Aliases for PDCD1 Gene
External Ids for PDCD1 Gene
Previous Symbols for PDCD1 Gene
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
GeneCards Summary for PDCD1 Gene
PDCD1 (Programmed Cell Death 1) is a Protein Coding gene. Diseases associated with PDCD1 include indolent b cell lymphoma and systemic lupus erythematosus 2. Among its related pathways are Class I MHC mediated antigen processing and presentation and B cell receptor signaling pathway (KEGG). GO annotations related to this gene include signal transducer activity.
UniProtKB/Swiss-Prot for PDCD1 Gene
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.