PDCD10 Gene
protein-coding GIFtS: 54
GCID: GC03M167381
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|
programmed cell death 10(Previous name: cerebral cavernous malformations 3 )
(Previous symbol: CCM3)
| |
Aliases
for PDCD10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Programmed Cell Death 101 2 | | TF-1 Cell Apoptosis-Related Protein 152 3 | | CCM31 2 3 5 | | Cerebral Cavernous Malformations 31 | | TFAR151 2 3 5 | | Apoptosis-Related Protein 152 | | Cerebral Cavernous Malformations 3 Protein2 3 | | Programmed Cell Death Protein 102 |
Export aliases for PDCD10 gene to outside databasesPrevious GC identifers: GC03M164691 GC03M168454 GC03M168803 GC03M168722 GC03M168884 |
Summaries
for PDCD10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PDCD10:
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with theserine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It alsointeracts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathwayessential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which arevascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encodingthe same protein, have been identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinaseactivity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex.Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required fornormal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonicdevelopment (By similarity)
Gene Wiki entry for PDCD10
|
Genomic Views
for PDCD10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PDCD10 gene promoter:
p300 NF-E2 p45 NF-E2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PDCD10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDCD10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.1 Ensembl cytogenetic band: 3q26.1 HGNC cytogenetic band: 3q26.1PDCD10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M167381: view genomic region
(about GC identifiers)
Start:
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167,401,086 bp from pter |
End:
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167,452,727 bp from pter |
Size:
|
51,642 bases |
Orientation:
|
minus strand |
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Proteins
for PDCD10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8 (See
protein sequence)Recommended Name: Programmed cell death protein 10 Size: 212 amino acids; 24702 Da
Subunit: Homodimer. Interacts (via C-terminus) with CCM2 and PXN. Interacts (via N-terminus) with MST4, STK24 andSTK25. Interacts with GOLGA2. Identified in a complex with CCM1 and CCM2. Interacts with KDR/VEGFR2. Interaction withKDR/VEGFR2 is enhanced by stimulation with VEGFA (By similarity)
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cellmembrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co-localizes with endogenous PXN at theleading edges of migrating cells
6 PDB 3D structures from  and Proteopedia  for PDCD10:3AJM (3D)
3L8I (3D)
3L8J (3D)
3RQE (3D)
3RQF (3D)
3RQG (3D)
Secondary accessions: A8K515 D3DNN5 O14811Explore the universe of human proteins at neXtProt for PDCD10: NX_Q9BUL8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BUL8
PDCD10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_009148.2 NP_665858.1 NP_665859.1
ENSEMBL proteins: ENSP00000376506 ENSP00000418317 ENSP00000420553 ENSP00000417309 ENSP00000420021 ENSP00000417202 ENSP00000417118 ENSP00000420266 ENSP00000417876 ENSP00000420308 ENSP00000420424 ENSP00000420014 ENSP00000420450 ENSP00000418160
Human Recombinant Protein Products for PDCD10:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
PDCD10 for ontologies About GeneDecksing
PDCD10 Antibody Products:
Assay Products for PDCD10: |
Protein
Domains /
Families
for PDCD10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PDCD10 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BUL8ProtoNet protein and cluster: Q9BUL8 UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8Similarity: Belongs to the PDCD10 family |
Function
for PDCD10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: PDC10_HUMAN, Q9BUL8Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinaseactivity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex.Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required fornormal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonicdevelopment (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
PDCD10 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for PDCD10:
15 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Pdcd10):
PDCD10 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Pdcd10tm1.1Wmin for PDCD10
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD10 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD10 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): PDCD10 (NM_145859) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDCD10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD10 |
|
Pathways & Interactions
for PDCD10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Validated targets of C-MYC transcriptional activation | |
1  BioSystems Pathway for PDCD10
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDCD10
5/28 Interacting proteins for PDCD10 (Q9BUL81, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CCM2 | Q9BSQ51, 2, 3 | EBI-2556229,EBI-1573056 MINT-8404432 I2D:
score=1 | | STK24 | Q9Y6E01, 3 | EBI-2556229,EBI-1054809 I2D:
score=5 | | STK25 | O005061, 3 | EBI-2556229,EBI-5773834 I2D:
score=5 | | STRN | O438151, 3 | EBI-2556229,EBI-1046642 I2D:
score=2 | | PTPN13 | Q129231, 3 | EBI-2556229,EBI-355227 I2D:
score=1 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
PDCD10 for ontologies About GeneDecksing
|
Drugs & Compounds
for PDCD10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PDCD10
Search CenterWatch for drugs/clinical trials and news about PDCD10 / PDC10
|
Transcripts
for PDCD10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PDCD10 gene (3 alternative transcripts): NM_007217.3 NM_145859.1 NM_145860.1 Unigene Cluster for PDCD10: Programmed cell death 10 Hs.478150 [show with all ESTs]Unigene Representative Sequence: BC00250618 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392750(uc003fex.3) ENST00000473645(uc003fey.3 uc003fez.3)
ENST00000497056 ENST00000492396 ENST00000461494 ENST00000470131 ENST00000475915
ENST00000487947 ENST00000471885 ENST00000479121 ENST00000462725 ENST00000492139
ENST00000483451 ENST00000494502 ENST00000462830 ENST00000464360 ENST00000481136
ENST00000487678
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD10 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD10 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): PDCD10 (NM_145859) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PDCD10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD10 |
Additional cDNA sequence: AF022385.1 AK291130.1 BC002506.1 BC016353.1 CR457107.1 17 DOTS entries: DT.92446702 DT.311371 DT.100886934 DT.91729418 DT.40110826 DT.100886933 DT.92446708 DT.91640498 DT.91651122 DT.97814093 DT.100886931 DT.120869271 DT.120869312 DT.92338755 DT.92446710 DT.92446712 DT.97777196 24/332 AceView cDNA sequences (see all 332): AW383024 AA195035 AI253079 BI260338 AA599041 AA195200 BU948431 BQ643761 BM843544 BQ428381 CR597382 BU677227 BQ018007 AI261276 CK823226 NM_007217 BE672189 AW383044 BQ650198 BM843416 NM_145860 BM804624 AI352636 CA425437
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD10 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PDCD10
|
Expression
for PDCD10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PDCD10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCCTGTGT
About this image
See PDCD10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PDCD10
SOURCE GeneReport for Unigene cluster: Hs.478150
UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for PDCD10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDCD10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDCD10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDCD10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDCD10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD10 |
Orthologs
for PDCD10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PDCD10 gene from 7/24 species (see all 24) About this table
ENSEMBL Gene Tree for PDCD10 (if available)
TreeFam Gene Tree for PDCD10 (if available) |
Paralogs
for PDCD10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PDCD10 gene
PDCD10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PDCD10
PGOHUM00000249655
|
Genomic Variants
for PDCD10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PDCD10 (167401086 - 167452727 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PDCD10: --
Human Gene Mutation Database (HGMD): PDCD10
| SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing PDCD10: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDCD10 |
|
Disorders
/ Diseases
for PDCD10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PDCD10 for disorders About GeneDecksing
OMIM gene information: 609118
OMIM disorders: 603285
UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8
Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:603285]. Cerebralcavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result inhemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5%in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions arecharacterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without anyintervening neural tissue, ranging in diameter from a few millimeters to several centimeters
18  diseases for PDCD10: About MalaCardscerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 cerebritis
klippel-trenaunay syndrome seizures cerebral hemorrhage vascular malformations
cerebrovascular accident venous malformations proteus syndrome headache
brain disease hematopoiesis meningioma retinitis
leukemia neuronitis
1 disease from the University of Copenhagen DISEASES database for PDCD10:Klippel-Trenaunay syndrome 4 Novoseek disease relationships for PDCD10 gene About this table
GeneTests: PDCD10
Familial Cerebral Cavernous Malformation
Human Genome Epidemiology (HuGE) Navigator: PDCD10 (5 documents)
Export disorders for PDCD10 gene to outside databases
|
Publications
for PDCD10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PDCD10 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with PDCD10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations. (PubMed id 15543491)1, 2, 3, 9 Bergametti F....Tournier-Lasserve E. (2005)
- Functional analyses of human and zebrafish 18-amino a cid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. (PubMed id 19370760)1, 2, 9 Voss K....Felbor U. (2009)
- CCM3/PDCD10 stabilizes GCKIII proteins to promote Gol gi assembly and cell orientation. (PubMed id 20332113)1, 2 Fidalgo M....Zalvide J. (2010)
- Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. (PubMed id 20489202)1, 2 Li X.... Boggon T.J. (2010)
- PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. (PubMed id 17360971)1, 2 Ma X....Ma D. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3. (PubMed id 16284570)1, 9 Guclu B....Gunel M. (2005)
- CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations. (PubMed id 17657516)1, 9 Voss K....Felbor U. (2007)
- Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus. (PubMed id 16329096)1, 9 Liquori C.L....Marchuk D.A. (2006)
- Identification of an Arg35X mutation in the PDCD10 gene in a patient with cerebral and multiple spinal cavernous malformations. (PubMed id 18035376)1, 9 Lee S.T....Cho Y.D. (2008)
|
External Searches for PDCD10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PDCD10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PDCD10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PDCD10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PDCD10 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PDCD10 |
|
| | |
About This Section
| Patent Information for PDCD10 gene:
Search GeneIP for patents involving PDCD10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PDCD10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PDCD10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PDCD10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PDCD10 | | | OriGene Protein Over-expression Lysate for PDCD10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PDCD10 | | OriGene 3'-UTR Clone for PDCD10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PDCD10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PDCD10 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PDCD10 | | OriGene Custom Protein Services for PDCD10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDCD10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PDCD10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDCD10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDCD10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDCD10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDCD10 |
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| | | | Search Tocris compounds for PDCD10 |
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 | | | PDCD10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD10 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for PDCD10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD10 |
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