Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDCD2L Gene

Aliases for PDCD2L Gene

  • Programmed Cell Death 2 Like 2 3 5

External Ids for PDCD2L Gene

Previous GeneCards Identifiers for PDCD2L Gene

  • GC19P039588
  • GC19P034895
  • GC19P031401

Summaries for PDCD2L Gene

GeneCards Summary for PDCD2L Gene

PDCD2L (Programmed Cell Death 2 Like) is a Protein Coding gene. An important paralog of this gene is ENSG00000266953.

UniProtKB/Swiss-Prot for PDCD2L Gene

  • Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.

Additional gene information for PDCD2L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD2L Gene

Genomics for PDCD2L Gene

GeneHancer (GH) Regulatory Elements for PDCD2L Gene

Promoters and enhancers for PDCD2L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I034403 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.2 200 1.6 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GC19P034405 PDCD2L ZNF599 LSM14A KIAA0355 ZNF302 ENSG00000268947 ZNF181 ZNF792 ENSG00000267219
GH19I034405 Enhancer 0.6 Ensembl 550.8 +1.4 1417 0.4 ZNF639 ZNF521 ZNF501 ZBTB7A ZNF148 ZFHX2 ZNF239 ZNF416 MLLT1 ZBTB33 GC19P034405 PDCD2L ZNF302 WTIP ENSG00000266953 RN7SL154P
GH19I034364 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 -38.3 -38286 4 HDGF ATF1 ZNF133 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 GPI ZNF599 ENSG00000268947 PDCD2L KIAA0355 GC19P034362 ENSG00000266953
GH19I034323 Enhancer 0.6 ENCODE 10.7 -80.8 -80768 1.2 MITF USF1 SCRT2 PRDM10 ZNF600 ZBTB33 ZEB2 ZIC2 PDCD2L KIAA0355 GC19P034326 RPL29P33
GH19I034325 Enhancer 0.6 ENCODE 10.7 -78.4 -78353 1.3 ZNF792 ATF2 ZEB1 ZNF155 ZFP69B ZNF791 ZNF274 PRDM6 ZNF692 ZNF138 GC19P034326 LSM14A ZNF792 KIAA0355 PDCD2L RPL29P33
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDCD2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDCD2L gene promoter:

Genomic Locations for PDCD2L Gene

Genomic Locations for PDCD2L Gene
chr19:34,404,384-34,426,168
(GRCh38/hg38)
Size:
21,785 bases
Orientation:
Plus strand
chr19:34,895,289-34,917,073
(GRCh37/hg19)

Genomic View for PDCD2L Gene

Genes around PDCD2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD2L Gene

Proteins for PDCD2L Gene

  • Protein details for PDCD2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP1-PDD2L_HUMAN
    Recommended name:
    Programmed cell death protein 2-like
    Protein Accession:
    Q9BRP1

    Protein attributes for PDCD2L Gene

    Size:
    358 amino acids
    Molecular mass:
    39417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDCD2L Gene

Post-translational modifications for PDCD2L Gene

Other Protein References for PDCD2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDCD2L Gene

Domains & Families for PDCD2L Gene

Gene Families for PDCD2L Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for PDCD2L Gene

Suggested Antigen Peptide Sequences for PDCD2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDCD2L: view

No data available for UniProtKB/Swiss-Prot for PDCD2L Gene

Function for PDCD2L Gene

Molecular function for PDCD2L Gene

UniProtKB/Swiss-Prot Function:
Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.

Phenotypes From GWAS Catalog for PDCD2L Gene

genes like me logo Genes that share phenotypes with PDCD2L: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PDCD2L Gene

Localization for PDCD2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDCD2L gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDCD2L Gene

Pathways & Interactions for PDCD2L Gene

SuperPathways for PDCD2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Pathways by source and SIGNOR curated interactions for PDCD2L Gene

Drugs & Compounds for PDCD2L Gene

No Compound Related Data Available

Transcripts for PDCD2L Gene

Unigene Clusters for PDCD2L Gene

Programmed cell death 2-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD2L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for PDCD2L Gene

GeneLoc Exon Structure for
PDCD2L
ECgene alternative splicing isoforms for
PDCD2L

Expression for PDCD2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDCD2L Gene

Protein differential expression in normal tissues from HIPED for PDCD2L Gene

This gene is overexpressed in Ovary (14.6), Bone marrow stromal cell (11.5), and Breast (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD2L Gene



Protein tissue co-expression partners for PDCD2L Gene

NURSA nuclear receptor signaling pathways regulating expression of PDCD2L Gene:

PDCD2L

SOURCE GeneReport for Unigene cluster for PDCD2L Gene:

Hs.515344

mRNA Expression by UniProt/SwissProt for PDCD2L Gene:

Q9BRP1-PDD2L_HUMAN
Tissue specificity: Higher expression in lung, colon, mammary gland, cervix, stomach and small intestine.

Evidence on tissue expression from TISSUES for PDCD2L Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with PDCD2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDCD2L Gene

Orthologs for PDCD2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD2L 33 34
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia PDCD2L 33
  • 86.59 (n)
cow
(Bos Taurus)
Mammalia PDCD2L 33 34
  • 85.01 (n)
mouse
(Mus musculus)
Mammalia Pdcd2l 33 16 34
  • 79.31 (n)
rat
(Rattus norvegicus)
Mammalia Pdcd2l 33
  • 78.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves PDCD2L 33 34
  • 63.76 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd2l 33
  • 54.73 (n)
zebrafish
(Danio rerio)
Actinopterygii pdcd2l 33 34
  • 52.85 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta trus 33 34
  • 48.4 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001972 33
  • 48.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR4 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G64830 33
  • 45.29 (n)
rice
(Oryza sativa)
Liliopsida Os04g0640800 33
  • 43.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToMany
Species where no ortholog for PDCD2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD2L Gene

ENSEMBL:
Gene Tree for PDCD2L (if available)
TreeFam:
Gene Tree for PDCD2L (if available)

Paralogs for PDCD2L Gene

Paralogs for PDCD2L Gene

Pseudogenes.org Pseudogenes for PDCD2L Gene

genes like me logo Genes that share paralogs with PDCD2L: view

Variants for PDCD2L Gene

Sequence variations from dbSNP and Humsavar for PDCD2L Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000118141 -- 34,417,244(+) A/G intron_variant
rs1000421670 -- 34,423,490(+) T/C intron_variant
rs1000547548 -- 34,412,095(+) T/C intron_variant
rs1000573407 -- 34,410,820(+) C/G intron_variant
rs1000630128 -- 34,412,367(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD2L Gene

Variant ID Type Subtype PubMed ID
esv3644206 CNV loss 21293372
nsv1127676 CNV deletion 24896259
nsv472210 CNV novel sequence insertion 20440878
nsv473900 CNV novel sequence insertion 20440878
nsv479153 CNV novel sequence insertion 20440878
nsv479414 CNV novel sequence insertion 20440878
nsv509738 CNV insertion 20534489

Variation tolerance for PDCD2L Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDCD2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCD2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD2L Gene

Disorders for PDCD2L Gene

Additional Disease Information for PDCD2L

No disorders were found for PDCD2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDCD2L Gene

Publications for PDCD2L Gene

  1. Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis. (PMID: 25566315) Burroughs AM … Aravind L (Frontiers in genetics 2014) 2 3 58
  2. The novel MGC13096 protein is correlated with proliferation. (PMID: 17393540) Chen Q … Qian K (Cell biochemistry and function 2008) 3 4 58
  3. Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells. (PMID: 16311922) Chen Q … Yan C (Molecular and cellular biochemistry 2005) 2 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PDCD2L Gene

Sources for PDCD2L Gene

Content
Loading form....