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Aliases for PCYT1B Gene

Aliases for PCYT1B Gene

  • Phosphate Cytidylyltransferase 1, Choline, Beta 2 3 5
  • CTP:Phosphocholine Cytidylyltransferase B 3 4
  • Phosphorylcholine Transferase B 3 4
  • EC 4 61
  • CCT-Beta 3 4
  • CCT B 3 4
  • CCTB 3 4
  • CT B 3 4
  • Phosphate Cytidylyltransferase 1, Choline, Beta Isoform 2
  • Choline-Phosphate Cytidylyltransferase B 3
  • EC 2.7.7 61
  • CTB 3

External Ids for PCYT1B Gene

Previous GeneCards Identifiers for PCYT1B Gene

  • GC0XM023407
  • GC0XM023238
  • GC0XM023778
  • GC0XM023941
  • GC0XM024339
  • GC0XM024486
  • GC0XM022318

Summaries for PCYT1B Gene

Entrez Gene Summary for PCYT1B Gene

  • The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for PCYT1B Gene

PCYT1B (Phosphate Cytidylyltransferase 1, Choline, Beta) is a Protein Coding gene. Diseases associated with PCYT1B include Newborn Respiratory Distress Syndrome. Among its related pathways are Glycerophospholipid biosynthesis and Phospholipase D signaling pathway. GO annotations related to this gene include choline-phosphate cytidylyltransferase activity. An important paralog of this gene is PCYT1A.

UniProtKB/Swiss-Prot for PCYT1B Gene

  • Controls phosphatidylcholine synthesis.

Gene Wiki entry for PCYT1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCYT1B Gene

Genomics for PCYT1B Gene

Regulatory Elements for PCYT1B Gene

Enhancers for PCYT1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PCYT1B on UCSC Golden Path with GeneCards custom track

Genomic Location for PCYT1B Gene

24,558,087 bp from pter
24,672,862 bp from pter
114,776 bases
Minus strand

Genomic View for PCYT1B Gene

Genes around PCYT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCYT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCYT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCYT1B Gene

Proteins for PCYT1B Gene

  • Protein details for PCYT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choline-phosphate cytidylyltransferase B
    Protein Accession:
    Secondary Accessions:
    • A8IX00
    • B2RCX8
    • B4DK10
    • E9PD84
    • O60621
    • Q86XC9

    Protein attributes for PCYT1B Gene

    369 amino acids
    Molecular mass:
    41940 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for PCYT1B Gene


neXtProt entry for PCYT1B Gene

Selected DME Specific Peptides for PCYT1B Gene

Post-translational modifications for PCYT1B Gene

  • Extensively phosphorylated. The beta-1 isoform seems to be much less phosphorylated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCYT1B Gene

Domains & Families for PCYT1B Gene

Protein Domains for PCYT1B Gene

Suggested Antigen Peptide Sequences for PCYT1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cytidylyltransferase family.
  • Belongs to the cytidylyltransferase family.
genes like me logo Genes that share domains with PCYT1B: view

No data available for Gene Families for PCYT1B Gene

Function for PCYT1B Gene

Molecular function for PCYT1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CTP + phosphocholine = diphosphate + CDP-choline.
UniProtKB/Swiss-Prot Function:
Controls phosphatidylcholine synthesis.

Enzyme Numbers (IUBMB) for PCYT1B Gene

Gene Ontology (GO) - Molecular Function for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004105 choline-phosphate cytidylyltransferase activity TAS --
genes like me logo Genes that share ontologies with PCYT1B: view
genes like me logo Genes that share phenotypes with PCYT1B: view

Animal Models for PCYT1B Gene

MGI Knock Outs for PCYT1B:

Animal Model Products

CRISPR Products

miRNA for PCYT1B Gene

miRTarBase miRNAs that target PCYT1B

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCYT1B Gene

Localization for PCYT1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCYT1B Gene

Endoplasmic reticulum.

Subcellular locations from

Jensen Localization Image for PCYT1B Gene COMPARTMENTS Subcellular localization image for PCYT1B gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9593753
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PCYT1B: view

Pathways & Interactions for PCYT1B Gene

genes like me logo Genes that share pathways with PCYT1B: view

Pathways by source for PCYT1B Gene

UniProtKB/Swiss-Prot Q9Y5K3-PCY1B_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.

Gene Ontology (GO) - Biological Process for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway IEA --
GO:0007283 spermatogenesis IEA --
GO:0008654 phospholipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with PCYT1B: view

No data available for SIGNOR curated interactions for PCYT1B Gene

Drugs & Compounds for PCYT1B Gene

(3) Drugs for PCYT1B Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Target, product of 147
Phosphoric acid Approved Pharma 0
Cytidine triphosphate Experimental Pharma 0

(7) Additional Compounds for PCYT1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Audes
  • CDP-Choline
  • Cereb
  • Choline 5'-cytidine diphosphate
  • Choline cytidine diphosphate
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
genes like me logo Genes that share compounds with PCYT1B: view

Transcripts for PCYT1B Gene

Unigene Clusters for PCYT1B Gene

Phosphate cytidylyltransferase 1, choline, beta:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCYT1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9

Relevant External Links for PCYT1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCYT1B Gene

mRNA expression in normal human tissues for PCYT1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCYT1B Gene

This gene is overexpressed in Brain - Amygdala (x4.3) and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for PCYT1B Gene

This gene is overexpressed in Synovial fluid (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCYT1B Gene

NURSA nuclear receptor signaling pathways regulating expression of PCYT1B Gene:


SOURCE GeneReport for Unigene cluster for PCYT1B Gene:


mRNA Expression by UniProt/SwissProt for PCYT1B Gene:

Tissue specificity: Highly expressed in testis, placenta, brain, ovary and fetus.
genes like me logo Genes that share expression patterns with PCYT1B: view

Primer Products

No data available for Protein tissue co-expression partners for PCYT1B Gene

Orthologs for PCYT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCYT1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCYT1B 34
  • 91.78 (n)
  • 96.48 (a)
  • 96 (a)
(Canis familiaris)
Mammalia PCYT1B 34
  • 92.77 (n)
  • 98.37 (a)
  • 92 (a)
(Mus musculus)
Mammalia Pcyt1b 34
  • 91.24 (n)
  • 98.1 (a)
Pcyt1b 16
Pcyt1b 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Pcyt1b 34
  • 91.78 (n)
  • 98.64 (a)
(Monodelphis domestica)
Mammalia PCYT1B 35
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
(Pan troglodytes)
Mammalia PCYT1B 35
  • 95 (a)
(Gallus gallus)
Aves PCYT1B 34
  • 81.76 (n)
  • 93.92 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia PCYT1B 35
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcyt1b 34
  • 78.14 (n)
  • 86.61 (a)
(Danio rerio)
Actinopterygii pcyt1ba 34
  • 74.15 (n)
  • 83.67 (a)
pcyt1ba 35
  • 82 (a)
pcyt1bb 35
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cct1 36
  • 55 (a)
Cct2 36
  • 55 (a)
Cct1 35
  • 32 (a)
Cct2 35
  • 45 (a)
(Caenorhabditis elegans)
Secernentea F08C6.2 36
  • 50 (a)
F28A10.10 36
  • 46 (a)
F28A10.10 35
  • 49 (a)
pcyt-1 35
  • 38 (a)
Y18H1A.11 35
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCT1 35
  • 31 (a)
PCT1 37
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2898 34
(Hordeum vulgare)
Liliopsida Hv.5080 34
(Oryza sativa)
Liliopsida Os08g0161800 34
  • 57.73 (n)
  • 55.91 (a)
(Triticum aestivum)
Liliopsida Ta.9635 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7625 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9202 35
  • 55 (a)
Species where no ortholog for PCYT1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PCYT1B Gene

Gene Tree for PCYT1B (if available)
Gene Tree for PCYT1B (if available)

Paralogs for PCYT1B Gene

Paralogs for PCYT1B Gene

(1) SIMAP similar genes for PCYT1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PCYT1B: view

Variants for PCYT1B Gene

Sequence variations from dbSNP and Humsavar for PCYT1B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747692632 -- 24,609,056(+) TCATT(C/T)TAAGC intron-variant
rs747699465 -- 24,614,600(+) TCTGC(-/TA)TGTTT intron-variant
rs747702209 -- 24,627,308(+) ACTCT(A/T)GGGAG intron-variant
rs747726701 -- 24,672,252(+) TTGTT(-/A)AAACA intron-variant
rs747730170 -- 24,646,938(+) AGGAA(C/T)TCTTT intron-variant

Variation tolerance for PCYT1B Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCYT1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PCYT1B Gene

Disorders for PCYT1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCYT1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
newborn respiratory distress syndrome
  • hmd - hyaline membrane disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PCYT1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PCYT1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCYT1B Gene

Publications for PCYT1B Gene

  1. Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. (PMID: 9593753) Lykidis A. … Jackowski S. (J. Biol. Chem. 1998) 2 3 4 22 65
  2. Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. (PMID: 10480912) Lykidis A. … Jackowski S. (J. Biol. Chem. 1999) 3 4 22 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for PCYT1B Gene

Sources for PCYT1B Gene

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