Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PCYT2 Gene

protein-coding   GIFtS: 60
GCID: GC17M079862

Phosphate Cytidylyltransferase 2, Ethanolamine

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phosphate Cytidylyltransferase 2, Ethanolamine1 2     ET2
Phosphorylethanolamine Transferase2 3     Ethanolamine-Phosphate Cytidylyltransferase2
CTP:Phosphoethanolamine Cytidylyltransferase2 3     EC 2.7.78
EC 2.7.7.143 8     

External Ids:    HGNC: 87561   Entrez Gene: 58332   Ensembl: ENSG000001858137   OMIM: 6026795   UniProtKB: Q994473   

Export aliases for PCYT2 gene to outside databases

Previous GC identifers: GC17M079354 GC17M9I0165 GC17M080397 GC17M9I0540 GC17M9I7455 GC17M077455 GC17M075262


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PCYT2 Gene:
This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in
the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, May 2010)

GeneCards Summary for PCYT2 Gene:
PCYT2 (phosphate cytidylyltransferase 2, ethanolamine) is a protein-coding gene. Diseases associated with PCYT2 include gastroduodenitis, and malaria. GO annotations related to this gene include ethanolamine-phosphate cytidylyltransferase activity.

UniProtKB/Swiss-Prot: PCY2_HUMAN, Q99447
Function: Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the
formation of CDP-ethanolamine




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010663.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCYT2 gene promoter:
         AP-1   ATF-2   MyoD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCYT2 promoter sequence
   Search Chromatin IP Primers for PCYT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCYT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

PCYT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCYT2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079862:  view genomic region     (about GC identifiers)

Start:
79,858,841 bp from pter      End:
79,869,340 bp from pter
Size:
10,500 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for PCYT2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PCY2_HUMAN, Q99447 (See protein sequence)
Recommended Name: Ethanolamine-phosphate cytidylyltransferase  
Size: 389 amino acids; 43835 Da
1 PDB 3D structure from and Proteopedia for PCYT2:
3ELB (3D)    
Secondary accessions: B7Z7A5 F5H8B1 Q6IBM3 Q96G08
Alternative splicing: 3 isoforms:  Q99447-1   Q99447-2   Q99447-3   (No experimental confirmation available. Gene prediction based on cDNA data)

Explore the universe of human proteins at neXtProt for PCYT2: NX_Q99447

Explore proteomics data for PCYT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PCYT2 (Q99447) (see all 7)
     WVDEVVP  GDYLIVG  PIMNLHER  NCDFCVHG 


    See PCYT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001171846.1  NP_001243362.1  NP_001243363.1  NP_001243364.1  NP_001269132.1  NP_001269133.1  NP_002852.1  

    ENSEMBL proteins: 
     ENSP00000439245   ENSP00000331719   ENSP00000442050   ENSP00000459044   ENSP00000461190  
     ENSP00000460767   ENSP00000458330   ENSP00000458931   ENSP00000459836   ENSP00000458472  
     ENSP00000458727   ENSP00000458805   ENSP00000461814  
    Reactome Protein details: Q99447

    PCYT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PCYT2
    OriGene Protein Over-expression Lysate for PCYT2
    OriGene MassSpec for PCYT2
    OriGene Custom Protein Services for PCYT2
    GenScript Custom Purified and Recombinant Proteins Services for PCYT2
    Novus Biologicals PCYT2 Proteins
    Novus Biologicals PCYT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PCYT2
    Cloud-Clone Corp. Proteins for PCYT2

    PCYT2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PCYT2
    Novus Biologicals PCYT2 Antibodies
    Abcam antibodies for PCYT2
    Cloud-Clone Corp. Antibodies for PCYT2
    ThermoFisher Antibody for PCYT2
    LSBio Antibodies in human, mouse, rat for PCYT2

    PCYT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PCYT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCYT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PCYT2
    Cloud-Clone Corp. CLIAs for PCYT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR004821 Cyt_trans-like
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q99447

    ProtoNet protein and cluster: Q99447

    1 Blocks protein domain: IPB004820 Cytidylyltransferase

    UniProtKB/Swiss-Prot: PCY2_HUMAN, Q99447
    Similarity: Belongs to the cytidylyltransferase family


    PCYT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCY2_HUMAN, Q99447
    Function: Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the
    formation of CDP-ethanolamine
    Catalytic activity: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine

         Enzyme Numbers (IUBMB): EC 2.7.7.141 2 EC 2.7.72

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004306ethanolamine-phosphate cytidylyltransferase activity TAS9083101
    GO:0016779nucleotidyltransferase activity ----
         
    PCYT2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pcyt2):
     homeostasis/metabolism  liver/biliary system  mortality/aging  reproductive system 

    PCYT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pcyt2tm1Mbak for PCYT2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCYT2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCYT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCYT2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCYT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PCYT2:
    hsa-mir-335-5p (MIRT017368), hsa-let-7b-5p (MIRT052191)

    Block miRNA regulation of human, mouse, rat PCYT2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PCYT2
    SwitchGear 3'UTR luciferase reporter plasmidPCYT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PCYT2
    Predesigned siRNA for gene silencing in human, mouse, rat PCYT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PCYT2

    Clone
    Products:
         
    OriGene clones in human, mouse for PCYT2 (see all 12)
    OriGene ORF clones in mouse, rat for PCYT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCYT2 (NM_002861)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCYT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCYT2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PCYT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PCYT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCYT2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005789endoplasmic reticulum membrane TAS--

    PCYT2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PCYT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Glycerophospholipid metabolism0.62
    Phospholipid metabolism0.64
    Synthesis of PE0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3phosphatidylethanolamine biosynthesis II
    phosphatidylethanolamine biosynthesis II
    4Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PCYT2
        phosphatidylethanolamine biosynthesis II

    1 Reactome Pathway for PCYT2
        Synthesis of PE

    1 PharmGKB Pathway for PCYT2
        Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

    2 Kegg Pathways  (Kegg details for PCYT2):
        Glycerophospholipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PCY2_HUMAN, Q99447
    Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from
    ethanolamine: step 2/3


    PCYT2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCYT2
    Interactions:

        Search GeneGlobe Interaction Network for PCYT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PCYT2 (Q994472, 3 ENSP000003317194) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAMTS10Q9H3242, 3, ENSP000002703284MINT-8265384 I2D: score=2 STRING: ENSP00000270328
    GDF9O603832, 3, ENSP000002968754MINT-8265417 I2D: score=2 STRING: ENSP00000296875
    CRIP2P529432, 3MINT-8265395 I2D: score=2 
    DNMT3BQ9UBC32, 3MINT-8265406 I2D: score=2 
    SETDB1Q150472, 3MINT-8265428 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006646phosphatidylethanolamine biosynthetic process TAS--
    GO:0008654phospholipid biosynthetic process TAS9083101
    GO:0009058biosynthetic process ----
    GO:0044281small molecule metabolic process TAS--

    PCYT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCYT2 (PCY2)

    1 HMDB Compound for PCYT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CDP-EthanolamineCDP-ethanolamine (see all 4)3036-18-8--

    4 Novoseek inferred chemical compound relationships for PCYT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cdp ethanolamine 94.2 4 9370320 (2), 9083101 (1), 10493918 (1)
    phosphoethanolamine 84.2 2 9370320 (1), 1323040 (1)
    phosphatidylethanolamine 72.4 5 9083101 (1), 18583706 (1), 14697519 (1), 10493918 (1)
    ethanolamine 66.3 2 9083101 (2)



    PCYT2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PCYT2 gene (7 alternative transcripts): 
    NM_001184917.2  NM_001256433.2  NM_001256434.2  NM_001256435.2  NM_001282203.1  NM_001282204.1  NM_002861.4  

    Unigene Cluster for PCYT2:

    Phosphate cytidylyltransferase 2, ethanolamine
    Hs.569843  [show with all ESTs]
    Unigene Representative Sequence: NR_033683
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538936(uc010wvb.2 uc002kce.2 uc002kch.2 uc002kci.2 uc002kcf.2 uc010wvc.2)
    ENST00000331285 ENST00000538721 ENST00000571105 ENST00000570391 ENST00000574343
    ENST00000572995 ENST00000570388 ENST00000572924 ENST00000576343 ENST00000571944
    ENST00000573636 ENST00000574155 ENST00000573401 ENST00000571581 ENST00000573927
    ENST00000572473 ENST00000572157
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PCYT2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PCYT2
    SwitchGear 3'UTR luciferase reporter plasmidPCYT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PCYT2
    Predesigned siRNA for gene silencing in human, mouse, rat PCYT2
    Clone
    Products:
         
    OriGene clones in human, mouse for PCYT2 (see all 12)
    OriGene ORF clones in mouse, rat for PCYT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCYT2 (NM_002861)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCYT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCYT2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PCYT2
    OriGene qSTAR qPCR primer pairs in human, mouse for PCYT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCYT2
      QuantiTect SYBR Green Assays in human, mouse, rat PCYT2
      QuantiFast Probe-based Assays in human, mouse, rat PCYT2

    Additional mRNA sequence: 

    AF525738.1 AK093328.1 AK297996.1 AK301723.1 AK315777.1 AK316385.1 AY251539.1 BC000351.2 
    BC010075.2 BC073815.1 CR456779.1 D84307.1 NR_033683.1 NR_033685.1 

    20 DOTS entries:

    DT.114024  DT.100800423  DT.100800435  DT.91755618  DT.100658069  DT.95361239  DT.91755607  DT.120912271 
    DT.120912312  DT.120912310  DT.95310500  DT.100800430  DT.100800436  DT.100804620  DT.120912317  DT.40111323 
    DT.91717901  DT.95361256  DT.97847600  DT.95361258 

    Selected AceView cDNA sequences (see all 669):

    BE905969 AW470582 CR600432 BF057435 BM981320 D31390 AW300989 BU625267 
    BU860593 CA389036 AK002027 AI879411 BE264273 BC017305 BM127837 AI833017 
    AI934867 AW167947 CA424339 BM456834 BU738568 BM922245 BF001964 CR617660 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PCYT2 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:                                -     -     -     -     -           -     -                                               -                                 
    SP2:                                -     -     -     -     -           -     -                                               -           -                     
    SP3:                                                                                                                          -           -                     
    SP4:                                -     -     -     -     -           -     -                                               -                                 
    SP5:                                -     -     -     -     -           -     -     -     -     -                             -           -                     

    ExUns: 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d · 18e
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for PCYT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PCYT2 expression in normal human tissues (normalized intensities)      PCYT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PCYT2 Expression
    About this image


    PCYT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Eye (Sensory Organs)
             Lens
     
     Testis (Reproductive System)
    PCYT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCYT2 Protein Expression

    Genevestigator expression for PCYT2

    SOURCE GeneReport for Unigene cluster: Hs.569843

    UniProtKB/Swiss-Prot: PCY2_HUMAN, Q99447
    Tissue specificity: Strongest expression in liver, heart, and skeletal muscle

        Custom PCR Arrays for PCYT2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PCYT2
    OriGene qSTAR qPCR primer pairs in human, mouse for PCYT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCYT2
    QuantiTect SYBR Green Assays in human, mouse, rat PCYT2
    QuantiFast Probe-based Assays in human, mouse, rat PCYT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCYT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PCYT2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcyt21 , 5 phosphate cytidylyltransferase 2, ethanolamine1, 5 87.38(n)1
    91.58(a)1
      11 (84.33 cM)5
    686711  NM_024229.21  NP_077191.21 
     1206100875 
    chicken
    (Gallus gallus)
    Aves PCYT26
    phosphate cytidylyltransferase 2, ethanolamine
    83(a)
    1 ↔ 1
    18(10223921-10233484)
    lizard
    (Anolis carolinensis)
    Reptilia PCYT26
    phosphate cytidylyltransferase 2, ethanolamine
    81(a)
    1 ↔ 1
    2(118494947-118520398)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pcyt21 phosphate cytidylyltransferase 2, ethanolamine 70.78(n)
    79(a)
      496753  NM_001011300.1  NP_001011300.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pcyt21 phosphate cytidylyltransferase 2, ethanolamine 72.96(n)
    78.46(a)
      450016  NM_001006037.1  NP_001006037.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pect1 , 3 ethanolamine-phosphate
    cytidylyltransferase3
    Phosphoethanolamine cytidylyltransferase1
    63(a)3
    62.26(n)1
    64.96(a)1
      34A93
    347161  NM_165028.21  NP_723789.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37E3.111 , 3 Y37E3.111 59(a)3
    58.74(n)1
    59.89(a)1
      I(2078970-2085492)3
    1717701  NM_001129065.11  NP_001122537.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECT1(YGR007W)4 Ethanolamine-phosphate cytidylyltransferase, catalyzes more   --   7(506969-507940) 852890  NP_011521.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PECT11 PECT1 53.39(n)
    49.44(a)
      818449  NM_129424.4  NP_181401.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g01213001 Os12g0121300 54.78(n)
    47.19(a)
      4351359  NM_001072556.1  NP_001066024.1 


    ENSEMBL Gene Tree for PCYT2 (if available)
    TreeFam Gene Tree for PCYT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PCYT2 gene
    1 SIMAP similar gene for PCYT2 using alignment to 10 protein entries:     PCY2_HUMAN (see all proteins):
    PCYT1A

    PCYT2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PCYT2 (see all 688)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152089761,2
    F--75271214(+) GCGCTC/GGGCTG 1 -- int11Minor allele frequency- G:0.30WA 118
    rs1386659101,2
    --75271309(+) TTTTCC/TTATTT 1 -- int10--------
    rs169406631,2
    C,F--75271311(-) AAAAA-/ATAAGA 1 -- int12Minor allele frequency- A:0.04MN EA 356
    rs1882983221,2
    C--75271409(+) GAGCCC/TGCGCC 1 -- int10--------
    rs1807707721,2
    C--75271414(+) CGCGCC/TGACCA 1 -- int10--------
    rs1488978391,2
    --75271557(+) TTAAGC/TAGTAG 1 -- int10--------
    rs1434584491,2
    C--75271611(+) AAGGCC/TGCTGG 1 -- int10--------
    rs1138762281,2
    C--75271857(+) CAGCCC/TTCACC 1 -- int11Minor allele frequency- T:0.33CSA 3
    rs2006486741,2
    C--75271863(+) TCACCA/GTGACA 1 -- int10--------
    rs740061341,2
    C--75271893(+) CAACTG/ATTCTT 1 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for PCYT2 (79858841 - 79869340 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PCYT2 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716461CNV Deletion23290073
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv833569CNV Loss17160897
    nsv909161CNV Loss21882294
    esv29964CNV Loss17803354
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3342n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCYT2
    DNA2.0 Custom Variant and Variant Library Synthesis for PCYT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602679    OMIM disorders: --

    4 diseases for PCYT2:    About MalaCards
    gastroduodenitis    malaria    cerebritis    breast cancer


    PCYT2 for disorders           About GeneDecksing


    Export disorders for PCYT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PCYT2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with PCYT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant. (PubMed id 9083101)1, 2, 3, 9 Nakashima A.... Nikawa J. (J. Biol. Chem. 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. CTP:phosphoethanolamine cytidylyltransferase. (PubMed id 9370320)1, 9 Bladergroen B.A. and van Golde L.M. (Biochim. Biophys. Acta 1997)
    5. Genomic organization and differential splicing of the mouse and human Pcyt2 genes. (PubMed id 14697519)1, 9 Poloumienko A....Bakovic M. (Gene 2004)
    6. Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). (PubMed id 17612623)1, 9 Bakovic M....Michel V. (Biochem. Cell Biol. 2007)
    7. Characterization of transcription factors and cis-acting elements that regulate human CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). (PubMed id 16023412)1, 9 Johnson C.M....Bakovic M. (Biochim. Biophys. Acta 2005)
    8. Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1. (PubMed id 18583706)1, 9 Zhu L....Bakovic M. (J. Lipid Res. 2008)
    9. Breast cancer cells adapt to metabolic stress by increasing ethanolamine phospholipid synthesis and CTP:ethanolaminephosphate cytidylyltransferase-Pcyt2 activity. (PubMed id 22339418)1 Zhu L. and Bakovic M. (Biochem. Cell Biol. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5833 HGNC: 8756 AceView: MAFGandPCYT2andSIRT7 Ensembl:ENSG00000185813 euGenes: HUgn5833
    ECgene: PCYT2 Kegg: 5833 H-InvDB: PCYT2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PCYT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PCYT2 gene:
    Search GeneIP for patents involving PCYT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PCYT2  
     OriGene qPCR primer pairs and template standards for PCYT2   OriGene Protein Over-expression Lysate for PCYT2  
     OriGene MassSpec something-or-other for PCYT2   OriGene clones in human, mouse for PCYT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PCYT2   OriGene Purified Protein for PCYT2  
     OriGene ORF clones in mouse, rat for PCYT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PCYT2   OriGene Custom Protein Services for PCYT2  

     
     
     Block miRNA regulation of human, mouse, rat PCYT2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PCYT2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCYT2 Predesigned siRNA for gene silencing in human, mouse, rat PCYT2
     QuantiFast Probe-based Assays in human, mouse, rat PCYT2 QuantiTect SYBR Green Assays in human, mouse, rat PCYT2
     Custom PCR Arrays for PCYT2 Search Chromatin IP Primers for PCYT2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCYT2  Search GeneGlobe Interaction Network for PCYT2
     Regulatory tfbs in PCYT2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PCYT2 GenScript cDNA clones with any tag delivered in your preferred vector for PCYT2
     GenScript Custom Assay Services for PCYT2 GenScript Custom overexpressing Cell Line Services for PCYT2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PCYT2 (PCY2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PCYT2 antibodies
     PCYT2 proteins
     PCYT2 lysates
     Antibodies for PCYT2
     See all of Abcam's Antibodies, Kits and Proteins for PCYT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PCYT2
     Proteins for PCYT2
     Antibodies for PCYT2
     ELISAs for PCYT2
     CLIAs for PCYT2



     Browse ESI BIO Cell Lines and PureStem Progenitors for PCYT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCYT2
     SwitchGear 3'UTR luciferase reporter plasmids for PCYT2
     SwitchGear Promoter luciferase reporter plasmids for PCYT2
     ThermoFisher Antibody for PCYT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCYT2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCYT2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCYT2
     LSBio Antibodies in human, mouse, rat for PCYT2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PCYT2 gene at Home site.
    Version: 3.12.130 7 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4