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PDCD2 Gene

protein-coding   GIFtS: 59
GCID: GC06M170884

Programmed Cell Death 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Programmed Cell Death 21 2
Zinc Finger MYND Domain-Containing Protein 72 3
Zinc Finger Protein Rp-82 3
RP82 3
ZMYND72 3
Programmed Cell Death Protein 22

External Ids:    HGNC: 87621   Entrez Gene: 51342   Ensembl: ENSG000000719947   OMIM: 6008665   UniProtKB: Q163423   

Export aliases for PDCD2 gene to outside databases

Previous GC identifers: GC06M170079 GC06M170500 GC06M170742 GC06M170804 GC06M168391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDCD2 Gene:
This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to
be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center
development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing
results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. (provided
by RefSeq, Dec 2010)

GeneCards Summary for PDCD2 Gene:
PDCD2 (programmed cell death 2) is a protein-coding gene. An important paralog of this gene is PDCD2L.

UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342
Function: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or
in regulation of cell proliferation

Gene Wiki entry for PDCD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDCD2 gene promoter:
         Bach1   STAT1   AML1a   GCNF   E47   NRF-2   GCNF-1   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDCD2 promoter sequence
   Search Chromatin IP Primers for PDCD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDCD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

PDCD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170884:  view genomic region     (about GC identifiers)

Start:
170,884,383 bp from pter      End:
170,893,780 bp from pter
Size:
9,398 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342 (See protein sequence)
Recommended Name: Programmed cell death protein 2  
Size: 344 amino acids; 38592 Da
Secondary accessions: Q58HM9 Q58HN0 Q9UH12
Alternative splicing: 3 isoforms:  Q16342-1   Q16342-2   Q16342-3   

Explore the universe of human proteins at neXtProt for PDCD2: NX_Q16342

Explore proteomics data for PDCD2 at MOPED

Post-translational modifications: 

  • Ubiquitinated by PARK2, promoting proteasomal degradation1
  • Ubiquitination2 at Lys302
  • Modification sites at PhosphoSitePlus

  • See PDCD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001186390.1  NP_001186391.1  NP_001186392.1  NP_001186393.1  NP_002589.2  NP_659005.1  

    ENSEMBL proteins: 
     ENSP00000439467   ENSP00000167218   ENSP00000375940   ENSP00000441977   ENSP00000439914  
     ENSP00000441098   ENSP00000439236   ENSP00000442815   ENSP00000402524   ENSP00000440572  
     ENSP00000444066   ENSP00000397272   ENSP00000440117  

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    Cloud-Clone Corp. Proteins for PDCD2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMYND: Zinc fingers, MYND-type

    2 InterPro protein domains:
     IPR007320 PDCD2_C
     IPR002893 Znf_MYND

    Graphical View of Domain Structure for InterPro Entry Q16342

    ProtoNet protein and cluster: Q16342

    2 Blocks protein domains:
    IPB002893 Zn-finger
    IPB007320 Programmed cell death protein 2


    UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342
    Similarity: Contains 1 MYND-type zinc finger


    Find genes that share domains with PDCD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDCD2_HUMAN, Q16342
    Function: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or
    in regulation of cell proliferation

         Genatlas biochemistry entry for PDCD2:
    programmed cell death (apoptosis) 2,rat RP8 homolog

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI19146857
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with PDCD2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PDCD2:
     Decreased TP53 protein express  Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pdcd2):
     embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with PDCD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pdcd2tm1Jcs for PDCD2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PDCD2
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    hsa-miR-1287 hsa-miR-3938 hsa-miR-3614-3p hsa-miR-651 hsa-miR-3918
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PDCD2_HUMAN, Q16342: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PDCD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PDCD2 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for PDCD2
        TNF-alpha/NF-kB Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDCD2
    Interactions:

        GeneGlobe Interaction Network for PDCD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for PDCD2 (Q163421, 2, 3 ENSP000001672184) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARK2O602601, 2, 3, ENSP000003558654EBI-359462,EBI-716346 MINT-6805975 MINT-6805947 MINT-6806032 MINT-6806051 MINT-6806070 I2D: score=2 STRING: ENSP00000355865
    UBCP0CG482, 3, ENSP000003448184MINT-6806000 I2D: score=1 STRING: ENSP00000344818
    NFKBIBQ156532, 3, ENSP000003129884MINT-47865 I2D: score=4 STRING: ENSP00000312988
    HCFC1P516103, ENSP000003095554I2D: score=3 STRING: ENSP00000309555
    USP43Q70EL43, ENSP000002851994I2D: score=2 STRING: ENSP00000285199
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0012501programmed cell death ----

    Find genes that share ontologies with PDCD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDCD2

    1 Novoseek inferred chemical compound relationship for PDCD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 33.3 1 17522156 (1)



    Find genes that share compounds with PDCD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDCD2 gene (6 alternative transcripts): 
    NM_001199461.1  NM_001199462.1  NM_001199463.1  NM_001199464.1  NM_002598.3  NM_144781.2  

    Unigene Cluster for PDCD2:

    Programmed cell death 2
    Hs.367900  [show with all ESTs]
    Unigene Representative Sequence: NM_002598
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541970(uc003qxv.3 uc003qxw.3) ENST00000543284 ENST00000167218
    ENST00000392090 ENST00000545869 ENST00000542896(uc003qxx.2) ENST00000544866
    ENST00000539212 ENST00000538195 ENST00000453163(uc003qxy.3 uc021ziq.1 uc003qxz.3)
    ENST00000537445(uc003qya.3) ENST00000544336(uc003qyb.2) ENST00000443345
    ENST00000544755
    miRNA
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    hsa-miR-1287 hsa-miR-3938 hsa-miR-3614-3p hsa-miR-651 hsa-miR-3918
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    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat PDCD2

    Additional mRNA sequence: 

    AJ420535.1 AK094428.1 AK297343.1 AY948416.1 AY948417.1 BC008378.1 BC015835.1 BC067759.1 
    S78085.1 

    18 DOTS entries:

    DT.452720  DT.100027385  DT.443478  DT.101968167  DT.121322486  DT.95261398  DT.40112154  DT.100807122 
    DT.95261444  DT.100807125  DT.40112153  DT.121322494  DT.95261399  DT.100724732  DT.92437907  DT.92437911 
    DT.100807126  DT.92437910 

    Selected AceView cDNA sequences (see all 217):

    CB148472 AW139875 AK055180 BC015835 CA429591 BM980212 AA493417 BU619946 
    AI250256 CA426527 AA442337 AI051699 AA127409 AI453838 NM_144781 BU193001 
    AA767204 AA627899 CA416372 CR615387 AI675823 BP431397 AA127397 BM976855 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDCD2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c
    SP1:                    -     -                                         -     -     -     -           -                       -                     
    SP2:                                      -     -                       -     -     -     -           -                                             
    SP3:                                                                    -     -     -     -           -                                             
    SP4:                    -     -                                         -     -                                                                     
    SP5:                                      -     -                       -     -                                                                     


    ECgene alternative splicing isoforms for PDCD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDCD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCAGCTCC
    PDCD2 Expression
    About this image

    PDCD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDCD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.367900

    UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDCD2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcd21 , 5 programmed cell death 21, 5 83.67(n)1
    85.13(a)1
      17 (8.95 cM)5
    185671  NM_008799.21  NP_032825.21 
     155192085 
    chicken
    (Gallus gallus)
    Aves PDCD21 programmed cell death 2 65.76(n)
    62.65(a)
      421550  NM_001031064.1  NP_001026235.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDCD26
    programmed cell death 2
    47(a)
    1 ↔ 1
    1(223171140-223182759)
    African clawed frog
    (Xenopus laevis)
    Amphibia pdcd2-prov2 programmed cell death 2 74.53(n)    BC047974.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636852 hypothetical protein MGC63685 72.93(n)   393370  BC054132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Zfrp81 Zinc finger protein RP-8 53.18(n)
    44.59(a)
      45021  NM_138046.1  NP_611890.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pdcd-21 pdcd-2 49.7(n)
    42.68(a)
      259501  NM_065495.7  NP_497896.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G022201 AT4G02220 46.4(n)
    40.43(a)
      828106  NM_116455.5  NP_567225.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03002001 Os03g0300200 49.79(n)
    39.38(a)
      4332566  NM_001056390.1  NP_001049855.1 


    ENSEMBL Gene Tree for PDCD2 (if available)
    TreeFam Gene Tree for PDCD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PDCD2 gene
    PDCD2L2  ENSG000002669532  

    Find genes that share paralogs with PDCD2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for PDCD2
    PGOHUM00000242512 PGOHUM00000239573 PGOHUM00000260484


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDCD2 (see all 309)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483206741,2
    C--170884199(+) TCAGCC/GTCTGG 2 -- ds50010--------
    rs178607851,2
    F--170884224(+) ACTACG/AGGTGC 2 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1415341571,2
    --170884284(+) ACTCAA/CCTGTT 2 -- ds50010--------
    rs1866428331,2
    --170884342(+) CACCAC/TAACAT 2 -- ds50010--------
    rs1898668231,2
    --170884367(+) AAAACA/CCTATC 2 -- ds50010--------
    rs1825805401,2
    --170884369(+) AACACC/TATCAC 2 -- ds50010--------
    rs1457482611,2
    --170884445(+) GGATAC/TTCAGT 2 -- ds50010--------
    rs1384848751,2
    --170884484(+) TGCTGC/TTCTCT 2 -- ds50010--------
    rs1872265331,2
    --170884508(+) CTGCTA/GTGGCT 2 -- ds50010--------
    rs592609021,2
    C--170884621(+) ACTTGC/TTCATT 2 -- ds50012Minor allele frequency- T:0.10WA 120

    HapMap Linkage Disequilibrium report for PDCD2 (170884383 - 170893780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PDCD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830874CNV Loss17160897
    nsv428158CNV Gain18775914
    esv344CNV CNV17122850
    dgv2041e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600866    OMIM disorders: --


    Find genes that share disorders with PDCD2           About GenesLikeMe

    Genetic Association Database (GAD): PDCD2
    Human Genome Epidemiology (HuGE) Navigator: PDCD2 (1 document)

    Export disorders for PDCD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDCD2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with PDCD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death. (PubMed id 7606924)1, 2, 3, 9 Kawakami T....Nakamura Y. (Cytogenet. Cell Genet. 1995)
    2. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease. (PubMed id 19146857)1, 2 Fukae J....Hattori N. (FEBS Lett. 2009)
    3. Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set. (PubMed id 15848047)1, 4 Chistiakov D.A....Nosikov V.V. (J. Autoimmun. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. (PubMed id 11854457)1, 9 Baron B.W....McKeithan T.W. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery. (PubMed id 24381196)1 Minakhina S....Steward R. (Development 2014)
    9. PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia. (PubMed id 23760497)1 Barboza N....Schaar D.G. (amp 2013)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5134 HGNC: 8762 AceView: PDCD2 Ensembl:ENSG00000071994 euGenes: HUgn5134
    ECgene: PDCD2 H-InvDB: PDCD2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PDCD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDCD2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDCD2 gene:
    Search GeneIP for patents involving PDCD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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