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Aliases for PDCD2L Gene

Aliases for PDCD2L Gene

  • Programmed Cell Death 2-Like 2 3
  • MGC13096 6

External Ids for PDCD2L Gene

Summaries for PDCD2L Gene

GeneCards Summary for PDCD2L Gene

PDCD2L (Programmed Cell Death 2-Like) is a Protein Coding gene. An important paralog of this gene is PDCD2.

UniProtKB/Swiss-Prot for PDCD2L Gene

  • Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD2L Gene

Genomics for PDCD2L Gene

Genomic Location for PDCD2L Gene

Start:
34,404,384 bp from pter
End:
34,426,168 bp from pter
Size:
21,785 bases
Orientation:
Plus strand

Genomic View for PDCD2L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDCD2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD2L Gene

Regulatory Elements for PDCD2L Gene

Proteins for PDCD2L Gene

  • Protein details for PDCD2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP1-PDD2L_HUMAN
    Recommended name:
    Programmed cell death protein 2-like
    Protein Accession:
    Q9BRP1
    Secondary Accessions:

    Protein attributes for PDCD2L Gene

    Size:
    358 amino acids
    Molecular mass:
    39417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDCD2L Gene

Proteomics data for PDCD2L Gene at MOPED

Post-translational modifications for PDCD2L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys6

Other Protein References for PDCD2L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDCD2L Gene

Domains for PDCD2L Gene

Protein Domains for PDCD2L Gene

Suggested Antigen Peptide Sequences for PDCD2L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDCD2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PDCD2L Gene

Function for PDCD2L Gene

Molecular function for PDCD2L Gene

UniProtKB/Swiss-Prot Function: Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PDCD2L Gene

Localization for PDCD2L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCD2L Gene COMPARTMENTS Subcellular localization image for PDCD2L gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDCD2L Gene

Pathways for PDCD2L Gene

SuperPathways for PDCD2L Gene

No Data Available

Interacting Proteins for PDCD2L Gene

Gene Ontology (GO) - Biological Process for PDCD2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PDCD2L: view

No data available for Pathways by source for PDCD2L Gene

Transcripts for PDCD2L Gene

mRNA/cDNA for PDCD2L Gene

Unigene Clusters for PDCD2L Gene

Programmed cell death 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD2L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for PDCD2L Gene

GeneLoc Exon Structure for
PDCD2L
ECgene alternative splicing isoforms for
PDCD2L

Expression for PDCD2L Gene

mRNA expression in normal human tissues for PDCD2L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDCD2L Gene

SOURCE GeneReport for Unigene cluster for PDCD2L Gene Hs.515344

mRNA Expression by UniProt/SwissProt for PDCD2L Gene

Q9BRP1-PDD2L_HUMAN
Tissue specificity: Higher expression in lung, colon, mammary gland, cervix, stomach and small intestine.
genes like me logo Genes that share expressions with PDCD2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PDCD2L Gene

Orthologs for PDCD2L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD2L 35
  • 98.98 (n)
  • 98.32 (a)
PDCD2L 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDCD2L 35
  • 85.01 (n)
  • 81.56 (a)
PDCD2L 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PDCD2L 35
  • 86.59 (n)
  • 82.4 (a)
mouse
(Mus musculus)
Mammalia Pdcd2l 35
  • 79.31 (n)
  • 72.19 (a)
Pdcd2l 16
Pdcd2l 36
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pdcd2l 35
  • 78.06 (n)
  • 70.59 (a)
chicken
(Gallus gallus)
Aves PDCD2L 35
  • 63.76 (n)
  • 53.65 (a)
PDCD2L 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd2l 35
  • 54.73 (n)
  • 47.34 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
pdcd2l 35
  • 52.85 (n)
  • 44.93 (a)
pdcd2l 36
  • 41 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001972 35
  • 48.26 (n)
  • 38.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta trus 35
  • 48.4 (n)
  • 39.22 (a)
trus 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSR4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G64830 35
  • 45.29 (n)
  • 32.89 (a)
rice
(Oryza sativa)
Liliopsida Os04g0640800 35
  • 43.88 (n)
  • 30.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for PDCD2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD2L Gene

ENSEMBL:
Gene Tree for PDCD2L (if available)
TreeFam:
Gene Tree for PDCD2L (if available)

Paralogs for PDCD2L Gene

Paralogs for PDCD2L Gene

Pseudogenes.org Pseudogenes for PDCD2L Gene

genes like me logo Genes that share paralogs with PDCD2L: view

Variants for PDCD2L Gene

Sequence variations from dbSNP and Humsavar for PDCD2L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1559195 -- 34,403,915(-) ACACA(C/T)CAAAA upstream-variant-2KB
rs1862489 -- 34,409,786(-) AGAAA(C/T)ATAAA intron-variant
rs2081063 -- 34,414,048(-) gacaa(A/G)tgagt intron-variant
rs2161473 -- 34,409,455(-) CCTCA(A/G)AAGGC reference, synonymous-codon
rs4806016 -- 34,410,764(+) atttt(A/T)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD2L Gene

Variant ID Type Subtype PubMed ID
nsv509738 CNV Insertion 20534489

Relevant External Links for PDCD2L Gene

HapMap Linkage Disequilibrium report
PDCD2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD2L Gene

Disorders for PDCD2L Gene

No disorders were found for PDCD2L Gene.

No data available for UniProtKB/Swiss-Prot for PDCD2L Gene

Publications for PDCD2L Gene

  1. The novel MGC13096 protein is correlated with proliferation. (PMID: 17393540) Chen Q. … Qian K. (Cell Biochem. Funct. 2008) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Cloning of cDNAs with PDCD2(C) domain and their expressions during apoptosis of HEK293T cells. (PMID: 16311922) Chen Q. … Yan C. (Mol. Cell. Biochem. 2005) 2 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PDCD2L Gene

Sources for PDCD2L Gene

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