Aliases for PDCD1 Gene
External Ids for PDCD1 Gene
Previous HGNC Symbols for PDCD1 Gene
Previous GeneCards Identifiers for PDCD1 Gene
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCD1 Gene
PDCD1 (Programmed Cell Death 1) is a Protein Coding gene. Diseases associated with PDCD1 include Systemic Lupus Erythematosus 2 and Multiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Translocation of ZAP-70 to Immunological synapse. GO annotations related to this gene include signal transducer activity.
UniProtKB/Swiss-Prot for PDCD1 Gene
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.