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Aliases for PDCD7 Gene

Aliases for PDCD7 Gene

  • Programmed Cell Death 7 2 3 5
  • U11/U12 SnRNP 59K 2 3
  • HES18 3 4
  • ES18 3 4
  • Programmed Cell Death Protein 7 3
  • Apoptosis-Related Protein ES18 3

External Ids for PDCD7 Gene

Previous GeneCards Identifiers for PDCD7 Gene

  • GC15M061187
  • GC15M058509
  • GC15M062988
  • GC15M063125
  • GC15M063196
  • GC15M065409
  • GC15M042234

Summaries for PDCD7 Gene

Entrez Gene Summary for PDCD7 Gene

  • This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDCD7 Gene

PDCD7 (Programmed Cell Death 7) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

UniProtKB/Swiss-Prot for PDCD7 Gene

  • Promotes apoptosis when overexpressed.

Gene Wiki entry for PDCD7 Gene

Additional gene information for PDCD7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD7 Gene

Genomics for PDCD7 Gene

Regulatory Elements for PDCD7 Gene

Enhancers for PDCD7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H065303 1.8 FANTOM5 ENCODE dbSUPER 68.3 -170.6 -170636 2.2 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 PARP16 ZNF609 PDCD7 INTS14 TRIP4 SLC24A1 CILP CSNK1G1 ENSG00000264937 ENSG00000259635
GH15H065609 1.2 ENCODE 71.6 -477.6 -477577 3.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 INTS14 PARP16 ENSG00000260773 SNORD16 PDCD7 RPL35AP32 ENSG00000264937 ENSG00000259635 SLC24A1 TIPIN
GH15H065868 1.6 FANTOM5 ENCODE 53.4 -736.7 -736745 3.7 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 ZNF610 PDCD7 PARP16 INTS14 MTFMT SLC24A1 HNRNPA1P44 UBAP1L RNU5A-1 RNU5B-1 ENSG00000259346
GH15H065295 1.7 FANTOM5 ENCODE dbSUPER 38.6 -163.5 -163531 4.1 HNRNPUL1 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PARP16 INTS14 ZNF609 TRIP4 ENSG00000264937 PDCD7 ENSG00000259635 MTFMT ENSG00000265967 CSNK1G1
GH15H065786 1.7 Ensembl ENCODE dbSUPER 29.8 -656.3 -656284 7.7 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC SSRP1 PDCD7 PARP16 SLC24A1 INTS14 ENSG00000260773 ZWILCH MTFMT SNORD16 DENND4A LOC646358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDCD7 on UCSC Golden Path with GeneCards custom track

Promoters for PDCD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078048 536 1801 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3

Genomic Locations for PDCD7 Gene

Genomic Locations for PDCD7 Gene
16,458 bases
Minus strand

Genomic View for PDCD7 Gene

Genes around PDCD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD7 Gene

Proteins for PDCD7 Gene

  • Protein details for PDCD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Programmed cell death protein 7
    Protein Accession:
    Secondary Accessions:
    • Q96AK8
    • Q9Y6D7

    Protein attributes for PDCD7 Gene

    485 amino acids
    Molecular mass:
    54700 Da
    Quaternary structure:
    • Interacts with RBM40. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

neXtProt entry for PDCD7 Gene

Post-translational modifications for PDCD7 Gene

  • Ubiquitination at posLast=280280
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDCD7 Gene

Domains & Families for PDCD7 Gene

Gene Families for PDCD7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PDCD7 Gene


Suggested Antigen Peptide Sequences for PDCD7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDCD7: view

No data available for UniProtKB/Swiss-Prot for PDCD7 Gene

Function for PDCD7 Gene

Molecular function for PDCD7 Gene

UniProtKB/Swiss-Prot Function:
Promotes apoptosis when overexpressed.

Phenotypes From GWAS Catalog for PDCD7 Gene

genes like me logo Genes that share phenotypes with PDCD7: view

Animal Model Products

CRISPR Products

miRNA for PDCD7 Gene

miRTarBase miRNAs that target PDCD7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCD7 Gene

Localization for PDCD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCD7 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDCD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with PDCD7: view

Pathways & Interactions for PDCD7 Gene

genes like me logo Genes that share pathways with PDCD7: view

Pathways by source for PDCD7 Gene

Gene Ontology (GO) - Biological Process for PDCD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006915 apoptotic process IEA --
GO:0008380 RNA splicing IC 15146077
GO:0051384 response to glucocorticoid ISS 10037816
genes like me logo Genes that share ontologies with PDCD7: view

No data available for SIGNOR curated interactions for PDCD7 Gene

Drugs & Compounds for PDCD7 Gene

No Compound Related Data Available

Transcripts for PDCD7 Gene

mRNA/cDNA for PDCD7 Gene

Unigene Clusters for PDCD7 Gene

Programmed cell death 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD7 Gene

No ASD Table

Relevant External Links for PDCD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDCD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDCD7 Gene

Protein differential expression in normal tissues from HIPED for PDCD7 Gene

This gene is overexpressed in Liver, secretome (55.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD7 Gene

Protein tissue co-expression partners for PDCD7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PDCD7 Gene:


SOURCE GeneReport for Unigene cluster for PDCD7 Gene:


Evidence on tissue expression from TISSUES for PDCD7 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with PDCD7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD7 Gene

Orthologs for PDCD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDCD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDCD7 33 34
  • 97.91 (n)
(Canis familiaris)
Mammalia PDCD7 33 34
  • 91.35 (n)
(Bos Taurus)
Mammalia PDCD7 33 34
  • 89.97 (n)
(Rattus norvegicus)
Mammalia Pdcd7 33
  • 89.72 (n)
(Mus musculus)
Mammalia Pdcd7 33 16 34
  • 86.57 (n)
(Monodelphis domestica)
Mammalia PDCD7 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PDCD7 34
  • 68 (a)
(Gallus gallus)
Aves PDCD7 34
  • 58 (a)
(Anolis carolinensis)
Reptilia PDCD7 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16005 33
(Danio rerio)
Actinopterygii pdcd7 33 34
  • 53.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3428 33
Species where no ortholog for PDCD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD7 Gene

Gene Tree for PDCD7 (if available)
Gene Tree for PDCD7 (if available)

Paralogs for PDCD7 Gene

No data available for Paralogs for PDCD7 Gene

Variants for PDCD7 Gene

Sequence variations from dbSNP and Humsavar for PDCD7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000071942 -- 65,135,277(+) TAGCT(A/G)GGATT upstream-variant-2KB
rs1000171767 -- 65,130,526(+) GAATC(C/T)TCTTG intron-variant
rs1000318788 -- 65,135,498(+) GGAAC(C/T)GGACC upstream-variant-2KB
rs1000509230 -- 65,131,839(+) CAATA(C/G)GCTTT intron-variant
rs1000578352 -- 65,117,782(+) GGCCC(A/G)CCTCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PDCD7 Gene

Variant ID Type Subtype PubMed ID
esv2763104 CNV gain 21179565

Variation tolerance for PDCD7 Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 62.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD7 Gene

Disorders for PDCD7 Gene

Relevant External Links for PDCD7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PDCD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDCD7 Gene

Publications for PDCD7 Gene

  1. Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells. (PMID: 10037816) Park EJ … Hong SH (Nucleic acids research 1999) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will CL … Lührmann R (RNA (New York, N.Y.) 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for PDCD7 Gene

Sources for PDCD7 Gene

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