Aliases for PDCD11 Gene
External Ids for PDCD11 Gene
Previous GeneCards Identifiers for PDCD11 Gene
PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]
GeneCards Summary for PDCD11 Gene
PDCD11 (Programmed Cell Death 11) is a Protein Coding gene. Diseases associated with PDCD11 include Epididymo-Orchitis. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor binding.
UniProtKB/Swiss-Prot for PDCD11 Gene
Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
Involved in the biogenesis of rRNA.