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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDCD1LG2 Gene

protein-coding   GIFtS: 59
GCID: GC09P005500

Programmed Cell Death 1 Ligand 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Programmed Cell Death 1 Ligand 21 2     CD2732 3
PDCD1L22 3 5     PD-L22 3
PDL22 3 5     PD-1 Ligand 22 3
B7 Dendritic Cell Molecule1 2     PDCD1 Ligand 22 3
Butyrophilin B7-DC2 3     Btdc2
Programmed Death Ligand 22 3     bA574F11.22
B7-DC2 3     PD-1-Ligand 22
B7DC2 3     CD273 Antigen3

External Ids:    HGNC: 187311   Entrez Gene: 803802   Ensembl: ENSG000001976467   OMIM: 6057235   UniProtKB: Q9BQ513   

Export aliases for PDCD1LG2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PDCD1LG2 Gene: 
PDCD1LG2 (programmed cell death 1 ligand 2) is a protein-coding gene. Diseases associated with PDCD1LG2 include angioimmunoblastic t-cell lymphoma, and oral lichen planus, and among its related super-pathways are Immune System and Phosphorylation of CD3 and TCR zeta chains. GO annotations related to this gene include molecular_function. An important paralog of this gene is CD274.

UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51
Function: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a
PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression
and cytokine production (By similarity)

Gene Wiki entry for PDCD1LG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDCD1LG2 gene promoter:
         p53   Brachyury   FOXD3   Tal-1beta   E47   SRY   POU2F1   HSF2   POU2F1a   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDCD1LG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDCD1LG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDCD1LG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.2   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.2

PDCD1LG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD1LG2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P005500:  view genomic region     (about GC identifiers)

Start:
5,510,545 bp from pter      End:
5,571,282 bp from pter
Size:
60,738 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51 (See protein sequence)
Recommended Name: Programmed cell death 1 ligand 2 precursor  
Size: 273 amino acids; 30957 Da
Subunit: Interacts with PDCD1 (By similarity)
Subcellular location: Isoform 3: Secreted (Probable)
Subcellular location: Isoform 2: Endomembrane system; Single-pass type I membrane protein
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q14CN8 Q5T7Z6 Q6JXL8 Q6JXL9
Alternative splicing: 3 isoforms:  Q9BQ51-1   Q9BQ51-2   Q9BQ51-3   

Explore the universe of human proteins at neXtProt for PDCD1LG2: NX_Q9BQ51

Explore proteomics data for PDCD1LG2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BQ51

  • PDCD1LG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDCD1LG2 Protein Expression
    REFSEQ proteins: NP_079515.2  
    ENSEMBL proteins: 
     ENSP00000380855   ENSP00000380853  
    Reactome Protein details: Q9BQ51
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0012505endomembrane system IEA--
    GO:0016021integral to membrane IEA--

    PDCD1LG2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9BQ51

    ProtoNet protein and cluster: Q9BQ51

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    PDCD1LG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PD1L2_HUMAN, Q9BQ51
    Function: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a
    PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression
    and cytokine production (By similarity)
    Induction: Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from
    peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    PDCD1LG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDCD1LG2:
     Decreased number of cells in m 

         8 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Pdcd1lg2):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  no phenotypic analysis  tumorigenesis 

    PDCD1LG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PDCD1LG2: Pdcd1lg2tm2Shr Pdcd1lg2tm1Shr Pdcd1lg2tm1.1Lex Pdcd1lg2tm3Shr Pdcd1lg2tm2Dmp Pdcd1lg2tm4Shr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDCD1LG2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDCD1LG2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDCD1LG2 

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    SwitchGear 3'UTR luciferase reporter plasmidPDCD1LG2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDCD1LG2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Translocation of ZAP-70 to Immunological synapse
    PD-1 signaling0.77
    3CD28 co-stimulation
    Costimulation by the CD28 family0.41
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for PDCD1LG2
        Costimulation by the CD28 family
    PD-1 signaling
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for PDCD1LG2):
        Cell adhesion molecules (CAMs)


    PDCD1LG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDCD1LG2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PDCD1LG2 (Q9BQ513 ENSP000003808554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD1Q151163, ENSP000003350624I2D: score=4 STRING: ENSP00000335062
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS11283156
    GO:0031295T cell costimulation TAS--
    GO:0042102positive regulation of T cell proliferation IEA--
    GO:0042130negative regulation of T cell proliferation IEA--

    PDCD1LG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDCD1LG2 (PD1L2)

    Search CenterWatch for drugs/clinical trials and news about PDCD1LG2 / PD1L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDCD1LG2 gene: 
    NM_025239.3  

    Unigene Cluster for PDCD1LG2:

    Programmed cell death 1 ligand 2
    Hs.532279  [show with all ESTs]
    Unigene Representative Sequence: NM_025239
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397747(uc003zjg.4 uc011lmc.2 uc011lmd.2) ENST00000397745(uc010mhp.1 uc010mho.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF329193.1 AF344424.1 AK001872.1 AK093681.1 AY254343.1 AY271901.1 AY271902.1 BC074766.2 
    BC113678.1 BC113680.1 BC143920.1 BC143921.1 DQ336699.1 EF444806.1 

    5 DOTS entries:

    DT.70103836  DT.97818884  DT.102831618  DT.99929705  DT.437754 

    24/34 AceView cDNA sequences (see all 34):

    AA044631 BX280151 AA303575 CD370090 BM683311 AI990290 AK001872 AK093681 
    AW961323 NM_025239 AW105205 AY271901 AF344424 BM929340 AF329193 BM914319 
    CA442083 CA489316 BU608319 BX951459 AU135908 BC074766 AY254343 AY271902 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD1LG2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                          -                     
    SP3:                          -                     


    ECgene alternative splicing isoforms for PDCD1LG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDCD1LG2 expression in normal human tissues (normalized intensities)      PDCD1LG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATCAGAG
    PDCD1LG2 Expression
    About this image


    PDCD1LG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Respiratory System)    fully expand to see all 2 entries
             monocyte-derived dendritic cells   
     
     Lung (Respiratory System)
             alveolar macrophages   
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...

    See PDCD1LG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDCD1LG2

    SOURCE GeneReport for Unigene cluster: Hs.532279

    UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51
    Tissue specificity: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen,
    lymph nodes and thymus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PDCD1LG2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcd1lg21 , 5 programmed cell death 1 ligand 21, 5 77.6(n)1
    69.64(a)1
      19 (23.93 cM)5
    582051  NM_021396.21  NP_067371.11 
     294109195 
    lizard
    (Anolis carolinensis)
    Reptilia PDCD1LG26
    programmed cell death 1 ligand 2
    26(a)
    1 ↔ 1
    2(52343481-52363797)
    zebrafish
    (Danio rerio)
    Actinopterygii PDCD1LG26
    programmed cell death 1 ligand 2
    13(a)
    1 → many
    21(2474996-2503430)


    ENSEMBL Gene Tree for PDCD1LG2 (if available)
    TreeFam Gene Tree for PDCD1LG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDCD1LG2 gene
    CD2742  
    2 SIMAP similar genes for PDCD1LG2 using alignment to 1 protein entry:     PD1L2_HUMAN:
    PDL2    CD274

    PDCD1LG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1387 SNPs in PDCD1LG2 are shown (see all 1387)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123506721,2
    H--5508545(+) ACCCAG/AAAATG 1 -- us2k14Minor allele frequency- A:0.00NS EA 416
    rs736416261,2
    C,F--5508598(+) TAGACA/GTATAG 1 -- us2k12Minor allele frequency- G:0.08WA 120
    rs1482384661,2
    C--5508618(+) GCAGGA/CTAATG 1 -- us2k10--------
    rs1146489961,2
    C,F--5508621(+) GGCTAA/GTGTGC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs625560691,2
    C,F--5508647(+) AGTTTC/TATTTG 1 -- us2k17Minor allele frequency- T:0.11WA NA CSA EA 366
    rs1817065801,2
    --5508878(+) AAACTC/TAAAGC 1 -- us2k10--------
    rs1143400731,2
    F--5508900(+) CATATG/ATCCAT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs38244481,2
    C,F,H--5508986(-) CCCACG/CGCTCC 1 -- us2k113Minor allele frequency- C:0.12NS EA NA WA CSA 786
    rs1412657361,2
    --5508987(+) GAGCCC/GTGGGT 1 -- us2k10--------
    rs1503651341,2
    --5509000(+) AGAAGC/GAGATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDCD1LG2 (5510545 - 5571282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PDCD1LG2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509292CNV Insertion20534489
    nsv466108CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605723    OMIM disorders: --

    20/35 diseases for PDCD1LG2 (see all 35):    About MalaCards
    angioimmunoblastic t-cell lymphoma    oral lichen planus    lichen planus    adult t-cell leukemia
    type 1 diabetes mellitus    ankylosing spondylitis    spondylitis    type 1 diabetes
    graves' disease    esophageal cancer    oral squamous cell carcinoma    t-cell leukemia
    chronic lymphocytic leukemia    diabetes mellitus    liver disease    hepatitis b
    systemic lupus erythematosus    pancreatic cancer    esophagitis    hodgkin's lymphoma


    PDCD1LG2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for PDCD1LG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 26.4 1 11323285 (1)
    tumors 13.4 9 19724910 (3), 15297412 (2), 19825956 (2), 16129490 (1) (see all 5)

    Genetic Association Database (GAD): PDCD1LG2
    Human Genome Epidemiology (HuGE) Navigator: PDCD1LG2 (5 documents)

    Export disorders for PDCD1LG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDCD1LG2 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with PDCD1LG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. (PubMed id 11224527)1, 2, 3 Latchman Y.... Freeman G.J. (2001)
    2. PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. (PubMed id 17203303)1, 4, 9 Ni R....Hara T. (2007)
    3. Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PubMed id 18322304)1, 4, 9 Hayashi M....Komiya I. (2008)
    4. PD1 as a common candidate susceptibility gene of suba cute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (2010)
    5. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. (PubMed id 18992148)1, 4 KA1ry S....BAczieau S. (2008)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    8. Cloning and identification of two novel splice variants of human PD- L2. (PubMed id 15253154)1, 2 He X.-H.... Zeng Y.-Y. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. (PubMed id 11283156)1, 2 Tseng S.-Y.... Tsuchiya H. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80380 HGNC: 18731 AceView: PDCD1LG2 Ensembl:ENSG00000197646 euGenes: HUgn80380
    ECgene: PDCD1LG2 Kegg: 80380 H-InvDB: PDCD1LG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDCD1LG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDCD1LG2 gene:
    Search GeneIP for patents involving PDCD1LG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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