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Aliases for PCYT2 Gene

Aliases for PCYT2 Gene

  • Phosphate Cytidylyltransferase 2, Ethanolamine 2 3
  • CTP:Phosphoethanolamine Cytidylyltransferase 3 4
  • Phosphorylethanolamine Transferase 3 4
  • EC 2.7.7.14 4 64
  • Ethanolamine-Phosphate Cytidylyltransferase 3
  • EC 2.7.7 64
  • ET 3

External Ids for PCYT2 Gene

Summaries for PCYT2 Gene

Entrez Gene Summary for PCYT2 Gene

  • This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PCYT2 Gene

PCYT2 (Phosphate Cytidylyltransferase 2, Ethanolamine) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include ethanolamine-phosphate cytidylyltransferase activity.

UniProtKB/Swiss-Prot for PCYT2 Gene

  • Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCYT2 Gene

Genomics for PCYT2 Gene

Genomic Location for PCYT2 Gene

Start:
81,900,965 bp from pter
End:
81,911,477 bp from pter
Size:
10,513 bases
Orientation:
Minus strand

Genomic View for PCYT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCYT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCYT2 Gene

Regulatory Elements for PCYT2 Gene

Proteins for PCYT2 Gene

  • Protein details for PCYT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99447-PCY2_HUMAN
    Recommended name:
    Ethanolamine-phosphate cytidylyltransferase
    Protein Accession:
    Q99447
    Secondary Accessions:
    • B7Z7A5
    • B7ZAS0
    • F5H8B1
    • Q6IBM3
    • Q96G08

    Protein attributes for PCYT2 Gene

    Size:
    389 amino acids
    Molecular mass:
    43835 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PCYT2 Gene

    Alternative splice isoforms for PCYT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCYT2 Gene

Proteomics data for PCYT2 Gene at MOPED

Selected DME Specific Peptides for PCYT2 Gene

Post-translational modifications for PCYT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for PCYT2 Gene

Protein Domains for PCYT2 Gene

UniProtKB/Swiss-Prot:

PCY2_HUMAN
Family:
  • Belongs to the cytidylyltransferase family.:
    • Q99447
genes like me logo Genes that share domains with PCYT2: view

No data available for Gene Families for PCYT2 Gene

Function for PCYT2 Gene

Molecular function for PCYT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
UniProtKB/Swiss-Prot Function: Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine

Enzyme Numbers (IUBMB) for PCYT2 Gene

Gene Ontology (GO) - Molecular Function for PCYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity TAS 9083101
genes like me logo Genes that share ontologies with PCYT2: view
genes like me logo Genes that share phenotypes with PCYT2: view

Animal Models for PCYT2 Gene

MGI Knock Outs for PCYT2:

miRNA for PCYT2 Gene

miRTarBase miRNAs that target PCYT2

No data available for Transcription Factor Targeting and HOMER Transcription for PCYT2 Gene

Localization for PCYT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCYT2 Gene COMPARTMENTS Subcellular localization image for PCYT2 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PCYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PCYT2: view

Pathways for PCYT2 Gene

genes like me logo Genes that share pathways with PCYT2: view

Pathways by source for PCYT2 Gene

UniProtKB/Swiss-Prot Q99447-PCY2_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3

Gene Ontology (GO) - Biological Process for PCYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0008654 phospholipid biosynthetic process TAS 9083101
GO:0009058 biosynthetic process --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PCYT2: view

Compounds for PCYT2 Gene

(1) HMDB Compounds for PCYT2 Gene

Compound Synonyms Cas Number PubMed IDs
CDP-Ethanolamine
  • CDP-ethanolamine
3036-18-8

(4) Novoseek inferred chemical compound relationships for PCYT2 Gene

Compound -log(P) Hits PubMed IDs
cdp ethanolamine 94.2 4
phosphoethanolamine 84.2 2
phosphatidylethanolamine 72.4 4
ethanolamine 66.3 2
genes like me logo Genes that share compounds with PCYT2: view

Transcripts for PCYT2 Gene

Unigene Clusters for PCYT2 Gene

Phosphate cytidylyltransferase 2, ethanolamine:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCYT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: -
SP9: - - - - - -
SP10: -
SP11: - - - - - - -
SP12: - - - -
SP13: -
SP14: - - - - - - - - - - - - - - - - -
SP15: - -
SP16:
SP17:
SP18:
SP19:

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - -
SP15:
SP16:
SP17:
SP18: - -
SP19:

Relevant External Links for PCYT2 Gene

GeneLoc Exon Structure for
PCYT2
ECgene alternative splicing isoforms for
PCYT2

Expression for PCYT2 Gene

mRNA expression in normal human tissues for PCYT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCYT2 Gene

This gene is overexpressed in Testis (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCYT2 Gene

SOURCE GeneReport for Unigene cluster for PCYT2 Gene Hs.569843

mRNA Expression by UniProt/SwissProt for PCYT2 Gene

Q99447-PCY2_HUMAN
Tissue specificity: Strongest expression in liver, heart, and skeletal muscle
genes like me logo Genes that share expressions with PCYT2: view

Orthologs for PCYT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCYT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCYT2 36
  • 99.18 (n)
  • 99.51 (a)
PCYT2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCYT2 36
  • 88.86 (n)
  • 92.54 (a)
PCYT2 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCYT2 36
  • 88.17 (n)
  • 92.31 (a)
PCYT2 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcyt2 36
  • 87.38 (n)
  • 91.58 (a)
Pcyt2 16
Pcyt2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCYT2 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCYT2 37
  • 33 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcyt2 36
  • 87.71 (n)
  • 92.08 (a)
chicken
(Gallus gallus)
Aves PCYT2 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCYT2 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcyt2 36
  • 70.78 (n)
  • 79 (a)
zebrafish
(Danio rerio)
Actinopterygii pcyt2 36
  • 72.96 (n)
  • 78.46 (a)
pcyt2 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009264 36
  • 65.75 (n)
  • 64.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pect 36
  • 62.26 (n)
  • 64.96 (a)
Pect 37
  • 62 (a)
OneToOne
Pect 38
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.11 36
  • 58.74 (n)
  • 59.89 (a)
Y37E3.11 37
  • 56 (a)
OneToOne
Y37E3.11 38
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECT1 37
  • 37 (a)
OneToOne
ECT1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons PECT1 36
  • 53.39 (n)
  • 49.44 (a)
rice
(Oryza sativa)
Liliopsida Os12g0121300 36
  • 54.78 (n)
  • 47.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04289 36
  • 53.98 (n)
  • 41.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC15E1.05c 36
  • 44.68 (n)
  • 40.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6745 37
  • 59 (a)
OneToOne
Species with no ortholog for PCYT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCYT2 Gene

ENSEMBL:
Gene Tree for PCYT2 (if available)
TreeFam:
Gene Tree for PCYT2 (if available)

Paralogs for PCYT2 Gene

Selected SIMAP similar genes for PCYT2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with PCYT2: view

No data available for Paralogs for PCYT2 Gene

Variants for PCYT2 Gene

Sequence variations from dbSNP and Humsavar for PCYT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1803411 -- 81,905,408(-) TCCCT(G/T)ACAGG reference, missense, intron-variant
rs2230472 -- 81,906,878(-) AACCC(C/T)TGGAC reference, synonymous-codon
rs2230473 -- 81,904,789(-) TTCTG(A/C/T)GCCTT utr-variant-3-prime
rs2230474 -- 81,904,728(-) CTCTG(C/G)AAGGG utr-variant-3-prime
rs4316808 -- 81,905,663(+) GCGGA(C/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCYT2 Gene

Variant ID Type Subtype PubMed ID
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
dgv3333n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
nsv909128 CNV Gain+Loss 21882294
nsv833569 CNV Loss 17160897
dgv3337n71 CNV Loss 21882294
dgv3338n71 CNV Loss 21882294
dgv3339n71 CNV Loss 21882294
nsv909151 CNV Gain+Loss 21882294
dgv3340n71 CNV Loss 21882294
dgv3341n71 CNV Loss 21882294
dgv3342n71 CNV Loss 21882294
esv29964 CNV Loss 17803354
esv33468 CNV Loss 17666407
nsv909160 CNV Gain 21882294
nsv909161 CNV Loss 21882294
esv2716461 CNV Deletion 23290073

Relevant External Links for PCYT2 Gene

HapMap Linkage Disequilibrium report
PCYT2

Disorders for PCYT2 Gene

No disorders were found for PCYT2 Gene.

No data available for UniProtKB/Swiss-Prot for PCYT2 Gene

Publications for PCYT2 Gene

  1. Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant. (PMID: 9083101) Nakashima A. … Nikawa J. (J. Biol. Chem. 1997) 2 3 4 23
  2. CTP:phosphoethanolamine cytidylyltransferase. (PMID: 9370320) Bladergroen B.A. … van Golde L.M. (Biochim. Biophys. Acta 1997) 3 23
  3. Genomic organization and differential splicing of the mouse and human Pcyt2 genes. (PMID: 14697519) Poloumienko A. … Bakovic M. (Gene 2004) 3 23
  4. Characterization of transcription factors and cis-acting elements that regulate human CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). (PMID: 16023412) Johnson C.M. … Bakovic M. (Biochim. Biophys. Acta 2005) 3 23
  5. Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). (PMID: 17612623) Bakovic M. … Michel V. (Biochem. Cell Biol. 2007) 3 23

Products for PCYT2 Gene

Sources for PCYT2 Gene

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