Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PDCL Gene

protein-coding   GIFtS: 60
GCID: GC09M125560

Phosducin-Like

  Search for PDCL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
phosducin-like1 2
PhLP2
Phosducin-Like Protein2
PHLOP13
PHLP3
PhLP13

External Ids:    HGNC: 87701   Entrez Gene: 50822   Ensembl: ENSG000001369407   OMIM: 6044215   UniProtKB: Q133713   

Export aliases for PDCL gene to outside databases

Previous GC identifers: GC09M116684 GC09M117226 GC09M119014 GC09M120955 GC09M122659 GC09M124620 GC09M095194


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PDCL Gene:
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino
acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like
protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of
G proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for PDCL Gene:
PDCL (phosducin-like) is a protein-coding gene. GO annotations related to this gene include protein complex binding. An important paralog of this gene is PDCL2.

UniProtKB/Swiss-Prot: PHLP_HUMAN, Q13371
Function: Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes,
facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers
Function: Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded
G beta subunits inside the CCT chaperonin

Gene Wiki entry for PDCL (Phosducin-like) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDCL gene promoter:
         USF1   POU2F1   GATA-3   POU2F1a   USF-1   Lmo2   MRF-2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDCL promoter sequence
   Search Chromatin IP Primers for PDCL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDCL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q12-q13   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q12-q13

PDCL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCL gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M125560:  view genomic region     (about GC identifiers)

Start:
125,560,668 bp from pter      End:
125,590,935 bp from pter
Size:
30,268 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PHLP_HUMAN, Q13371 (See protein sequence)
Recommended Name: Phosducin-like protein  
Size: 301 amino acids; 34282 Da
Subunit: Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with
the CCT chaperonin complex
Secondary accessions: Q4VXB6 Q96AF1 Q9UEW7 Q9UFL0 Q9UNX1 Q9UNX2
Alternative splicing: 2 isoforms:  Q13371-1   Q13371-2   (Expressed ubiquitously, highest levels are found in neural tissues amounting to 10% of total PDCL mRNA)

Explore the universe of human proteins at neXtProt for PDCL: NX_Q13371

Explore proteomics data for PDCL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys240
  • Modification sites at PhosphoSitePlus

  • See PDCL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005379.3  
    ENSEMBL proteins: 
     ENSP00000397984   ENSP00000259467   ENSP00000377826  

    PDCL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PDCL
    OriGene Protein Over-expression Lysate for PDCL
    OriGene MassSpec for PDCL
    OriGene Custom Protein Services for PDCL
    GenScript Custom Purified and Recombinant Proteins Services for PDCL
    Novus Biologicals PDCL Proteins
    Novus Biologicals PDCL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PDCL
    Cloud-Clone Corp. Proteins for PDCL

     
    Search eBioscience for Proteins for PDCL 

    PDCL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDCL
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PDCL
    OriGene Custom Antibody Services for PDCL
    Novus Biologicals PDCL Antibodies
    Abcam antibodies for PDCL
    Cloud-Clone Corp. Antibodies for PDCL
    ThermoFisher Antibody for PDCL
    LSBio Antibodies in human, mouse, rat for PDCL

    PDCL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDCL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDCL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDCL
    Cloud-Clone Corp. CLIAs for PDCL
    Search eBioscience for ELISAs for PDCL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR023196 Phosducin_N_dom
     IPR001200 Phosducin
     IPR012336 Thioredoxin-like_fold
     IPR024253 Phosducin_thioredoxin-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13371

    ProtoNet protein and cluster: Q13371

    1 Blocks protein domain: IPB001200 Phosducin signature

    UniProtKB/Swiss-Prot: PHLP_HUMAN, Q13371
    Similarity: Belongs to the phosducin family


    Find genes that share domains with PDCL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHLP_HUMAN, Q13371
    Function: Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes,
    facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers
    Function: Isoform 2: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded
    G beta subunits inside the CCT chaperonin

         Genatlas biochemistry entry for PDCL:
    phosducin-like protein,a putative heterotrimeric G protein modulator

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity TAS10095058
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with PDCL           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PDCL:
     Decreased viability with pacli  Increased S DNA content  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pdcl):
     homeostasis/metabolism  nervous system  vision/eye 

    Find genes that share phenotypes with PDCL           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDCL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDCL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDCL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDCL

    miRNA
    Products:
        
    miRTarBase miRNAs that target PDCL:
    hsa-mir-423-3p (MIRT042501)

    Block miRNA regulation of human, mouse, rat PDCL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDCL (see all 30):
    hsa-miR-579 hsa-miR-30c hsa-miR-875-3p hsa-miR-137 hsa-miR-520d-5p hsa-miR-539 hsa-miR-30d hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidPDCL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDCL
    Predesigned siRNA for gene silencing in human, mouse, rat PDCL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDCL

    Clone
    Products:
         
    OriGene clones in human, mouse for PDCL (see all 6)
    OriGene ORF clones in mouse, rat for PDCL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDCL (NM_005388)
    Sino Biological Human cDNA Clone for PDCL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PDCL
    Browse ESI BIO Cell Lines and PureStem Progenitors for PDCL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3
    plasma membrane2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with PDCL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDCL
    Interactions:

        GeneGlobe Interaction Network for PDCL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PDCL (Q133713 ENSP000002594674) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703I2D: score=5 
    ENSG00000206406P678703I2D: score=5 
    ENSG00000224398P678703I2D: score=5 
    ENSG00000224774P678703I2D: score=5 
    ENSG00000228875P678703I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0007165signal transduction NAS10524200
    GO:0007601visual perception IEA--
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway TAS10095058
    GO:0035556intracellular signal transduction TAS10095058

    Find genes that share ontologies with PDCL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDCL (PHLP)

    1 HMDB Compound for PDCL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PDCL gene: 
    NM_005388.4  

    Unigene Cluster for PDCL:

    Phosducin-like
    Hs.271749  [show with all ESTs]
    Unigene Representative Sequence: NM_005388
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436632 ENST00000259467(uc004bmz.2) ENST00000394285
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDCL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDCL (see all 30):
    hsa-miR-579 hsa-miR-30c hsa-miR-875-3p hsa-miR-137 hsa-miR-520d-5p hsa-miR-539 hsa-miR-30d hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidPDCL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDCL
    Predesigned siRNA for gene silencing in human, mouse, rat PDCL
    Clone
    Products:
         
    OriGene clones in human, mouse for PDCL (see all 6)
    OriGene ORF clones in mouse, rat for PDCL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDCL (NM_005388)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PDCL
    OriGene qSTAR qPCR primer pairs in human, mouse for PDCL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDCL
      QuantiTect SYBR Green Assays in human, mouse, rat PDCL
      QuantiFast Probe-based Assays in human, mouse, rat PDCL

    Additional mRNA sequence: 

    AF031463.1 AK024980.1 AK313429.1 AL117602.1 BC017227.2 

    10 DOTS entries:

    DT.451948  DT.75183595  DT.100782262  DT.101975722  DT.102828118  DT.121197563  DT.121197580  DT.102828121 
    DT.121197560  DT.121337863 

    Selected AceView cDNA sequences (see all 121):

    BQ722523 BC017227 BQ771901 BE741376 CR618655 CB995465 BX392668 BM463225 
    BM725573 BE673507 AI149393 CD370452 BU741693 BM676280 CA430469 CF593679 
    BU509778 BM553285 CR618226 CF593719 AA833695 BQ020763 AA256160 CD365367 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PDCL    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
    SP1:                                            -     -                           
    SP2:                                            -                                 
    SP3:                                      -     -     -                           
    SP4:                                -           -     -                           
    SP5:                                                                              


    ECgene alternative splicing isoforms for PDCL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PDCL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATTTTGT
    PDCL Expression
    About this image


    PDCL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PDCL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDCL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.271749
        Custom PCR Arrays for PDCL
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDCL
    OriGene qSTAR qPCR primer pairs in human, mouse for PDCL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDCL
    QuantiTect SYBR Green Assays in human, mouse, rat PDCL
    QuantiFast Probe-based Assays in human, mouse, rat PDCL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PDCL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcl1 , 5 phosducin-like1, 5 89.04(n)1
    92.03(a)1
      2 (24.19 cM)5
    674661  NM_026176.31  NP_080452.21 
     373500745 
    chicken
    (Gallus gallus)
    Aves PDCL1 phosducin-like 73.29(n)
    76.77(a)
      772371  XM_004946004.1  XP_004946061.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDCL6
    phosducin-like
    51(a)
    1 ↔ 1
    GL344642.1(802-8602)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.63392 Transcribed sequence with weak similarity to protein more 77.76(n)    142018115 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc06a082 wufc06a08 77.59(n)   323645  BC059596.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76501 , 3 phototransduction3
    CG76501
    44(a)3
    54.72(n)1
    47.92(a)1
      71E23
    396941  NM_140529.31  NP_648786.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mau-86
    Protein MAU-8, isoform b (mau-8) mRNA, complete cd...
    30(a)
    1 → many
    IV(13378014-13380477) WBGene00003142
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PLP26
    Essential protein that interacts with the CCT (cha...
    16(a)
    1 → many
    XV(846269-847129) YOR281C


    ENSEMBL Gene Tree for PDCL (if available)
    TreeFam Gene Tree for PDCL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PDCL gene
    PDCL22  PDCL32  PDC2  
    1 SIMAP similar gene for PDCL using alignment to 3 protein entries:     PHLP_HUMAN (see all proteins):
    PDC

    Find genes that share paralogs with PDCL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PDCL (see all 237)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs750622831,2
    C,F--125579917(+) CGTGCC/TCAGCT 1 -- ds50011Minor allele frequency- T:0.06EA 120
    rs1471500021,2
    --125580041(+) TCTGTG/TCTTGA 1 -- ds50010--------
    rs1885861871,2
    --125580077(+) TGCATA/GATATA 1 -- ds50010--------
    rs1181147331,2
    C,F--125580189(+) AAAATA/GTAGCC 1 -- ds50011Minor allele frequency- G:0.02NA 120
    rs1818576231,2
    --125580245(+) AATAAA/CCAATA 1 -- ds50010--------
    rs1131200971,2
    C--125580297(+) ATCCCA/GGCACT 1 -- ds50010--------
    rs1921155131,2
    --125580419(+) GCATGC/TGCCTG 1 -- ut310--------
    rs1402748471,2
    C--125580533(+) CAGAGC/TGAGAC 1 -- ut310--------
    rs78537781,2
    C,F,H--125580609(+) atataT/Cccaaa 1 -- ut318Minor allele frequency- C:0.07NS NA WA 1006
    rs1823988281,2
    --125580912(+) AGTTAA/GTCAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PDCL (125560668 - 125590935 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PDCL: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDCL
    DNA2.0 Custom Variant and Variant Library Synthesis for PDCL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604421    OMIM disorders: --

    3 diseases from the University of Copenhagen DISEASES database for PDCL:
    Hypersensitivity reaction type I disease     Allergic rhinitis     Progressive myoclonus epilepsy

    Find genes that share disorders with PDCL           About GenesLikeMe


    Export disorders for PDCL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PDCL gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with PDCL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization. (PubMed id 10095058)1, 2, 3, 9 Thibault C.... Miles M.F. (Biochim. Biophys. Acta 1999)
    2. Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins. (PubMed id 23888055)1, 2 Gao X....Sokolov M. (J. Biol. Chem. 2013)
    3. Role of molecular chaperones in G protein beta5/regulator of G protein signaling dimer assembly and G protein betagamma dimer specificity. (PubMed id 19376773)1, 2 Howlett A.C....Willardson B.M. (J. Biol. Chem. 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry. (PubMed id 15585822)1, 2 Carter M.D.... Thulin C.D. (J. Biomol. Tech. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. (PubMed id 15889144)1, 9 Lukov G.L....Willardson B.M. (EMBO J. 2005)
    9. Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex. (PubMed id 16717095)1, 9 Lukov G.L....Willardson B.M. (J. Biol. Chem. 2006)
    10. Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding. (PubMed id 15745879)1, 9 Humrich J....Lohse M.J. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5082 HGNC: 8770 AceView: PDCL Ensembl:ENSG00000136940 euGenes: HUgn5082
    ECgene: PDCL H-InvDB: PDCL

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PDCL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PDCL gene:
    Search GeneIP for patents involving PDCL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PDCL
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PDCL   OriGene RNAi products in human, mouse, rat for PDCL  
     OriGene qPCR primer pairs and template standards for PDCL   OriGene Protein Over-expression Lysate for PDCL  
     OriGene MassSpec something-or-other for PDCL   OriGene clones in human, mouse for PDCL  
     OriGene qSTAR qPCR primer pairs in human, mouse for PDCL   OriGene Purified Protein for PDCL  
     OriGene ORF clones in mouse, rat for PDCL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PDCL   OriGene Custom Protein Services for PDCL  

     
     
     Block miRNA regulation of human, mouse, rat PDCL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PDCL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDCL Predesigned siRNA for gene silencing in human, mouse, rat PDCL
     QuantiFast Probe-based Assays in human, mouse, rat PDCL QuantiTect SYBR Green Assays in human, mouse, rat PDCL
     Custom PCR Arrays for PDCL Search Chromatin IP Primers for PDCL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDCL  GeneGlobe Interaction Network for PDCL
     Regulatory tfbs in PDCL promoter
     GenScript Custom Purified and Recombinant Proteins Services for PDCL GenScript cDNA clones with any tag delivered in your preferred vector for PDCL
     GenScript Custom Assay Services for PDCL GenScript Custom overexpressing Cell Line Services for PDCL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PDCL (PHLP)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PDCL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PDCL antibodies
     PDCL proteins
     PDCL lysates
     Antibodies for PDCL
     See all of Abcam's Antibodies, Kits and Proteins for PDCL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PDCL
     Proteins for PDCL
     Antibodies for PDCL
     ELISAs for PDCL
     CLIAs for PDCL



     Browse ESI BIO Cell Lines and PureStem Progenitors for PDCL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCL
     SwitchGear 3'UTR luciferase reporter plasmids for PDCL
     SwitchGear Promoter luciferase reporter plasmids for PDCL
     ThermoFisher Antibody for PDCL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCL
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDCL
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PDCL
     LSBio Antibodies in human, mouse, rat for PDCL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PDCL
      Search eBioscience for proteins for PDCL
      Search eBioscience for elisas for PDCL
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PDCL gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4