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Aliases for PDE10A Gene

Aliases for PDE10A Gene

  • Phosphodiesterase 10A 2 3 5
  • CAMP And CAMP-Inhibited CGMP 3,5-Cyclic Phosphodiesterase 10A 2
  • DJ416F21.1 (Phosphodiesterase 10A) 3
  • Phosphodiesterase 10A1 (PDE10A1) 3
  • Phosphodiesterase 10A7 (PDE10A7) 3
  • EC 3.1.4.17 4
  • EC 3.1.4.35 4
  • HSPDE10A 3
  • PDE10A19 3
  • EC 3.1.4 63

External Ids for PDE10A Gene

Previous GeneCards Identifiers for PDE10A Gene

  • GC06M165097
  • GC06M165618
  • GC06M165653
  • GC06M165714
  • GC06M163202

Summaries for PDE10A Gene

Entrez Gene Summary for PDE10A Gene

  • The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for PDE10A Gene

PDE10A (Phosphodiesterase 10A) is a Protein Coding gene. Diseases associated with PDE10A include huntington disease. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and cGMP binding. An important paralog of this gene is PDE6A.

UniProtKB/Swiss-Prot for PDE10A Gene

  • Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.

Tocris Summary for PDE10A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE10A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE10A Gene

Genomics for PDE10A Gene

Regulatory Elements for PDE10A Gene

Promoters for PDE10A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDE10A on UCSC Golden Path with GeneCards custom track

Genomic Location for PDE10A Gene

Chromosome:
6
Start:
165,327,287 bp from pter
End:
165,986,603 bp from pter
Size:
659,317 bases
Orientation:
Minus strand

Genomic View for PDE10A Gene

Genes around PDE10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE10A Gene

Proteins for PDE10A Gene

  • Protein details for PDE10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y233-PDE10_HUMAN
    Recommended name:
    cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A
    Protein Accession:
    Q9Y233
    Secondary Accessions:
    • Q6FHX1
    • Q9HCP9
    • Q9NTV4
    • Q9ULW9
    • Q9Y5T1

    Protein attributes for PDE10A Gene

    Size:
    779 amino acids
    Molecular mass:
    88412 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAD32596.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDE10A Gene

    Alternative splice isoforms for PDE10A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE10A Gene

Proteomics data for PDE10A Gene at MOPED

Selected DME Specific Peptides for PDE10A Gene

Post-translational modifications for PDE10A Gene

Other Protein References for PDE10A Gene

Antibody Products

Domains & Families for PDE10A Gene

Gene Families for PDE10A Gene

Protein Domains for PDE10A Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y233

UniProtKB/Swiss-Prot:

PDE10_HUMAN :
  • The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.
  • Belongs to the cyclic nucleotide phosphodiesterase family.
Domain:
  • The tandem GAF domains bind cAMP, and regulate enzyme activity. The binding of cAMP stimulates enzyme activity.
  • Composed of a C-terminal catalytic domain containing two divalent metal sites and an N-terminal regulatory domain which contains one cyclic nucleotide-binding region.
  • Contains 2 GAF domains.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family.
genes like me logo Genes that share domains with PDE10A: view

Function for PDE10A Gene

Molecular function for PDE10A Gene

GENATLAS Biochemistry:
cGMP,cAMP inhibited nucleotide phosphodiesterase class10A,predominantly expressed in the putamen and caudate nucleus and in the testis
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=56 nM for cAMP {ECO:0000269 PubMed:17389385}; KM=4.4 uM for cGMP {ECO:0000269 PubMed:17389385}; Vmax=507 nmol/min/mg enzyme for cAMP {ECO:0000269 PubMed:17389385}; Vmax=1860 nmol/min/mg enzyme for cGMP {ECO:0000269 PubMed:17389385};
UniProtKB/Swiss-Prot CatalyticActivity:
Nucleoside 3,5-cyclic phosphate + H(2)O = nucleoside 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Guanosine 3,5-cyclic phosphate + H(2)O = guanosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by dipyridamole and moderately by IBMX. cAMP acts as an allosteric activator.
UniProtKB/Swiss-Prot Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.

Enzyme Numbers (IUBMB) for PDE10A Gene

Gene Ontology (GO) - Molecular Function for PDE10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity IEA,TAS 10373451
GO:0005515 protein binding IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0047555 3,5-cyclic-GMP phosphodiesterase activity IEA,TAS --
genes like me logo Genes that share ontologies with PDE10A: view
genes like me logo Genes that share phenotypes with PDE10A: view

Animal Models for PDE10A Gene

MGI Knock Outs for PDE10A:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE10A Gene

Localization for PDE10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE10A Gene

Cytoplasm. Note=Located mostly to soluble cellular fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE10A Gene COMPARTMENTS Subcellular localization image for PDE10A gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDE10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PDE10A: view

Pathways & Interactions for PDE10A Gene

genes like me logo Genes that share pathways with PDE10A: view

Pathways by source for PDE10A Gene

UniProtKB/Swiss-Prot Q9Y233-PDE10_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic AMP degradation; AMP from 3,5-cyclic AMP: step 1/1.
  • Pathway: Purine metabolism; 3,5-cyclic GMP degradation; GMP from 3,5-cyclic GMP: step 1/1.

SIGNOR curated interactions for PDE10A Gene

Other effect:

Gene Ontology (GO) - Biological Process for PDE10A Gene

None

Drugs & Compounds for PDE10A Gene

(17) Drugs for PDE10A Gene - From: HMDB, DrugBank, Novoseek, ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dipyridamole Approved Pharma Inhibition, Inhibitor, inhibitor, Target Adenosine transport inhibitor 76
Papaverine Approved Pharma Target, inhibitor 12
Tofisopam Approved Pharma Target, inhibitor 2
Triflusal Approved Pharma Target, antagonist 5
Caffeine Approved Nutra Antagonist, Target, inhibitor, competitive 339

(5) Additional Compounds for PDE10A Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MMPX
78033-08-6
MY-5445
78351-75-4
Ro 20-1724
29925-17-5
genes like me logo Genes that share compounds with PDE10A: view

Transcripts for PDE10A Gene

Unigene Clusters for PDE10A Gene

Phosphodiesterase 10A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE10A Gene

No ASD Table

Relevant External Links for PDE10A Gene

GeneLoc Exon Structure for
PDE10A
ECgene alternative splicing isoforms for
PDE10A

Expression for PDE10A Gene

mRNA expression in normal human tissues for PDE10A Gene

mRNA differential expression in normal tissues according to GTEx for PDE10A Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x12.4), Brain - Caudate (basal ganglia) (x10.2), and Brain - Nucleus accumbens (basal ganglia) (x6.0).

Protein differential expression in normal tissues from HIPED for PDE10A Gene

This gene is overexpressed in Lung (37.6) and Fetal Brain (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE10A Gene



SOURCE GeneReport for Unigene cluster for PDE10A Gene Hs.348762

mRNA Expression by UniProt/SwissProt for PDE10A Gene

Q9Y233-PDE10_HUMAN
Tissue specificity: Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
genes like me logo Genes that share expression patterns with PDE10A: view

Protein tissue co-expression partners for PDE10A Gene

Primer Products

In Situ Assay Products

Orthologs for PDE10A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE10A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE10A 36
  • 98 (a)
OneToOne
PDE10A 35
  • 99.54 (n)
  • 99.87 (a)
cow
(Bos Taurus)
Mammalia PDE10A 35
  • 87.29 (n)
  • 95.17 (a)
PDE10A 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE10A 36
  • 96 (a)
OneToOne
PDE10A 35
  • 91.77 (n)
  • 97.57 (a)
mouse
(Mus musculus)
Mammalia Pde10a 36
  • 95 (a)
OneToOne
Pde10a 16
Pde10a 35
  • 86.38 (n)
  • 95.56 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE10A 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE10A 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde10a 35
  • 85.82 (n)
  • 96.18 (a)
chicken
(Gallus gallus)
Aves PDE10A 35
  • 83.29 (n)
  • 91.48 (a)
PDE10A 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE10A 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde10a 35
  • 78.15 (n)
  • 85.2 (a)
zebrafish
(Danio rerio)
Actinopterygii pde10a 36
  • 78 (a)
OneToOne
pde10a 35
  • 76.65 (n)
  • 84.77 (a)
zgc56689 35
worm
(Caenorhabditis elegans)
Secernentea pde-5 35
  • 51.69 (n)
  • 45.7 (a)
C32E12.2 37
  • 47 (a)
pde-5 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for PDE10A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDE10A Gene

ENSEMBL:
Gene Tree for PDE10A (if available)
TreeFam:
Gene Tree for PDE10A (if available)

Paralogs for PDE10A Gene

Paralogs for PDE10A Gene

(3) SIMAP similar genes for PDE10A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PDE10A: view

Variants for PDE10A Gene

Sequence variations from dbSNP and Humsavar for PDE10A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_008797 -
rs2224252 - 165,339,309(-) GGACA(A/G)AGACA nc-transcript-variant, reference, missense
rs2860112 - 165,339,307(-) ACAGA(A/G)ACAAG nc-transcript-variant, reference, missense
rs220745 -- 165,417,770(-) TGTGC(C/G)TCACC intron-variant
rs220746 -- 165,417,764(+) CCCCA(C/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE10A Gene

Variant ID Type Subtype PubMed ID
nsv5586 CNV Loss 18451855
nsv508438 CNV Loss 20534489
nsv886928 CNV Gain 21882294
nsv523973 CNV Loss 19592680
nsv830863 CNV Gain 17160897
nsv510061 CNV Loss 20534489
nsv522249 CNV Loss 19592680
dgv7034n71 CNV Loss 21882294
nsv464136 CNV Loss 19166990
nsv818468 CNV Gain 17921354
dgv399n21 CNV Gain 19592680
dgv790n27 CNV Loss 19166990
nsv5588 CNV Insertion 18451855
esv25375 CNV Loss 19812545
esv275086 CNV Loss 21479260
esv2636877 CNV Insertion 19546169
esv1728655 CNV Insertion 17803354
nsv523862 CNV Loss 19592680
nsv823925 CNV Gain 20364138
esv33295 CNV Gain 17666407

Variation tolerance for PDE10A Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE10A Gene

HapMap Linkage Disequilibrium report
PDE10A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE10A Gene

Disorders for PDE10A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDE10A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • congenital anomalies of kidney and urinary tract 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PDE10A

Genetic Association Database (GAD)
PDE10A
Human Genome Epidemiology (HuGE) Navigator
PDE10A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE10A
genes like me logo Genes that share disorders with PDE10A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE10A Gene

Publications for PDE10A Gene

  1. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). (PMID: 10373451) Fujishige K. … Omori K. (J. Biol. Chem. 1999) 2 3 4 25 26 67
  2. Confirmed rare copy number variants implicate novel genes in schizophrenia. (PMID: 20298200) Tam G.W. … Grant S.G. (Biochem. Soc. Trans. 2010) 3 23
  3. The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. (PMID: 20967473) Rundfeldt C. … WlaA_ P. (J Neural Transm 2010) 25 26
  4. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. (PMID: 19689430) Matthiesen K. … Nielsen J. (Biochem. J. 2009) 3 23
  5. Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine. (PMID: 19066855) Weber M. … Swerdlow N.R. (Psychopharmacology (Berl.) 2009) 25 26

Products for PDE10A Gene

Sources for PDE10A Gene

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