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PDCD4 Gene

protein-coding   GIFtS: 63
GCID: GC10P112618

Programmed Cell Death 4 (Neoplastic Transformation Inhibitor)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Programmed Cell Death 4 (Neoplastic Transformation Inhibitor)1 2     H7312 3
Nuclear Antigen H7311 2     Programmed Cell Death Protein 42
Neoplastic Transformation Inhibitor Protein2 3     Nuclear Antigen H731-Like3
Protein 197/15a2 3     

External Ids:    HGNC: 87631   Entrez Gene: 272502   Ensembl: ENSG000001505937   OMIM: 6086105   UniProtKB: Q53EL63   

Export aliases for PDCD4 gene to outside databases

Previous GC identifers: GC10P111524 GC10P111865 GC10P112762 GC10P112296 GC10P106260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDCD4 Gene:
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor
4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Dec 2010)

GeneCards Summary for PDCD4 Gene:
PDCD4 (programmed cell death 4 (neoplastic transformation inhibitor)) is a protein-coding gene. Diseases associated with PDCD4 include inverted papilloma, and laryngeal carcinoma. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the
interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN
kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely,
MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor.
Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)

Gene Wiki entry for PDCD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PDCD4 gene promoter:
         AP-1   ATF-2   c-Jun   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDCD4 promoter sequence
   Search Chromatin IP Primers for PDCD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDCD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q25.2   HGNC cytogenetic band: 10q24

PDCD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P112618:  view genomic region     (about GC identifiers)

Start:
112,631,553 bp from pter      End:
112,659,764 bp from pter
Size:
28,212 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6 (See protein sequence)
Recommended Name: Programmed cell death protein 4  
Size: 469 amino acids; 51735 Da
Subunit: Interacts (via MI domains) with EIF4A2 (By similarity). Interacts (via MI domains) with EIF4A1 (via
N-terminal domain). Heterotrimer with EIF4A1; one molecule of PDCD4 binds two molecules of EIF4A1. Interacts with
EIF4G1. May form a complex with EIF4A1 and EIF4G1. The interaction between PDCD4 and EIF4A1 interferes with the
interaction between EIF4A1 and EIF4G. When phosphorylated, interacts with BTRC and FBXW11
Sequence caution: Sequence=AAB42218.1; Type=Erroneous gene model prediction; Sequence=AAH15036.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
5 PDB 3D structures from and Proteopedia for PDCD4:
2GGF (3D)        2KZT (3D)        2RG8 (3D)        2ZU6 (3D)        3EIJ (3D)    
Secondary accessions: B2RCV4 B5ME91 O15501 Q5VZS6 Q6PJI5 Q8TAR5 Q99834
Alternative splicing: 2 isoforms:  Q53EL6-1   Q53EL6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PDCD4: NX_Q53EL6

Explore proteomics data for PDCD4 at MOPED

Post-translational modifications: 

  • Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens.
    Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation1
  • Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of
    PDCD41
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PDCD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186421.1  NP_055271.2  NP_663314.1  

    ENSEMBL proteins: 
     ENSP00000280154   ENSP00000394668   ENSP00000376816  

    PDCD4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016021 MIF4-like_typ_1/2/3
     IPR003891 Initiation_fac_eIF4g_MI
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q53EL6

    ProtoNet protein and cluster: Q53EL6

    UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
    Domain: Binds EIF4A1 via both MI domains
    Similarity: Belongs to the PDCD4 family
    Similarity: Contains 2 MI domains


    PDCD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDCD4_HUMAN, Q53EL6
    Function: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the
    interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN
    kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely,
    MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor.
    Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)
    Induction: IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression

         Genatlas biochemistry entry for PDCD4:
    programmed cell death (apoptosis),inhibited by topoisomerase inhibitors (TIS)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI12054647
         
    PDCD4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDCD4:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pdcd4):
     endocrine/exocrine gland  immune system  mortality/aging  no phenotypic analysis  renal/urinary system 
     reproductive system  tumorigenesis 

    PDCD4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PDCD4: Pdcd4tm1Yhcn Pdcd4tm1.1Tosc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDCD4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDCD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDCD4

    miRNA
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    miRTarBase miRNAs that target PDCD4:
    hsa-mir-335-5p (MIRT019086), hsa-mir-197-3p (MIRT048135), hsa-mir-15a-5p (MIRT000810), hsa-mir-21-5p (MIRT003054), hsa-mir-16-5p (MIRT000809), hsa-mir-182-5p (MIRT007155), hsa-mir-196a-5p (MIRT026027), hsa-mir-499a-5p (MIRT006699), hsa-mir-1 (MIRT002785), hsa-mir-200a-3p (MIRT004005), hsa-mir-183-5p (MIRT005547)

    Block miRNA regulation of human, mouse, rat PDCD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDCD4 (see all 98):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidPDCD4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDCD4_HUMAN, Q53EL6: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear
    under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of
    serum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IMP16357133
    GO:0005829cytosol IDA12054647

    PDCD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDCD4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Proteoglycans in cancer
    Proteoglycans in cancer
    3mTOR signaling pathway
    mTOR signaling pathway
    4MicroRNAs in cancer
    MicroRNAs in cancer
    5Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PDCD4
        Akt Signaling Pathway


    2 Cell Signaling Technology (CST) Pathways for PDCD4
        Apoptosis and Autophagy
    Translational Control

    1 BioSystems Pathway for PDCD4
        mTOR signaling pathway



    2 Kegg Pathways  (Kegg details for PDCD4):
        Proteoglycans in cancer
    MicroRNAs in cancer


    PDCD4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDCD4
    Interactions:

        GeneGlobe Interaction Network for PDCD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDCD4 (Q53EL61, 3 ENSP000002801544) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPS13P622771, 3, ENSP000002281404EBI-935824,EBI-351850 I2D: score=4 STRING: ENSP00000228140
    APOEP026491, 3, ENSP000002524864EBI-935824,EBI-1222467 I2D: score=1 STRING: ENSP00000252486
    PSEN2P498101, 3EBI-935824,EBI-2010251 I2D: score=1 
    BTRCQ9Y2973, ENSP000003592064I2D: score=3 STRING: ENSP00000359206
    EIF4A2Q142403, ENSP000003263814I2D: score=2 STRING: ENSP00000326381
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process NAS12054647
    GO:0007569cell aging IDA12054647
    GO:0043508negative regulation of JUN kinase activity ISS--
    GO:0045786negative regulation of cell cycle NAS12054647
    GO:0045892negative regulation of transcription, DNA-templated ISS--

    PDCD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDCD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PDCD4 gene (3 alternative transcripts): 
    NM_001199492.1  NM_014456.4  NM_145341.3  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280154(uc001kzh.3 uc010qre.2) ENST00000467574 ENST00000483670
    ENST00000444997 ENST00000492932 ENST00000481353 ENST00000462577 ENST00000489049
    ENST00000483595 ENST00000498367 ENST00000393104(uc001kzg.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PDCD4 (see all 98):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-576-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-200a
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    Selected AceView cDNA sequences (see all 434):

    BU077442 AA908461 BE712900 AI832283 CB270162 AW192359 BG941562 BQ216513 
    BE175696 CD721938 BU621309 AI420607 AL708961 BG319447 AW841879 CD722966 
    AW467298 AI866793 AI077964 AA195117 CR617800 CB216122 AW373649 BX494220 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDCD4 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^
    SP1:                                                  -     -                                               -     -     -                                       
    SP2:                                                                                                        -     -     -                                   -   
    SP3:                                                  -     -                 -     -                       -     -     -                                       
    SP4:                                                  -     -     -                 -     -                 -     -     -                                       
    SP5:                                                  -     -     -                                         -     -     -                                       

    ExUns: 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:        -                 -                 -                     
    SP2:  -     -     -           -                 -                     
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for PDCD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDCD4 expression in normal human tissues (normalized intensities)      PDCD4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGCAGTA
    PDCD4 Expression
    About this image


    PDCD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Metencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             Thymus
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
    PDCD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDCD4 Protein Expression

    UniProtKB/Swiss-Prot: PDCD4_HUMAN, Q53EL6
    Tissue specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary
    gland. Reduced expression in lung cancer and colon carcinoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDCD4 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcd41 , 5 programmed cell death 41, 5 89.55(n)1
    96.8(a)1
      19 (48.73 cM)5
    185691  NM_001168492.11  NP_001161964.11 
     538922315 
    chicken
    (Gallus gallus)
    Aves PDCD41 programmed cell death 4 (neoplastic transformation more 80.23(n)
    85.22(a)
      374191  NM_204304.1  NP_989635.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDCD46
    programmed cell death 4 (neoplastic transformation...
    84(a)
    1 ↔ 1
    3(45698966-45731503)
    African clawed frog
    (Xenopus laevis)
    Amphibia pdcd4-prov2 programmed cell death 4 77.12(n)    BC048225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdcd42 programmed cell death 4 74.29(n)   321061  BC045513.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109903
    Pdcd41
    Programmed cell death 4 ortholog1 39(a)3
    47.88(n)1
    42.69(a)1
      323371  NM_001103507.31  NP_001096977.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G248001 AT4G24800 46.25(n)
    34.32(a)
      828582  NM_001036631.1  NP_001031708.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01205001 Os08g0120500 48.25(n)
    36.11(a)
      4344544  NM_001067414.1  NP_001060879.1 


    ENSEMBL Gene Tree for PDCD4 (if available)
    TreeFam Gene Tree for PDCD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDCD4 (see all 450)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363754
    A breast cancer sample4--see VAR_0363752 G R mis40--------
    rs1841286591,2
    --112632682(+) GCTACG/TTAGCC 3 -- int10--------
    rs1162056031,2
    F--112632738(+) GATTAG/AGTGTC 3 -- int11Minor allele frequency- A:0.02WA 118
    rs790893721,2
    --112632761(+) GTTTCC/TCCTGT 3 -- int10--------
    rs758532271,2
    C--112632987(+) AATATC/TAGGAC 3 -- int10--------
    rs1906766581,2
    --112633081(+) CTGCTA/CATTAG 3 -- int10--------
    rs1502776111,2
    --112633111(+) GAATAC/TAAGTA 3 -- int10--------
    rs1388750541,2
    --112633146(+) CTTGAC/TTCCCC 3 -- int10--------
    rs122585591,2
    C,F--112633172(+) TTTATG/AAGGTA 3 -- int13Minor allele frequency- A:0.04WA NA EA 358
    rs1489840711,2
    C--112633261(+) TACTTA/CTGATT 3 -- int10--------

    HapMap Linkage Disequilibrium report for PDCD4 (112631553 - 112659764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PDCD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7548CNV Insertion18451855
    dgv819n71CNV Gain21882294
    nsv831985CNV Gain+Loss17160897
    nsv7211OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): PDCD4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDCD4
    DNA2.0 Custom Variant and Variant Library Synthesis for PDCD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608610    OMIM disorders: --

    Selected diseases for PDCD4 (see all 38):    About MalaCards
    inverted papilloma    laryngeal carcinoma    laryngeal squamous cell carcinoma    laryngitis
    pancreatic ductal adenocarcinoma    cholesteatoma    neuroendocrine tumor    esophageal cancer
    leiomyoma    colorectal cancer    adenoid cystic carcinoma    oral squamous cell carcinoma
    gastrointestinal stromal tumor    papilloma    adenoiditis    squamous cell carcinoma
    breast and colorectal cancer    oral cancer    renal cell carcinoma    cholangiocarcinoma


    PDCD4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for PDCD4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neoplastic transformation 75.2 6 10570194 (2), 19728867 (1), 19836969 (1), 17828298 (1) (see all 5)
    colon carcinoma 42 4 16449643 (2), 17828298 (1)
    tumors 37.8 60 17849461 (5), 17955371 (4), 18296647 (3), 17828298 (3) (see all 22)
    colorectal cancer 37.5 10 17849461 (3), 17968323 (1), 19836969 (1)
    cancer 26.4 14 14985450 (3), 18296647 (2), 14630388 (1), 17968323 (1) (see all 8)

    Genetic Association Database (GAD): PDCD4
    Human Genome Epidemiology (HuGE) Navigator: PDCD4 (2 documents)

    Export disorders for PDCD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDCD4 gene, integrated from 10 sources (see all 167):
    (articles sorted by number of sources associating them with PDCD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. (PubMed id 9759869)1, 2, 3 Azzoni L....Perussia B. (J. Immunol. 1998)
    2. Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. (PubMed id 16357133)1, 2, 9 Palamarchuk A....Pekarsky Y. (Cancer Res. 2005)
    3. Structural basis for translational inhibition by the tumour suppressor Pdcd4. (PubMed id 19153607)1, 2, 9 Loh P.G....Song H. (EMBO J. 2009)
    4. Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. (PubMed id 16449643)1, 2, 9 Yang H.-S.... Colburn N.H. (Mol. Cell. Biol. 2006)
    5. Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody. (PubMed id 10632927)1, 2, 9 Yoshinaga H.... Masaki Z. (Pathol. Int. 1999)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. Crystal structure of the eIF4A-PDCD4 complex. (PubMed id 19204291)1, 2 Chang J.H.... Cho Y. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    8. PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. (PubMed id 18296639)1, 2 Suzuki C.... Wagner G. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27250 HGNC: 8763 AceView: PDCD4 Ensembl:ENSG00000150593 euGenes: HUgn27250
    ECgene: PDCD4 Kegg: 27250 H-InvDB: PDCD4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDCD4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDCD4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDCD4 gene:
    Search GeneIP for patents involving PDCD4

    Licensable Technologies for PDCD4 gene:
     Tufts University:  Use of miRNAs to selectively modulate TGF-beta/BMP signaling to treat TGF-beta/BMP mediated disorders
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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