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Aliases for PDCD1LG2 Gene

Aliases for PDCD1LG2 Gene

  • Programmed Cell Death 1 Ligand 2 2 3 5
  • B7 Dendritic Cell Molecule 2 3
  • Programmed Death Ligand 2 3 4
  • Butyrophilin B7-DC 3 4
  • PDCD1 Ligand 2 3 4
  • PD-1 Ligand 2 3 4
  • PDCD1L2 3 4
  • B7-DC 3 4
  • CD273 3 4
  • PD-L2 3 4
  • B7DC 3 4
  • PDL2 3 4
  • PD-1-Ligand 2 3
  • CD273 Antigen 4
  • BA574F11.2 3
  • Btdc 3

External Ids for PDCD1LG2 Gene

Summaries for PDCD1LG2 Gene

GeneCards Summary for PDCD1LG2 Gene

PDCD1LG2 (Programmed Cell Death 1 Ligand 2) is a Protein Coding gene. Diseases associated with PDCD1LG2 include Cysticercosis and Primary Mediastinal Large B-Cell Lymphoma. Among its related pathways are NF-kappaB Signaling and Immune System. An important paralog of this gene is CD274.

UniProtKB/Swiss-Prot for PDCD1LG2 Gene

  • Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).

Gene Wiki entry for PDCD1LG2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDCD1LG2 Gene

Genomics for PDCD1LG2 Gene

Regulatory Elements for PDCD1LG2 Gene

Enhancers for PDCD1LG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDCD1LG2 on UCSC Golden Path with GeneCards custom track

Promoters for PDCD1LG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDCD1LG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDCD1LG2 Gene

Chromosome:
9
Start:
5,510,491 bp from pter
End:
5,571,282 bp from pter
Size:
60,792 bases
Orientation:
Plus strand

Genomic View for PDCD1LG2 Gene

Genes around PDCD1LG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDCD1LG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDCD1LG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDCD1LG2 Gene

Proteins for PDCD1LG2 Gene

  • Protein details for PDCD1LG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ51-PD1L2_HUMAN
    Recommended name:
    Programmed cell death 1 ligand 2
    Protein Accession:
    Q9BQ51
    Secondary Accessions:
    • Q14CN8
    • Q5T7Z6
    • Q6JXL8
    • Q6JXL9

    Protein attributes for PDCD1LG2 Gene

    Size:
    273 amino acids
    Molecular mass:
    30957 Da
    Quaternary structure:
    • Interacts with PDCD1.

    Alternative splice isoforms for PDCD1LG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDCD1LG2 Gene

Proteomics data for PDCD1LG2 Gene at MOPED

Post-translational modifications for PDCD1LG2 Gene

  • Glycosylation at Asn 37, Asn 64, Asn 157, Asn 163, and Asn 189
  • Modification sites at PhosphoSitePlus

Other Protein References for PDCD1LG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PDCD1LG2 (PD-L2/B7-DC)
  • Cell Signaling Technology (CST) Antibodies for PDCD1LG2 (PDCD1LG2)

No data available for DME Specific Peptides for PDCD1LG2 Gene

Domains & Families for PDCD1LG2 Gene

Protein Domains for PDCD1LG2 Gene

Suggested Antigen Peptide Sequences for PDCD1LG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ51

UniProtKB/Swiss-Prot:

PD1L2_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with PDCD1LG2: view

Function for PDCD1LG2 Gene

Molecular function for PDCD1LG2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4/interleukin-4.
genes like me logo Genes that share phenotypes with PDCD1LG2: view

Animal Models for PDCD1LG2 Gene

MGI Knock Outs for PDCD1LG2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PDCD1LG2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PDCD1LG2 Gene

Localization for PDCD1LG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDCD1LG2 Gene

Isoform 3: Secreted.
Isoform 2: Endomembrane system; Single-pass type I membrane protein.
Isoform 1: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDCD1LG2 Gene COMPARTMENTS Subcellular localization image for PDCD1LG2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PDCD1LG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PDCD1LG2: view

Pathways & Interactions for PDCD1LG2 Gene

genes like me logo Genes that share pathways with PDCD1LG2: view

Pathways by source for PDCD1LG2 Gene

1 Cell Signaling Technology pathway for PDCD1LG2 Gene

Interacting Proteins for PDCD1LG2 Gene

Gene Ontology (GO) - Biological Process for PDCD1LG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 11283156
GO:0032689 negative regulation of interferon-gamma production IMP 12538684
GO:0042130 negative regulation of T cell proliferation IEA --
GO:0046007 negative regulation of activated T cell proliferation IMP 12538684
genes like me logo Genes that share ontologies with PDCD1LG2: view

No data available for SIGNOR curated interactions for PDCD1LG2 Gene

Drugs & Compounds for PDCD1LG2 Gene

No Compound Related Data Available

Transcripts for PDCD1LG2 Gene

mRNA/cDNA for PDCD1LG2 Gene

Unigene Clusters for PDCD1LG2 Gene

Programmed cell death 1 ligand 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDCD1LG2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3: -

Relevant External Links for PDCD1LG2 Gene

GeneLoc Exon Structure for
PDCD1LG2
ECgene alternative splicing isoforms for
PDCD1LG2

Expression for PDCD1LG2 Gene

mRNA expression in normal human tissues for PDCD1LG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDCD1LG2 Gene

This gene is overexpressed in Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for PDCD1LG2 Gene

This gene is overexpressed in Urine (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PDCD1LG2 Gene



SOURCE GeneReport for Unigene cluster for PDCD1LG2 Gene Hs.532279

mRNA Expression by UniProt/SwissProt for PDCD1LG2 Gene

Q9BQ51-PD1L2_HUMAN
Tissue specificity: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.
genes like me logo Genes that share expression patterns with PDCD1LG2: view

Protein tissue co-expression partners for PDCD1LG2 Gene

- Elite partner

Primer Products

Orthologs for PDCD1LG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDCD1LG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDCD1LG2 35
  • 81.44 (n)
  • 70.59 (a)
PDCD1LG2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDCD1LG2 35
  • 79.9 (n)
  • 67.56 (a)
PDCD1LG2 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdcd1lg2 35
  • 78.25 (n)
  • 70.39 (a)
Pdcd1lg2 16
Pdcd1lg2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDCD1LG2 35
  • 99.63 (n)
  • 98.9 (a)
PDCD1LG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdcd1lg2 35
  • 77.5 (n)
  • 69.55 (a)
oppossum
(Monodelphis domestica)
Mammalia PDCD1LG2 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDCD1LG2 36
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDCD1LG2 35
  • 52.93 (n)
  • 39.6 (a)
lizard
(Anolis carolinensis)
Reptilia PDCD1LG2 36
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CD274 36
  • 14 (a)
OneToMany
Species with no ortholog for PDCD1LG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDCD1LG2 Gene

ENSEMBL:
Gene Tree for PDCD1LG2 (if available)
TreeFam:
Gene Tree for PDCD1LG2 (if available)

Paralogs for PDCD1LG2 Gene

Paralogs for PDCD1LG2 Gene

(2) SIMAP similar genes for PDCD1LG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PDCD1LG2: view

Variants for PDCD1LG2 Gene

Sequence variations from dbSNP and Humsavar for PDCD1LG2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7854303 - 5,557,672(+) CCCCT(C/T)CTGCA reference, missense
rs12339171 - 5,534,862(+) AGCCA(C/G)TTTGC reference, missense
rs7854413 - 5,557,708(+) AGTGA(C/T)AGCCC reference, missense
rs951145 -- 5,536,361(-) CACTG(C/T)CCCTG intron-variant
rs1009759 -- 5,556,786(-) GGTAC(C/T)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDCD1LG2 Gene

Variant ID Type Subtype PubMed ID
nsv466108 CNV Gain 19166990
nsv509292 CNV Insertion 20534489

Variation tolerance for PDCD1LG2 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.22; 81.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PDCD1LG2 Gene

Disorders for PDCD1LG2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PDCD1LG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cysticercosis
  • taeniasis
primary mediastinal large b-cell lymphoma
  • large cell lymphoma of the mediastinum
mediastinal gray zone lymphoma
  • mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
mediastinal malignant lymphoma
  • lymphoma of mediastinum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PDCD1LG2

Genetic Association Database (GAD)
PDCD1LG2
Human Genome Epidemiology (HuGE) Navigator
PDCD1LG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDCD1LG2
genes like me logo Genes that share disorders with PDCD1LG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDCD1LG2 Gene

Publications for PDCD1LG2 Gene

  1. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. (PMID: 11224527) Latchman Y. … Freeman G.J. (Nat. Immunol. 2001) 2 3 4 67
  2. Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions. (PMID: 19729380) Nagamatsu T. … Barrier B.F. (Hum. Reprod. 2009) 3 23
  3. Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients. (PMID: 18322304) Hayashi M. … Komiya I. (Eur. J. Endocrinol. 2008) 3 23
  4. Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studies. (PMID: 18378285) Heinecke L. … Kim J. (J. Allergy Clin. Immunol. 2008) 3 23
  5. Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis. (PMID: 18566376) Jurado J.O. … GarcA-a V.E. (J. Immunol. 2008) 3 23

Products for PDCD1LG2 Gene

Sources for PDCD1LG2 Gene

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