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Aliases for PCYT2 Gene

Aliases for PCYT2 Gene

  • Phosphate Cytidylyltransferase 2, Ethanolamine 2 3 5
  • CTP:Phosphoethanolamine Cytidylyltransferase 2 3 4
  • Phosphorylethanolamine Transferase 3 4
  • EC 2.7.7.14 4 61
  • Ethanolamine-Phosphate Cytidylyltransferase 3
  • EC 2.7.7 61
  • ET 3

External Ids for PCYT2 Gene

Previous GeneCards Identifiers for PCYT2 Gene

  • GC17M079354
  • GC17M9I0165
  • GC17M080397
  • GC17M9I0540
  • GC17M9I7455
  • GC17M077455
  • GC17M079862
  • GC17M075262

Summaries for PCYT2 Gene

Entrez Gene Summary for PCYT2 Gene

  • This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PCYT2 Gene

PCYT2 (Phosphate Cytidylyltransferase 2, Ethanolamine) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and phosphatidylethanolamine biosynthesis II. GO annotations related to this gene include ethanolamine-phosphate cytidylyltransferase activity.

UniProtKB/Swiss-Prot for PCYT2 Gene

  • Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCYT2 Gene

Genomics for PCYT2 Gene

Regulatory Elements for PCYT2 Gene

Enhancers for PCYT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PCYT2 on UCSC Golden Path with GeneCards custom track

Promoters for PCYT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCYT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCYT2 Gene

Chromosome:
17
Start:
81,900,965 bp from pter
End:
81,911,477 bp from pter
Size:
10,513 bases
Orientation:
Minus strand

Genomic View for PCYT2 Gene

Genes around PCYT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCYT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCYT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCYT2 Gene

Proteins for PCYT2 Gene

  • Protein details for PCYT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99447-PCY2_HUMAN
    Recommended name:
    Ethanolamine-phosphate cytidylyltransferase
    Protein Accession:
    Q99447
    Secondary Accessions:
    • B7Z7A5
    • B7ZAS0
    • F5H8B1
    • Q6IBM3
    • Q96G08

    Protein attributes for PCYT2 Gene

    Size:
    389 amino acids
    Molecular mass:
    43835 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PCYT2 Gene

    Alternative splice isoforms for PCYT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCYT2 Gene

Selected DME Specific Peptides for PCYT2 Gene

Post-translational modifications for PCYT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PCYT2 Gene

Protein Domains for PCYT2 Gene

Suggested Antigen Peptide Sequences for PCYT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99447

UniProtKB/Swiss-Prot:

PCY2_HUMAN :
  • Belongs to the cytidylyltransferase family.
Family:
  • Belongs to the cytidylyltransferase family.
genes like me logo Genes that share domains with PCYT2: view

No data available for Gene Families for PCYT2 Gene

Function for PCYT2 Gene

Molecular function for PCYT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.
UniProtKB/Swiss-Prot Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.

Enzyme Numbers (IUBMB) for PCYT2 Gene

Gene Ontology (GO) - Molecular Function for PCYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity TAS 9083101
genes like me logo Genes that share ontologies with PCYT2: view
genes like me logo Genes that share phenotypes with PCYT2: view

Animal Models for PCYT2 Gene

MGI Knock Outs for PCYT2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PCYT2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCYT2 Gene

Localization for PCYT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCYT2 Gene COMPARTMENTS Subcellular localization image for PCYT2 gene
Compartment Confidence
endoplasmic reticulum 5
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PCYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PCYT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PCYT2 Gene

Pathways & Interactions for PCYT2 Gene

genes like me logo Genes that share pathways with PCYT2: view

Pathways by source for PCYT2 Gene

UniProtKB/Swiss-Prot Q99447-PCY2_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.

Gene Ontology (GO) - Biological Process for PCYT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0008654 phospholipid biosynthetic process TAS 9083101
genes like me logo Genes that share ontologies with PCYT2: view

No data available for SIGNOR curated interactions for PCYT2 Gene

Drugs & Compounds for PCYT2 Gene

(5) Drugs for PCYT2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 605
Cytidine triphosphate Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0

(6) Additional Compounds for PCYT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CDP-Ethanolamine
  • CDP Ethanolamine
  • CDP-Ethanolamine
  • CDPethanolamine
  • Cytidine diphosphate ethanolamine
3036-18-8
Ciliatine
  • beta-Aminoethylphosphonic acid
  • (2-Aminoethane)phosphonic acid
  • (2-aminoethyl)phosphonate
  • (2-Aminoethyl)phosphonic acid
  • 2-Aminoethylphosphonate
2041-14-7
CMP-2-aminoethylphosphonate
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with PCYT2: view

Transcripts for PCYT2 Gene

Unigene Clusters for PCYT2 Gene

Phosphate cytidylyltransferase 2, ethanolamine:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PCYT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCYT2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: -
SP9: - - - - - -
SP10: -
SP11: - - - - - - -
SP12: - - - -
SP13: -
SP14: - - - - - - - - - - - - - - - - -
SP15: - -
SP16:
SP17:
SP18:
SP19:

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - - -
SP15:
SP16:
SP17:
SP18: - -
SP19:

Relevant External Links for PCYT2 Gene

GeneLoc Exon Structure for
PCYT2
ECgene alternative splicing isoforms for
PCYT2

Expression for PCYT2 Gene

mRNA expression in normal human tissues for PCYT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCYT2 Gene

This gene is overexpressed in Testis (x8.4).

Protein differential expression in normal tissues from HIPED for PCYT2 Gene

This gene is overexpressed in Gallbladder (6.3) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCYT2 Gene



Protein tissue co-expression partners for PCYT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCYT2 Gene:

PCYT2

SOURCE GeneReport for Unigene cluster for PCYT2 Gene:

Hs.569843

mRNA Expression by UniProt/SwissProt for PCYT2 Gene:

Q99447-PCY2_HUMAN
Tissue specificity: Strongest expression in liver, heart, and skeletal muscle.
genes like me logo Genes that share expression patterns with PCYT2: view

Primer Products

Orthologs for PCYT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCYT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCYT2 34
  • 88.86 (n)
  • 92.54 (a)
PCYT2 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCYT2 34
  • 88.17 (n)
  • 92.31 (a)
PCYT2 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcyt2 34
  • 87.38 (n)
  • 91.58 (a)
Pcyt2 16
Pcyt2 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCYT2 34
  • 99.18 (n)
  • 99.51 (a)
PCYT2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcyt2 34
  • 87.71 (n)
  • 92.08 (a)
oppossum
(Monodelphis domestica)
Mammalia PCYT2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCYT2 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCYT2 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCYT2 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcyt2 34
  • 70.78 (n)
  • 79 (a)
zebrafish
(Danio rerio)
Actinopterygii pcyt2 34
  • 72.96 (n)
  • 78.46 (a)
pcyt2 35
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pect 36
  • 63 (a)
Pect 34
  • 62.26 (n)
  • 64.96 (a)
Pect 35
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009264 34
  • 65.75 (n)
  • 64.93 (a)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.11 36
  • 59 (a)
Y37E3.11 34
  • 58.74 (n)
  • 59.89 (a)
Y37E3.11 35
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECT1 35
  • 37 (a)
OneToOne
ECT1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons PECT1 34
  • 53.39 (n)
  • 49.44 (a)
rice
(Oryza sativa)
Liliopsida Os12g0121300 34
  • 54.78 (n)
  • 47.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04289 34
  • 53.98 (n)
  • 41.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC15E1.05c 34
  • 44.68 (n)
  • 40.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6745 35
  • 59 (a)
OneToOne
Species where no ortholog for PCYT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCYT2 Gene

ENSEMBL:
Gene Tree for PCYT2 (if available)
TreeFam:
Gene Tree for PCYT2 (if available)

Paralogs for PCYT2 Gene

(1) SIMAP similar genes for PCYT2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with PCYT2: view

No data available for Paralogs for PCYT2 Gene

Variants for PCYT2 Gene

Sequence variations from dbSNP and Humsavar for PCYT2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1803411 -- 81,905,408(-) TCCCT(G/T)ACAGG intron-variant, reference, missense
rs2230472 -- 81,906,878(-) AACCC(C/T)TGGAC reference, synonymous-codon
rs2230473 -- 81,904,789(-) TTCTG(A/C/T)GCCTT utr-variant-3-prime
rs2230474 -- 81,904,728(-) CTCTG(C/G)AAGGG utr-variant-3-prime
rs4316808 -- 81,905,663(+) GCGGA(C/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCYT2 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2716461 CNV deletion 23290073
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv1144821 CNV deletion 24896259
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for PCYT2 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCYT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCYT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCYT2 Gene

Disorders for PCYT2 Gene

Relevant External Links for PCYT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCYT2

No disorders were found for PCYT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCYT2 Gene

Publications for PCYT2 Gene

  1. Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant. (PMID: 9083101) Nakashima A. … Nikawa J. (J. Biol. Chem. 1997) 2 3 4 22 65
  2. Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1. (PMID: 18583706) Zhu L. … Bakovic M. (J. Lipid Res. 2008) 3 22 65
  3. Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). (PMID: 17612623) Bakovic M. … Michel V. (Biochem. Cell Biol. 2007) 3 22 65
  4. Characterization of transcription factors and cis-acting elements that regulate human CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). (PMID: 16023412) Johnson C.M. … Bakovic M. (Biochim. Biophys. Acta 2005) 3 22 65
  5. Genomic organization and differential splicing of the mouse and human Pcyt2 genes. (PMID: 14697519) Poloumienko A. … Bakovic M. (Gene 2004) 3 22 65

Products for PCYT2 Gene

Sources for PCYT2 Gene

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