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PDCD11 Gene

protein-coding   GIFtS: 53
GCID: GC10P105156

Programmed Cell Death 11

  See PDCD11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Programmed Cell Death 111 2     KIAA01853 5
NFBP2 3 5     ALG-42
Programmed Cell Death Protein 112 3     RRP52
NF-Kappa-B-Binding Protein2 3     Apoptosis-Linked Gene 42
ALG42 5     Protein RRP5 Homolog2

External Ids:    HGNC: 134081   Entrez Gene: 229842   Ensembl: ENSG000001488437   OMIM: 6123335   UniProtKB: Q146903   

Export aliases for PDCD11 gene to outside databases

Previous GC identifers: GC10P104049 GC10P104390 GC10P105287 GC10P104821 GC10P104819 GC10P105146 GC10U900633 GC10P098787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PDCD11 Gene:
PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus
and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 (PubMed 14624448); Sweet et
al., 2008 (PubMed 17654514)).(supplied by OMIM, Oct 2008)

GeneCards Summary for PDCD11 Gene:
PDCD11 (programmed cell death 11) is a protein-coding gene. Diseases associated with PDCD11 include epididymo-orchitis, and orchitis. GO annotations related to this gene include RNA binding and transcription factor binding.

UniProtKB/Swiss-Prot: RRP5_HUMAN, Q14690
Function: Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and
2 of the 47S precursor. Directly interacts with U3 snoRNA
Function: Involved in the biogenesis of rRNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PDCD11 gene promoter:
         RP58   AML1a   FOXO3   CUTL1   Nkx2-5   POU3F2   Evi-1   FOXO3b   SRY   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDCD11 promoter sequence
   Search Chromatin IP Primers for PDCD11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PDCD11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24.32

PDCD11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD11 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105156:  view genomic region     (about GC identifiers)

Start:
105,156,405 bp from pter      End:
105,206,049 bp from pter
Size:
49,645 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RRP5_HUMAN, Q14690 (See protein sequence)
Recommended Name: Protein RRP5 homolog  
Size: 1871 amino acids; 208701 Da
Subunit: Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA
Sequence caution: Sequence=AAG01992.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=AAH49838.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH64486.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAH80560.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAI11041.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAA11502.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PDCD11:
1WI5 (3D)    
Secondary accessions: Q2TA92 Q5W093 Q6P2J3 Q86VQ8 Q9H4P1

Explore the universe of human proteins at neXtProt for PDCD11: NX_Q14690

Explore proteomics data for PDCD11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys219, Lys1781
  • Modification sites at PhosphoSitePlus

  • See PDCD11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055791.1  
    ENSEMBL proteins: 
     ENSP00000358812   ENSP00000474606  

    PDCD11 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR003029 Rbsml_prot_S1_RNA-bd_dom
     IPR011990 TPR-like_helical
     IPR012340 NA-bd_OB-fold
     IPR003107 HAT
     IPR008847 Suf

    Graphical View of Domain Structure for InterPro Entry Q14690

    ProtoNet protein and cluster: Q14690

    2 Blocks protein domains:
    IPB003029 RNA binding S1
    IPB003107 RNA-processing protein


    UniProtKB/Swiss-Prot: RRP5_HUMAN, Q14690
    Similarity: Contains 4 HAT repeats
    Similarity: Contains 12 S1 motif domains


    Find genes that share domains with PDCD11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRP5_HUMAN, Q14690
    Function: Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and
    2 of the 47S precursor. Directly interacts with U3 snoRNA
    Function: Involved in the biogenesis of rRNA (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI14624448
    GO:0008134transcription factor binding IPI14624448
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with PDCD11           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for PDCD11:
     Decreased cell number  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased number of mitotic ce 
     Nucleolar pre-40S maturation d  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PDCD11

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    hsa-mir-361-3p (MIRT038273), hsa-let-7b-5p (MIRT032267), hsa-mir-320b (MIRT036204), hsa-mir-98-5p (MIRT027547), hsa-let-7e-5p (MIRT051587), hsa-mir-4286 (MIRT052845), hsa-mir-17-3p (MIRT050784), hsa-mir-615-3p (MIRT040145)

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    8 qRT-PCR Assays for microRNAs that regulate PDCD11:
    hsa-miR-424 hsa-miR-298 hsa-miR-15a hsa-miR-16 hsa-miR-195 hsa-miR-497 hsa-miR-15b hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidPDCD11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PDCD11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RRP5_HUMAN, Q14690: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA14624448
    GO:0005730nucleolus IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with PDCD11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PDCD11
    Interactions:

        GeneGlobe Interaction Network for PDCD11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PDCD11 (Q146901, 2, 3 ENSP000003588124) via UniProtKB, MINT, STRING, and/or I2D (see all 446)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0006396RNA processing ----
    GO:0006397mRNA processing IEA--

    Find genes that share ontologies with PDCD11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PDCD11 (RRP5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PDCD11 gene: 
    NM_014976.1  

    Unigene Cluster for PDCD11:

    Programmed cell death 11
    Hs.239499  [show with all ESTs]
    Unigene Representative Sequence: NM_014976
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369797(uc001kwy.1) ENST00000493610 ENST00000471061 ENST00000490787
    ENST00000466959 ENST00000478543
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate PDCD11:
    hsa-miR-424 hsa-miR-298 hsa-miR-15a hsa-miR-16 hsa-miR-195 hsa-miR-497 hsa-miR-15b hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidPDCD11 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PDCD11
      QuantiFast Probe-based Assays in human, mouse, rat PDCD11

    Additional mRNA sequence: 

    AK294971.1 AK307418.1 AY007124.1 BC007698.2 BC023615.2 BC049838.1 BC064486.1 BC080560.1 
    BC111040.1 D80007.1 

    13 DOTS entries:

    DT.313964  DT.101967972  DT.95092796  DT.95212448  DT.100816941  DT.91932826  DT.92434690  DT.100036613 
    DT.100816939  DT.40188920  DT.92324298  DT.92434687  DT.95212445 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PDCD11 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:              -                                                                                                                                             
    SP5:                                            -                                                                                                               

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
    SP1:                          -                       -     -                                                               
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for PDCD11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PDCD11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACTGAGAA
    PDCD11 Expression
    About this image


    PDCD11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PDCD11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PDCD11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.239499
        Custom PCR Arrays for PDCD11
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PDCD11 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcd111 , 5 programmed cell death 111, 5 82.96(n)1
    81.9(a)1
      19 (39.24 cM)5
    185721  NM_011053.21  NP_035183.21 
     470907665 
    chicken
    (Gallus gallus)
    Aves PDCD111 programmed cell death 11 62.82(n)
    58.21(a)
      423874  XM_421739.4  XP_421739.4 
    lizard
    (Anolis carolinensis)
    Reptilia PDCD116
    programmed cell death 11
    55(a)
    1 ↔ 1
    3(40652240-40692041)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pdcd111 programmed cell death 11 58.72(n)
    52.06(a)
      100327235  XM_004915851.1  XP_004915908.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pdcd111 programmed cell death 11 54.77(n)
    45.21(a)
      794079  NM_001089368.2  NP_001082837.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG57286
    --
    25(a)
    1 ↔ 1
    3R(20154177-20159036)
    worm
    (Caenorhabditis elegans)
    Secernentea let-7166
    Protein LET-716 (let-716) mRNA, complete cds
    23(a)
    1 ↔ 1
    III(6383552-6389413) WBGene00002850
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRP5(YMR229C)4 RNA binding protein with preference for single stranded more   --   13(731123-725934) 855269  NP_013956.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G119641 AT3G11964 44.8(n)
    32.6(a)
      820370  NM_112030.4  NP_187803.4 
    rice
    (Oryza sativa)
    Liliopsida Os07g02033001 Os07g0203300 48.57(n)
    39.11(a)
      4342673  NM_001065674.1  NP_001059139.1 


    ENSEMBL Gene Tree for PDCD11 (if available)
    TreeFam Gene Tree for PDCD11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PDCD11 (see all 1060)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs107867521,2
    C--105158639(+) ATGGTG/AGTATA 1 -- int113Minor allele frequency- A:0.06NA WA CSA EA 376
    rs1157207021,2
    F--105158721(+) ACCCAA/GTATTG 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1415651511,2
    --105158891(+) TGAGAC/TGAAGT 1 -- int10--------
    rs1850997371,2
    --105158924(+) AGTGCA/GGTGGC 1 -- int10--------
    rs1882013181,2
    --105159012(+) ATGTTA/GGCCAG 1 -- int10--------
    rs1809963371,2
    --105159526(+) CTGCAA/GCCTCC 1 -- int10--------
    rs1479729981,2
    --105159592(+) GGTGCA/GTGCTG 1 -- int10--------
    rs2002091101,2
    --105159632(+) AGTGG-/AAAAAA 1 -- int10--------
    rs749663831,2
    F--105159770(+) AAACCA/TCATAG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1467041971,2
    C--105159974(+) GGCGG-/CCCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PDCD11 (105156405 - 105206049 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PDCD11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7529CNV Insertion18451855
    nsv524966CNV Loss19592680
    nsv518987CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PDCD11
    DNA2.0 Custom Variant and Variant Library Synthesis for PDCD11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612333    OMIM disorders: --

    2 diseases for PDCD11:    
    About MalaCards
    epididymo-orchitis    orchitis

    1 disease from the University of Copenhagen DISEASES database for PDCD11:
    epididymo-orchitis

    Find genes that share disorders with PDCD11           About GenesLikeMe


    Export disorders for PDCD11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PDCD11 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with PDCD11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence for involvement of NFBP in processing of ribosomal RNA. (PubMed id 17654514)1, 2 Sweet T.... Amini S. (J. Cell. Physiol. 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification of a novel protein from glial cells based on its ability to interact with NF-kappaB subunits. (PubMed id 14624448)1, 2 Sweet T.... Amini S. (J. Cell. Biochem. 2003)
    4. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    5. Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4. (PubMed id 10229231)1, 3 Lacana E. and D'Adamio L. (Nat. Med. 1999)
    6. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22984 HGNC: 13408 Ensembl:ENSG00000148843 euGenes: HUgn22984 ECgene: PDCD11
    H-InvDB: PDCD11

    (According to HUGE)
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    HUGE: KIAA0185

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PDCD11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PDCD11 gene:
    Search GeneIP for patents involving PDCD11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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