Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PDCD1LG2 Gene

protein-coding   GIFtS: 59
GCID: GC09P005500

Programmed Cell Death 1 Ligand 2

  See PDCD1LG2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Programmed Cell Death 1 Ligand 21 2     CD2732 3
PDCD1L22 3 5     PD-L22 3
PDL22 3 5     PD-1 Ligand 22 3
B7 Dendritic Cell Molecule1 2     PDCD1 Ligand 22 3
Butyrophilin B7-DC2 3     Btdc2
Programmed Death Ligand 22 3     bA574F11.22
B7-DC2 3     PD-1-Ligand 22
B7DC2 3     CD273 Antigen3

External Ids:    HGNC: 187311   Entrez Gene: 803802   Ensembl: ENSG000001976467   OMIM: 6057235   UniProtKB: Q9BQ513   

Export aliases for PDCD1LG2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PDCD1LG2 Gene:
PDCD1LG2 (programmed cell death 1 ligand 2) is a protein-coding gene. Diseases associated with PDCD1LG2 include cysticercosis. An important paralog of this gene is CD274.

UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51
Function: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a
PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression
and cytokine production (By similarity)

Gene Wiki entry for PDCD1LG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDCD1LG2 gene promoter:
         p53   Brachyury   FOXD3   Tal-1beta   E47   SRY   POU2F1   HSF2   POU2F1a   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDCD1LG2 promoter sequence
   Search Chromatin IP Primers for PDCD1LG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDCD1LG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.2   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.2

PDCD1LG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD1LG2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P005500:  view genomic region     (about GC identifiers)

Start:
5,510,545 bp from pter      End:
5,571,282 bp from pter
Size:
60,738 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51 (See protein sequence)
Recommended Name: Programmed cell death 1 ligand 2 precursor  
Size: 273 amino acids; 30957 Da
Subunit: Interacts with PDCD1 (By similarity)
Secondary accessions: Q14CN8 Q5T7Z6 Q6JXL8 Q6JXL9
Alternative splicing: 3 isoforms:  Q9BQ51-1   Q9BQ51-2   Q9BQ51-3   

Explore the universe of human proteins at neXtProt for PDCD1LG2: NX_Q9BQ51

Explore proteomics data for PDCD1LG2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn37, Asn64, Asn157, Asn163, Asn189

  • See PDCD1LG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079515.2  
    ENSEMBL proteins: 
     ENSP00000380855   ENSP00000380853  
    Reactome Protein details: Q9BQ51

    PDCD1LG2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PDCD1LG2 (PD-L2/B7-DC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PDCD1LG2
    OriGene Protein Over-expression Lysate for PDCD1LG2
    OriGene MassSpec for PDCD1LG2
    OriGene Custom Protein Services for PDCD1LG2
    GenScript Custom Purified and Recombinant Proteins Services for PDCD1LG2
    Novus Biologicals PDCD1LG2 Proteins
    Novus Biologicals PDCD1LG2 Lysate
    Sino Biological Recombinant Protein for PDCD1LG2
    Sino Biological Cell Lysate for PDCD1LG2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDCD1LG2

     
    Search eBioscience for Proteins for PDCD1LG2 

     
    antibodies-online proteins for PDCD1LG2 (15 products) 

     
    antibodies-online peptides for PDCD1LG2

    PDCD1LG2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PDCD1LG2
    R&D Systems Antibodies for PDCD1LG2 (PD-L2/B7-DC)
    OriGene Antibodies for PDCD1LG2
    OriGene Custom Antibody Services for PDCD1LG2
    Novus Biologicals PDCD1LG2 Antibodies
    Abcam antibodies for PDCD1LG2
    Cloud-Clone Corp. Antibodies for PDCD1LG2
    ThermoFisher Antibodies for PDCD1LG2
    antibodies-online antibodies for PDCD1LG2 (134 products) 

    PDCD1LG2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDCD1LG2
    R&D Systems ELISAs for PDCD1LG2 (PD-L2/B7-DC)
    GenScript Custom Assay Services for PDCD1LG2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDCD1LG2
    Cloud-Clone Corp. CLIAs for PDCD1LG2
    Search eBioscience for ELISAs for PDCD1LG2 
    antibodies-online kits for PDCD1LG2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    ENDOLIG: Endogenous ligands
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q9BQ51

    ProtoNet protein and cluster: Q9BQ51

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with PDCD1LG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PD1L2_HUMAN, Q9BQ51
    Function: Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a
    PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression
    and cytokine production (By similarity)
    Induction: Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from
    peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PDCD1LG2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PDCD1LG2:
     Decreased number of cells in m 

         7 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Pdcd1lg2):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with PDCD1LG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PDCD1LG2: Pdcd1lg2tm2Shr Pdcd1lg2tm1Shr Pdcd1lg2tm1.1Lex Pdcd1lg2tm3Shr Pdcd1lg2tm2Dmp Pdcd1lg2tm4Shr

       genOway: Develop your customized and physiologically relevant rodent model for PDCD1LG2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PDCD1LG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDCD1LG2 (see all 32):
    hsa-miR-520f hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-372 hsa-miR-93 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidPDCD1LG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PDCD1LG2
    Predesigned siRNA for gene silencing in human, mouse, rat PDCD1LG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDCD1LG2

    Clone
    Products:
         
    OriGene clones in human, mouse for PDCD1LG2 (see all 6)
    OriGene ORF clones in mouse, rat for PDCD1LG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDCD1LG2 (NM_025239)
    Sino Biological Human cDNA Clone for PDCD1LG2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCD1LG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD1LG2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PDCD1LG2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PDCD1LG2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD1LG2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14068 VA6-11453) for PDCD1LG2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PD1L2_HUMAN, Q9BQ51: Isoform 3: Secreted (Probable)
    PD1L2_HUMAN, Q9BQ51: Isoform 2: Endomembrane system; Single-pass type I membrane protein
    PD1L2_HUMAN, Q9BQ51: Isoform 1: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PDCD1LG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PDCD1LG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Translocation of ZAP-70 to Immunological synapse
    PD-1 signaling0.72
    2CD28 co-stimulation
    Costimulation by the CD28 family0.44
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with PDCD1LG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PDCD1LG2
        PD-1 signaling


    1 Kegg Pathway  (Kegg details for PDCD1LG2):
        Cell adhesion molecules (CAMs)

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDCD1LG2
    Interactions:

        GeneGlobe Interaction Network for PDCD1LG2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for PDCD1LG2 (Q9BQ513 ENSP000003808554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD1Q151163, ENSP000003350624I2D: score=4 STRING: ENSP00000335062
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS11283156
    GO:0031295T cell costimulation TAS--
    GO:0042102positive regulation of T cell proliferation IEA--
    GO:0042130negative regulation of T cell proliferation IEA--

    Find genes that share ontologies with PDCD1LG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDCD1LG2 (PD1L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PDCD1LG2 gene: 
    NM_025239.3  

    Unigene Cluster for PDCD1LG2:

    Programmed cell death 1 ligand 2
    Hs.532279  [show with all ESTs]
    Unigene Representative Sequence: NM_025239
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397747(uc003zjg.4 uc011lmc.2 uc011lmd.2) ENST00000397745(uc010mhp.1 uc010mho.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PDCD1LG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PDCD1LG2 (see all 32):
    hsa-miR-520f hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-519a hsa-miR-372 hsa-miR-93 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidPDCD1LG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PDCD1LG2
    Predesigned siRNA for gene silencing in human, mouse, rat PDCD1LG2
    Clone
    Products:
         
    OriGene clones in human, mouse for PDCD1LG2 (see all 6)
    OriGene ORF clones in mouse, rat for PDCD1LG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PDCD1LG2 (NM_025239)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCD1LG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD1LG2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PDCD1LG2
    OriGene qSTAR qPCR primer pairs in human, mouse for PDCD1LG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDCD1LG2
      QuantiTect SYBR Green Assays in human, mouse, rat PDCD1LG2
      QuantiFast Probe-based Assays in human, mouse, rat PDCD1LG2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14068 VA6-11453) for PDCD1LG2 

    Additional mRNA sequence: 

    AF329193.1 AF344424.1 AK001872.1 AK093681.1 AY254343.1 AY271901.1 AY271902.1 BC074766.2 
    BC113678.1 BC113680.1 BC143920.1 BC143921.1 DQ336699.1 EF444806.1 

    5 DOTS entries:

    DT.70103836  DT.97818884  DT.102831618  DT.99929705  DT.437754 

    Selected AceView cDNA sequences (see all 34):

    CD370090 BX280151 AA303575 AA044631 BX951459 AF344424 BM929340 AK093681 
    AU135908 BM914319 BC074766 AI990290 CA449391 BM683311 CA442083 CA489316 
    AY271902 AW961323 AK001872 AY254343 AW105205 NM_025239 BU608319 AY271901 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD1LG2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                          -                     
    SP3:                          -                     


    ECgene alternative splicing isoforms for PDCD1LG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PDCD1LG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATCAGAG
    PDCD1LG2 Expression
    About this image


    PDCD1LG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    PDCD1LG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDCD1LG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532279

    UniProtKB/Swiss-Prot: PD1L2_HUMAN, Q9BQ51
    Tissue specificity: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen,
    lymph nodes and thymus

        Custom PCR Arrays for PDCD1LG2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDCD1LG2
    OriGene qSTAR qPCR primer pairs in human, mouse for PDCD1LG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDCD1LG2
    QuantiTect SYBR Green Assays in human, mouse, rat PDCD1LG2
    QuantiFast Probe-based Assays in human, mouse, rat PDCD1LG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD1LG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PDCD1LG2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcd1lg21 , 5 programmed cell death 1 ligand 21, 5 78.25(n)1
    70.39(a)1
      19 (23.93 cM)5
    582051  NM_021396.21  NP_067371.11 
     294109195 
    chicken
    (Gallus gallus)
    Aves PDCD1LG21 programmed cell death 1 ligand 2 52.93(n)
    39.6(a)
      427225  XM_424812.4  XP_424812.4 
    lizard
    (Anolis carolinensis)
    Reptilia PDCD1LG26
    programmed cell death 1 ligand 2
    28(a)
    1 ↔ 1
    2(52343481-52363797)
    zebrafish
    (Danio rerio)
    Actinopterygii CD2746
    CD274 molecule
    14(a)
    1 → many
    21(2474996-2503430) ENSDARG00000059310


    ENSEMBL Gene Tree for PDCD1LG2 (if available)
    TreeFam Gene Tree for PDCD1LG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PDCD1LG2 gene
    CD2742  
    2 SIMAP similar genes for PDCD1LG2 using alignment to 1 protein entry:     PD1L2_HUMAN:
    PDL2    CD274

    Find genes that share paralogs with PDCD1LG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PDCD1LG2 (see all 1387)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123506721,2
    H--5508545(+) ACCCAG/AAAATG 1 -- us2k14Minor allele frequency- A:0.00NS EA 416
    rs736416261,2
    C,F--5508598(+) TAGACA/GTATAG 1 -- us2k12Minor allele frequency- G:0.08WA 120
    rs1482384661,2
    C--5508618(+) GCAGGA/CTAATG 1 -- us2k10--------
    rs1146489961,2
    C,F--5508621(+) GGCTAA/GTGTGC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs625560691,2
    C,F--5508647(+) AGTTTC/TATTTG 1 -- us2k17Minor allele frequency- T:0.11WA NA CSA EA 366
    rs1817065801,2
    --5508878(+) AAACTC/TAAAGC 1 -- us2k10--------
    rs1143400731,2
    F--5508900(+) CATATG/ATCCAT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs38244481,2
    C,F,H--5508986(-) CCCACG/CGCTCC 1 -- us2k113Minor allele frequency- C:0.12NS EA NA WA CSA 786
    rs1412657361,2
    --5508987(+) GAGCCC/GTGGGT 1 -- us2k10--------
    rs1503651341,2
    --5509000(+) AGAAGC/GAGATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PDCD1LG2 (5510545 - 5571282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PDCD1LG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509292CNV Insertion20534489
    nsv466108CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDCD1LG2
    DNA2.0 Custom Variant and Variant Library Synthesis for PDCD1LG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605723    OMIM disorders: --

    1 disease for PDCD1LG2:    
    About MalaCards
    cysticercosis


    Find genes that share disorders with PDCD1LG2           About GenesLikeMe

    2 Novoseek inferred disease relationships for PDCD1LG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 26.4 1 11323285 (1)
    tumors 13.4 9 19724910 (3), 15297412 (2), 19825956 (2), 16129490 (1) (see all 5)

    Genetic Association Database (GAD): PDCD1LG2
    Human Genome Epidemiology (HuGE) Navigator: PDCD1LG2 (5 documents)

    Export disorders for PDCD1LG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PDCD1LG2 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with PDCD1LG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. (PubMed id 11224527)1, 2, 3 Latchman Y.... Freeman G.J. (Nat. Immunol. 2001)
    2. PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children. (PubMed id 17203303)1, 4, 9 Ni R....Hara T. (Hum. Genet. 2007)
    3. Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PubMed id 18322304)1, 4, 9 Hayashi M....Komiya I. (Eur. J. Endocrinol. 2008)
    4. PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (Hum. Genet. 2010)
    5. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. (PubMed id 18992148)1, 4 KA1ry S....BAczieau S. (BMC Cancer 2008)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. Cloning and identification of two novel splice variants of human PD- L2. (PubMed id 15253154)1, 2 He X.-H.... Zeng Y.-Y. (Acta Biochim. Biophys. Sin. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. (PubMed id 11283156)1, 2 Tseng S.-Y.... Tsuchiya H. (J. Exp. Med. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80380 HGNC: 18731 AceView: PDCD1LG2 Ensembl:ENSG00000197646 euGenes: HUgn80380
    ECgene: PDCD1LG2 Kegg: 80380 H-InvDB: PDCD1LG2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PDCD1LG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PDCD1LG2 gene:
    Search GeneIP for patents involving PDCD1LG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PDCD1LG2
     
     EMD Millipore genomic analysis products

      
     Antibodies for PDCD1LG2 (PD-L2/B7-DC)   Browse Cell Culture Products  
     ELISAs for PDCD1LG2 (PD-L2/B7-DC)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for PDCD1LG2 (PD-L2/B7-DC)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PDCD1LG2   OriGene RNAi products in human, mouse, rat for PDCD1LG2  
     OriGene qPCR primer pairs and template standards for PDCD1LG2   OriGene Protein Over-expression Lysate for PDCD1LG2  
     OriGene MassSpec for PDCD1LG2   OriGene clones in human, mouse for PDCD1LG2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PDCD1LG2   OriGene Purified Protein for PDCD1LG2  
     OriGene ORF clones in mouse, rat for PDCD1LG2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PDCD1LG2   OriGene Custom Protein Services for PDCD1LG2  

     
     
     Block miRNA regulation of human, mouse, rat PDCD1LG2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PDCD1LG2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDCD1LG2 Predesigned siRNA for gene silencing in human, mouse, rat PDCD1LG2
     QuantiFast Probe-based Assays in human, mouse, rat PDCD1LG2 QuantiTect SYBR Green Assays in human, mouse, rat PDCD1LG2
     Custom PCR Arrays for PDCD1LG2 Search Chromatin IP Primers for PDCD1LG2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PDCD1LG2  GeneGlobe Interaction Network for PDCD1LG2
     Regulatory tfbs in PDCD1LG2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PDCD1LG2 GenScript cDNA clones with any tag delivered in your preferred vector for PDCD1LG2
     GenScript Custom Assay Services for PDCD1LG2 GenScript Custom overexpressing Cell Line Services for PDCD1LG2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PDCD1LG2 (PD1L2)
     Proteins for PDCD1LG2
     Cell Lysates for PDCD1LG2
     cDNA Clones for PDCD1LG2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PDCD1LG2 antibodies
     PDCD1LG2 proteins
     PDCD1LG2 lysates
     Antibodies for PDCD1LG2
     See all of Abcam's Antibodies, Kits and Proteins for PDCD1LG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PDCD1LG2
     Antibodies for PDCD1LG2
     ELISAs for PDCD1LG2
     CLIAs for PDCD1LG2



     Browse ESI BIO Cell Lines and PureStem Progenitors for PDCD1LG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD1LG2
     SwitchGear 3'UTR luciferase reporter plasmids for PDCD1LG2
     SwitchGear Promoter luciferase reporter plasmids for PDCD1LG2
     ThermoFisher Antibodies for PDCD1LG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD1LG2
     Browse compounds at ApexBio
     Search Addgene for plasmids for PDCD1LG2
      Search eBioscience for proteins for PDCD1LG2
      Search eBioscience for elisas for PDCD1LG2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PDCD1LG2
     antibodies-online antibodies for PDCD1LG2 (134 products)
     antibodies-online kits for PDCD1LG2 (6 products)
     antibodies-online peptides for PDCD1LG2
     antibodies-online proteins for PDCD1LG2 (15 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PDCD1LG2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4