Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PDCD2 Gene

Aliases for PDCD2 Gene

  • Programmed Cell Death 2 2 3
  • Zinc Finger MYND Domain-Containing Protein 7 3 4
  • Zinc Finger Protein Rp-8 3 4
  • ZMYND7 3 4
  • RP8 3 4
  • Programmed Cell Death Protein 2 3

External Ids for PDCD2 Gene

Previous GeneCards Identifiers for PDCD2 Gene

  • GC06M170079
  • GC06M170500
  • GC06M170742
  • GC06M170804
  • GC06M168391
  • GC06M170884

Summaries for PDCD2 Gene

Entrez Gene Summary for PDCD2 Gene

  • This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDCD2 Gene

PDCD2 (Programmed Cell Death 2) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. An important paralog of this gene is ENSG00000266953.

UniProtKB/Swiss-Prot for PDCD2 Gene

  • May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation

Gene Wiki entry for PDCD2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD2 Gene

Genomics for PDCD2 Gene

Regulatory Elements for PDCD2 Gene

Genomic Location for PDCD2 Gene

Start:
170,575,295 bp from pter
End:
170,584,692 bp from pter
Size:
9,398 bases
Orientation:
Minus strand

Genomic View for PDCD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD2 Gene

Proteins for PDCD2 Gene

  • Protein details for PDCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16342-PDCD2_HUMAN
    Recommended name:
    Programmed cell death protein 2
    Protein Accession:
    Q16342
    Secondary Accessions:
    • E9PCU7
    • F5GYS7
    • Q58HM9
    • Q58HN0
    • Q9UH12

    Protein attributes for PDCD2 Gene

    Size:
    344 amino acids
    Molecular mass:
    38592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PDCD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCD2 Gene

Proteomics data for PDCD2 Gene at MOPED

Post-translational modifications for PDCD2 Gene

No data available for DME Specific Peptides for PDCD2 Gene

Domains for PDCD2 Gene

Gene Families for PDCD2 Gene

HGNC:
  • ZMYND :Zinc fingers, MYND-type

Protein Domains for PDCD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q16342

UniProtKB/Swiss-Prot:

PDCD2_HUMAN :
  • Q16342
Similarity:
  • Contains 1 MYND-type zinc finger.
genes like me logo Genes that share domains with PDCD2: view

Function for PDCD2 Gene

Molecular function for PDCD2 Gene

GENATLAS Biochemistry: programmed cell death (apoptosis) 2,rat RP8 homolog
UniProtKB/Swiss-Prot Function: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation

Gene Ontology (GO) - Molecular Function for PDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 19146857
GO:0019899 enzyme binding IPI 23382074
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDCD2: view
genes like me logo Genes that share phenotypes with PDCD2: view

Animal Models for PDCD2 Gene

MGI Knock Outs for PDCD2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PDCD2 Gene

Localization for PDCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCD2 Gene COMPARTMENTS Subcellular localization image for PDCD2 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PDCD2: view

Pathways for PDCD2 Gene

genes like me logo Genes that share pathways with PDCD2: view

Pathways by source for PDCD2 Gene

1 BioSystems pathway for PDCD2 Gene

Gene Ontology (GO) - Biological Process for PDCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7606924
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 20605493
GO:0012501 programmed cell death --
GO:0043065 positive regulation of apoptotic process IDA 20605493
GO:1901532 regulation of hematopoietic progenitor cell differentiation IMP 22922207
genes like me logo Genes that share ontologies with PDCD2: view

Compounds for PDCD2 Gene

(1) Novoseek inferred chemical compound relationships for PDCD2 Gene

Compound -log(P) Hits PubMed IDs
zinc 33.3 1
genes like me logo Genes that share compounds with PDCD2: view

Transcripts for PDCD2 Gene

Unigene Clusters for PDCD2 Gene

Programmed cell death 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - -
SP8: - -
SP9: - - - - - - -
SP10: -

Relevant External Links for PDCD2 Gene

GeneLoc Exon Structure for
PDCD2
ECgene alternative splicing isoforms for
PDCD2

Expression for PDCD2 Gene

mRNA expression in normal human tissues for PDCD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDCD2 Gene

SOURCE GeneReport for Unigene cluster for PDCD2 Gene Hs.367900

mRNA Expression by UniProt/SwissProt for PDCD2 Gene

Q16342-PDCD2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PDCD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PDCD2 Gene

Orthologs for PDCD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PDCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDCD2 35
  • 98.03 (n)
  • 97.94 (a)
PDCD2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDCD2 35
  • 86.3 (n)
  • 83.67 (a)
PDCD2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDCD2 35
  • 86.59 (n)
  • 88.05 (a)
PDCD2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcd2 35
  • 83.67 (n)
  • 85.13 (a)
Pdcd2 16
Pdcd2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDCD2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDCD2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdcd2 35
  • 82.22 (n)
  • 83.38 (a)
chicken
(Gallus gallus)
Aves PDCD2 35
  • 65.76 (n)
  • 62.65 (a)
PDCD2 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDCD2 36
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia pdcd2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pdcd2 35
  • 61.79 (n)
  • 60.3 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1807 35
zebrafish
(Danio rerio)
Actinopterygii pdcd2 35
  • 57.11 (n)
  • 52.74 (a)
pdcd2 36
  • 48 (a)
OneToOne
zgc63685 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005582 35
  • 52.68 (n)
  • 47.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Zfrp8 35
  • 53.18 (n)
  • 44.59 (a)
Zfrp8 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pdcd-2 35
  • 49.7 (n)
  • 42.68 (a)
pdcd-2 36
  • 33 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02220 35
  • 46.4 (n)
  • 40.43 (a)
rice
(Oryza sativa)
Liliopsida Os03g0300200 35
  • 49.79 (n)
  • 39.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6606 36
  • 43 (a)
OneToOne
Species with no ortholog for PDCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PDCD2 Gene

ENSEMBL:
Gene Tree for PDCD2 (if available)
TreeFam:
Gene Tree for PDCD2 (if available)

Paralogs for PDCD2 Gene

Paralogs for PDCD2 Gene

Pseudogenes.org Pseudogenes for PDCD2 Gene

genes like me logo Genes that share paralogs with PDCD2: view

Variants for PDCD2 Gene

Sequence variations from dbSNP and Humsavar for PDCD2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8770 -- 170,577,443(-) TTGAC(A/G)GATTG utr-variant-3-prime, nc-transcript-variant
rs734249 -- 170,584,930(-) GTTTG(A/C)GGGAG upstream-variant-2KB
rs960744 -- 170,579,120(-) ACTGG(C/T)ACAGC intron-variant
rs1129634 -- 170,584,305(+) TCGCA(A/G)GCCGG reference, synonymous-codon, nc-transcript-variant
rs2066954 -- 170,582,405(-) TGAGC(A/C)ATACA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PDCD2 Gene

Variant ID Type Subtype PubMed ID
esv344 CNV CNV 17122850
nsv428158 CNV Gain 18775914
dgv2041e1 CNV Complex 17122850
nsv830874 CNV Loss 17160897

Relevant External Links for PDCD2 Gene

HapMap Linkage Disequilibrium report
PDCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDCD2 Gene

Disorders for PDCD2 Gene

Relevant External Links for PDCD2

Genetic Association Database (GAD)
PDCD2
Human Genome Epidemiology (HuGE) Navigator
PDCD2
genes like me logo Genes that share disorders with PDCD2: view

No data available for UniProtKB/Swiss-Prot for PDCD2 Gene

Publications for PDCD2 Gene

  1. Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death. (PMID: 7606924) Kawakami T. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set. (PMID: 15848047) Chistiakov D.A. … Nosikov V.V. (J. Autoimmun. 2005) 3 48
  4. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. (PMID: 11854457) Baron B.W. … McKeithan T.W. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for PDCD2 Gene

Sources for PDCD2 Gene

Back to Top

Content