa-miR-218 hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-186 hsa-miR-3613-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPDE12 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of PDE12 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDE12

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for PDE12 (Q6L8Q73 ENSP000003091424) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBL4AP114413, ENSP000003586744I2D: score=2 STRING: ENSP00000358674
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    C12orf44Q9BSB43I2D: score=1 
    NSMAFQ926363I2D: score=1 
    PRKAG1P546193I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDE12

    Search CenterWatch for drugs/clinical trials and news about PDE12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDE12 gene: 
    NM_177966.5  

    Unigene Cluster for PDE12:

    Phosphodiesterase 12
    Hs.572993  [show with all ESTs]
    Unigene Representative Sequence: NM_177966
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487257(uc003div.3) ENST00000311180(uc003diw.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDE12
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate PDE12 (see all 36):
    hsa-let-7d hsa-miR-218 hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-186 hsa-miR-3613-3p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidPDE12 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PDE12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDE12
    Clone
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    OriGene clones in human, mouse for PDE12 (see all 7)
    OriGene ORF clones in mouse, rat for PDE12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDE12 (NM_177966)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDE12
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PDE12
    Sirion Biotech Customized lentivirus for stable overexpression of PDE12 
                         Customized lentivirus expression plasmids for stable overexpression of PDE12 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PDE12
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDE12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDE12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDE12

    Additional mRNA sequence: 

    AB115695.1 AK001526.1 AK300374.1 AL831824.1 BX647169.1 U79276.1 

    6 DOTS entries:

    DT.97783470  DT.212755  DT.212754  DT.97775889  DT.102836853  DT.100775105 

    24/125 AceView cDNA sequences (see all 125):

    BQ229223 BC034978 AI925395 AA937775 AI078399 NM_177966 AL831824 BM676538 
    CB161864 AI434620 AI382811 AI432398 AI369813 AA565476 BM691775 AI436695 
    BM665856 AB115695 BU738755 AI761667 BM715149 AA971515 AA885134 BM713922 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDE12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTTTGCT
    PDE12 Expression
    About this image


    See PDE12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDE12

    SOURCE GeneReport for Unigene cluster: Hs.572993

    UniProtKB/Swiss-Prot: PDE12_HUMAN, Q6L8Q7
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PDE12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDE12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PDE12 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pde121 , 5 phosphodiesterase 121, 5 86.57(n)1
    88.49(a)1
      14 (16.09 cM)5
    2119481  NM_178668.31  NP_848783.31 
     266599585 
    chicken
    (Gallus gallus)
    Aves PDE121 phosphodiesterase 12 72.44(n)
    72.2(a)
      416005  XM_003641977.1  XP_003642025.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDE126
    Uncharacterized protein
    66(a)
    1 ↔ 1
    2(163284371-163290104)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.256792 Xenopus laevis transcribed sequence with weak similarity more 72.86(n)    CA971246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI429084.12   -- 75(n)   325182  BI429084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG317591 CG31759 44.86(n)
    36.78(a)
      326158  NM_165001.2  NP_723736.2 
    worm
    (Caenorhabditis elegans)
    Secernentea R17.26
    Protein R17.2
    17(a)
    1 ↔ 1
    III(10840012-10844935)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NGL3(YML118W)4 Putative endonuclease, has a domain similar to a magnesium-dependent more   --   13(32334-33851) 854921  NP_013588.1 


    ENSEMBL Gene Tree for PDE12 (if available)
    TreeFam Gene Tree for PDE12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDE12 gene
    ANGEL12  CCRN4L2  ANGEL22  CNOT6L2  CNOT62  

    PDE12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/200 SNPs in PDE12 are shown (see all 200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125287601,2
    C,F--57540004(+) GTGAGG/ACTCCA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs668305491,2
    C--57540019(+) AAAAA-/TAAAAA 1 -- us2k10--------
    rs98121391,2
    C,A--57540027(+) aaaaaT/Aaaaaa 1 -- us2k1 tfbs32Minor allele frequency- A:0.25NA WA 4
    rs671165651,2
    C--57540027(+) AAAAA-/TAAAAA 1 -- us2k10--------
    rs1916576011,2
    --57540129(+) GAAAAC/TGAAAA 1 -- us2k10--------
    rs1842554041,2
    --57540186(+) TTAGAA/GGAAAT 1 -- us2k10--------
    rs1400365371,2
    C--57540211(+) TATGGC/GTTAGA 1 -- us2k10--------
    rs1874376351,2
    --57540255(+) CTTATC/GTGCTA 1 -- us2k10--------
    rs1927345431,2
    --57540263(+) CTACTC/GTCCCC 1 -- us2k10--------
    rs1455798001,2
    --57540384(+) GTTGCC/TCAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDE12 (57541981 - 57552571 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PDE12: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PDE12
    DNA2.0 Custom Variant and Variant Library Synthesis for PDE12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for PDE12:    About MalaCards
    toxic shock syndrome    

    1 disease from the University of Copenhagen DISEASES database for PDE12:
    Pharyngitis

    PDE12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PDE12
    Human Genome Epidemiology (HuGE) Navigator: PDE12 (1 document)

    Export disorders for PDE12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDE12 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with PDE12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of 2'-phosphodiesterase, which plays a role in the 2- 5A system regulated by interferon. (PubMed id 15231837)1, 2, 3 Kubota K.... Iijima Y. (2004)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Human 2'-phosphodiesterase localizes to the mitochond rial matrix with a putative function in mitochondrial RNA turnover. (PubMed id 21245038)1 Poulsen J.B....KjA (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 201626 HGNC: 25386 AceView: 2'-PDE Ensembl:ENSG00000174840 euGenes: HUgn201626
    ECgene: PDE12 H-InvDB: PDE12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDE12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDE12 gene:
    Search GeneIP for patents involving PDE12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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