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Aliases for PDCD6IP Gene

Aliases for PDCD6IP Gene

  • Programmed Cell Death 6 Interacting Protein 2 3 5
  • Programmed Cell Death 6-Interacting Protein 2 3
  • ALG-2-Interacting Protein X 3 4
  • PDCD6-Interacting Protein 3 4
  • AIP1 3 4
  • HP95 3 4
  • ALIX 3 4
  • Apoptosis-Linked Gene 2-Interacting Protein X 3
  • Dopamine Receptor Interacting Protein 4 3
  • ALG-2 Interacting Protein X 2
  • ALG-2 Interacting Protein 1 3
  • ALG-2-Interacting Protein 1 4
  • KIAA1375 4
  • DRIP4 3

External Ids for PDCD6IP Gene

Previous GeneCards Identifiers for PDCD6IP Gene

  • GC03P033126
  • GC03P033686
  • GC03P033811
  • GC03P033814
  • GC03P033781

Summaries for PDCD6IP Gene

Entrez Gene Summary for PDCD6IP Gene

  • This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

GeneCards Summary for PDCD6IP Gene

PDCD6IP (Programmed Cell Death 6 Interacting Protein) is a Protein Coding gene. Diseases associated with PDCD6IP include Adult Neuronal Ceroid Lipofuscinosis and Neuronal Ceroid Lipofuscinosis. Among its related pathways are HIV Life Cycle and Apoptosis and Autophagy. GO annotations related to this gene include protein homodimerization activity and SH3 domain binding. An important paralog of this gene is PTPN23.

UniProtKB/Swiss-Prot for PDCD6IP Gene

  • Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).

  • (Microbial infection) Involved in HIV-1 virus budding (PubMed:14505569, PubMed:14505570, PubMed:14519844). Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).

Gene Wiki entry for PDCD6IP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD6IP Gene

Genomics for PDCD6IP Gene

Regulatory Elements for PDCD6IP Gene

Enhancers for PDCD6IP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G033797 1.1 ENCODE 45.1 +1.0 975 3.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 PDCD6IP TMPPE CLASP2 UBP1 ENSG00000271324 GC03M033793 LOC105377024
GH03G033437 1.4 ENCODE dbSUPER 24.6 -358.4 -358416 5.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 PDCD6IP FBXL2 UBP1 TMPPE CMTM6 PIR40256 GC03M033417
GH03G033790 1.7 FANTOM5 Ensembl ENCODE 18.3 -7.0 -7031 2.5 PKNOX1 ATF1 CREB3L1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 FOS PDCD6IP CLASP2 ENSG00000271643 ENSG00000271324 SDAD1P3
GH03G032832 1.1 ENCODE dbSUPER 27.7 -965.1 -965058 0.7 ZFP64 ZNF654 ZNF680 CEBPB ZNF426 REST ZNF623 ZNF518A ZNF781 ZNF555 PDCD6IP FBXL2 UBP1 TRIM71 PIR32571
GH03G034010 1.3 Ensembl ENCODE 17.4 +213.7 213727 4.0 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 FOS DEK SP5 PDCD6IP ENSG00000271324 GC03M034126 LOC105377024
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDCD6IP on UCSC Golden Path with GeneCards custom track

Promoters for PDCD6IP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000150667 748 2201 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1

Genomic Location for PDCD6IP Gene

Chromosome:
3
Start:
33,798,352 bp from pter
End:
33,869,707 bp from pter
Size:
71,356 bases
Orientation:
Plus strand

Genomic View for PDCD6IP Gene

Genes around PDCD6IP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD6IP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD6IP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD6IP Gene

Proteins for PDCD6IP Gene

  • Protein details for PDCD6IP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUM4-PDC6I_HUMAN
    Recommended name:
    Programmed cell death 6-interacting protein
    Protein Accession:
    Q8WUM4
    Secondary Accessions:
    • C5MQH7
    • E9PFU1
    • Q6NUS1
    • Q9BX86
    • Q9NUN0
    • Q9P2H2
    • Q9UKL5

    Protein attributes for PDCD6IP Gene

    Size:
    868 amino acids
    Molecular mass:
    96023 Da
    Quaternary structure:
    • Interacts with SH3KBP1. Interacts with PDCD6 and TSG101 in a calcium-dependent manner. Interacts with and SGSM3. Self-associates. Interacts with CHMP4A; the interaction is direct. Interacts with CHMP4B; the interaction is direct. Interacts with CHMP4C; the interaction is direct. Interacts with CEP55; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry. May interact with PDGFRB. Interacts with SH3GL1 and SH3GL2. Interacts with SDCBP (PubMed:22660413). Forms a complex with SDCBP and SDC2 (PubMed:22660413). Found in a complex with F-actin, TJP1 and PARD3 (By similarity).
    • (Microbial infection) Interacts with HIV-1 p6 (PubMed:14505569). Interacts with EIAV p9; the interaction has been shown in vitro (PubMed:14505569, PubMed:14519844). Interacts with murine leukemia virus Gag polyprotein (via LYPX(n)L motif) (PubMed:15908698).
    SequenceCaution:
    • Sequence=BAA92092.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDCD6IP Gene

    Alternative splice isoforms for PDCD6IP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCD6IP Gene

Post-translational modifications for PDCD6IP Gene

  • May be phosphorylated on tyrosine residues by activated PDGFRB.
  • Ubiquitination at posLast=2323, posLast=350350, Lys501, Lys640, posLast=707707, and posLast=751751
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDCD6IP (Alix)
  • Cloud-Clone Corp. Antibodies for PDCD6IP

No data available for DME Specific Peptides for PDCD6IP Gene

Domains & Families for PDCD6IP Gene

Protein Domains for PDCD6IP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDCD6IP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PDCD6IP Gene

Function for PDCD6IP Gene

Molecular function for PDCD6IP Gene

UniProtKB/Swiss-Prot Function:
Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (PubMed:22660413). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in HIV-1 virus budding (PubMed:14505569, PubMed:14505570, PubMed:14519844). Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).

Gene Ontology (GO) - Molecular Function for PDCD6IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11883939
GO:0031871 proteinase activated receptor binding IPI 22547407
GO:0042803 protein homodimerization activity IPI 14505570
GO:0046983 protein dimerization activity IEA --
GO:0048306 calcium-dependent protein binding IPI 18256029
genes like me logo Genes that share ontologies with PDCD6IP: view
genes like me logo Genes that share phenotypes with PDCD6IP: view

Animal Models for PDCD6IP Gene

MGI Knock Outs for PDCD6IP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDCD6IP Gene

Localization for PDCD6IP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD6IP Gene

Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted, exosome. Cell junction, tight junction. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells Component of the actomyosin-tight junction complex (By similarity). {ECO:0000250 UniProtKB:Q9QZA2, ECO:0000250 UniProtKB:Q9WU78, ECO:0000269 PubMed:17081065, ECO:0000269 PubMed:17556548, ECO:0000269 PubMed:17853893}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCD6IP gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
cytoskeleton 4
endoplasmic reticulum 4
nucleus 2
endosome 2
lysosome 1

Gene Ontology (GO) - Cellular Components for PDCD6IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 19706535
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDCD6IP: view

Pathways & Interactions for PDCD6IP Gene

genes like me logo Genes that share pathways with PDCD6IP: view

Pathways by source for PDCD6IP Gene

2 Cell Signaling Technology pathways for PDCD6IP Gene
1 KEGG pathway for PDCD6IP Gene

Gene Ontology (GO) - Biological Process for PDCD6IP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IDA 18641129
GO:0000915 actomyosin contractile ring assembly ISS --
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006810 transport IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with PDCD6IP: view

No data available for SIGNOR curated interactions for PDCD6IP Gene

Drugs & Compounds for PDCD6IP Gene

(2) Drugs for PDCD6IP Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PDCD6IP: view

Transcripts for PDCD6IP Gene

Unigene Clusters for PDCD6IP Gene

Programmed cell death 6 interacting protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD6IP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7: - -
SP8: -
SP9:
SP10: - - - -
SP11: -
SP12:
SP13: - - - -

ExUns: 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PDCD6IP Gene

GeneLoc Exon Structure for
PDCD6IP
ECgene alternative splicing isoforms for
PDCD6IP

Expression for PDCD6IP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDCD6IP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PDCD6IP Gene

This gene is overexpressed in Lymph node (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD6IP Gene



Protein tissue co-expression partners for PDCD6IP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDCD6IP Gene:

PDCD6IP

SOURCE GeneReport for Unigene cluster for PDCD6IP Gene:

Hs.475896

Evidence on tissue expression from TISSUES for PDCD6IP Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Lung(3.4)
  • Kidney(2.2)
  • Eye(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PDCD6IP: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD6IP Gene

Orthologs for PDCD6IP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD6IP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD6IP 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia PDCD6IP 34 35
  • 93.7 (n)
cow
(Bos Taurus)
Mammalia PDCD6IP 34 35
  • 91.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PDCD6IP 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcd6ip 34 16 35
  • 88.28 (n)
rat
(Rattus norvegicus)
Mammalia Pdcd6ip 34
  • 87.89 (n)
oppossum
(Monodelphis domestica)
Mammalia PDCD6IP 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDCD6IP 34 35
  • 78.02 (n)
lizard
(Anolis carolinensis)
Reptilia PDCD6IP 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd6ip 34
  • 72.93 (n)
Str.3976 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398095 34
zebrafish
(Danio rerio)
Actinopterygii pdcd6ip 34 35
  • 67.13 (n)
wufb70d03 34
fruit fly
(Drosophila melanogaster)
Insecta ALiX 34 35
  • 50.24 (n)
CG12876 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005531 34
  • 48.3 (n)
worm
(Caenorhabditis elegans)
Secernentea alx-1 34 35
  • 50.7 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER342C 34
  • 43.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM20 34 35 37
  • 43.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07348g 34
  • 43.09 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15130 34
  • 43.27 (n)
rice
(Oryza sativa)
Liliopsida Os10g0495300 34
  • 43.24 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05876 34
  • 40.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for PDCD6IP was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDCD6IP Gene

ENSEMBL:
Gene Tree for PDCD6IP (if available)
TreeFam:
Gene Tree for PDCD6IP (if available)

Paralogs for PDCD6IP Gene

Paralogs for PDCD6IP Gene

(1) SIMAP similar genes for PDCD6IP Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PDCD6IP Gene

genes like me logo Genes that share paralogs with PDCD6IP: view

Variants for PDCD6IP Gene

Sequence variations from dbSNP and Humsavar for PDCD6IP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000038613 -- 33,827,957(+) CACAC(A/C)AGGTA intron-variant
rs1000105852 -- 33,834,466(+) GTGCA(A/G)TTTCC intron-variant
rs1000150528 -- 33,835,545(+) AACCC(A/G)ATGTC intron-variant
rs1000204860 -- 33,835,042(+) TTTTA(C/T)ATCTT intron-variant
rs1000348510 -- 33,840,251(+) AGAAA(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD6IP Gene

Variant ID Type Subtype PubMed ID
nsv3758 CNV insertion 18451855
nsv522881 CNV gain 19592680
nsv979819 CNV duplication 23825009

Variation tolerance for PDCD6IP Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.82; 98.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCD6IP Gene

Human Gene Mutation Database (HGMD)
PDCD6IP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCD6IP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD6IP Gene

Disorders for PDCD6IP Gene

MalaCards: The human disease database

(3) MalaCards diseases for PDCD6IP Gene - From: GeneCards

Disorder Aliases PubMed IDs
adult neuronal ceroid lipofuscinosis
  • adult ncl
neuronal ceroid lipofuscinosis
  • hereditary ceroid lipofuscinosis
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PDCD6IP

Genetic Association Database (GAD)
PDCD6IP
Human Genome Epidemiology (HuGE) Navigator
PDCD6IP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCD6IP
genes like me logo Genes that share disorders with PDCD6IP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD6IP Gene

Publications for PDCD6IP Gene

  1. Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101. (PMID: 19520058) Okumura M. … Maki M. (Biochem. Biophys. Res. Commun. 2009) 3 4 22 64
  2. Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PMID: 18256029) Shibata H. … Maki M. (J. Biol. Chem. 2008) 3 4 22 64
  3. ALIX-CHMP4 interactions in the human ESCRT pathway. (PMID: 18511562) McCullough J. … Hill C.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 22 64
  4. Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. (PMID: 18940611) Suzuki H. … Maki M. (Structure 2008) 3 4 22 64
  5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PMID: 17853893) Morita E. … Sundquist W.I. (EMBO J. 2007) 3 4 22 64

Products for PDCD6IP Gene

Sources for PDCD6IP Gene

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