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Aliases for PCTP Gene

Aliases for PCTP Gene

  • Phosphatidylcholine Transfer Protein 2 3 5
  • StAR-Related Lipid Transfer (START) Domain Containing 2 2 3
  • StAR-Related Lipid Transfer Protein 2 3 4
  • START Domain-Containing Protein 2 3 4
  • STARD2 3 4
  • PC-TP 3 4

External Ids for PCTP Gene

Previous GeneCards Identifiers for PCTP Gene

  • GC17P053563
  • GC17P056309
  • GC17P054170
  • GC17P054303
  • GC17P054302
  • GC17P051183
  • GC17P053828
  • GC17P049187

Summaries for PCTP Gene

GeneCards Summary for PCTP Gene

PCTP (Phosphatidylcholine Transfer Protein) is a Protein Coding gene. GO annotations related to this gene include lipid binding and phosphatidylcholine transporter activity. An important paralog of this gene is STARD7.

UniProtKB/Swiss-Prot for PCTP Gene

  • Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.

Gene Wiki entry for PCTP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCTP Gene

Genomics for PCTP Gene

Regulatory Elements for PCTP Gene

Enhancers for PCTP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PCTP on UCSC Golden Path with GeneCards custom track

Promoters for PCTP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCTP on UCSC Golden Path with GeneCards custom track

Genomic Location for PCTP Gene

Chromosome:
17
Start:
55,750,979 bp from pter
End:
55,843,209 bp from pter
Size:
92,231 bases
Orientation:
Plus strand

Genomic View for PCTP Gene

Genes around PCTP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCTP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCTP Gene

Proteins for PCTP Gene

  • Protein details for PCTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKL6-PPCT_HUMAN
    Recommended name:
    Phosphatidylcholine transfer protein
    Protein Accession:
    Q9UKL6
    Secondary Accessions:
    • Q9BSC9
    • Q9UIT3
    • Q9UKW7

    Protein attributes for PCTP Gene

    Size:
    214 amino acids
    Molecular mass:
    24843 Da
    Quaternary structure:
    • Interacts with ACOT13/THEM2.
    SequenceCaution:
    • Sequence=AAH05112.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PCTP Gene

    Alternative splice isoforms for PCTP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCTP Gene

Post-translational modifications for PCTP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCTP Gene

Domains & Families for PCTP Gene

Gene Families for PCTP Gene

Protein Domains for PCTP Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKL6

UniProtKB/Swiss-Prot:

PPCT_HUMAN :
  • Contains 1 START domain.
Domain:
  • Contains 1 START domain.
genes like me logo Genes that share domains with PCTP: view

Function for PCTP Gene

Molecular function for PCTP Gene

GENATLAS Biochemistry:
phosphatidylcholine transfer protein,cytosolic protein catalyzing intermembrane transfer of phosphatidylcholines in vitro
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.

Gene Ontology (GO) - Molecular Function for PCTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008289 lipid binding IEA --
GO:0008525 phosphatidylcholine transporter activity TAS 10500206
GO:0031210 phosphatidylcholine binding IDA 12055623
genes like me logo Genes that share ontologies with PCTP: view
genes like me logo Genes that share phenotypes with PCTP: view

Animal Models for PCTP Gene

MGI Knock Outs for PCTP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCTP Gene

Localization for PCTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCTP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCTP Gene COMPARTMENTS Subcellular localization image for PCTP gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PCTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 12055623
genes like me logo Genes that share ontologies with PCTP: view

Pathways & Interactions for PCTP Gene

SuperPathways for PCTP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006869 lipid transport NAS 10542325
GO:0015914 phospholipid transport IDA 12055623
genes like me logo Genes that share ontologies with PCTP: view

No data available for Pathways by source and SIGNOR curated interactions for PCTP Gene

Drugs & Compounds for PCTP Gene

(2) Drugs for PCTP Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Di-Linoleoyl-3-Sn-Phosphatidylcholine Experimental Pharma Target 0
Palmitoyl-Linoleoyl Phosphatidylcholine Experimental Pharma Target 0

(10) Additional Compounds for PCTP Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
Phosphatidylcholines Group C
  • 1,2-Di(1-enyl-palmitoyl)-rac-glycero-3-phosphocholine
  • GPCho(16:0/16:0)
  • GPCho(32:0)
  • Lecithin
  • PC aa C32:0
genes like me logo Genes that share compounds with PCTP: view

Transcripts for PCTP Gene

Unigene Clusters for PCTP Gene

Phosphatidylcholine transfer protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCTP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - - - -
SP5: - - -

Relevant External Links for PCTP Gene

GeneLoc Exon Structure for
PCTP
ECgene alternative splicing isoforms for
PCTP

Expression for PCTP Gene

mRNA expression in normal human tissues for PCTP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCTP Gene

This gene is overexpressed in Liver (x6.0).

Protein differential expression in normal tissues from HIPED for PCTP Gene

This gene is overexpressed in Gallbladder (13.3) and Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCTP Gene



Protein tissue co-expression partners for PCTP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCTP Gene:

PCTP

SOURCE GeneReport for Unigene cluster for PCTP Gene:

Hs.285218

mRNA Expression by UniProt/SwissProt for PCTP Gene:

Q9UKL6-PPCT_HUMAN
Tissue specificity: Highest expression in liver, placenta, testis, kidney and heart. Low levels in brain and lung. No expression detected in thymus.
genes like me logo Genes that share expression patterns with PCTP: view

Primer Products

Orthologs for PCTP Gene

This gene was present in the common ancestor of animals.

Orthologs for PCTP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCTP 34
  • 85.53 (n)
  • 80.66 (a)
-- 35
  • 58 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
PCTP 35
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PCTP 34
  • 86.6 (n)
  • 81.78 (a)
PCTP 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pctp 34
  • 83.33 (n)
  • 81.31 (a)
Pctp 16
Pctp 35
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCTP 34
  • 99.07 (n)
  • 99.07 (a)
PCTP 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pctp 34
  • 82.87 (n)
  • 79.44 (a)
oppossum
(Monodelphis domestica)
Mammalia PCTP 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCTP 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCTP 34
  • 70.87 (n)
  • 69.9 (a)
PCTP 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCTP 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pctp 34
  • 65.37 (n)
  • 63.9 (a)
pctp 35
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10579 34
fruit fly
(Drosophila melanogaster)
Insecta CG6565 35
  • 14 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for PCTP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCTP Gene

ENSEMBL:
Gene Tree for PCTP (if available)
TreeFam:
Gene Tree for PCTP (if available)

Paralogs for PCTP Gene

Paralogs for PCTP Gene

genes like me logo Genes that share paralogs with PCTP: view

Variants for PCTP Gene

Sequence variations from dbSNP and Humsavar for PCTP Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs12941739 - 55,751,132(+) CTCGG(A/C)GGAGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs13477 -- 55,777,070(-) AAAAG(A/G)TGCAG intron-variant, utr-variant-3-prime
rs467984 -- 55,804,058(-) gtctg(C/T)tcatg intron-variant
rs1014513 -- 55,753,743(+) CTGTG(C/G)CATCT intron-variant
rs1073419 -- 55,765,849(+) CTTTT(A/G)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCTP Gene

Variant ID Type Subtype PubMed ID
nsv1076450 CNV duplication 25765185
nsv2100 CNV deletion 18451855

Variation tolerance for PCTP Gene

Residual Variation Intolerance Score: 81.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.75; 93.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCTP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCTP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCTP Gene

Disorders for PCTP Gene

Relevant External Links for PCTP

Genetic Association Database (GAD)
PCTP
Human Genome Epidemiology (HuGE) Navigator
PCTP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCTP

No disorders were found for PCTP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCTP Gene

Publications for PCTP Gene

  1. Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data. (PMID: 11983415) Chan W.W. … Cohen D.E. (Biochim. Biophys. Acta 2002) 3 4 22 65
  2. Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein. (PMID: 10542325) Cohen D.E. … Beier D.R. (Biochim. Biophys. Acta 1999) 3 4 22 65
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 65
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 65
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 65

Products for PCTP Gene

Sources for PCTP Gene

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