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Aliases for PDE12 Gene

Aliases for PDE12 Gene

  • Phosphodiesterase 12 2 3 5
  • Mitochondrial Deadenylase 3 4
  • 2-Phosphodiesterase 2 3
  • 2-PDE 3 4
  • EC 3.1.13.4 4
  • EC 3.1.4.- 4
  • EC 3.1.4 63

External Ids for PDE12 Gene

Previous GeneCards Identifiers for PDE12 Gene

  • GC03P057520
  • GC03P057521
  • GC03P057541

Summaries for PDE12 Gene

GeneCards Summary for PDE12 Gene

PDE12 (Phosphodiesterase 12) is a Protein Coding gene. GO annotations related to this gene include poly(A)-specific ribonuclease activity. An important paralog of this gene is CNOT6.

UniProtKB/Swiss-Prot for PDE12 Gene

  • Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3,5-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE12 Gene

Genomics for PDE12 Gene

Regulatory Elements for PDE12 Gene

Enhancers for PDE12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDE12 on UCSC Golden Path with GeneCards custom track

Promoters for PDE12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDE12 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDE12 Gene

Chromosome:
3
Start:
57,556,252 bp from pter
End:
57,654,979 bp from pter
Size:
98,728 bases
Orientation:
Plus strand

Genomic View for PDE12 Gene

Genes around PDE12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE12 Gene

Proteins for PDE12 Gene

  • Protein details for PDE12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8Q7-PDE12_HUMAN
    Recommended name:
    2,5-phosphodiesterase 12
    Protein Accession:
    Q6L8Q7
    Secondary Accessions:
    • B4DTU8
    • Q8IYU3
    • Q8NDU2
    • Q8TE78

    Protein attributes for PDE12 Gene

    Size:
    609 amino acids
    Molecular mass:
    67352 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDE12 Gene

    Alternative splice isoforms for PDE12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE12 Gene

Proteomics data for PDE12 Gene at MOPED

Selected DME Specific Peptides for PDE12 Gene

Post-translational modifications for PDE12 Gene

  • Ubiquitination at Lys 61, Lys 84, and Lys 97
  • Modification sites at PhosphoSitePlus

Other Protein References for PDE12 Gene

Antibody Products

Domains & Families for PDE12 Gene

Protein Domains for PDE12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDE12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L8Q7

UniProtKB/Swiss-Prot:

PDE12_HUMAN :
  • Belongs to the CCR4/nocturin family.
Family:
  • Belongs to the CCR4/nocturin family.
genes like me logo Genes that share domains with PDE12: view

No data available for Gene Families for PDE12 Gene

Function for PDE12 Gene

Molecular function for PDE12 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.0 for 2-5 oligoadenylate exonuclease activity. {ECO:0000269 PubMed:22285541};
UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage of poly(A) to 5-AMP.
UniProtKB/Swiss-Prot Function:
Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3,5-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Enzyme Numbers (IUBMB) for PDE12 Gene

genes like me logo Genes that share phenotypes with PDE12: view

Animal Models for PDE12 Gene

MGI Knock Outs for PDE12:

Animal Model Products

CRISPR Products

miRNA for PDE12 Gene

miRTarBase miRNAs that target PDE12

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE12 Gene

Localization for PDE12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE12 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE12 Gene COMPARTMENTS Subcellular localization image for PDE12 gene
Compartment Confidence
mitochondrion 4
cytoskeleton 2
cytosol 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PDE12 Gene

Pathways & Interactions for PDE12 Gene

SuperPathways for PDE12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDE12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PDE12 Gene

Drugs & Compounds for PDE12 Gene

No Compound Related Data Available

Transcripts for PDE12 Gene

Unigene Clusters for PDE12 Gene

Phosphodiesterase 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE12 Gene

No ASD Table

Relevant External Links for PDE12 Gene

GeneLoc Exon Structure for
PDE12
ECgene alternative splicing isoforms for
PDE12

Expression for PDE12 Gene

mRNA expression in normal human tissues for PDE12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE12 Gene



SOURCE GeneReport for Unigene cluster for PDE12 Gene Hs.572993

mRNA Expression by UniProt/SwissProt for PDE12 Gene

Q6L8Q7-PDE12_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PDE12: view

Protein tissue co-expression partners for PDE12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PDE12 Gene

Orthologs for PDE12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PDE12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE12 35
  • 88.45 (n)
  • 91.63 (a)
PDE12 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE12 35
  • 88.12 (n)
  • 92.45 (a)
PDE12 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde12 35
  • 86.57 (n)
  • 88.49 (a)
Pde12 16
Pde12 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE12 35
  • 99.34 (n)
  • 99.18 (a)
PDE12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde12 35
  • 86.47 (n)
  • 90.41 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE12 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE12 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE12 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE12 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2468 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25679 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
pde12 35
  • 57.74 (n)
  • 59.02 (a)
pde12 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009079 35
  • 48.29 (n)
  • 40.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31759 35
  • 45.26 (n)
  • 36.53 (a)
CG31759 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pde-12 36
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CCR4 36
  • 13 (a)
OneToMany
NGL3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9594 36
  • 40 (a)
OneToOne
Species with no ortholog for PDE12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE12 Gene

ENSEMBL:
Gene Tree for PDE12 (if available)
TreeFam:
Gene Tree for PDE12 (if available)

Paralogs for PDE12 Gene

Paralogs for PDE12 Gene

genes like me logo Genes that share paralogs with PDE12: view

Variants for PDE12 Gene

Sequence variations from dbSNP and Humsavar for PDE12 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2241988 - 57,556,446(-) AGCCC(A/C/G)GCTCA reference, missense
rs1056537 -- 57,563,354(+) TTTTT(C/T)TTTTT intron-variant
rs2278755 -- 57,557,887(-) GCAGT(A/G)TGGCA intron-variant
rs1979074 -- 57,560,471(-) GCGCA(C/T)GCCTG intron-variant, utr-variant-3-prime
rs4402904 -- 57,605,655(+) CAATA(C/T)CAAAC intron-variant

Variation tolerance for PDE12 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.31; 88.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE12 Gene

HapMap Linkage Disequilibrium report
PDE12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PDE12 Gene

Disorders for PDE12 Gene

Relevant External Links for PDE12

Genetic Association Database (GAD)
PDE12
Human Genome Epidemiology (HuGE) Navigator
PDE12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE12

No disorders were found for PDE12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDE12 Gene

Publications for PDE12 Gene

  1. Identification of 2'-phosphodiesterase, which plays a role in the 2- 5A system regulated by interferon. (PMID: 15231837) Kubota K. … Iijima Y. (J. Biol. Chem. 2004) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. (PMID: 26055709) Wood E.R. … Dickson H. (J. Biol. Chem. 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PDE12 Gene

Sources for PDE12 Gene

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