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PDCD4 Gene

protein-coding GIFtS: 59

GC10P112618

programmed cell death 4 (neoplastic transformation inhibitor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
H731 ^¹, ², ³
MGC33046 ^²
MGC33047 ^²
OTTHUMP00000020483 ^²

Descriptions
Neoplastic transformation inhibitor protein ^³
Nuclear antigen H731-like ^³
Protein 197/15a ^³
nuclear antigen H731 ^²
programmed cell death 4 ^²
programmed cell death 4 (neoplastic transformation inhibitor) ^²

External Ids
HGNC: 8763¹
Entrez Gene: 27250²
UniProtKB: Q53EL6³
Ensembl: ENSG00000150593⁷

Search outside databases for aliases for PDCD4 gene

Previous GC identifers: GC10P111524 GC10P111865 GC10P112762 GC10P112296

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for PDCD4:

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this

gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play

a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding

different isoforms have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6

Function: Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation.

Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion,

namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in

apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA (By

similarity)

Gene Wiki entry for PDCD4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PDCD4 gene

Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q24

PDCD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P112618: (about GC identifiers)

Start:	112,621,586 bp from pter
End:	112,649,754 bp from pter
Size:	28,169 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_030059.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6 (See protein sequence)

Recommended Name: Programmed cell death protein 4

Size: 469 amino acids; 51721 Da

Subunit: Interacts with EIF4A1 and EIF4A2 (By similarity)

Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm.

Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of

serum

Sequence caution: Sequence=AAB42218.1; Type=Erroneous gene model prediction; Sequence=AAH15036.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

PDB structures from and Proteopedia :

2GGF (3D)

2RG8 (3D)

2ZU6 (3D)

3EIJ (3D)

Secondary accessions: O15501 Q5VZS6 Q6PJI5 Q8TAR5 Q99834

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_055271.2 NP_663314.1

ENSEMBL proteins:

ENSP00000280154 ENSP00000376816

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PDCD4)
	Human Recombinant Proteins from Abnova (PDCD4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IMP	16357133
GO:0005829	cytosol	IDA	12054647

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Antibodies for PDCD4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PDCD4
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PDCD4
	Antibodies from Abcam (PDCD4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PDCD4)
	Novus Biologicals Antibodies for PDCD4

Assays for PDCD4:

	Invitrogen Assays for PDCD4
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q53EL6

ProtoNet protein and cluster: Q53EL6

UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6

Domain: Binds EIF4A1 via the MA3 domains (By similarity)

Similarity: Belongs to the PDCD4 family

Similarity: Contains 2 MI domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDCD4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_145341

Applied Biosystems Silencer® siRNAs for PDCD4

Sigma-Aldrich siRNA for PDCD4

Sigma-Aldrich shRNA for PDCD4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PDCD4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014456
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014456
untagged cDNA clones in CMV expression vector (see all 2): NM_014456

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014456

UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6

Function: Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation.

Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion,

namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in

apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA (By

similarity)

Induction: IL2 stimulation inhibits expression, while IL12 increases expression

Genatlas biochemistry entry for PDCD4:

programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pdcd4):

endocrine/exocrine gland	immune system	life span-post-weaning/aging	renal/urinary system	reproductive system
tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	12054647 16357133

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PDCD4

5/19 Interacting proteins for PDCD4 (ENSP00000280154³ Q53EL6¹) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EIF4A1	P60842¹	STRING (score=.999) EBI-935824, EBI-73449
EIF4A2	Q14240¹	EBI-935824, EBI-73473
EIF4G1	Q04637¹	EBI-935824, EBI-73711
RPS13	P62277¹	EBI-935824, EBI-351850
DDX19B	ENSP00000288071³	STRING (score=.987)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	NAS	12054647
GO:0007569	cell aging	IDA	12054647
GO:0016481	negative regulation of transcription	ISS	--
GO:0043508	negative regulation of JUN kinase activity	ISS	--
GO:0045786	negative regulation of cell cycle	NAS	12054647

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PDCD4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PDCD4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_145341

Sigma-Aldrich siRNA for PDCD4

Sigma-Aldrich shRNA for PDCD4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014456 NM_145341

REFSEQ mRNAs for PDCD4 gene (2 alternative transcripts):

NM_014456.3 NM_145341.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014456 NM_145341

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014456
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014456
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_014456

Additional cDNA sequence:

AK223623.1 AK296753.1 AK312540.1 AK315295.1 AL049932.1 BC015036.2 BC026104.2 BC031049.1

BC043171.1 BX537500.1 BX641168.1 BX647834.1 CR617800.1 U96628.1

24/33 DOTS entries (see all 33 ):

DT.99974205 DT.92448947 DT.100692869 DT.100719086 DT.100879329 DT.121276789 DT.100879344 DT.40268444

DT.121276767 DT.453233 DT.100030431 DT.100879336 DT.121276707 DT.217032 DT.95337944 DT.100879324

DT.95098873 DT.100648348 DT.75165023 DT.91753660 DT.95145816 DT.95337939 DT.95337952 DT.101964489

24/434 AceView cDNA sequences (see all 434 ):

NM_145341 BM806403 AW192359 BM802759 BM550622 BU077442 BE163926 CR617800

BG319447 N57162 AW196927 AI077964 AW373649 AW841879 AA236923 AA973698

AL708961 AI420607 AA908461 BX494220 BU621309 NM_014456 AA190211 CB216122

highest scoring ESTs for PDCD4:

AL049932 AA081192 AA081300 AA115859 AA129597 AA190222 AA190224 AA194988 AA195117 AA236767

Unigene Cluster for PDCD4:

Programmed cell death 4 (neoplastic transformation inhibitor)

Hs.711490 [show with all ESTs]

Unigene Representative Sequence: BX537500

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD4 (see all 16 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	·	12d	^
SP1:																	-		-																-		-		-
SP2:																																			-		-		-												-
SP3:																	-		-						-		-								-		-		-
SP4:																	-		-		-						-		-						-		-		-
SP5:																	-		-		-														-		-		-

ExUns:	13a	·	13b	^	14a	·	14b	·	14c	^	15	^	16	^	17a	·	17b	·	17c	^	18
SP1:			-						-						-
SP2:	-		-		-				-						-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PDCD4

2 Ensembl transcripts including schematic representations:

ENST00000280154 ENST00000393104

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PDCD4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PDCD4

¹ / ² / ³

10 probe-sets matching PDCD4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39510_r_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AL049932	1.00	1.00	1.00	1
212594_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI185160	0.80	1.00	0.91	1
212593_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	N92498	0.80	1.00	0.91	1
202730_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014456	0.60	1.00	0.82	1
202731_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014456	0.60	1.00	0.82	1
212594_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212593_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202730_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557166_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202731_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PDCD4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.711490
Expression variation in blood from EXPOLDB for PDCD4
UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
Tissue specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of
the mammary gland

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDCD4 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PDCD4¹	--	programmed cell death 4 (neoplastic transformation more	95.17(n) 98.51(a)	477818 XM_535012.2 XP_535012.1
chimpanzee (Pan troglodytes)	PDCD4¹	--	programmed cell death 4 (neoplastic transformation more	99.64(n) 99.57(a)	450735 XM_001143772.1 XP_001143772.1
cow (Bos taurus)	PDCD4¹	--	programmed cell death 4 (neoplastic transformation more	93.82(n) 96.59(a)	506724 XM_583210.3 XP_583210.3
rat (Rattus norvegicus)	Pdcd4¹	--	programmed cell death 4	88.7(n) 96.8(a)	64031 NM_022265.2 NP_071601.2
mouse (Mus musculus)	Pdcd4^{1, 5}	19 (20.00 cM)⁵	programmed cell death 4^{1, 5}	89.55(n)¹ 96.8(a)¹	18569¹ NM_011050.3¹ NP_035180.2¹ AB010129⁵ AB010130⁵ (see all 26)

About this table Species with no ortholog for PDCD4

ENSEMBL Gene Tree for PDCD4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/112 NCBI SNPs in PDCD4 are shown (see all 112 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 68)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7081726^1,2	A,C,F,H	112631043(+)	`AGGAAG/ATAAAG`	2	V/I	mis¹		12		NA EU EA WA	1046
	rs12248739^1,2	C,F,H	112648050(+)	`GAAAAG/ATAACC`	2	--	ut3¹		4		EU EA WA	418
	rs2146544^1,2	C,F,H	112648954(+)	`AAACTG/TCCAAA`	2	--	ut3¹		8		EU EA WA	834
	rs1322997^1,2	C,F,H	112620847(+)	`GAAGCA/CTAAGG`	2	--	ng5¹		12		EA NA EU WA	988
--	rs1322995^1,2	A,C	112619901(+)	`CACAGA/GTCTTT`	2	--	ng5¹ tfbs³		0	--	--	--	--
	rs1322996^1,2	C,H	112620014(+)	`GCCAAT/CACTGT`	2	--	ng5¹		4		EU EA WA	420
--	rs1052550^1,2	A	112648017(+)	`TTTTTC/TTGTTT`	2	--	ut3¹		0	--	--	--	--
--	rs11548765^1,2	H	112631080(+)	`AGCATC/ACTCCA`	2	Y/S	mis¹ ese³		4		EU EA WA	406
	rs11597928^1,2	C	112620031(+)	`TCAGCC/GGCAGG`	2	--	ng5¹		0	--	--	--	--
--	rs17128095^1,2	F	112619919(+)	`CAAGGT/CTACAG`	2	--	ng5¹		4		NA EA	214

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HapMap Linkage Disequilibrium images for PDCD4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 608610

UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6

Loss of expression correlated with tumor progression of lung and colon carcinoma

5 Novoseek disease relationships for PDCD4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neoplastic transformation	72.88	4	10570194 (2), 16449643 (1), 17828298 (1)
colon carcinoma	45.48	4	16449643 (2), 17828298 (1)
colorectal cancer	36.59	8	17849461 (3), 17968323 (1)
tumors	32.90	47	17849461 (5), 17955371 (4), 18296647 (3), 17828298 (3) (see all 16)
cancer	15.39	11	14985450 (3), 18296647 (2), 14630388 (1), 18427550 (1) (see all 5)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/56 PubMed articles for PDCD4 gene (see all 56 ):

Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PubMed id 9759869)^{2, 3, 4} Azzoni L....Perussia B. (1998)
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PubMed id 16449643)^{1, 3, 4} Yang H.-S.... Colburn N.H. (2006)
Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PubMed id 10632927)^{1, 3, 4} Yoshinaga H.... Masaki Z. (1999)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. (PubMed id 12898601)^{3, 4} Chen Y.... Petersen I. (2003)
Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. (PubMed id 17849461)^{1, 3} Mudduluru G....Allgayer H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 27250	HGNC: 8763	AceView: PDCD4	Ensembl:ENSG00000150593	euGenes: HUgn27250
ECgene: PDCD4	H-InvDB: PDCD4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PDCD4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PDCD4
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for PDCD4 gene:

Tufts University:

Use of miRNAs to selectively modulate TGF-?/BMP signaling to treat TGF-?/BMP mediated disorders

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PDCD4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PDCD4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PDCD4		Antibodies for PDCD4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PDCD4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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Antibodies & Assays for PDCD4

	Recombinant Proteins (PDCD4)
	Antibodies (PDCD4)

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Antibodies for PDCD4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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PDCD4 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for PDCD4

Summaries
for PDCD4

Genomic Location
for PDCD4

Proteins
for PDCD4

Protein Domains/
Families
for PDCD4

Gene Function
for PDCD4

Pathways & Interactions
for PDCD4

Drugs & Compounds
for PDCD4

Transcripts
for PDCD4

Expression
for PDCD4

Orthologs
for PDCD4

Paralogs
for PDCD4

SNPs/Variants
for PDCD4

Disorders & Mutations
for PDCD4

Medical News
for PDCD4

Publications
for PDCD4

Search for PDCD4

Genome Databases showing PDCD4

Other Databases showing PDCD4

Specialized Databases showing PDCD4

Licensable Technologies
for PDCD4

Services
for PDCD4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PDCD4 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor PDCD4

Summariesfor PDCD4

Genomic Locationfor PDCD4

Proteinsfor PDCD4

Protein Domains/Familiesfor PDCD4

Gene Functionfor PDCD4

Pathways & Interactionsfor PDCD4

Drugs & Compoundsfor PDCD4

Transcriptsfor PDCD4

Expression for PDCD4

Orthologsfor PDCD4

Paralogsfor PDCD4

SNPs/Variantsfor PDCD4

Disorders & Mutationsfor PDCD4

Medical Newsfor PDCD4

Publicationsfor PDCD4

Search for PDCD4

Genome Databases showing PDCD4

Other Databases showing PDCD4

Specialized Databases showing PDCD4

Licensable Technologiesfor PDCD4

Servicesfor PDCD4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PDCD4

Summaries
for PDCD4

Genomic Location
for PDCD4

Proteins
for PDCD4

Protein Domains/
Families
for PDCD4

Gene Function
for PDCD4

Pathways & Interactions
for PDCD4

Drugs & Compounds
for PDCD4

Transcripts
for PDCD4

Expression
for PDCD4

Orthologs
for PDCD4

Paralogs
for PDCD4

SNPs/Variants
for PDCD4

Disorders & Mutations
for PDCD4

Medical News
for PDCD4

Publications
for PDCD4

Licensable Technologies
for PDCD4

Services
for PDCD4