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Aliases for PDAP1 Gene

Aliases for PDAP1 Gene

  • PDGFA Associated Protein 1 2 3 5
  • PDGF-Associated Protein 3 4
  • HASPP28 3 4
  • PAP1 3 4
  • PAP 3 4
  • 28 KDa Heat- And Acid-Stable Phosphoprotein 3
  • PDGFA-Associated Protein 1 4
  • PDGF Associated Protein 2

External Ids for PDAP1 Gene

Previous GeneCards Identifiers for PDAP1 Gene

  • GC07M097528
  • GC07M098591
  • GC07M098605
  • GC07M098638
  • GC07M098830
  • GC07M098989
  • GC07M093628

Summaries for PDAP1 Gene

Entrez Gene Summary for PDAP1 Gene

  • The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]

GeneCards Summary for PDAP1 Gene

PDAP1 (PDGFA Associated Protein 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Tyrosine Kinases / Adaptors. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for PDAP1 Gene

  • Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.

Gene Wiki entry for PDAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDAP1 Gene

Genomics for PDAP1 Gene

Regulatory Elements for PDAP1 Gene

Enhancers for PDAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G098416 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +990.4 990369 4.0 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS TRRAP SMURF1 PDAP1 LOC100419643 RPS3AP26 BRI3 BAIAP2L1 PIR35529
GH07G099140 1.7 FANTOM5 ENCODE dbSUPER 11 +266.0 265967 4.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF766 ZNF548 KLF13 ZSCAN25 LOC100131859 RPS3AP26 ZNF655 LOC101927550 SMURF1 LOC100419643 TRRAP ARPC1B COPS6
GH07G099557 1.7 Ensembl ENCODE dbSUPER 10.6 -152.2 -152158 7.9 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 ATP5J2 BUD31 TMEM225B ZSCAN25 ZNF789 PTCD1 ATP5J2-PTCD1 MBLAC1 TRRAP ENSG00000242798
GH07G099579 1.5 FANTOM5 Ensembl ENCODE 11 -171.6 -171572 1.2 AGO1 ZNF2 RAD21 ZBTB40 ZNF354C ZNF366 ZNF263 ZNF202 ZNF680 ELF4 ZSCAN25 LOC100131859 TRRAP AP4M1 ZNF655 LOC101927550 LOC100419643 ENSG00000242798 STAG3L5P SMURF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PDAP1 on UCSC Golden Path with GeneCards custom track

Promoters for PDAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215664 29 2401 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3

Genomic Location for PDAP1 Gene

99,392,048 bp from pter
99,408,829 bp from pter
16,782 bases
Minus strand

Genomic View for PDAP1 Gene

Genes around PDAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDAP1 Gene

Proteins for PDAP1 Gene

  • Protein details for PDAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28 kDa heat- and acid-stable phosphoprotein
    Protein Accession:
    Secondary Accessions:
    • D6W5S5
    • Q92906

    Protein attributes for PDAP1 Gene

    181 amino acids
    Molecular mass:
    20630 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PDAP1 Gene

Post-translational modifications for PDAP1 Gene

  • Ubiquitination at Lys105
  • Modification sites at PhosphoSitePlus

Other Protein References for PDAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PDAP1 Gene

Domains & Families for PDAP1 Gene

Protein Domains for PDAP1 Gene


Suggested Antigen Peptide Sequences for PDAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PDAP1 family.
  • Belongs to the PDAP1 family.
genes like me logo Genes that share domains with PDAP1: view

No data available for Gene Families for PDAP1 Gene

Function for PDAP1 Gene

Molecular function for PDAP1 Gene

UniProtKB/Swiss-Prot Function:
Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.

Gene Ontology (GO) - Molecular Function for PDAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PDAP1: view
genes like me logo Genes that share phenotypes with PDAP1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDAP1 Gene

Localization for PDAP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDAP1 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PDAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with PDAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDAP1 Gene

Pathways & Interactions for PDAP1 Gene

genes like me logo Genes that share pathways with PDAP1: view

Pathways by source for PDAP1 Gene

1 Cell Signaling Technology pathway for PDAP1 Gene
3 Reactome pathways for PDAP1 Gene

Gene Ontology (GO) - Biological Process for PDAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8780057
GO:0008283 cell proliferation TAS 8780057
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with PDAP1: view

No data available for SIGNOR curated interactions for PDAP1 Gene

Transcripts for PDAP1 Gene

Unigene Clusters for PDAP1 Gene

PDGFA associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6
SP1: - -
SP3: -

Relevant External Links for PDAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDAP1 Gene

Protein differential expression in normal tissues from HIPED for PDAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6) and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDAP1 Gene

Protein tissue co-expression partners for PDAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PDAP1 Gene:


SOURCE GeneReport for Unigene cluster for PDAP1 Gene:


Evidence on tissue expression from TISSUES for PDAP1 Gene

  • Blood(4.3)
  • Eye(4.3)
  • Kidney(4.3)
  • Liver(4.3)
  • Nervous system(2.2)
  • Pancreas(2.1)
  • Lung(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PDAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDAP1 Gene

Orthologs for PDAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PDAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDAP1 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia PDAP1 35
  • 92 (a)
(Canis familiaris)
Mammalia PDAP1 34 35
  • 90.98 (n)
(Rattus norvegicus)
Mammalia Pdap1 34
  • 90.42 (n)
(Mus musculus)
Mammalia Pdap1 34 16 35
  • 89.69 (n)
(Bos Taurus)
Mammalia PDAP1 34 35
  • 88.77 (n)
(Ornithorhynchus anatinus)
Mammalia PDAP1 35
  • 81 (a)
(Gallus gallus)
Aves PDAP1 34 35
  • 80 (n)
(Anolis carolinensis)
Reptilia PDAP1 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135404 34
  • 71.14 (n)
Str.1709 34
(Danio rerio)
Actinopterygii pdap1b 34 35
  • 66.44 (n)
zgc56213 34
fruit fly
(Drosophila melanogaster)
Insecta CG11444 35
  • 37 (a)
CG4438 35
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1447 35
  • 49 (a)
Species where no ortholog for PDAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDAP1 Gene

Gene Tree for PDAP1 (if available)
Gene Tree for PDAP1 (if available)

Paralogs for PDAP1 Gene Pseudogenes for PDAP1 Gene

genes like me logo Genes that share paralogs with PDAP1: view

No data available for Paralogs for PDAP1 Gene

Variants for PDAP1 Gene

Sequence variations from dbSNP and Humsavar for PDAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000305397 -- 99,399,234(+) TGCCT(C/T)ACTAC intron-variant
rs1000375588 -- 99,410,460(+) CCTGG(A/G)CTCAA intron-variant, upstream-variant-2KB
rs1000515755 -- 99,403,526(+) ACAAC(C/T)TGCAG intron-variant
rs1000581038 -- 99,397,611(+) GTGAC(C/T)GTCCA intron-variant
rs1000698508 -- 99,409,159(+) AGCTC(C/T)CGAGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PDAP1 Gene

Variant ID Type Subtype PubMed ID
nsv831068 CNV loss 17160897
nsv831069 CNV loss 17160897
nsv951379 CNV deletion 24416366

Variation tolerance for PDAP1 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDAP1 Gene

Disorders for PDAP1 Gene

Relevant External Links for PDAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PDAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PDAP1 Gene

Publications for PDAP1 Gene

  1. Characterization of a novel platelet-derived growth factor-associated protein. (PMID: 8780057) Fischer W.H. … Schubert D. (J. Neurochem. 1996) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 64
  5. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3 64

Products for PDAP1 Gene

Sources for PDAP1 Gene

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