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Aliases for PDCD5 Gene

Aliases for PDCD5 Gene

  • Programmed Cell Death 5 2 3
  • TF-1 Cell Apoptosis-Related Protein 19 3 4
  • TF1 Cell Apoptosis-Related Gene 19 2 3
  • TFAR19 Novel Apoptosis-Related 2 3
  • TFAR19 3 4
  • Protein TFAR19 4

External Ids for PDCD5 Gene

Previous GeneCards Identifiers for PDCD5 Gene

  • GC19P033689
  • GC19P033521
  • GC19P037749
  • GC19P037763
  • GC19P033072
  • GC19P029575

Summaries for PDCD5 Gene

Entrez Gene Summary for PDCD5 Gene

  • This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

GeneCards Summary for PDCD5 Gene

PDCD5 (Programmed Cell Death 5) is a Protein Coding gene. Diseases associated with PDCD5 include childhood oligodendroglioma. GO annotations related to this gene include heparin binding and acetyltransferase activator activity.

UniProtKB/Swiss-Prot for PDCD5 Gene

  • May function in the process of apoptosis

Gene Wiki entry for PDCD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD5 Gene

Genomics for PDCD5 Gene

Regulatory Elements for PDCD5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDCD5 Gene

Chromosome:
19
Start:
32,581,068 bp from pter
End:
32,587,452 bp from pter
Size:
6,385 bases
Orientation:
Plus strand

Genomic View for PDCD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDCD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD5 Gene

Proteins for PDCD5 Gene

  • Protein details for PDCD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14737-PDCD5_HUMAN
    Recommended name:
    Programmed cell death protein 5
    Protein Accession:
    O14737
    Secondary Accessions:
    • B4DE64
    • Q53YC9
    • Q6IB70

    Protein attributes for PDCD5 Gene

    Size:
    125 amino acids
    Molecular mass:
    14285 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDCD5 Gene

    Alternative splice isoforms for PDCD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCD5 Gene

Proteomics data for PDCD5 Gene at MOPED

Post-translational modifications for PDCD5 Gene

  • Ubiquitination at Lys 20, Lys 33, and Lys 68
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD5 Gene

Antibody Products

No data available for DME Specific Peptides for PDCD5 Gene

Domains & Families for PDCD5 Gene

Protein Domains for PDCD5 Gene

Suggested Antigen Peptide Sequences for PDCD5 Gene

Graphical View of Domain Structure for InterPro Entry

O14737

UniProtKB/Swiss-Prot:

PDCD5_HUMAN :
  • Belongs to the PDCD5 family.
Family:
  • Belongs to the PDCD5 family.
genes like me logo Genes that share domains with PDCD5: view

No data available for Gene Families for PDCD5 Gene

Function for PDCD5 Gene

Molecular function for PDCD5 Gene

GENATLAS Biochemistry:
programmed cell death 5,ubiquitously expressed in tumor cells and enhancing apoptosis triggered by growth factor or serum deprivatio,putatively playing a general role in the apoptotic process
UniProtKB/Swiss-Prot Function:
May function in the process of apoptosis
UniProtKB/Swiss-Prot Induction:
Activated in cells undergoing apoptosis

Gene Ontology (GO) - Molecular Function for PDCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 24012345
GO:0008201 heparin binding IDA 17165023
GO:0010698 acetyltransferase activator activity IDA 24012345
GO:0048487 beta-tubulin binding IPI 24375412
genes like me logo Genes that share ontologies with PDCD5: view
genes like me logo Genes that share phenotypes with PDCD5: view

Animal Model Products

miRNA for PDCD5 Gene

miRTarBase miRNAs that target PDCD5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDCD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCD5 Gene

Localization for PDCD5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCD5 Gene COMPARTMENTS Subcellular localization image for PDCD5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PDCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24012345
GO:0005737 cytoplasm IDA 16791210
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PDCD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDCD5 Gene

Pathways & Interactions for PDCD5 Gene

SuperPathways for PDCD5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PDCD5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PDCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IMP 16374546
GO:0010628 positive regulation of gene expression IDA 24012345
GO:0043065 positive regulation of apoptotic process IMP 9920759
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 16374546
GO:0071560 cellular response to transforming growth factor beta stimulus IDA 24012345
genes like me logo Genes that share ontologies with PDCD5: view

No data available for Pathways by source for PDCD5 Gene

Drugs & Compounds for PDCD5 Gene

No Compound Related Data Available

Transcripts for PDCD5 Gene

Unigene Clusters for PDCD5 Gene

Programmed cell death 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDCD5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD5 Gene

No ASD Table

Relevant External Links for PDCD5 Gene

GeneLoc Exon Structure for
PDCD5
ECgene alternative splicing isoforms for
PDCD5

Expression for PDCD5 Gene

mRNA expression in normal human tissues for PDCD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDCD5 Gene



SOURCE GeneReport for Unigene cluster for PDCD5 Gene Hs.443831

mRNA Expression by UniProt/SwissProt for PDCD5 Gene

O14737-PDCD5_HUMAN
Tissue specificity: Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta
genes like me logo Genes that share expression patterns with PDCD5: view

Protein tissue co-expression partners for PDCD5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PDCD5 Gene

Orthologs for PDCD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDCD5 35
  • 94.67 (n)
  • 95.2 (a)
PDCD5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDCD5 35
  • 94.5 (n)
  • 96.12 (a)
PDCD5 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcd5 35
  • 92 (n)
  • 96 (a)
Pdcd5 16
Pdcd5 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDCD5 35
  • 99.47 (n)
  • 100 (a)
PDCD5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdcd5 35
  • 90.93 (n)
  • 96 (a)
oppossum
(Monodelphis domestica)
Mammalia PDCD5 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDCD5 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDCD5 35
  • 83.2 (n)
  • 84.8 (a)
PDCD5 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCD5 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd5 35
  • 75.81 (n)
  • 81.45 (a)
zebrafish
(Danio rerio)
Actinopterygii pdcd5 35
  • 71.77 (n)
  • 81.45 (a)
pdcd5 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005432 35
  • 51.09 (n)
  • 46.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta PDCD-5 35
  • 52.8 (n)
  • 46.4 (a)
PDCD-5 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D2005.3 35
  • 55.88 (n)
  • 50 (a)
D2005.3 36
  • 40 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29850 35
  • 53.61 (n)
  • 48.33 (a)
rice
(Oryza sativa)
Liliopsida Os05g0547850 35
  • 52.07 (n)
  • 49.59 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC23C4.09c 35
  • 51.26 (n)
  • 47.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToOne
Species with no ortholog for PDCD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDCD5 Gene

ENSEMBL:
Gene Tree for PDCD5 (if available)
TreeFam:
Gene Tree for PDCD5 (if available)

Paralogs for PDCD5 Gene

Pseudogenes.org Pseudogenes for PDCD5 Gene

genes like me logo Genes that share paralogs with PDCD5: view

No data available for Paralogs for PDCD5 Gene

Variants for PDCD5 Gene

Sequence variations from dbSNP and Humsavar for PDCD5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4723 -- 32,586,909(+) AAACA(A/G)AAAAG missense, reference, downstream-variant-500B
rs10396 -- 32,587,043(+) CGTGT(C/T)TGACA intron-variant, downstream-variant-500B
rs888767 -- 32,585,709(+) CTGAG(A/G)GACAA intron-variant
rs3179957 -- 32,587,421(+) CAAAA(A/T)AAAAC utr-variant-3-prime
rs4499344 -- 32,582,525(+) GTGAC(A/G)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD5 Gene

Variant ID Type Subtype PubMed ID
nsv519794 CNV Gain 19592680

Variation tolerance for PDCD5 Gene

Residual Variation Intolerance Score: 48.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCD5 Gene

HapMap Linkage Disequilibrium report
PDCD5
Human Gene Mutation Database (HGMD)
PDCD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD5 Gene

Disorders for PDCD5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDCD5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
childhood oligodendroglioma
  • pediatric oligodendroglioma
- elite association
Search PDCD5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDCD5

Genetic Association Database (GAD)
PDCD5
Human Genome Epidemiology (HuGE) Navigator
PDCD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCD5
genes like me logo Genes that share disorders with PDCD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD5 Gene

Publications for PDCD5 Gene

  1. TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. (PMID: 9920759) Liu H.T. … Ma D.L. (Biochem. Biophys. Res. Commun. 1999) 2 23 67
  2. [Analysis, identification and correction of some errors of model refseqs appeared in NCBI Human Gene Database by in silico cloning and experimental verification of novel human genes]. (PMID: 15478601) Zhang D.L. … Li Y.D. (Yi Chuan Xue Bao 2004) 23 67
  3. [A preliminary study on the relationship between TF-1 cell apoptosis-related gene 19 and thyroid tumor]. (PMID: 12921612) Du Y. … Hong T.P. (Zhonghua Nei Ke Za Zhi 2003) 23 67
  4. Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis? (PMID: 11741587) Chen Y. … Ma D. (FEBS Lett. 2001) 23 67
  5. [Effect of rhTFAR19 protein on cell cycle and apoptosis of MCF-7 induced by gamma-ray]. (PMID: 11776632) Jiao J. … Huang M. (Zhonghua Zhong Liu Za Zhi 2000) 23 67

Products for PDCD5 Gene

Sources for PDCD5 Gene

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