Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDCD4 Gene

Aliases for PDCD4 Gene

  • Programmed Cell Death 4 (Neoplastic Transformation Inhibitor) 2 3
  • Neoplastic Transformation Inhibitor Protein 3 4
  • Nuclear Antigen H731 2 3
  • Protein 197/15a 3 4
  • H731 3 4
  • Programmed Cell Death Protein 4 3
  • Nuclear Antigen H731-Like 4

External Ids for PDCD4 Gene

Previous GeneCards Identifiers for PDCD4 Gene

  • GC10P111524
  • GC10P111865
  • GC10P112762
  • GC10P112296
  • GC10P112618
  • GC10P106260

Summaries for PDCD4 Gene

Entrez Gene Summary for PDCD4 Gene

  • This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDCD4 Gene

PDCD4 (Programmed Cell Death 4 (Neoplastic Transformation Inhibitor)) is a Protein Coding gene. Diseases associated with PDCD4 include colorectal cancer. Among its related pathways are Proteoglycans in cancer and MicroRNAs in cancer. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for PDCD4 Gene

  • Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

Gene Wiki entry for PDCD4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD4 Gene

Genomics for PDCD4 Gene

Regulatory Elements for PDCD4 Gene

Genomic Location for PDCD4 Gene

Start:
110,871,795 bp from pter
End:
110,900,006 bp from pter
Size:
28,212 bases
Orientation:
Plus strand

Genomic View for PDCD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD4 Gene

Proteins for PDCD4 Gene

  • Protein details for PDCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53EL6-PDCD4_HUMAN
    Recommended name:
    Programmed cell death protein 4
    Protein Accession:
    Q53EL6
    Secondary Accessions:
    • B2RCV4
    • B5ME91
    • O15501
    • Q5VZS6
    • Q6PJI5
    • Q8TAR5
    • Q99834

    Protein attributes for PDCD4 Gene

    Size:
    469 amino acids
    Molecular mass:
    51735 Da
    Quaternary structure:
    • Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11.
    SequenceCaution:
    • Sequence=AAB42218.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH15036.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDCD4 Gene

    Alternative splice isoforms for PDCD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCD4 Gene

Proteomics data for PDCD4 Gene at MOPED

Post-translational modifications for PDCD4 Gene

  • Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4.
  • Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDCD4 Gene

No data available for DME Specific Peptides for PDCD4 Gene

Domains for PDCD4 Gene

Protein Domains for PDCD4 Gene

Suggested Antigen Peptide Sequences for PDCD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53EL6

UniProtKB/Swiss-Prot:

PDCD4_HUMAN :
  • Q53EL6
Domain:
  • Binds EIF4A1 via both MI domains.
  • Contains 2 MI domains.
Family:
  • Belongs to the PDCD4 family.
genes like me logo Genes that share domains with PDCD4: view

No data available for Gene Families for PDCD4 Gene

Function for PDCD4 Gene

Molecular function for PDCD4 Gene

GENATLAS Biochemistry: programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)
UniProtKB/Swiss-Prot Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
UniProtKB/Swiss-Prot Induction: IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression.

Gene Ontology (GO) - Molecular Function for PDCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 12054647
genes like me logo Genes that share ontologies with PDCD4: view
genes like me logo Genes that share phenotypes with PDCD4: view

Animal Models for PDCD4 Gene

MGI Knock Outs for PDCD4:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PDCD4 Gene

Localization for PDCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD4 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCD4 Gene COMPARTMENTS Subcellular localization image for PDCD4 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for PDCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IMP 16357133
GO:0005829 cytosol IDA 12054647
genes like me logo Genes that share ontologies with PDCD4: view

Pathways for PDCD4 Gene

genes like me logo Genes that share pathways with PDCD4: view

Pathways by source for PDCD4 Gene

2 Cell Signaling Technology pathways for PDCD4 Gene
1 BioSystems pathway for PDCD4 Gene
2 KEGG pathways for PDCD4 Gene
1 R&D Systems pathway for PDCD4 Gene

Gene Ontology (GO) - Biological Process for PDCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process NAS 12054647
GO:0007569 cell aging IDA 12054647
GO:0043508 negative regulation of JUN kinase activity ISS --
GO:0045786 negative regulation of cell cycle NAS 12054647
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with PDCD4: view

Transcripts for PDCD4 Gene

Unigene Clusters for PDCD4 Gene

Programmed cell death 4 (neoplastic transformation inhibitor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^
SP1: - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10: - - - - - - -
SP11: - -
SP12:
SP13:
SP14: - - - -
SP15:
SP16:

ExUns: 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - -
SP2: - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:

Relevant External Links for PDCD4 Gene

GeneLoc Exon Structure for
PDCD4
ECgene alternative splicing isoforms for
PDCD4

Expression for PDCD4 Gene

mRNA expression in normal human tissues for PDCD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDCD4 Gene

This gene is overexpressed in Pancreas (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDCD4 Gene

SOURCE GeneReport for Unigene cluster for PDCD4 Gene Hs.711490

mRNA Expression by UniProt/SwissProt for PDCD4 Gene

Q53EL6-PDCD4_HUMAN
Tissue specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
genes like me logo Genes that share expressions with PDCD4: view

Orthologs for PDCD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD4 35
  • 99.64 (n)
  • 99.57 (a)
PDCD4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDCD4 35
  • 93.89 (n)
  • 96.59 (a)
PDCD4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDCD4 35
  • 95.17 (n)
  • 98.51 (a)
PDCD4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcd4 35
  • 89.55 (n)
  • 96.8 (a)
Pdcd4 16
Pdcd4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDCD4 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pdcd4 35
  • 88.7 (n)
  • 96.8 (a)
chicken
(Gallus gallus)
Aves PDCD4 35
  • 80.23 (n)
  • 85.22 (a)
PDCD4 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCD4 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia pdcd4-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd4 35
  • 70.97 (n)
  • 74.84 (a)
Str.6786 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1132 35
zebrafish
(Danio rerio)
Actinopterygii pdcd4 35
pdcd4b 35
  • 66.31 (n)
  • 70.02 (a)
pdcd4b 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000378 35
  • 49.82 (n)
  • 50.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pdcd4 35
  • 47.88 (n)
  • 42.69 (a)
Pdcd4 36
  • 38 (a)
OneToOne
CG10990 37
  • 39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24800 35
  • 46.25 (n)
  • 34.32 (a)
rice
(Oryza sativa)
Liliopsida Os08g0120500 35
  • 48.25 (n)
  • 36.11 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4897 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2910 36
  • 40 (a)
OneToOne
Species with no ortholog for PDCD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD4 Gene

ENSEMBL:
Gene Tree for PDCD4 (if available)
TreeFam:
Gene Tree for PDCD4 (if available)

Paralogs for PDCD4 Gene

No data available for Paralogs for PDCD4 Gene

Variants for PDCD4 Gene

Sequence variations from dbSNP and Humsavar for PDCD4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs927931 -- 110,886,183(+) AAATA(C/T)GTGAA intron-variant
rs1327548 -- 110,893,115(+) ATGAC(A/G)GAGTC intron-variant
rs1327549 -- 110,893,196(+) AATAC(C/T)CAAAT intron-variant
rs1327550 -- 110,893,358(+) TTTTT(A/T)AATTC intron-variant
rs1407696 -- 110,878,270(+) TATAC(G/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD4 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
dgv819n71 CNV Gain 21882294
nsv831985 CNV Gain+Loss 17160897
nsv7548 CNV Insertion 18451855

Relevant External Links for PDCD4 Gene

HapMap Linkage Disequilibrium report
PDCD4
Human Gene Mutation Database (HGMD)
PDCD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD4 Gene

Disorders for PDCD4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PDCD4 Gene including...

Search for PDCD4 Gene in MalaCards »

(5) Novoseek inferred disease relationships for PDCD4 Gene

Disease -log(P) Hits PubMed IDs
neoplastic transformation 75.2 6
colon carcinoma 42 3
tumors 37.8 43
colorectal cancer 37.5 5
cancer 26.4 11

Relevant External Links for PDCD4

Genetic Association Database (GAD)
PDCD4
Human Genome Epidemiology (HuGE) Navigator
PDCD4
genes like me logo Genes that share disorders with PDCD4: view

No data available for UniProtKB/Swiss-Prot for PDCD4 Gene

Publications for PDCD4 Gene

  1. Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PMID: 10632927) Yoshinaga H. … Masaki Z. (Pathol. Int. 1999) 3 4 23
  2. Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. (PMID: 16357133) Palamarchuk A. … Pekarsky Y. (Cancer Res. 2005) 3 4 23
  3. Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PMID: 16449643) Yang H.-S. … Colburn N.H. (Mol. Cell. Biol. 2006) 3 4 23
  4. Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PMID: 19153607) Loh P.G. … Song H. (EMBO J. 2009) 3 4 23
  5. Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PMID: 9759869) Azzoni L. … Perussia B. (J. Immunol. 1998) 2 3 4

Products for PDCD4 Gene

  • Addgene plasmids for PDCD4

Sources for PDCD4 Gene

Back to Top

Content