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Aliases for PCYOX1 Gene

Aliases for PCYOX1 Gene

  • Prenylcysteine Oxidase 1 2 3 5
  • Prenylcysteine Lyase 3 4
  • EC 1.8.3.5 4 63
  • PCL1 3 4
  • KIAA0908 4

External Ids for PCYOX1 Gene

Previous GeneCards Identifiers for PCYOX1 Gene

  • GC02P070442
  • GC02P070459
  • GC02P070396
  • GC02P070484

Summaries for PCYOX1 Gene

Entrez Gene Summary for PCYOX1 Gene

  • Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PCYOX1 Gene

PCYOX1 (Prenylcysteine Oxidase 1) is a Protein Coding gene. Among its related pathways are Terpenoid backbone biosynthesis. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor. An important paralog of this gene is PCYOX1L.

UniProtKB/Swiss-Prot for PCYOX1 Gene

  • Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.

Gene Wiki entry for PCYOX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCYOX1 Gene

Genomics for PCYOX1 Gene

Regulatory Elements for PCYOX1 Gene

Promoters for PCYOX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCYOX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCYOX1 Gene

Chromosome:
2
Start:
70,257,386 bp from pter
End:
70,281,191 bp from pter
Size:
23,806 bases
Orientation:
Plus strand

Genomic View for PCYOX1 Gene

Genes around PCYOX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCYOX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCYOX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCYOX1 Gene

Proteins for PCYOX1 Gene

  • Protein details for PCYOX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHG3-PCYOX_HUMAN
    Recommended name:
    Prenylcysteine oxidase 1
    Protein Accession:
    Q9UHG3
    Secondary Accessions:
    • B2RB14
    • B7Z9P8
    • O94982
    • Q8N4N5
    • Q96QM8

    Protein attributes for PCYOX1 Gene

    Size:
    505 amino acids
    Molecular mass:
    56640 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA74931.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCYOX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCYOX1 Gene

Proteomics data for PCYOX1 Gene at MOPED

Post-translational modifications for PCYOX1 Gene

  • The protein is glycosylated at one or more potential N-glycosylation sites.
  • Ubiquitination at Lys 162 and Lys 205
  • Glycosylation at Asn 196, Asn 323, and Asn 353
  • Modification sites at PhosphoSitePlus

Other Protein References for PCYOX1 Gene

Antibody Products

Domains & Families for PCYOX1 Gene

Protein Domains for PCYOX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHG3

UniProtKB/Swiss-Prot:

PCYOX_HUMAN :
  • Belongs to the prenylcysteine oxidase family.
Family:
  • Belongs to the prenylcysteine oxidase family.
genes like me logo Genes that share domains with PCYOX1: view

No data available for Gene Families for PCYOX1 Gene

Function for PCYOX1 Gene

Molecular function for PCYOX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An S-prenyl-L-cysteine + O(2) + H(2)O = a prenal + L-cysteine + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.

Enzyme Numbers (IUBMB) for PCYOX1 Gene

Gene Ontology (GO) - Molecular Function for PCYOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PCYOX1: view
genes like me logo Genes that share phenotypes with PCYOX1: view

Animal Models for PCYOX1 Gene

MGI Knock Outs for PCYOX1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCYOX1 Gene

Localization for PCYOX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCYOX1 Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCYOX1 Gene COMPARTMENTS Subcellular localization image for PCYOX1 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
plasma membrane 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCYOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034361 very-low-density lipoprotein particle IDA 17154273
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PCYOX1: view

Pathways & Interactions for PCYOX1 Gene

SuperPathways for PCYOX1 Gene

genes like me logo Genes that share pathways with PCYOX1: view

Pathways by source for PCYOX1 Gene

1 KEGG pathway for PCYOX1 Gene

Interacting Proteins for PCYOX1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000387654%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000262613%0d%0a9606.ENSP00000327268%0d%0a
Selected Interacting proteins: Q9UHG3-PCYOX_HUMAN ENSP00000387654 for PCYOX1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for PCYOX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006821 chloride transport IEA --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with PCYOX1: view

No data available for SIGNOR curated interactions for PCYOX1 Gene

Drugs & Compounds for PCYOX1 Gene

(4) Drugs for PCYOX1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
L-Cysteine Approved Nutra 0
Hydrogen peroxide Pharma 46

(5) Additional Compounds for PCYOX1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-trans,6-trans-Farnesal
Farnesylcysteine
  • (E,E)-L-S-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-Cysteine
  • Farnesylcysteine
  • S-All-trans-Farnesyl-L-cysteine
  • S-trans-trans-Farnesylcysteine
  • S-[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]-L-Cysteine
68000-92-0
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PCYOX1: view

Transcripts for PCYOX1 Gene

Unigene Clusters for PCYOX1 Gene

Prenylcysteine oxidase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCYOX1 Gene

No ASD Table

Relevant External Links for PCYOX1 Gene

GeneLoc Exon Structure for
PCYOX1
ECgene alternative splicing isoforms for
PCYOX1

Expression for PCYOX1 Gene

mRNA expression in normal human tissues for PCYOX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCYOX1 Gene

This gene is overexpressed in Nasopharynx (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCYOX1 Gene



SOURCE GeneReport for Unigene cluster for PCYOX1 Gene Hs.567502

mRNA Expression by UniProt/SwissProt for PCYOX1 Gene

Q9UHG3-PCYOX_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PCYOX1: view

Protein tissue co-expression partners for PCYOX1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PCYOX1 Gene

Orthologs for PCYOX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCYOX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCYOX1 35
  • 85.6 (n)
  • 78.81 (a)
PCYOX1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC481418 35
  • 84.49 (n)
  • 85.35 (a)
PCYOX1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcyox1 35
  • 77.29 (n)
  • 78.81 (a)
Pcyox1 16
Pcyox1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCYOX1 35
  • 99.38 (n)
  • 99.3 (a)
PCYOX1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcyox1 35
  • 76.65 (n)
  • 77.58 (a)
oppossum
(Monodelphis domestica)
Mammalia PCYOX1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCYOX1 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCYOX1 35
  • 64.59 (n)
  • 61.41 (a)
PCYOX1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCYOX1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcyox1 35
  • 62.18 (n)
  • 59.45 (a)
zebrafish
(Danio rerio)
Actinopterygii pcyox1 35
  • 57.47 (n)
  • 52.7 (a)
pcyox1 36
  • 50 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons FCLY 35
  • 47.3 (n)
  • 37.25 (a)
rice
(Oryza sativa)
Liliopsida Os04g0692800 35
  • 53.82 (n)
  • 45.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PCYOX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCYOX1 Gene

ENSEMBL:
Gene Tree for PCYOX1 (if available)
TreeFam:
Gene Tree for PCYOX1 (if available)

Paralogs for PCYOX1 Gene

Paralogs for PCYOX1 Gene

(1) SIMAP similar genes for PCYOX1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for PCYOX1 Gene

genes like me logo Genes that share paralogs with PCYOX1: view

Variants for PCYOX1 Gene

Sequence variations from dbSNP and Humsavar for PCYOX1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2706762 - 70,261,338(+) TCAAT(C/T)CCTCC reference, missense
rs17005441 - 70,277,115(+) TCTTA(C/G)TAAAG reference, missense
rs34041544 - 70,277,267(-) GGCAC(C/T)TGCTG reference, missense
rs750156 -- 70,259,275(+) ACCTC(C/T)GCTAT intron-variant
rs1134089 -- 70,279,677(+) ctact(C/T)gggag utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PCYOX1 Gene

Variant ID Type Subtype PubMed ID
nsv518294 CNV Loss 19592680
esv2667817 CNV Deletion 23128226
esv2523050 CNV Deletion 19546169

Variation tolerance for PCYOX1 Gene

Residual Variation Intolerance Score: 85.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.07; 68.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCYOX1 Gene

HapMap Linkage Disequilibrium report
PCYOX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCYOX1 Gene

Disorders for PCYOX1 Gene

Relevant External Links for PCYOX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCYOX1

No disorders were found for PCYOX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCYOX1 Gene

Publications for PCYOX1 Gene

  1. Cloning, expression, and cellular localization of a human prenylcysteine lyase. (PMID: 10585463) Tschantz W.R. … Casey P.J. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase. (PMID: 12186880) Digits J.A. … Casey P.J. (J. Biol. Chem. 2002) 2 3 23
  3. Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme. (PMID: 19253276) Banfi C. … Tremoli E. (Proteomics 2009) 3 23
  4. Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF. (PMID: 17154273) Mancone C. … Alonzi T. (Proteomics 2007) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PCYOX1 Gene

Sources for PCYOX1 Gene

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