PDCD6IP Gene
protein-coding GIFtS : 62 GCID: GC03 P033839
programmed cell death 6 interacting protein programmed cell death 6-interacting protein )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor PDCD6IP gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Programmed Cell Death 6 Interacting Protein 1 2 DRIP42 AIP11 2 3 5 HP952 ALIX2 3 5 ALG-2 Interacting Protein 12 Programmed Cell Death 6-Interacting Protein1 2 Apoptosis-Linked Gene 2-Interacting Protein X2 Hp951 3 Dopamine Receptor Interacting Protein 42 PDCD6-Interacting Protein2 3 ALG-2-Interacting Protein 13 KIAA13753 5 ALG-2-Interacting Protein X3 Alix1
External Ids: HGNC: 8766 1 Entrez Gene: 10015 2 Ensembl: ENSG00000170248 7 OMIM: 608074 5 UniProtKB: Q8WUM4 3 ORGUL members: NONCODE:n408055
Export aliases for PDCD6IP gene to outside databases Previous GC identifers: GC03P033126 GC03P033686 GC03P033811 GC03P033814 GC03P033781
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor PDCD6IP gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PDCD6IP : This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. (provided by RefSeq, Jan 2012) UniProtKB/Swiss-Prot: PDC6I_HUMAN, Q8WUM4 Function : Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB)for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation Gene Wiki entry for PDCD6IP
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor PDCD6IP gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PDCD6IP gene promoter:GATA-3 AML1a Pax-5 Egr-1 Arnt GATA-2 GATA-1 AREB6 HOXA5 SEF-1 (1) Other transcription factors Search SABiosciences Chromatin IP Primers for PDCD6IP Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p22.3 Ensembl cytogenetic band: 3p22.3 HGNC cytogenetic band: 3p22.3 PDCD6IP Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P033839: view genomic region
(about GC identifiers )
Start: 33,839,844 bp from pter End:
33,911,195 bp from pter
Size: 71,352 bases Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor PDCD6IP gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PDC6I_HUMAN, Q8WUM4 See
protein sequence )Recommended Name: Size : 868 amino acids; 96023 DaSubunit : Interacts with SH3KBP1. Interacts with PDCD6 and TSG101 in a calcium-dependent manner. Interacts with andSGSM3. Self-associates. Interacts with CHMP4A; the interaction is direct. Interacts with CHMP4B; the interaction is direct. Interacts with CHMP4C; the interaction is direct. Interacts with HIV-1 p6. Interacts with EIAV p9; the interaction has been shown in vitro. Interacts with CEP55; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry. May interact with PDGFRB. Interacts with SH3GL1 and SH3GL2. Interacts with murine leukemia virus Gag polyprotein (via LYPX(n)L motif). Interacts with murine leukemia virus Gag polyprotein (via LYPX(n)L motif)
Subcellular location : Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, centrosome. Note=Identified by massspectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells
Sequence caution : Sequence=BAA92092.1; Type=Erroneous initiation;6/14 PDB 3D structures from (see all 14 ):2OEV (3D) 2OEW (3D) 2OEX (3D) 2OJQ (3D) 2R02 (3D) 2R03 (3D) Secondary accessions : E9PFU1 Q6NUS1 Q9BX86 Q9NUN0 Q9P2H2 Q9UKL5Alternative splicing : 2 isoforms : Q8WUM4-1 Q8WUM4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PDCD6IP: NX_Q8WUM4 Post-translational modifications:
May be phosphorylated on tyrosine residues by activated PDGFRB1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8WUM4 PDCD6IP Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001155901.1 NP_001243121.1 NP_037506.2 ENSEMBL proteins: ENSP00000307387 ENSP00000393777 ENSP00000398895 ENSP00000406693 ENSP00000415150 ENSP00000411825 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing PDCD6IP Antibody Products: Assay Products for PDCD6IP:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains /for PDCD6IP gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8WUM4 ProtoNet protein and cluster: Q8WUM4
1 Blocks protein family : IPB004328 UniProtKB/Swiss-Prot: PDC6I_HUMAN, Q8WUM4 Similarity : Contains 1 BRO1 domain
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor PDCD6IP gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PDC6I_HUMAN, Q8WUM4 Function : Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB)for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): PDCD6IP (NM_013374 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDCD6IP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PDCD6IP
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD6IP
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 1 GenomeRNAi human phenotype for PDCD6IP :
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor PDCD6IP gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Adhesion 2 Endocytosis 3 Apoptosis and Autophagy
Pathway sources See GeneCards unified pathways Show all pathways 2 1 (Kegg details for PDCD6IP) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDCD6IP STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/690 Interacting proteins for PDCD6IP (Q8WUM4 1 , 2 , 3 ENSP00000307387 4 via UniProtKB, MINT, STRING , and/or I2D (see all 690 )Interactant Interaction Details GeneCard External ID(s) CEP55 Q53EZ4 2 , 3 ENSP00000360540 4 MINT-6173613 MINT-6173720 MINT-6173792 MINT-6175173 MINT-6173644 MINT-6169566 MINT-6173415 MINT-6173556 I2D:
score=2 STRING: ENSP00000360540 HCK P08631 2 , 3 ENSP00000365012 4 MINT-8109689 MINT-8374796 MINT-8374708 MINT-8374882 I2D:
score=1 STRING: ENSP00000365012 TSG101 Q99816 2 , 3 ENSP00000251968 4 MINT-6173720 MINT-7945693 I2D:
score=5 STRING: ENSP00000251968 EGFR P00533 2 , 3 ENSP00000275493 4 MINT-68514 MINT-68513 I2D:
score=3 STRING: ENSP00000275493 CD2AP Q9Y5K6 2 , 3 ENSP00000352264 4 MINT-6173759 MINT-6173665 I2D:
score=2 STRING: ENSP00000352264
About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor PDCD6IP gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for PDCD6IP 1 HMDB Compound for PDCD6IP About this table 2 Novoseek chemical compound relationships for PDCD6IP gene About this table PDCD6IP / PDC6I
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor PDCD6IP gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PDCD6IP gene (3 alternative transcripts): NM_001162429.2 NM_001256192.1 NM_013374.5 Unigene Cluster for PDCD6IP:
Programmed cell death 6 interacting protein Hs.475896 [show with all ESTs ] Unigene Representative Sequence: NM_001162429 18 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000307296 ENST00000435909 ENST00000430877 ENST00000413073 ENST00000477798 ENST00000498147 ENST00000484478 ENST00000494810 ENST00000459659 ENST00000412887 ENST00000482561 ENST00000487821 ENST00000465122 ENST00000462070 ENST00000495235 ENST00000489869 ENST00000473593 ENST00000457054 (uc011axv.2 uc003cfy.3 uc003cfx.3 uc011axw.2 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): PDCD6IP (NM_013374 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDCD6IP Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PDCD6IP
Additional cDNA sequence: AB037796.1 AF151793.1 AF250394.1 AF349951.1 AK002122.1 AK298727.1 BC020066.1 BC068454.1 BT007367.1 GQ131806.1
20 DOTS entries : DT.117496 DT.91717667
DT.91961435 DT.303523 DT.100009113 DT.100809586 DT.100887563 DT.120875303 DT.70100905 DT.91763936 DT.100887559 DT.100887553 DT.120875244 DT.120875252 DT.121053954 DT.121067077 DT.86855509 DT.91949038 DT.95373942 DT.307440 24/554 AceView cDNA sequences (see all 554 ):
BP356685 BP356807 AI016197 BU633599 AA364351 BG259764 BG109730 AI889591 BQ919180 AA262641 BM851537 AA729147 AI346505 BX952305 BG741896 BU543761 AA569878 BU165197 AA777248 BQ892829 CD366446 CB164362 AI339801 BQ024882 GeneLoc Exon Structure 5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD6IP (see all 13 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ SP1 : - SP2 : - - SP3 : - SP4 : - - SP5 : - -
ExUns: 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b SP1 : - - SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for PDCD6IP
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for PDCD6IP gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PDCD6IP expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTTGGGACAT
About this image PDCD6IP expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Reproductive System Early Gonad Testis Somatic Cells Testis Expression: Experimental details:
In-situ hybridization
See PDCD6IP Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PDCD6IP SOURCE GeneReport for Unigene cluster: Hs.475896 SABiosciences Custom PCR Arrays for PDCD6IP Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD6IP
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor PDCD6IP gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for PDCD6IP gene from 9/33 species (see all 33 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves PDCD6IP1
programmed cell death 6 interacting protein
79.17(n) 85.5(a)
420725 NM_001030993.1 NP_001026164.1
lizard Reptilia PDCD6IP6
--
84(a)
1 ↔ 1
GL343324.1(1160999-1204228)
African clawed frog Amphibia LOC3980952
putative signal tranduction protein Xp95
77.15(n)
AF115497.1
zebrafish Actinopterygii wufb70d032
Danio rerio cDNA clone MGC63638 IMAGE5604723, complete more
75.86(n)
BC055177.1
fruit fly Insecta CG128763 1
signal transducer3 1
43(a) 3 50.32(n) 1 43.6(a) 1
98B13 43330 1 NM_143325.2 1 NP_651582.1 1
worm Secernentea alx-11
Protein ALX-1
49.76(n) 41.16(a)
176410 NM_001027542.1 NP_001022713.1
baker's yeast Saccharomycetes RIM20(YOR275C)4 1
Protein involved in proteolytic activation of Rim1 more 4 1
42.32(n) 1 29.13(a) 1
15(841069-839084) 4 854449 1, 4 NP_014918.1 1, 4
thale cress eudicotyledons AT1G151301
programmed cell death 6-interacting protein
43.17(n) 29.64(a)
838077 NM_101381.2 NP_172965.1
rice Liliopsida Os10g04953001
hypothetical protein
43.41(n) 31.18(a)
4348999 NM_001071485.1 NP_001064950.2
ENSEMBL Gene Tree for PDCD6IP (if available)TreeFam Gene Tree for PDCD6IP (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor PDCD6IP gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PDCD6IP gene PTPN23 2 1 SIMAP similar gene for PDCD6IP using alignment to 6 protein entries: PDC6I_HUMAN (see all proteins ):DRIP4 About GeneDecksing 2 Pseudogenes.org Pseudogenes for PDCD6IP PGOHUM00000258815 PGOHUM00000258930
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor PDCD6IP gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 3 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for PDCD6IP (33839844 - 33911195 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for PDCD6IP: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor PDCD6IP gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 608074
OMIM disorders : --8 : About MalaCards herpes simplex hepatitis b neurodegeneration immunodeficiency hepatitis cholesterol leukemia neuronitis 2 Novoseek disease relationships for PDCD6IP gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis
0
2
18936101 (1), 19143631 (1)
immunodeficiency
0
1
15276209 (1)
Human Genome Epidemiology (HuGE) Navigator: PDCD6IP (2 documents) Export disorders for PDCD6IP gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor PDCD6IP gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PDCD6IP gene, integrated from 9 sources (see all 177 ):(articles sorted by number of sources associating them with PDCD6IP) Utopia : connect your pdf to the dynamic
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893) 1 , 2 , 9(2007) The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. (PubMed id 12860994) 1 , 2 , 9(2003) CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. (PubMed id 14678797) 1 , 2 , 9(2004) Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101. (PubMed id 19520058) 1 , 2 , 9(2009) Structure and function of human Vps20 and Snf7 proteins. (PubMed id 14583093) 1 , 2 , 9(2004) Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. (PubMed id 18940611) 1 , 2 , 9(2008) ALIX-CHMP4 interactions in the human ESCRT pathway. (PubMed id 18511562) 1 , 2 , 9(2008) Identification of Alix-type and non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants. (PubMed id 18256029) 1 , 2 , 9(2008) The protein network of HIV budding. (PubMed id 14505570) 1 , 2 , 9(2003) Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. (PubMed id 18948538) 1 , 2 (2008)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for PDCD6IP gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing PDCD6IP gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing PDCD6IP gene
(According to HUGE )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing PDCD6IP gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for PDCD6IP Pharmacogenomics, SNPs, Pathways
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for PDCD6IP gene: PDCD6IP GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor PDCD6IP gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for PDCD6IP OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for PDCD6IP Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PDCD6IP OriGene 3'-UTR Clone for PDCD6IP OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for PDCD6IP OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PDCD6IP OriGene Custom Protein Services for PDCD6IP OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDCD6IP QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for PDCD6IP (Alix)
Search Tocris compounds for PDCD6IP
PDCD6IP Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD6IP
ThermoFisher Antibodies for PDCD6IP
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PDCD6IP
Jump to Section...
Aliases for PDCD6IP
Databases for PDCD6IP
Disorders / Diseases for PDCD6IP
Domains / Families for PDCD6IP
Drugs / Compounds for PDCD6IP
Expression for PDCD6IP
Function for PDCD6IP
Genomic Views for PDCD6IP
Intellectual Property for PDCD6IP
Orthologs for PDCD6IP
Paralogs for PDCD6IP
Pathways / Interactions for PDCD6IP
Products for PDCD6IP
Proteins for PDCD6IP
Publications for PDCD6IP
Search Box for PDCD6IP
Summaries for PDCD6IP
Transcripts for PDCD6IP
Variants for PDCD6IP
TOP
BOTTOM
GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
View Random Gene
Category
Protein-coding
RNA genes
Genetic Loci
Pseudogenes
Gene clusters
Uncategorized
Any
Go
von Willebrand factor
GIFtS Group
High
Medium
Low
Any
Developed at the Crown Human Genome Center Department of Molecular Genetics
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 100 solr: 1.4
and Proteopedia 
for PDCD6IP (
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
