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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDCD2 Gene

protein-coding   GIFtS: 59
GCID: GC06M170884

Programmed Cell Death 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Programmed Cell Death 21 2
Zinc Finger MYND Domain-Containing Protein 72 3
Zinc Finger Protein Rp-82 3
RP82 3
ZMYND72 3
Programmed Cell Death Protein 22

External Ids:    HGNC: 87621   Entrez Gene: 51342   Ensembl: ENSG000000719947   OMIM: 6008665   UniProtKB: Q163423   

Export aliases for PDCD2 gene to outside databases

Previous GC identifers: GC06M170079 GC06M170500 GC06M170742 GC06M170804 GC06M168391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDCD2 Gene:
This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to
be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center
development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing
results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. (provided
by RefSeq, Dec 2010)

GeneCards Summary for PDCD2 Gene: 
PDCD2 (programmed cell death 2) is a protein-coding gene. Diseases associated with PDCD2 include chronic fatigue syndrome, and encephalomyelitis. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is PDCD2L.

UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342
Function: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or
in regulation of cell proliferation

Gene Wiki entry for PDCD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDCD2 gene promoter:
         Bach1   STAT1   AML1a   GCNF   E47   NRF-2   GCNF-1   Hand1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PDCD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDCD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDCD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

PDCD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170884:  view genomic region     (about GC identifiers)

Start:
170,884,383 bp from pter      End:
170,893,780 bp from pter
Size:
9,398 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342 (See protein sequence)
Recommended Name: Programmed cell death protein 2  
Size: 344 amino acids; 38592 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q58HM9 Q58HN0 Q9UH12
Alternative splicing: 3 isoforms:  Q16342-1   Q16342-2   Q16342-3   

Explore the universe of human proteins at neXtProt for PDCD2: NX_Q16342

Explore proteomics data for PDCD2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by PARK2, promoting proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16342

  • PDCD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDCD2 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001186390.1  NP_001186391.1  NP_001186392.1  NP_001186393.1  NP_002589.2  NP_659005.1  

    ENSEMBL proteins: 
     ENSP00000439467   ENSP00000167218   ENSP00000375940   ENSP00000441977   ENSP00000439914  
     ENSP00000441098   ENSP00000439236   ENSP00000442815   ENSP00000402524   ENSP00000440572  
     ENSP00000444066   ENSP00000397272   ENSP00000440117  

    Human Recombinant Protein Products for PDCD2: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDCD2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    PDCD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZMYND: Zinc fingers, MYND-type

    2 InterPro protein domains:
     IPR007320 PDCD2_C
     IPR002893 Znf_MYND

    Graphical View of Domain Structure for InterPro Entry Q16342

    ProtoNet protein and cluster: Q16342

    2 Blocks protein domains:
    IPB002893 Zn-finger
    IPB007320 Programmed cell death protein 2


    UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342
    Similarity: Contains 1 MYND-type zinc finger


    PDCD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDCD2_HUMAN, Q16342
    Function: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or
    in regulation of cell proliferation

         Genatlas biochemistry entry for PDCD2:
    programmed cell death (apoptosis) 2,rat RP8 homolog

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI19146857
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    PDCD2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PDCD2:
     Decreased TP53 protein express  Increased cell death HMECs cel 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pdcd2):
     embryogenesis  growth/size  mortality/aging 

    PDCD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pdcd2tm1Jcs for PDCD2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDCD2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDCD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDCD2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDCD2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDCD2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for PDCD2
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDCD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for PDCD2 (Q163422, 3 ENSP000001672184) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARK2O602602, 3, ENSP000003558654MINT-6805975 MINT-6805947 MINT-6806032 MINT-6806051 MINT-6806070 I2D: score=2 STRING: ENSP00000355865
    UBCP0CG482, 3, ENSP000003448184MINT-6806000 I2D: score=1 STRING: ENSP00000344818
    NFKBIBQ156532, 3, ENSP000003129884MINT-47865 I2D: score=4 STRING: ENSP00000312988
    HCFC1P516103, ENSP000003095554I2D: score=3 STRING: ENSP00000309555
    USP43Q70EL43, ENSP000002851994I2D: score=2 STRING: ENSP00000285199
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0012501programmed cell death ----

    PDCD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PDCD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDCD2

    1 Novoseek inferred chemical compound relationship for PDCD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 33.3 1 17522156 (1)

    Search CenterWatch for drugs/clinical trials and news about PDCD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDCD2 gene (6 alternative transcripts): 
    NM_001199461.1  NM_001199462.1  NM_001199463.1  NM_001199464.1  NM_002598.3  NM_144781.2  

    Unigene Cluster for PDCD2:

    Programmed cell death 2
    Hs.367900  [show with all ESTs]
    Unigene Representative Sequence: NM_002598
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541970(uc003qxv.3 uc003qxw.3) ENST00000543284 ENST00000167218
    ENST00000392090 ENST00000545869 ENST00000542896(uc003qxx.2) ENST00000544866
    ENST00000539212 ENST00000538195 ENST00000453163(uc003qxy.3 uc021ziq.1 uc003qxz.3)
    ENST00000537445(uc003qya.3) ENST00000544336(uc003qyb.2) ENST00000443345
    ENST00000544755
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PDCD2:
    hsa-miR-1287 hsa-miR-3938 hsa-miR-3614-3p hsa-miR-651 hsa-miR-3918
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Additional mRNA sequence: 

    AJ420535.1 AK094428.1 AK297343.1 AY948416.1 AY948417.1 BC008378.1 BC015835.1 BC067759.1 
    S78085.1 

    18 DOTS entries:

    DT.452720  DT.100027385  DT.443478  DT.101968167  DT.121322486  DT.95261398  DT.40112154  DT.100807122 
    DT.95261444  DT.100807125  DT.40112153  DT.121322494  DT.95261399  DT.100724732  DT.92437907  DT.92437911 
    DT.100807126  DT.92437910 

    24/217 AceView cDNA sequences (see all 217):

    BM471165 CA428477 BG324974 BQ954371 BX114236 BE885466 AI453838 AI214567 
    BQ070421 R96432 BM746567 BP431397 BC008378 BQ024039 AA127397 BQ056508 
    AA127409 CA429591 BU619946 AW237443 NM_144781 CR608467 AI675823 BM544909 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c
    SP1:                    -     -                                         -     -     -     -           -                       -                     
    SP2:                                      -     -                       -     -     -     -           -                                             
    SP3:                                                                    -     -     -     -           -                                             
    SP4:                    -     -                                         -     -                                                                     
    SP5:                                      -     -                       -     -                                                                     


    ECgene alternative splicing isoforms for PDCD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDCD2 expression in normal human tissues (normalized intensities)      PDCD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCAGCTCC
    PDCD2 Expression
    About this image


    PDCD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Lymph (Hematopoietic System)
             lymph node   
     
     Neural Tube (Nervous System)
             Prosencephalon

    See PDCD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDCD2

    SOURCE GeneReport for Unigene cluster: Hs.367900

    UniProtKB/Swiss-Prot: PDCD2_HUMAN, Q16342
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PDCD2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDCD2 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcd21 , 5 programmed cell death 21, 5 83.67(n)1
    85.13(a)1
      17 (8.95 cM)5
    185671  NM_008799.21  NP_032825.21 
     155192085 
    chicken
    (Gallus gallus)
    Aves PDCD21 programmed cell death 2 65.96(n)
    63.03(a)
      421550  NM_001031064.1  NP_001026235.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDCD26
    programmed cell death 2
    48(a)
    1 ↔ 1
    1(223171140-223182759)
    African clawed frog
    (Xenopus laevis)
    Amphibia pdcd2-prov2 programmed cell death 2 74.53(n)    BC047974.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636852 hypothetical protein MGC63685 72.93(n)   393370  BC054132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Zfrp81 Zinc finger protein RP-8 52.37(n)
    44.48(a)
      45021  NM_138046.1  NP_611890.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pdcd-21 Protein PDCD-2 49.7(n)
    42.99(a)
      259501  NM_065495.6  NP_497896.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G022201 MYND type zinc finger and programmed cell death 2 C-terminal domain-containing protein less 46.91(n)
    41.03(a)
      828106  NM_116455.5  NP_567225.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03002001 hypothetical protein 50.73(n)
    40.62(a)
      4332566  NM_001056390.1  NP_001049855.1 


    ENSEMBL Gene Tree for PDCD2 (if available)
    TreeFam Gene Tree for PDCD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDCD2 gene
    PDCD2L2  ENSG000002669532  
    1 SIMAP similar gene for PDCD2 using alignment to 11 protein entries:     PDCD2_HUMAN (see all proteins):
    PDCD2L

    PDCD2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PDCD2
    PGOHUM00000242512 PGOHUM00000239573 PGOHUM00000260484


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/309 SNPs in PDCD2 are shown (see all 309)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483206741,2
    C--170884199(+) TCAGCC/GTCTGG 2 -- ds50010--------
    rs178607851,2
    F--170884224(+) ACTACG/AGGTGC 2 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1415341571,2
    --170884284(+) ACTCAA/CCTGTT 2 -- ds50010--------
    rs1866428331,2
    --170884342(+) CACCAC/TAACAT 2 -- ds50010--------
    rs1898668231,2
    --170884367(+) AAAACA/CCTATC 2 -- ds50010--------
    rs1825805401,2
    --170884369(+) AACACC/TATCAC 2 -- ds50010--------
    rs1457482611,2
    --170884445(+) GGATAC/TTCAGT 2 -- ds50010--------
    rs1384848751,2
    --170884484(+) TGCTGC/TTCTCT 2 -- ds50010--------
    rs1872265331,2
    --170884508(+) CTGCTA/GTGGCT 2 -- ds50010--------
    rs592609021,2
    C--170884621(+) ACTTGC/TTCATT 2 -- ds50012Minor allele frequency- T:0.10WA 120

    HapMap Linkage Disequilibrium report for PDCD2 (170884383 - 170893780 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PDCD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830874CNV Loss17160897
    nsv428158CNV Gain18775914
    esv344CNV CNV17122850
    dgv2041e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600866    OMIM disorders: --

    5 diseases for PDCD2:    About MalaCards
    chronic fatigue syndrome    encephalomyelitis    b-cell lymphomas    parkinson's disease
    neuronitis


    PDCD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PDCD2
    Human Genome Epidemiology (HuGE) Navigator: PDCD2 (1 document)

    Export disorders for PDCD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDCD2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with PDCD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death. (PubMed id 7606924)1, 2, 3, 9 Kawakami T....Nakamura Y. (1995)
    2. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease. (PubMed id 19146857)1, 2 Fukae J....Hattori N. (2009)
    3. Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set. (PubMed id 15848047)1, 4 Chistiakov D.A....Nosikov V.V. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. (PubMed id 11854457)1, 9 Baron B.W....McKeithan T.W. (2002)
    8. PDCD2 knockdown inhibits erythroid but not megakaryocy tic lineage differentiation of human hematopoietic stem/progenitor cells. (PubMed id 22922207)1 Kokorina N.A....Sabaawy H.E. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5134 HGNC: 8762 AceView: PDCD2 Ensembl:ENSG00000071994 euGenes: HUgn5134
    ECgene: PDCD2 H-InvDB: PDCD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDCD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PDCD2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDCD2 gene:
    Search GeneIP for patents involving PDCD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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