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Aliases for PDCD2L Gene

Aliases for PDCD2L Gene

  • Programmed Cell Death 2 Like 2 3
  • Programmed Cell Death 2-Like 5

External Ids for PDCD2L Gene

Previous GeneCards Identifiers for PDCD2L Gene

  • GC19P039588
  • GC19P034895
  • GC19P031401

Summaries for PDCD2L Gene

GeneCards Summary for PDCD2L Gene

PDCD2L (Programmed Cell Death 2 Like) is a Protein Coding gene. An important paralog of this gene is ENSG00000266953.

UniProtKB/Swiss-Prot for PDCD2L Gene

  • Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD2L Gene

Genomics for PDCD2L Gene

Regulatory Elements for PDCD2L Gene

Enhancers for PDCD2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PDCD2L on UCSC Golden Path with GeneCards custom track

Promoters for PDCD2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDCD2L on UCSC Golden Path with GeneCards custom track

Genomic Location for PDCD2L Gene

Chromosome:
19
Start:
34,404,384 bp from pter
End:
34,426,168 bp from pter
Size:
21,785 bases
Orientation:
Plus strand

Genomic View for PDCD2L Gene

Genes around PDCD2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD2L Gene

Proteins for PDCD2L Gene

  • Protein details for PDCD2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP1-PDD2L_HUMAN
    Recommended name:
    Programmed cell death protein 2-like
    Protein Accession:
    Q9BRP1

    Protein attributes for PDCD2L Gene

    Size:
    358 amino acids
    Molecular mass:
    39417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDCD2L Gene

Post-translational modifications for PDCD2L Gene

  • Ubiquitination at Lys 6
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDCD2L Gene

Domains & Families for PDCD2L Gene

Protein Domains for PDCD2L Gene

Suggested Antigen Peptide Sequences for PDCD2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDCD2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PDCD2L Gene

Function for PDCD2L Gene

Molecular function for PDCD2L Gene

UniProtKB/Swiss-Prot Function:
Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.
genes like me logo Genes that share phenotypes with PDCD2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PDCD2L Gene

Localization for PDCD2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCD2L Gene COMPARTMENTS Subcellular localization image for PDCD2L gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDCD2L Gene

Pathways & Interactions for PDCD2L Gene

SuperPathways for PDCD2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Pathways by source and SIGNOR curated interactions for PDCD2L Gene

Drugs & Compounds for PDCD2L Gene

No Compound Related Data Available

Transcripts for PDCD2L Gene

mRNA/cDNA for PDCD2L Gene

Unigene Clusters for PDCD2L Gene

Programmed cell death 2-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD2L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for PDCD2L Gene

GeneLoc Exon Structure for
PDCD2L
ECgene alternative splicing isoforms for
PDCD2L

Expression for PDCD2L Gene

mRNA expression in normal human tissues for PDCD2L Gene

Protein differential expression in normal tissues from HIPED for PDCD2L Gene

This gene is overexpressed in Ovary (14.6), Bone marrow stromal cell (11.5), and Breast (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDCD2L Gene



Protein tissue co-expression partners for PDCD2L Gene

NURSA nuclear receptor signaling pathways regulating expression of PDCD2L Gene:

PDCD2L

SOURCE GeneReport for Unigene cluster for PDCD2L Gene:

Hs.515344

mRNA Expression by UniProt/SwissProt for PDCD2L Gene:

Q9BRP1-PDD2L_HUMAN
Tissue specificity: Higher expression in lung, colon, mammary gland, cervix, stomach and small intestine.
genes like me logo Genes that share expression patterns with PDCD2L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PDCD2L Gene

Orthologs for PDCD2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD2L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDCD2L 34
  • 85.01 (n)
  • 81.56 (a)
PDCD2L 35
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PDCD2L 34
  • 86.59 (n)
  • 82.4 (a)
mouse
(Mus musculus)
Mammalia Pdcd2l 34
  • 79.31 (n)
  • 72.19 (a)
Pdcd2l 16
Pdcd2l 35
  • 69 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PDCD2L 34
  • 98.98 (n)
  • 98.32 (a)
PDCD2L 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdcd2l 34
  • 78.06 (n)
  • 70.59 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves PDCD2L 34
  • 63.76 (n)
  • 53.65 (a)
PDCD2L 35
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd2l 34
  • 54.73 (n)
  • 47.34 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 34
pdcd2l 34
  • 52.85 (n)
  • 44.93 (a)
pdcd2l 35
  • 41 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001972 34
  • 48.26 (n)
  • 38.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta trus 34
  • 48.4 (n)
  • 39.22 (a)
trus 35
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR4 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G64830 34
  • 45.29 (n)
  • 32.89 (a)
rice
(Oryza sativa)
Liliopsida Os04g0640800 34
  • 43.88 (n)
  • 30.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for PDCD2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD2L Gene

ENSEMBL:
Gene Tree for PDCD2L (if available)
TreeFam:
Gene Tree for PDCD2L (if available)

Paralogs for PDCD2L Gene

Paralogs for PDCD2L Gene

Pseudogenes.org Pseudogenes for PDCD2L Gene

genes like me logo Genes that share paralogs with PDCD2L: view

Variants for PDCD2L Gene

Sequence variations from dbSNP and Humsavar for PDCD2L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10706238 -- 34,419,500(+) TTTCC(-/T)TTTTT intron-variant
rs10853935 -- 34,407,474(+) CTCTA(C/T)TTCTT intron-variant
rs10853936 -- 34,424,546(+) cttcc(C/T)gggtc intron-variant
rs10853937 -- 34,424,952(+) TGTTG(A/G)CCAGG intron-variant
rs10853938 -- 34,425,106(+) TGCCT(A/C)CGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD2L Gene

Variant ID Type Subtype PubMed ID
esv3644206 CNV loss 21293372
nsv1127676 CNV deletion 24896259
nsv472210 CNV novel sequence insertion 20440878
nsv473900 CNV novel sequence insertion 20440878
nsv479153 CNV novel sequence insertion 20440878
nsv479414 CNV novel sequence insertion 20440878
nsv509738 CNV insertion 20534489

Variation tolerance for PDCD2L Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDCD2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PDCD2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD2L Gene

Disorders for PDCD2L Gene

Relevant External Links for PDCD2L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCD2L

No disorders were found for PDCD2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDCD2L Gene

Publications for PDCD2L Gene

  1. Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis. (PMID: 25566315) Burroughs A.M. … Aravind L. (Front Genet 2014) 2 3 65
  2. The novel MGC13096 protein is correlated with proliferation. (PMID: 17393540) Chen Q. … Qian K. (Cell Biochem. Funct. 2008) 3 4 65
  3. Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells. (PMID: 16311922) Chen Q. … Yan C. (Mol. Cell. Biochem. 2005) 2 3 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for PDCD2L Gene

Sources for PDCD2L Gene

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