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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDCD4 Gene

protein-coding   GIFtS: 62
GCID: GC10P112618

programmed cell death 4 (neoplastic transformation inhibitor)
 Explore 29 diseases affiliated with
PDCD4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PDCD4    

Aliases
for PDCD4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Programmed Cell Death 4 (Neoplastic Transformation Inhibitor)1 2     Nuclear Antigen H7312
H7311 2 3     Programmed Cell Death Protein 42
Neoplastic Transformation Inhibitor Protein2 3     Nuclear Antigen H731-Like3
Protein 197/15a2 3     

External Ids:    HGNC: 87631   Entrez Gene: 272502   Ensembl: ENSG000001505937   OMIM: 6086105   UniProtKB: Q53EL63   

Export aliases for PDCD4 gene to outside databases

Previous GC identifers: GC10P111524 GC10P111865 GC10P112762 GC10P112296 GC10P106260


Summaries
for PDCD4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PDCD4:
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1
and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the
interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase.
Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85
activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor
promoter-induced neoplastic transformation. Binds RNA (By similarity)

Gene Wiki entry for PDCD4


Genomic Views
for PDCD4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDCD4 gene promoter:
         AP-1   ATF-2   c-Jun   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PDCD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDCD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDCD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q24

PDCD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P112618:  view genomic region     (about GC identifiers)

Start:
 112,631,565 bp from pter      End:
 112,659,764 bp from pter
Size:
 28,200 bases      Orientation:
 plus strand

Proteins
for PDCD4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6 (See protein sequence)
Recommended Name: Programmed cell death protein 4  
Size: 469 amino acids; 51735 Da
Subunit: Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal
domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May
form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction
between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under
normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum
Sequence caution: Sequence=AAB42218.1; Type=Erroneous gene model prediction; Sequence=AAH15036.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
5 PDB 3D structures from and Proteopedia for PDCD4:
2GGF (3D)        2KZT (3D)        2RG8 (3D)        2ZU6 (3D)        3EIJ (3D)    
Secondary accessions: B2RCV4 B5ME91 O15501 Q5VZS6 Q6PJI5 Q8TAR5 Q99834
Alternative splicing: 2 isoforms:  Q53EL6-1   Q53EL6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDCD4: NX_Q53EL6

Post-translational modifications:

  • Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of
    • the phosphodegron promotes interaction with BTRC and proteasomal degradation1
  • Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD41
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q53EL6

    • PDCD4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186421.1  NP_055271.2  NP_663314.1  

    ENSEMBL proteins: 
     ENSP00000280154   ENSP00000394668   ENSP00000376816  

    Human Recombinant Protein Products: 
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    Novus Biologicals PDCD4 Proteins
    Novus Biologicals PDCD4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PDCD4
    Uscn Proteins for PDCD4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IMP16357133
    GO:0005829cytosol IDA12054647


    PDCD4 for ontologies           About GeneDecksing



    PDCD4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDCD4
    R&D Systems Antibodies for PDCD4
    Cell Signaling Technology (CST) Antibodies for PDCD4 
    OriGene Antibodies (see all 3): PDCD4
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    GenScript Custom Superior Antibodies Services for PDCD4
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    ThermoFisher Antibodies for PDCD4

    Assay Products for PDCD4: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for PDCD4

    Protein Domains /
    Families
    for PDCD4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PDCD4 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016021 MIF4-like_typ_1/2/3
     IPR003891 Initiation_fac_eIF4g_MI
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q53EL6

    ProtoNet protein and cluster: Q53EL6

    UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
    Domain: Binds EIF4A1 via both MI domains
    Similarity: Belongs to the PDCD4 family
    Similarity: Contains 2 MI domains


    Function
    for PDCD4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
    Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the
    interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase.
    Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85
    activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor
    promoter-induced neoplastic transformation. Binds RNA (By similarity)
    Induction: IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression

         Genatlas biochemistry entry for PDCD4:
    programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)

    miRNA
    Products:            		miRTarBase miRNAs that target PDCD4:
    hsa-mir-1 (MIRT002785), hsa-mir-183 (MIRT005547), hsa-mir-200a (MIRT004005), hsa-mir-21 (MIRT003054)

    OriGene 3'-UTR Clone (see all 2): PDCD4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDCD4
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate PDCD4 (see all 98):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmid: PDCD4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDCD4 (see all 7)
    OriGene shRNA RFP: PDCD4
    OriGene siRNA: PDCD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDCD4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PDCD4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD4 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): PDCD4 (NM_014456)
    Sino Biological Human cDNA Clone for PDCD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD4 

    Cell Line
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    Search LifeMap BioReagents cell lines for PDCD4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--


    PDCD4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PDCD4:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for PDCD4: Pdcd4tm1Yhcn Pdcd4tm1.1Tosc
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Pdcd4):
     endocrine/exocrine gland  immune system  mortality/aging  no phenotypic analysis  renal/urinary system 
     reproductive system  tumorigenesis 

    PDCD4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PDCD4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2mTOR signaling pathway
    		mTOR signaling pathway1.00
    3Translational Control
    		Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PDCD4
        Apoptosis and Autophagy
    Translational Control

    1 BioSystems Pathway for PDCD4 
        mTOR signaling pathway



    PDCD4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDCD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/25 Interacting proteins for PDCD4 (Q53EL61, 3 ENSP000002801544) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS13P622771, 3, ENSP000002281404EBI-935824,EBI-351850 I2D: score=4 STRING: ENSP00000228140
    APOEP026491, 3, ENSP000002524864EBI-935824,EBI-1222467 I2D: score=1 STRING: ENSP00000252486
    PSEN2P498101, 3EBI-935824,EBI-2010251 I2D: score=1 
    BTRCQ9Y2973, ENSP000003592064I2D: score=3 STRING: ENSP00000359206
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS12054647
    GO:0007569cell aging IDA12054647
    GO:0016070RNA metabolic process IEA--
    GO:0043508negative regulation of JUN kinase activity ISS--
    GO:0045786negative regulation of cell cycle NAS12054647


    PDCD4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PDCD4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDCD4
    Search CenterWatch for drugs/clinical trials and news about PDCD4 

    Transcripts
    for PDCD4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PDCD4 gene (3 alternative transcripts): 
    NM_001199492.1  NM_014456.4  NM_145341.3  

    Unigene Cluster for PDCD4:

    Programmed cell death 4 (neoplastic transformation inhibitor)
    Hs.711490  [show with all ESTs]
    Unigene Representative Sequence: NM_145341
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280154(uc001kzh.3 uc010qre.2) ENST00000467574 ENST00000483670
    ENST00000444997 ENST00000492932 ENST00000481353 ENST00000462577 ENST00000489049
    ENST00000483595 ENST00000498367 ENST00000393104(uc001kzg.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): PDCD4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDCD4
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate PDCD4 (see all 98):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmid: PDCD4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDCD4 (see all 7)
    OriGene shRNA RFP: PDCD4
    OriGene siRNA: PDCD4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDCD4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD4 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): PDCD4 (NM_014456)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDCD4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDCD4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDCD4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDCD4

    Additional cDNA sequence: 

    AK223623.1 AK296753.1 AK312540.1 AK315295.1 AL049932.1 BC015036.2 BC026104.2 BC031049.1 
    BX647834.1 U96628.1 

    24/30 DOTS entries (see all 30):

    DT.99974205  DT.92448947  DT.100719086  DT.100879329  DT.100692869  DT.121276789  DT.100879344  DT.121276767 
    DT.40268444  DT.453233  DT.100030431  DT.121276707  DT.95337944  DT.100879324  DT.100879336  DT.95145816 
    DT.95337952  DT.75165023  DT.91753660  DT.92448948  DT.97805409  DT.101964489  DT.121276666  DT.121276697 

    24/434 AceView cDNA sequences (see all 434):

    AA370140 CA976061 AA832436 AW373649 AA195117 N57162 AI866793 AA725493 
    BE712900 AA190211 BG941562 BU735154 AA236767 BM550622 BG319447 AI077964 
    BM802759 AA908461 BM693682 AW196927 BQ786763 AA236923 BM806403 AI420607 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD4 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^
    SP1:                                                  -     -                                               -     -     -                                       
    SP2:                                                                                                        -     -     -                                   -   
    SP3:                                                  -     -                 -     -                       -     -     -                                       
    SP4:                                                  -     -     -                 -     -                 -     -     -                                       
    SP5:                                                  -     -     -                                         -     -     -                                       

    ExUns: 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:        -                 -                 -                     
    SP2:  -     -     -           -                 -                     
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for PDCD4

    Expression
    for PDCD4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDCD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAGCAGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PDCD4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Floor PlateNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Trophoblast-like cells (Generation of tropho...)

    See PDCD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDCD4

    SOURCE GeneReport for Unigene cluster: Hs.711490

    UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
    Tissue specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland.
    Reduced expression in lung cancer and colon carcinoma

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    Orthologs
    for PDCD4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDCD4 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pdcd41 , 5 programmed cell death 41, 5 89.55(n)1
    96.8(a)1    		   19 (48.73 cM)5
    185691  NM_001168491.11  NP_001161963.11 
     538922315 
    chicken
    (Gallus gallus)    		 Aves PDCD41 programmed cell death 4 (neoplastic transformation more 80.23(n)
    85.22(a)    		   374191  NM_204304.1  NP_989635.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PDCD46
    		 --
    		 84(a)
    		 1 ↔ 1
    		 3(45720855-45731503)
    African clawed frog
    (Xenopus laevis)    		 Amphibia pdcd4-prov2 programmed cell death 4 77.12(n)    BC048225.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii pdcd42 programmed cell death 4 74.29(n)   321061  BC045513.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG109901 , 3 CG109901 39(a)3
    47.35(n)1
    41.37(a)1    		   323371  NM_132690.31  NP_572918.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G631901 MA3 domain-containing protein 44.24(n)
    33.24(a)    		   836440  NM_125714.3  NP_568968.1 
    rice
    (Oryza sativa)    		 Liliopsida Os08g01205001 hypothetical protein 49.03(n)
    36.7(a)    		   4344544  NM_001067414.1  NP_001060879.1 


    ENSEMBL Gene Tree for PDCD4 (if available)
    TreeFam Gene Tree for PDCD4 (if available) 

    Paralogs
    for PDCD4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PDCD4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/440 NCBI SNPs in PDCD4 are shown (see all 440)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1398098061,2
    		--112629568(+) AGTACC/TACAAT 4 -- us2k1 nc-transcript-variant0--------
    rs1499267611,2
    		--112629606(+) CTCACA/GCCTGT 4 -- us2k1 nc-transcript-variant0--------
    rs1892421881,2
    		--112629633(+) GAGGCC/TGAGGC 4 -- us2k1 nc-transcript-variant0--------
    rs13229951,2
    		C,F,A,H,--112629911(+) CACAGA/GTCTTT 4 -- nc-transcript-variantus2k1 tfbs311Minor allele frequency- G:0.45NA WA CSA EA 376
    rs171280951,2
    		C,F,--112629929(+) NNNNGT/CTACAG 4 -- nc-transcript-variantus2k17Minor allele frequency- C:0.08NA EA WA 572
    rs13229961,2
    		C,H,--112630024(+) GCCAAT/CACTGT 4 -- us2k1 nc-transcript-variant18Minor allele frequency- C:0.00NS EA NA WA CSA 799
    rs115979281,2
    		C,F,H,--112630041(+) TCAGCG/CGCAGG 4 -- us2k1 nc-transcript-variant6Minor allele frequency- C:0.10NA WA 248
    rs37636911,2
    		C,F,--112630122(+) CTCAAC/TGCTTT 4 -- nc-transcript-variantus2k13Minor allele frequency- T:0.09WA NA EA 358
    rs1930036051,2
    		--112630123(+) TCAACA/GCTTTG 4 -- us2k1 nc-transcript-variant0--------
    rs1837070031,2
    		--112630175(+) GACCAA/GCCTGG 4 -- us2k1 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for PDCD4 (112631565 - 112659764 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PDCD4: --

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    Disorders / Diseases
    for PDCD4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PDCD4 for disorders           About GeneDecksing

    OMIM gene information: 608610    OMIM disorders: --

    20/29 diseases for PDCD4 (see all 29):    About MalaCards
    oral squamous cell carcinoma    squamous cell carcinoma    neuroendocrine tumor    colon carcinoma
    cholesteatoma    laryngitis    laryngeal carcinoma    colorectal cancer
    carcinoma    endometrial cancer    hepatocellular carcinoma    ovarian carcinoma
    esophageal cancer    alzheimer's disease    esophagitis    colon cancer
    ovarian cancer    gastric cancer    cholangiocarcinoma    lung cancer

    5 Novoseek disease relationships for PDCD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neoplastic transformation 75.2 6 10570194 (2), 19728867 (1), 19836969 (1), 17828298 (1) (see all 5)
    colon carcinoma 42 4 16449643 (2), 17828298 (1)
    tumors 37.8 60 17849461 (5), 17955371 (4), 18296647 (3), 17828298 (3) (see all 22)
    colorectal cancer 37.5 10 17849461 (3), 17968323 (1), 19836969 (1)
    cancer 26.4 14 14985450 (3), 18296647 (2), 14630388 (1), 17968323 (1) (see all 8)

    Human Genome Epidemiology (HuGE) Navigator: PDCD4 (2 documents)

    Export disorders for PDCD4 gene to outside databases

    Publications
    for PDCD4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDCD4 gene, integrated from 9 sources (see all 134):
    (articles sorted by number of sources associating them with PDCD4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PubMed id 9759869)1, 2, 3 Azzoni L....Perussia B. (1998)
    2. Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. (PubMed id 16357133)1, 2, 9 Palamarchuk A....Pekarsky Y. (2005)
    3. Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PubMed id 19153607)1, 2, 9 Loh P.G....Song H. (2009)
    4. Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PubMed id 16449643)1, 2, 9 Yang H.-S.... Colburn N.H. (2006)
    5. Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PubMed id 10632927)1, 2, 9 Yoshinaga H.... Masaki Z. (1999)
    6. Crystal structure of the eIF4A-PDCD4 complex. (PubMed id 19204291)1, 2 Chang J.H....Cho Y. (2009)
    7. PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. (PubMed id 18296639)1, 2 Suzuki C....Wagner G. (2008)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. (PubMed id 17053147)1, 2 Dorrello N.V....Pagano M. (2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    External Searches for PDCD4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PDCD4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27250 HGNC: 8763 AceView: PDCD4 Ensembl:ENSG00000150593 euGenes: HUgn27250
    ECgene: PDCD4 H-InvDB: PDCD4

    Other Databases showing PDCD4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PDCD4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDCD4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDCD4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PDCD4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PDCD4 gene:
    Search GeneIP for patents involving PDCD4

    Licensable Technologies for PDCD4 gene:
     Tufts University:  Use of miRNAs to selectively modulate TGF-?/BMP signaling to treat TGF-?/BMP mediated disorders
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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