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Aliases for PDCD5 Gene

Aliases for PDCD5 Gene

  • Programmed Cell Death 5 2 3 5
  • TF-1 Cell Apoptosis-Related Protein 19 3 4
  • TF1 Cell Apoptosis-Related Gene 19 2 3
  • TFAR19 Novel Apoptosis-Related 2 3
  • TFAR19 3 4
  • Programmed Cell Death Protein 5 3
  • Protein TFAR19 4

External Ids for PDCD5 Gene

Previous GeneCards Identifiers for PDCD5 Gene

  • GC19P033689
  • GC19P033521
  • GC19P037749
  • GC19P037763
  • GC19P033072
  • GC19P029575

Summaries for PDCD5 Gene

Entrez Gene Summary for PDCD5 Gene

  • This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

GeneCards Summary for PDCD5 Gene

PDCD5 (Programmed Cell Death 5) is a Protein Coding gene. Diseases associated with PDCD5 include Childhood Oligodendroglioma. GO annotations related to this gene include heparin binding and acetyltransferase activator activity.

UniProtKB/Swiss-Prot for PDCD5 Gene

  • May function in the process of apoptosis.

Gene Wiki entry for PDCD5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD5 Gene

Genomics for PDCD5 Gene

Regulatory Elements for PDCD5 Gene

Enhancers for PDCD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G033039 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.2 +460.8 460806 6.3 HNRNPUL1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 FOS SP3 GPATCH1 PDCD5 RHPN2 FAAP24 CHST8 CEP89 ANKRD27 NUDT19 ENSG00000267611 GC19M033010
GH19G032580 1.1 ENCODE 33.1 +0.5 536 2.1 HDGF CREB3L1 AGO1 SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 SP3 GPATCH1 PDCD5 ENSG00000201388 ANKRD27 GC19P032583
GH19G033289 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.2 +711.3 711272 6.5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 GPATCH1 LSM14A KIAA0355 PDCD5 CEBPG FAAP24 CHST8 CEBPA-AS1 PEPD CEBPA
GH19G033296 1.7 FANTOM5 ENCODE dbSUPER 18.7 +720.3 720338 10.6 MLX CREB3L1 AGO1 DMAP1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 GPATCH1 LSM14A KIAA0355 PDCD5 CEBPA-AS1 CEBPG PEPD SLC7A9 CEBPA GC19M033302
GH19G033247 1.6 Ensembl ENCODE dbSUPER 18.7 +667.8 667803 3.0 HDGF YBX1 ZNF2 ZBTB7B YY1 ZNF143 ZNF207 FOS ZNF548 ZNF263 GPATCH1 LSM14A PDCD5 FAAP24 SLC7A10 PIR37620
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDCD5 on UCSC Golden Path with GeneCards custom track

Promoters for PDCD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108722 233 1800 HDGF CREB3L1 AGO1 SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 SP3

Genomic Location for PDCD5 Gene

Chromosome:
19
Start:
32,581,068 bp from pter
End:
32,587,452 bp from pter
Size:
6,385 bases
Orientation:
Plus strand

Genomic View for PDCD5 Gene

Genes around PDCD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD5 Gene

Proteins for PDCD5 Gene

  • Protein details for PDCD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14737-PDCD5_HUMAN
    Recommended name:
    Programmed cell death protein 5
    Protein Accession:
    O14737
    Secondary Accessions:
    • B4DE64
    • Q53YC9
    • Q6IB70

    Protein attributes for PDCD5 Gene

    Size:
    125 amino acids
    Molecular mass:
    14285 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDCD5 Gene

    Alternative splice isoforms for PDCD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCD5 Gene

Post-translational modifications for PDCD5 Gene

  • Ubiquitination at posLast=2020, Lys33, and Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD5 Gene

No data available for DME Specific Peptides for PDCD5 Gene

Domains & Families for PDCD5 Gene

Protein Domains for PDCD5 Gene

Suggested Antigen Peptide Sequences for PDCD5 Gene

Graphical View of Domain Structure for InterPro Entry

O14737

UniProtKB/Swiss-Prot:

PDCD5_HUMAN :
  • Belongs to the PDCD5 family.
Family:
  • Belongs to the PDCD5 family.
genes like me logo Genes that share domains with PDCD5: view

No data available for Gene Families for PDCD5 Gene

Function for PDCD5 Gene

Molecular function for PDCD5 Gene

GENATLAS Biochemistry:
programmed cell death 5,ubiquitously expressed in tumor cells and enhancing apoptosis triggered by growth factor or serum deprivatio,putatively playing a general role in the apoptotic process
UniProtKB/Swiss-Prot Function:
May function in the process of apoptosis.
UniProtKB/Swiss-Prot Induction:
Activated in cells undergoing apoptosis.

Gene Ontology (GO) - Molecular Function for PDCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 24012345
GO:0008201 heparin binding IDA 17165023
GO:0010698 acetyltransferase activator activity IDA 24012345
GO:0048487 beta-tubulin binding IPI 24375412
genes like me logo Genes that share ontologies with PDCD5: view
genes like me logo Genes that share phenotypes with PDCD5: view

Animal Model Products

CRISPR Products

miRNA for PDCD5 Gene

miRTarBase miRNAs that target PDCD5

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDCD5 Gene

Localization for PDCD5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCD5 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PDCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24012345
GO:0005737 cytoplasm IDA 16791210
GO:0005829 cytosol IBA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with PDCD5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDCD5 Gene

Pathways & Interactions for PDCD5 Gene

SuperPathways for PDCD5 Gene

No Data Available

SIGNOR curated interactions for PDCD5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PDCD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0008285 negative regulation of cell proliferation IMP 16374546
GO:0010628 positive regulation of gene expression IDA 24012345
GO:0043065 positive regulation of apoptotic process IMP 9920759
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP 16374546
genes like me logo Genes that share ontologies with PDCD5: view

No data available for Pathways by source for PDCD5 Gene

Drugs & Compounds for PDCD5 Gene

No Compound Related Data Available

Transcripts for PDCD5 Gene

Unigene Clusters for PDCD5 Gene

Programmed cell death 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD5 Gene

No ASD Table

Relevant External Links for PDCD5 Gene

GeneLoc Exon Structure for
PDCD5
ECgene alternative splicing isoforms for
PDCD5

Expression for PDCD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDCD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD5 Gene



Protein tissue co-expression partners for PDCD5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDCD5 Gene:

PDCD5

SOURCE GeneReport for Unigene cluster for PDCD5 Gene:

Hs.443831

mRNA Expression by UniProt/SwissProt for PDCD5 Gene:

O14737-PDCD5_HUMAN
Tissue specificity: Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta.

Evidence on tissue expression from TISSUES for PDCD5 Gene

  • Lung(4.4)
  • Blood(4.3)
  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PDCD5: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD5 Gene

Orthologs for PDCD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD5 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia PDCD5 34 35
  • 94.67 (n)
dog
(Canis familiaris)
Mammalia PDCD5 34 35
  • 94.5 (n)
mouse
(Mus musculus)
Mammalia Pdcd5 34 35
  • 92 (n)
Pdcd5-ps 16
rat
(Rattus norvegicus)
Mammalia Pdcd5 34
  • 90.93 (n)
oppossum
(Monodelphis domestica)
Mammalia PDCD5 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDCD5 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDCD5 34 35
  • 83.2 (n)
lizard
(Anolis carolinensis)
Reptilia PDCD5 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd5 34
  • 75.81 (n)
zebrafish
(Danio rerio)
Actinopterygii pdcd5 34 35
  • 71.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta PDCD-5 34 35
  • 52.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005432 34
  • 51.09 (n)
worm
(Caenorhabditis elegans)
Secernentea D2005.3 34 35
  • 55.88 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G29850 34
  • 53.61 (n)
rice
(Oryza sativa)
Liliopsida Os05g0547850 34
  • 52.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 59 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC23C4.09c 34
  • 51.26 (n)
Species where no ortholog for PDCD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDCD5 Gene

ENSEMBL:
Gene Tree for PDCD5 (if available)
TreeFam:
Gene Tree for PDCD5 (if available)

Paralogs for PDCD5 Gene

Pseudogenes.org Pseudogenes for PDCD5 Gene

genes like me logo Genes that share paralogs with PDCD5: view

No data available for Paralogs for PDCD5 Gene

Variants for PDCD5 Gene

Sequence variations from dbSNP and Humsavar for PDCD5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000053061 -- 32,583,687(+) CCAGG(G/T)GTGGT intron-variant
rs1000357277 -- 32,581,013(+) AGAGG(C/T)GCCGA upstream-variant-2KB
rs1000396744 -- 32,583,429(+) CGTGC(A/G)CCACC intron-variant
rs1000704140 -- 32,581,526(+) GCGGC(A/G)GGGGC intron-variant
rs1000767747 -- 32,583,097(+) CTTTT(C/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD5 Gene

Variant ID Type Subtype PubMed ID
nsv519794 CNV gain 19592680

Variation tolerance for PDCD5 Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCD5 Gene

Human Gene Mutation Database (HGMD)
PDCD5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD5 Gene

Disorders for PDCD5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PDCD5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
childhood oligodendroglioma
  • pediatric oligodendroglioma
- elite association - COSMIC cancer census association via MalaCards
Search PDCD5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDCD5

Genetic Association Database (GAD)
PDCD5
Human Genome Epidemiology (HuGE) Navigator
PDCD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCD5
genes like me logo Genes that share disorders with PDCD5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD5 Gene

Publications for PDCD5 Gene

  1. TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. (PMID: 9920759) Liu H.T. … Ma D.L. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  3. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PMID: 19789190) Young R.P. … Gamble G.D. (Postgrad Med J 2009) 3 46 64
  4. Structure-function correlation of human programmed cell death 5 protein. (PMID: 19358820) Yao H. … Wang J. (Arch. Biochem. Biophys. 2009) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for PDCD5 Gene

Sources for PDCD5 Gene

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