Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PDCD10 Gene

protein-coding   GIFtS: 58
GCID: GC03M167381

Programmed Cell Death 10

(Previous name: cerebral cavernous malformations 3)
(Previous symbol: CCM3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Programmed Cell Death 101 2     TF-1 Cell Apoptosis-Related Protein 152 3
CCM31 2 3 5     Cerebral Cavernous Malformations 31
TFAR152 3 5     Apoptosis-Related Protein 152
Cerebral Cavernous Malformations 3 Protein2 3     Programmed Cell Death Protein 102

External Ids:    HGNC: 87611   Entrez Gene: 112352   Ensembl: ENSG000001142097   OMIM: 6091185   UniProtKB: Q9BUL83   

Export aliases for PDCD10 gene to outside databases

Previous GC identifers: GC03M164691 GC03M168454 GC03M168803 GC03M168722 GC03M168884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDCD10 Gene:
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with
the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It
also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling
pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous
malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple
alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PDCD10 Gene: 
PDCD10 (programmed cell death 10) is a protein-coding gene. Diseases associated with PDCD10 include cerebral cavernous malformations 3, and familial cerebral cavernous malformation 3. GO annotations related to this gene include protein homodimerization activity and protein N-terminus binding.

UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8
Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase
activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi
complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown.
Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and
hematopoiesis during embryonic development (By similarity)

Gene Wiki entry for PDCD10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDCD10 gene promoter:
         p300   NF-E2 p45   NF-E2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPDCD10 promoter sequence
   Search SABiosciences Chromatin IP Primers for PDCD10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDCD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1   Ensembl cytogenetic band:  3q26.1   HGNC cytogenetic band: 3q26.1

PDCD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDCD10 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M167381:  view genomic region     (about GC identifiers)

Start:
167,401,086 bp from pter      End:
167,452,727 bp from pter
Size:
51,642 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8 (See protein sequence)
Recommended Name: Programmed cell death protein 10  
Size: 212 amino acids; 24702 Da
Subunit: Homodimer. Interacts (via C-terminus) with CCM2 and PXN. Interacts (via N-terminus) with MST4, STK24 and
STK25. Interacts with GOLGA2. Identified in a complex with CCM1 and CCM2. Interacts with KDR/VEGFR2. Interaction
with KDR/VEGFR2 is enhanced by stimulation with VEGFA (By similarity)
Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell
membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co-localizes with endogenous PXN at the
leading edges of migrating cells
6/7 PDB 3D structures from and Proteopedia for PDCD10 (see all 7):
3AJM (3D)        3L8I (3D)        3L8J (3D)        3RQE (3D)        3RQF (3D)        3RQG (3D)    
Secondary accessions: A8K515 D3DNN5 O14811

Explore the universe of human proteins at neXtProt for PDCD10: NX_Q9BUL8

Explore proteomics data for PDCD10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BUL8

  • PDCD10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PDCD10 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_009148.2  NP_665858.1  NP_665859.1  

    ENSEMBL proteins: 
     ENSP00000376506   ENSP00000418317   ENSP00000420553   ENSP00000417309   ENSP00000420021  
     ENSP00000417202   ENSP00000417118   ENSP00000420266   ENSP00000417876   ENSP00000420308  
     ENSP00000420424   ENSP00000420014   ENSP00000420450   ENSP00000418160  

    Human Recombinant Protein Products for PDCD10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PDCD10
    OriGene Protein Over-expression Lysate for PDCD10
    OriGene MassSpec for PDCD10 
    OriGene Custom Protein Services for PDCD10
    GenScript Custom Purified and Recombinant Proteins Services for PDCD10
    Novus Biologicals PDCD10 Proteins
    Novus Biologicals PDCD10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PDCD10 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005829cytosol IDA17360971
    GO:0005886plasma membrane IEA--

    PDCD10 for ontologies           About GeneDecksing



    PDCD10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PDCD10
    GenScript Custom Superior Antibodies Services for PDCD10
    Novus Biologicals PDCD10 Antibodies
    Abcam antibodies for PDCD10
    Cloud-Clone Corp. Antibodies for PDCD10 
    Search ThermoFisher Antibodies for PDCD10
    LSBio Antibodies in human, mouse, rat for PDCD10 

    Assay Products for PDCD10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PDCD10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDCD10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PDCD10 
    Cloud-Clone Corp. CLIAs for PDCD10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009652 DUF1241

    Graphical View of Domain Structure for InterPro Entry Q9BUL8

    ProtoNet protein and cluster: Q9BUL8

    UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8
    Similarity: Belongs to the PDCD10 family


    PDCD10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PDC10_HUMAN, Q9BUL8
    Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase
    activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi
    complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown.
    Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and
    hematopoiesis during embryonic development (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0042803protein homodimerization activity IPI--
    GO:0047485protein N-terminus binding IPI--
         
    PDCD10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PDCD10:
     Increased cell death HMECs cel 

         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Pdcd10):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size  hematopoietic system  immune system  integument  mortality/aging 
     muscle  nervous system  normal  tumorigenesis  vision/eye 

    PDCD10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pdcd10tm1.1Wami for PDCD10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PDCD10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDCD10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PDCD10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PDCD10 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDCD10
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PDCD10 (see all 39):
    hsa-miR-21* hsa-miR-4272 hsa-miR-30d hsa-miR-4315 hsa-miR-374a hsa-miR-30a hsa-miR-186 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidPDCD10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PDCD10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDCD10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PDCD10
    Sirion Biotech Customized adenovirus for overexpression of PDCD10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PDCD10 (see all 19)
    OriGene ORF clones in mouse, rat for PDCD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PDCD10 (NM_145859)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD10
    Sirion Biotech Customized lentivirus for stable overexpression of PDCD10 
                         Customized lentivirus expression plasmids for stable overexpression of PDCD10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PDCD10
    Search LifeMap BioReagents cell lines for PDCD10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PDCD10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    1 BioSystems Pathway for PDCD10
        Validated targets of C-MYC transcriptional activation


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDCD10

    5/28 Interacting proteins for PDCD10 (Q9BUL81, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCM2Q9BSQ51, 2, 3EBI-740195,EBI-1573056 MINT-8404432 I2D: score=1 
    STK24Q9Y6E01, 3EBI-740195,EBI-740175 I2D: score=5 
    STK25O005061, 3EBI-740195,EBI-618295 I2D: score=5 
    STRNO438151, 3EBI-740195,EBI-1046642 I2D: score=2 
    PTPN13Q129231, 3EBI-740195,EBI-355227 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006915apoptotic process IEA--
    GO:0008284positive regulation of cell proliferation IDA17360971
    GO:0043066negative regulation of apoptotic process IDA17360971
    GO:0043406positive regulation of MAP kinase activity IDA17360971

    PDCD10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDCD10 (PDC10)

    Search CenterWatch for drugs/clinical trials and news about PDCD10 / PDC10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PDCD10 gene (3 alternative transcripts): 
    NM_007217.3  NM_145859.1  NM_145860.1  

    Unigene Cluster for PDCD10:

    Programmed cell death 10
    Hs.478150  [show with all ESTs]
    Unigene Representative Sequence: BC002506
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392750(uc003fex.3) ENST00000473645(uc003fey.3 uc003fez.3)
    ENST00000497056 ENST00000492396 ENST00000461494 ENST00000470131 ENST00000475915
    ENST00000487947 ENST00000471885 ENST00000479121 ENST00000462725 ENST00000492139
    ENST00000483451 ENST00000494502 ENST00000462830 ENST00000464360 ENST00000481136
    ENST00000487678
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PDCD10
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PDCD10 (see all 39):
    hsa-miR-21* hsa-miR-4272 hsa-miR-30d hsa-miR-4315 hsa-miR-374a hsa-miR-30a hsa-miR-186 hsa-miR-642b
    SwitchGear 3'UTR luciferase reporter plasmidPDCD10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PDCD10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDCD10
    Clone
    Products:
         
    OriGene clones in human, mouse for PDCD10 (see all 19)
    OriGene ORF clones in mouse, rat for PDCD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PDCD10 (NM_145859)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PDCD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD10
    Sirion Biotech Customized lentivirus for stable overexpression of PDCD10 
                         Customized lentivirus expression plasmids for stable overexpression of PDCD10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PDCD10
    OriGene qSTAR qPCR primer pairs in human, mouse for PDCD10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDCD10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDCD10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDCD10

    Additional mRNA sequence: 

    AF022385.1 AK291130.1 BC002506.1 BC016353.1 CR457107.1 

    17 DOTS entries:

    DT.92446702  DT.311371  DT.100886934  DT.91729418  DT.40110826  DT.100886933  DT.92446708  DT.91640498 
    DT.91651122  DT.97814093  DT.100886931  DT.120869271  DT.120869312  DT.92338755  DT.92446710  DT.92446712 
    DT.97777196 

    24/332 AceView cDNA sequences (see all 332):

    NM_007217 AW383024 BU677227 CD512747 CR616910 BQ428381 BQ214640 NM_145860 
    CB241583 AI261276 AI253079 AI915587 AI352636 CB528710 AA599041 BU948431 
    BE504502 BM843416 AW383044 BM986930 AA195200 BM843544 BM804624 BE672189 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PDCD10 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                          -     -     -     -                             -     -     -                                                   
    SP2:                                -     -           -                       -     -     -                                                   
    SP3:                          -     -     -     -     -                       -     -     -                                                   
    SP4:                          -     -     -           -                       -     -     -                                                   
    SP5:                                            -     -                       -     -     -                                                   


    ECgene alternative splicing isoforms for PDCD10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PDCD10 expression in normal human tissues (normalized intensities)      PDCD10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCCTGTGT
    PDCD10 Expression
    About this image


    PDCD10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See PDCD10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PDCD10

    SOURCE GeneReport for Unigene cluster: Hs.478150

    UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for PDCD10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PDCD10
    OriGene qSTAR qPCR primer pairs in human, mouse for PDCD10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PDCD10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDCD10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDCD10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PDCD10 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pdcd101 , 5 programmed cell death 101, 5 94.81(n)1
    99.53(a)1
      3 (33.76 cM)5
    564261  NM_019745.31  NP_062719.21 
     755164905 
    chicken
    (Gallus gallus)
    Aves PDCD101 programmed cell death 10 90.72(n)
    99.06(a)
      425003  NM_001006554.1  NP_001006554.1 
    lizard
    (Anolis carolinensis)
    Reptilia PDCD106
    Uncharacterized protein
    100(a)
    1 ↔ 1
    3(9311759-9336131)
    African clawed frog
    (Xenopus laevis)
    Amphibia pdcd10-prov2 programmed cell death 10 87.1(n)    BC041501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056552.12   -- 80.84(n)   393527  BC056552.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50731 , 3 CG50731 48(a)3
    54.93(n)1
    50.51(a)1
      418761  NM_142202.21  NP_650459.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C14A4.111 Protein C14A4.11 51.59(n)
    40.48(a)
      174638  NM_063889.4  NP_496290.2 


    ENSEMBL Gene Tree for PDCD10 (if available)
    TreeFam Gene Tree for PDCD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PDCD10 gene

    PDCD10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PDCD10
    PGOHUM00000249655


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/909 SNPs in PDCD10 are shown (see all 909)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs771443491,2
    C,F--164781248(+) TACAAC/TTGAGG 3 -- int11Minor allele frequency- T:0.15WA 118
    rs749005521,2
    C,F--167264336(+) ATATAA/GTATTA 3 -- ds50011Minor allele frequency- G:0.05NA 120
    rs1883206551,2
    --167264366(+) TCCAAC/TCGTTG 3 -- ds50010--------
    rs2019230931,2
    C--167264410(-) TTTCCA/CAAAAA 3 -- ds50010--------
    rs1808424631,2
    --167264440(+) AGGGCA/CCAGTA 3 -- ds50010--------
    rs778988391,2
    C,F--167264449(+) TATACG/AAAAGG 3 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1861383511,2
    --167264681(+) ATTATC/TTGATA 3 -- ds50010--------
    rs1909414161,2
    --167264935(+) CAATTA/CTTTTA 3 -- ut310--------
    rs1835892841,2
    --167265021(+) AGTGAG/TGCAAA 3 -- ut310--------
    rs1868831111,2
    --167265057(+) GCTACA/GTTTTA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for PDCD10 (167401086 - 167452727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PDCD10:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4105CNV Insertion18451855


    Human Gene Mutation Database (HGMD): PDCD10
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing PDCD10:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing PDCD10
    DNA2.0 Custom Variant and Variant Library Synthesis for PDCD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609118   
    OMIM disorders: 603285  
    UniProtKB/Swiss-Prot: PDC10_HUMAN, Q9BUL8
  • Cerebral cavernous malformations 3 (CCM3) [MIM:603285]: A congenital vascular anomaly of the central
    nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic
    deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of
    endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several
    centimeters. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 19 diseases for PDCD10:    About MalaCards
    cerebral cavernous malformations 3    familial cerebral cavernous malformation 3    vascular malformations    cerebritis
    cerebral hemorrhage    cavernous malformation    cerebral cavernous malformation    cerebral cavernous malformation, familial
    klippel-trenaunay syndrome    proteus syndrome    cerebrovascular accident    headache
    brain disease    narcolepsy    meningioma    retinitis
    endotheliitis    leukemia    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for PDCD10:
    Klippel-Trenaunay syndrome     Coats disease

    PDCD10 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PDCD10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebral cavernous malformations 98.4 19 16284570 (2), 18496199 (2), 17657516 (2), 19151727 (1) (see all 11)
    vascular anomaly 72 1 15905966 (1)
    malformation venous 70.2 1 16379592 (1)
    klippel-trenaunay syndrome 65.4 1 16379592 (1)

    GeneTests: PDCD10
    GeneReviews: PDCD10
    Genetic Association Database (GAD): PDCD10
    Human Genome Epidemiology (HuGE) Navigator: PDCD10 (5 documents)

    Export disorders for PDCD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PDCD10 gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with PDCD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations. (PubMed id 15543491)1, 2, 3, 9 Bergametti F....Tournier-Lasserve E. (2005)
    2. Functional analyses of human and zebrafish 18-amino a cid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein. (PubMed id 19370760)1, 2, 9 Voss K....Felbor U. (2009)
    3. CCM3/PDCD10 stabilizes GCKIII proteins to promote Gol gi assembly and cell orientation. (PubMed id 20332113)1, 2 Fidalgo M....Zalvide J. (2010)
    4. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    5. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. (PubMed id 20489202)1, 2 Li X.... Boggon T.J. (2010)
    6. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    7. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    8. PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway. (PubMed id 17360971)1, 2 Ma X....Ma D. (2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3. (PubMed id 16284570)1, 9 Guclu B....Gunel M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11235 HGNC: 8761 AceView: PDCD10 Ensembl:ENSG00000114209 euGenes: HUgn11235
    ECgene: PDCD10 H-InvDB: PDCD10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PDCD10 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PDCD10

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PDCD10 gene:
    Search GeneIP for patents involving PDCD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PDCD10  
     OriGene qPCR primer pairs and template standards for PDCD10   OriGene Protein Over-expression Lysate for PDCD10  
     OriGene MassSpec something-or-other for PDCD10   OriGene clones in human, mouse for PDCD10  
     OriGene qSTAR qPCR primer pairs in human, mouse for PDCD10   OriGene Purified Protein for PDCD10  
     OriGene ORF clones in mouse, rat for PDCD10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PDCD10   OriGene Custom Protein Services for PDCD10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PDCD10
     QIAGEN SeqTarget long-range PCR primers for resequencing PDCD10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PDCD10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PDCD10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PDCD10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PDCD10
     GenScript Custom Purified and Recombinant Proteins Services for PDCD10 GenScript cDNA clones with any tag delivered in your preferred vector for PDCD10
     GenScript Custom Assay Services for PDCD10 GenScript Custom Superior Antibodies Services for PDCD10
     GenScript Custom overexpressing Cell Line Services for PDCD10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PDCD10 promoter
     Search Chromatin IP Primers for PDCD10
     RT2 qPCR Primer Assay in human, mouse, rat PDCD10
     GNC Network for PDCD10
     SABiosciences Custom PCR Arrays for PDCD10
     Search Tocris compounds for PDCD10 (PDC10)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PDCD10 antibodies
     PDCD10 proteins
     PDCD10 lysates
     Antibodies for PDCD10
     See all of Abcam's Antibodies, Kits and Proteins for PDCD10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PDCD10
     Antibodies for PDCD10
     ELISAs for PDCD10
     CLIAs for PDCD10
     Search LifeMap BioReagents cell lines for PDCD10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PDCD10
     SwitchGear 3'UTR luciferase reporter plasmids for PDCD10
     SwitchGear Promoter luciferase reporter plasmids for PDCD10
     Search ThermoFisher Antibodies for PDCD10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PDCD10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PDCD10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PDCD10
    Customized:
     lentivirus for stable overexpression of PDCD10
     lentivirus expression plasmids for stable overexpression of PDCD10
     adenovirus for overexpression of PDCD10
     LSBio Antibodies in human, mouse, rat for PDCD10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PDCD10 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4