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Aliases for PDAP1 Gene

Aliases for PDAP1 Gene

  • PDGFA Associated Protein 1 2 3 5
  • PDGF-Associated Protein 3 4
  • HASPP28 3 4
  • PAP1 3 4
  • PAP 3 4
  • PDGFA-Associated Protein 1 4
  • PDGF Associated Protein 2

External Ids for PDAP1 Gene

Previous GeneCards Identifiers for PDAP1 Gene

  • GC07M097528
  • GC07M098591
  • GC07M098605
  • GC07M098638
  • GC07M098830
  • GC07M098989
  • GC07M093628

Summaries for PDAP1 Gene

Entrez Gene Summary for PDAP1 Gene

  • The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDAP1 Gene

PDAP1 (PDGFA Associated Protein 1) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for PDAP1 Gene

  • Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.

Gene Wiki entry for PDAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDAP1 Gene

Genomics for PDAP1 Gene

Regulatory Elements for PDAP1 Gene

Enhancers for PDAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PDAP1 on UCSC Golden Path with GeneCards custom track

Promoters for PDAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PDAP1 Gene

Chromosome:
7
Start:
99,392,048 bp from pter
End:
99,408,829 bp from pter
Size:
16,782 bases
Orientation:
Minus strand

Genomic View for PDAP1 Gene

Genes around PDAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDAP1 Gene

Proteins for PDAP1 Gene

  • Protein details for PDAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13442-HAP28_HUMAN
    Recommended name:
    28 kDa heat- and acid-stable phosphoprotein
    Protein Accession:
    Q13442
    Secondary Accessions:
    • D6W5S5
    • Q92906

    Protein attributes for PDAP1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDAP1 Gene

Proteomics data for PDAP1 Gene at MOPED

Post-translational modifications for PDAP1 Gene

  • Ubiquitination at Lys 105
  • Modification sites at PhosphoSitePlus

Other Protein References for PDAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDAP1 (PDAP1)

No data available for DME Specific Peptides for PDAP1 Gene

Domains & Families for PDAP1 Gene

Protein Domains for PDAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PDAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13442

UniProtKB/Swiss-Prot:

HAP28_HUMAN :
  • Belongs to the PDAP1 family.
Family:
  • Belongs to the PDAP1 family.
genes like me logo Genes that share domains with PDAP1: view

No data available for Gene Families for PDAP1 Gene

Function for PDAP1 Gene

Molecular function for PDAP1 Gene

UniProtKB/Swiss-Prot Function:
Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.
genes like me logo Genes that share phenotypes with PDAP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDAP1 Gene

Localization for PDAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDAP1 Gene COMPARTMENTS Subcellular localization image for PDAP1 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PDAP1 Gene

Pathways & Interactions for PDAP1 Gene

SuperPathways for PDAP1 Gene

Superpath Contained pathways
1 Tyrosine Kinases / Adaptors
genes like me logo Genes that share pathways with PDAP1: view

Pathways by source for PDAP1 Gene

1 Cell Signaling Technology pathway for PDAP1 Gene

Gene Ontology (GO) - Biological Process for PDAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 8780057
genes like me logo Genes that share ontologies with PDAP1: view

No data available for SIGNOR curated interactions for PDAP1 Gene

Drugs & Compounds for PDAP1 Gene

No Compound Related Data Available

Transcripts for PDAP1 Gene

Unigene Clusters for PDAP1 Gene

PDGFA associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP2:
SP3: -

Relevant External Links for PDAP1 Gene

GeneLoc Exon Structure for
PDAP1
ECgene alternative splicing isoforms for
PDAP1

Expression for PDAP1 Gene

mRNA expression in normal human tissues for PDAP1 Gene

Protein differential expression in normal tissues from HIPED for PDAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6) and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDAP1 Gene



SOURCE GeneReport for Unigene cluster for PDAP1 Gene Hs.632296

genes like me logo Genes that share expression patterns with PDAP1: view

Protein tissue co-expression partners for PDAP1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PDAP1 Gene

Orthologs for PDAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDAP1 35
  • 88.77 (n)
  • 97.24 (a)
PDAP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDAP1 35
  • 90.98 (n)
  • 97.24 (a)
PDAP1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdap1 35
  • 89.69 (n)
  • 96.69 (a)
Pdap1 16
Pdap1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDAP1 35
  • 100 (n)
  • 100 (a)
PDAP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdap1 35
  • 90.42 (n)
  • 96.69 (a)
oppossum
(Monodelphis domestica)
Mammalia PDAP1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDAP1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDAP1 35
  • 80 (n)
  • 91.67 (a)
PDAP1 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDAP1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135404 35
  • 71.14 (n)
  • 75.42 (a)
Str.1709 35
zebrafish
(Danio rerio)
Actinopterygii pdap1b 35
  • 66.44 (n)
  • 72.92 (a)
zgc56213 35
pdap1b 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11444 36
  • 37 (a)
OneToMany
CG4438 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1447 36
  • 49 (a)
OneToOne
Species with no ortholog for PDAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDAP1 Gene

ENSEMBL:
Gene Tree for PDAP1 (if available)
TreeFam:
Gene Tree for PDAP1 (if available)

Paralogs for PDAP1 Gene

Pseudogenes.org Pseudogenes for PDAP1 Gene

genes like me logo Genes that share paralogs with PDAP1: view

No data available for Paralogs for PDAP1 Gene

Variants for PDAP1 Gene

Sequence variations from dbSNP and Humsavar for PDAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1044101 -- 99,396,159(-) GCCTC(A/G)CCTCT utr-variant-3-prime
rs1044111 -- 99,396,137(-) TGCCC(A/G)GTTCC utr-variant-3-prime
rs7457303 -- 99,395,887(+) CCCTG(A/G)ACCTT utr-variant-3-prime
rs7778859 -- 99,405,448(+) tccac(A/C)accct intron-variant
rs2072181 -- 99,400,848(-) GAATT(A/G)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDAP1 Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV Loss 17160897
nsv831069 CNV Loss 17160897

Variation tolerance for PDAP1 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PDAP1 Gene

Disorders for PDAP1 Gene

Relevant External Links for PDAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDAP1

No disorders were found for PDAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDAP1 Gene

Publications for PDAP1 Gene

  1. Characterization of a novel platelet-derived growth factor-associated protein. (PMID: 8780057) Fischer W.H. … Schubert D. (J. Neurochem. 1996) 2 3 4 23 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PDAP1 Gene

Sources for PDAP1 Gene

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