Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PCTP Gene

protein-coding   GIFtS: 52
GCID: GC17P053828

Phosphatidylcholine Transfer Protein

  See PCTP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phosphatidylcholine Transfer Protein1 2     STARD22 3
StAR-Related Lipid Transfer (START) Domain Containing 21 2     START Domain-Containing Protein 22 3
StAR-Related Lipid Transfer Protein 22 3     StARD23
PC-TP2 3     

External Ids:    HGNC: 87521   Entrez Gene: 584882   Ensembl: ENSG000001411797   OMIM: 6060555   UniProtKB: Q9UKL63   

Export aliases for PCTP gene to outside databases

Previous GC identifers: GC17P053563 GC17P056309 GC17P054170 GC17P054303 GC17P054302 GC17P051183 GC17P049187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PCTP Gene:
PCTP (phosphatidylcholine transfer protein) is a protein-coding gene. Diseases associated with PCTP include cannabis dependence. GO annotations related to this gene include phosphatidylcholine binding and phosphatidylcholine transporter activity. An important paralog of this gene is STARD7.

UniProtKB/Swiss-Prot: PPCT_HUMAN, Q9UKL6
Function: Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule

Gene Wiki entry for PCTP (Phosphatidylcholine transfer protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCTP gene promoter:
         AML1a   GATA-3   Cdc5   C/EBPalpha   Gfi-1   GATA-1   GATA-2   POU2F1   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCTP promoter sequence
   Search Chromatin IP Primers for PCTP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCTP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21-q24   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q21-q24

PCTP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCTP gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P053828:  view genomic region     (about GC identifiers)

Start:
53,828,340 bp from pter      End:
53,920,191 bp from pter
Size:
91,852 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PPCT_HUMAN, Q9UKL6 (See protein sequence)
Recommended Name: Phosphatidylcholine transfer protein  
Size: 214 amino acids; 24843 Da
Subunit: Interacts with ACOT13/THEM2 (By similarity)
Sequence caution: Sequence=AAH05112.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for PCTP:
1LN1 (3D)        1LN2 (3D)        1LN3 (3D)    
Secondary accessions: Q9BSC9 Q9UIT3 Q9UKW7
Alternative splicing: 2 isoforms:  Q9UKL6-1   Q9UKL6-2   

Explore the universe of human proteins at neXtProt for PCTP: NX_Q9UKL6

Explore proteomics data for PCTP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PCTP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001095872.1  NP_067036.2  

    ENSEMBL proteins: 
     ENSP00000268896   ENSP00000459793   ENSP00000460437   ENSP00000415185   ENSP00000325181  
     ENSP00000461676  

    PCTP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PCTP
    OriGene Protein Over-expression Lysate for PCTP
    OriGene MassSpec for PCTP
    OriGene Custom Protein Services for PCTP
    GenScript Custom Purified and Recombinant Proteins Services for PCTP
    Novus Biologicals PCTP Proteins
    Novus Biologicals PCTP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PCTP

     
    Search eBioscience for Proteins for PCTP 

    PCTP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PCTP
    Novus Biologicals PCTP Antibodies
    Abcam antibodies for PCTP
    Cloud-Clone Corp. Antibodies for PCTP
    Search ThermoFisher Antibodies for PCTP
    LSBio Antibodies in human, mouse, rat for PCTP

    PCTP Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PCTP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCTP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PCTP
    Cloud-Clone Corp. CLIAs for PCTP
    Search eBioscience for ELISAs for PCTP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    StARD: StAR-related lipid transfer (START) domain containing

    2 InterPro protein domains:
     IPR023393 START-like_dom
     IPR002913 START_lipid-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9UKL6

    ProtoNet protein and cluster: Q9UKL6

    UniProtKB/Swiss-Prot: PPCT_HUMAN, Q9UKL6
    Similarity: Contains 1 START domain


    Find genes that share domains with PCTP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPCT_HUMAN, Q9UKL6
    Function: Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule

         Genatlas biochemistry entry for PCTP:
    phosphatidylcholine transfer protein,cytosolic protein catalyzing intermembrane transfer of phosphatidylcholines
    in vitro

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding ----
    GO:0008525phosphatidylcholine transporter activity TAS10500206
    GO:0031210phosphatidylcholine binding IDA12055623
         
    Find genes that share ontologies with PCTP           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pctp):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     normal 

    Find genes that share phenotypes with PCTP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pctptm1Bor for PCTP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCTP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCTP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCTP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCTP

    miRNA
    Products:
        
    miRTarBase miRNAs that target PCTP:
    hsa-mir-98-5p (MIRT027775), hsa-mir-32-5p (MIRT028326)

    Block miRNA regulation of human, mouse, rat PCTP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCTP (see all 12):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-3673 hsa-miR-4251 hsa-miR-539 hsa-miR-202 hsa-miR-544b hsa-miR-670
    SwitchGear 3'UTR luciferase reporter plasmidPCTP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PCTP
    Predesigned siRNA for gene silencing in human, mouse, rat PCTP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PCTP

    Clone
    Products:
         
    OriGene clones in human, mouse for PCTP (see all 11)
    OriGene ORF clones in mouse, rat for PCTP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCTP (NM_021213)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCTP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCTP

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PCTP
    Browse ESI BIO Cell Lines and PureStem Progenitors for PCTP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCTP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PPCT_HUMAN, Q9UKL6: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion2
    nucleus2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS12055623

    Find genes that share ontologies with PCTP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCTP
    Interactions:

        GeneGlobe Interaction Network for PCTP

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport NAS10542325
    GO:0008203cholesterol metabolic process IEA--
    GO:0015914phospholipid transport IDA12055623

    Find genes that share ontologies with PCTP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCTP (PPCT)

    Selected HMDB Compounds for PCTP (see all 1135)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PC(14:0/14:0)Phosphatidylcholine(14:0/14:0) (see all 8)----
    PC(14:0/14:1(9Z))Phosphatidylcholine(14:0/14:1) (see all 14)----
    PC(14:0/15:0)GPCho(14:0/15:0) (see all 8)----
    PC(14:0/16:0)GPCho(30:0) (see all 8)----
    PC(14:0/16:1(9Z))1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine (see all 14)----
    PC(14:0/18:0)1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine (see all 8)----
    PC(14:0/18:1(11Z))Phosphatidylcholine(14:0/18:1w7) (see all 14)----
    PC(14:0/18:1(9Z))1-myristoyl-2-oleoyl-sn-glycero-3-phosphocholine (see all 14)----
    PC(14:0/18:2(9Z,12Z))Phosphatidylcholine(32:2) (see all 14)----

    2 DrugBank Compounds for PCTP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Di-Linoleoyl-3-Sn-Phosphatidylcholine-- --target--17139284 17016423
    Palmitoyl-Linoleoyl Phosphatidylcholine-- --target--17139284 17016423

    6 Novoseek inferred chemical compound relationships for PCTP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pctp 97 19 17266964 (3), 11343249 (2), 17701056 (2), 15013637 (1) (see all 6)
    phosphatidylcholine 81.6 57 11855861 (7), 11112525 (3), 11983415 (2), 17266964 (2) (see all 19)
    phospholipid 50.8 5 17266964 (1), 9555005 (1), 11112525 (1)
    phosphatidylinositol 45.6 5 19416650 (1), 10224048 (1), 11279184 (1), 16828756 (1)
    sterol 39.2 2 16828756 (1)
    lipid 37.1 7 11855861 (1), 15013637 (1), 17701056 (1), 16828756 (1)



    Find genes that share compounds with PCTP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PCTP gene (2 alternative transcripts): 
    NM_001102402.2  NM_021213.3  

    Unigene Cluster for PCTP:

    Phosphatidylcholine transfer protein
    Hs.285218  [show with all ESTs]
    Unigene Representative Sequence: BX648199
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268896(uc002iul.4) ENST00000576183 ENST00000573500 ENST00000417982(uc002ium.4 uc010dch.3)
    ENST00000325214 ENST00000571489 ENST00000576221 ENST00000572536
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PCTP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCTP (see all 12):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-3673 hsa-miR-4251 hsa-miR-539 hsa-miR-202 hsa-miR-544b hsa-miR-670
    SwitchGear 3'UTR luciferase reporter plasmidPCTP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PCTP
    Predesigned siRNA for gene silencing in human, mouse, rat PCTP
    Clone
    Products:
         
    OriGene clones in human, mouse for PCTP (see all 11)
    OriGene ORF clones in mouse, rat for PCTP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCTP (NM_021213)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCTP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCTP
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PCTP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCTP
      QuantiTect SYBR Green Assays in human, mouse, rat PCTP
      QuantiFast Probe-based Assays in human, mouse, rat PCTP

    Additional mRNA sequence: 

    AF087857.1 AF114430.1 AF151638.1 AK024667.1 AK058120.1 AK314509.1 BC005112.1 BC012084.1 
    BX648199.1 

    11 DOTS entries:

    DT.114766  DT.101963072  DT.100779416  DT.100779424  DT.70100917  DT.444125  DT.100801257  DT.100739460 
    DT.100779413  DT.100806885  DT.95351898 

    Selected AceView cDNA sequences (see all 179):

    AI991436 AA303510 AI359870 BE463440 CR618541 BX448079 AI884928 CR608698 
    AW613015 AI741288 CR608827 AF151638 CR605133 CR625866 F21873 CA432391 
    CR609651 CR590755 AI824946 BF064005 AI248982 AI283846 AI985558 AI360406 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PCTP    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:              -     -           -           -     -                 -                           
    SP2:              -     -           -           -     -                                             
    SP3:                                -                                   -                           
    SP4:                                -           -     -                 -                           
    SP5:                                            -     -                 -                           


    ECgene alternative splicing isoforms for PCTP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PCTP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAAATGGA
    PCTP Expression
    About this image


    PCTP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Liver (Hepatobiliary System)
    PCTP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCTP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.285218

    UniProtKB/Swiss-Prot: PPCT_HUMAN, Q9UKL6
    Tissue specificity: Highest expression in liver, placenta, testis, kidney and heart. Low levels in brain and lung.
    No expression detected in thymus

        Custom PCR Arrays for PCTP
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PCTP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCTP
    QuantiTect SYBR Green Assays in human, mouse, rat PCTP
    QuantiFast Probe-based Assays in human, mouse, rat PCTP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCTP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PCTP gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pctp1 , 5 phosphatidylcholine transfer protein1, 5 83.33(n)1
    81.31(a)1
      11 (54.70 cM)5
    185591  NM_008796.21  NP_032822.21 
     899826655 
    chicken
    (Gallus gallus)
    Aves PCTP1 phosphatidylcholine transfer protein 70.87(n)
    69.9(a)
      417399  XM_415652.4  XP_415652.1 
    lizard
    (Anolis carolinensis)
    Reptilia PCTP6
    phosphatidylcholine transfer protein
    48(a)
    1 ↔ 1
    GL343646.1(83767-103286)
    zebrafish
    (Danio rerio)
    Actinopterygii pctp1 phosphatidylcholine transfer protein 65.37(n)
    63.9(a)
      566726  NM_001130786.1  NP_001124258.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65656
    --
    14(a)
    1 ↔ 1
    2L(13374179-13376182)


    ENSEMBL Gene Tree for PCTP (if available)
    TreeFam Gene Tree for PCTP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PCTP gene
    STARD72  
    8 SIMAP similar genes for PCTP using alignment to 7 protein entries:     PPCT_HUMAN (see all proteins):
    KIAA1651    OK/SW-cl.41    C14orf178    PPP2R1A    FAM138C    ARL13B
    PLA2G15    FLJ20555

    Find genes that share paralogs with PCTP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PCTP (see all 600)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs758690381,2
    F--53826359(+) TGTCAC/TTAAGC 1 -- us2k10--------
    rs771319711,2
    F--53826422(+) AATGAG/ATGAGG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1413217301,2
    --53826573(+) AGTATA/CCTTTT 2 -- us2k10--------
    rs1503583331,2
    --53826730(+) GCAACC/TTCTCA 2 -- us2k10--------
    rs286549811,2
    C,F--53826784(+) TTAGAG/CATACC 2 -- us2k1 tfbs31Minor allele frequency- C:0.14WA 118
    rs569796451,2
    C,F--53826930(+) ACAATT/CTGAAG 2 -- us2k12Minor allele frequency- C:0.08WA 120
    rs286086041,2
    C,F--53826939(+) AGTGCG/ATGCTT 2 -- us2k11Minor allele frequency- A:0.12WA 118
    rs1381979141,2
    C--53827004(+) CCATAC/TAGTAA 2 -- us2k10--------
    rs757696811,2
    C,F--53827226(+) AATTTC/AACATC 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs21144431,2
    C,F,O,A,H--53827252(+) ATAAAA/GCCAAA 2 -- us2k135Minor allele frequency- G:0.25EA NA MN NS WA CSA 4786

    HapMap Linkage Disequilibrium report for PCTP (53828340 - 53920191 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PCTP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2100CNV Loss18451855
    nsv908620CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCTP
    DNA2.0 Custom Variant and Variant Library Synthesis for PCTP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606055    OMIM disorders: --

    1 disease for PCTP:    
    About MalaCards
    cannabis dependence


    Find genes that share disorders with PCTP           About GenesLikeMe

    Genetic Association Database (GAD): PCTP
    Human Genome Epidemiology (HuGE) Navigator: PCTP (8 documents)

    Export disorders for PCTP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PCTP gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with PCTP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data. (PubMed id 11983415)1, 2, 9 Chan W.W.... Cohen D.E. (Biochim. Biophys. Acta 2002)
    2. Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein. (PubMed id 10542325)1, 2, 9 Cohen D.E.... Beier D.R. (Biochim. Biophys. Acta 1999)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Structure of human phosphatidylcholine transfer protein in complex with its ligand. (PubMed id 12055623)1, 2 Roderick S.L.... Cohen D.E. (Nat. Struct. Biol. 2002)
    9. Mice without phosphatidylcholine transfer protein have no defects in the secretion of PC into bile or into the lung airspaces. (PubMed id 10500206)1, 2 van Helvoort A.... Borst P. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    10. Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size. (PubMed id 17266964)1, 9 Dolley G....Vohl M.C. (Atherosclerosis 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 58488 HGNC: 8752 AceView: PCTP Ensembl:ENSG00000141179 euGenes: HUgn58488
    ECgene: PCTP H-InvDB: PCTP

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PCTP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PCTP gene:
    Search GeneIP for patents involving PCTP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PCTP  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PCTP  
     OriGene MassSpec something-or-other for PCTP   OriGene clones in human, mouse for PCTP  
     OriGene qSTAR qPCR primer pairs in human, mouse for PCTP   OriGene Purified Protein for PCTP  
     OriGene ORF clones in mouse, rat for PCTP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PCTP   OriGene Custom Protein Services for PCTP  

     
     
     Block miRNA regulation of human, mouse, rat PCTP using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PCTP
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCTP Predesigned siRNA for gene silencing in human, mouse, rat PCTP
     QuantiFast Probe-based Assays in human, mouse, rat PCTP QuantiTect SYBR Green Assays in human, mouse, rat PCTP
     Custom PCR Arrays for PCTP Search Chromatin IP Primers for PCTP
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCTP  GeneGlobe Interaction Network for PCTP
     Regulatory tfbs in PCTP promoter
     GenScript Custom Purified and Recombinant Proteins Services for PCTP GenScript cDNA clones with any tag delivered in your preferred vector for PCTP
     GenScript Custom Assay Services for PCTP GenScript Custom overexpressing Cell Line Services for PCTP
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PCTP (PPCT)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PCTP antibodies
     PCTP proteins
     PCTP lysates
     Antibodies for PCTP
     See all of Abcam's Antibodies, Kits and Proteins for PCTP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PCTP
     Antibodies for PCTP
     ELISAs for PCTP
     CLIAs for PCTP



     Browse ESI BIO Cell Lines and PureStem Progenitors for PCTP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCTP
     SwitchGear 3'UTR luciferase reporter plasmids for PCTP
     SwitchGear Promoter luciferase reporter plasmids for PCTP
     Search ThermoFisher Antibodies for PCTP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCTP
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCTP
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PCTP
     LSBio Antibodies in human, mouse, rat for PCTP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PCTP
      Search eBioscience for proteins for PCTP
      Search eBioscience for elisas for PCTP
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PCTP gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4