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Aliases for PCSK6 Gene

Aliases for PCSK6 Gene

  • Proprotein Convertase Subtilisin/Kexin Type 6 2 3 5
  • Subtilisin-Like Proprotein Convertase 4 2 3 4
  • Subtilisin/Kexin-Like Protease PACE4 2 3 4
  • Paired Basic Amino Acid Cleaving System 4 2 3
  • Paired Basic Amino Acid Cleaving Enzyme 4 3 4
  • PACE4 3 4
  • SPC4 3 4
  • Subtilisin-Like Protease 2
  • EC 3.4.21.75 61
  • EC 3.4.21.61 61
  • EC 3.4.21.- 4
  • EC 3.4.21 61

External Ids for PCSK6 Gene

Previous HGNC Symbols for PCSK6 Gene

  • PACE4

Previous GeneCards Identifiers for PCSK6 Gene

  • GC15M099580
  • GC15M099661
  • GC15M101844
  • GC15M077966

Summaries for PCSK6 Gene

Entrez Gene Summary for PCSK6 Gene

  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

GeneCards Summary for PCSK6 Gene

PCSK6 (Proprotein Convertase Subtilisin/Kexin Type 6) is a Protein Coding gene. Diseases associated with PCSK6 include Avian Influenza and Retinitis Pigmentosa 31. Among its related pathways are Signaling by NODAL and Lipoprotein metabolism. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is PCSK5.

UniProtKB/Swiss-Prot for PCSK6 Gene

  • Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif.

Gene Wiki entry for PCSK6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCSK6 Gene

Genomics for PCSK6 Gene

Regulatory Elements for PCSK6 Gene

Enhancers for PCSK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G101438 1.9 FANTOM5 Ensembl ENCODE dbSUPER 32.3 +85.5 85517 2.4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 MCM3 SP5 MCM5 PCSK6 PIR54076 LOC105371028
GH15G101454 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.4 +69.2 69246 2.0 HDAC1 PKNOX1 YY1 CREM USF2 ZEB2 NR2F2 ZNF592 MEF2D RAD51 PCSK6 TM2D3 CHSY1 PIR54076 LOC105371028
GH15G101458 1.2 Ensembl ENCODE dbSUPER 12.8 +65.8 65826 2.4 ELF3 PKNOX1 HLF CEBPB CEBPG CEBPA GLIS1 FOXP2 PRDM10 MLLT1 PCSK6 PIR54076 LOC105371028
GH15G101445 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +78.8 78829 2.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B DMAP1 YY1 SLC30A9 PRKXP1 TM2D3 LOC100419174 ASB7 ENSG00000270127 PCSK6 CHSY1 PIR54076 LOC105371028
GH15G101462 0.8 ENCODE dbSUPER 13 +61.8 61780 1.1 CTBP1 ESRRA DPF2 EGR2 PCSK6 RNU6-807P LOC105371028 PIR54076
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCSK6 on UCSC Golden Path with GeneCards custom track

Promoters for PCSK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082044 584 1201 RB1 ARNT SIN3A ZNF76 KLF17 DMAP1 ZNF2 GLIS2 CREM ZNF341

Genomic Location for PCSK6 Gene

Chromosome:
15
Start:
101,297,142 bp from pter
End:
101,525,202 bp from pter
Size:
228,061 bases
Orientation:
Minus strand

Genomic View for PCSK6 Gene

Genes around PCSK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCSK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCSK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCSK6 Gene

Proteins for PCSK6 Gene

  • Protein details for PCSK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29122-PCSK6_HUMAN
    Recommended name:
    Proprotein convertase subtilisin/kexin type 6
    Protein Accession:
    P29122
    Secondary Accessions:
    • Q15099
    • Q15100
    • Q9UEG7
    • Q9UEJ1
    • Q9UEJ2
    • Q9UEJ7
    • Q9UEJ8
    • Q9UEJ9
    • Q9Y4G9
    • Q9Y4H0
    • Q9Y4H1

    Protein attributes for PCSK6 Gene

    Size:
    969 amino acids
    Molecular mass:
    106420 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • The PACE4A-I precursor protein seems to exist in the reticulum endoplasmic as both a monomer and a dimer-sized complex whereas mature PACE4A-I exists only as a monomer, suggesting that propeptide cleavage affects its tertiary or quaternary structure.

    Alternative splice isoforms for PCSK6 Gene

neXtProt entry for PCSK6 Gene

Selected DME Specific Peptides for PCSK6 Gene

P29122:
  • GKLKEWSL
  • HGTRCAGEVAA
  • GSIFVWA
  • HGTRCAGE
  • YLEHVVV
  • PWYLEEC
  • STLATTYSSG
  • LTWRDVQ
  • SWGPDDDGKTVDGP
  • DYYHFYHS
  • CDGYTNSI
  • AWKRGYTGKN
  • DGYTNSI
  • WASGNGG

Post-translational modifications for PCSK6 Gene

  • Ubiquitination at Lys136
  • Glycosylation at Asn259, Asn914, and Asn932
  • Modification sites at PhosphoSitePlus

Domains & Families for PCSK6 Gene

Gene Families for PCSK6 Gene

Suggested Antigen Peptide Sequences for PCSK6 Gene

Graphical View of Domain Structure for InterPro Entry

P29122

UniProtKB/Swiss-Prot:

PCSK6_HUMAN :
  • The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. Isoform PACE4D lacks the propeptide domain.
  • Belongs to the peptidase S8 family.
Domain:
  • The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. Isoform PACE4D lacks the propeptide domain.
Family:
  • Belongs to the peptidase S8 family.
genes like me logo Genes that share domains with PCSK6: view

Function for PCSK6 Gene

Molecular function for PCSK6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg- -Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.
UniProtKB/Swiss-Prot Function:
Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif.

Enzyme Numbers (IUBMB) for PCSK6 Gene

Gene Ontology (GO) - Molecular Function for PCSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity IDA,IEA 8218226
GO:0008201 heparin binding IDA 12535616
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with PCSK6: view
genes like me logo Genes that share phenotypes with PCSK6: view

Animal Models for PCSK6 Gene

MGI Knock Outs for PCSK6:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCSK6 Gene

Localization for PCSK6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCSK6 Gene

Isoform PACE4A-I: Secreted.
Isoform PACE4A-II: Secreted.
Isoform PACE4C: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Isoform PACE4CS: Endoplasmic reticulum. Note=Not secreted, remains probably in zymogen form in endoplasmic reticulum.
Isoform PACE4E-I: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Isoform PACE4E-II: Endomembrane system; Peripheral membrane protein. Note=Retained intracellularly probably through a hydrophobic cluster in their C-terminus.
Isoform PACE4B: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCSK6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PCSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 8906861
GO:0005783 endoplasmic reticulum IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with PCSK6: view

Pathways & Interactions for PCSK6 Gene

genes like me logo Genes that share pathways with PCSK6: view

Interacting Proteins for PCSK6 Gene

Selected Interacting proteins: P29122-PCSK6_HUMAN for PCSK6 Gene via IID

Gene Ontology (GO) - Biological Process for PCSK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007354 zygotic determination of anterior/posterior axis, embryo IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0009100 glycoprotein metabolic process IDA 8218226
GO:0016485 protein processing IDA 8218226
genes like me logo Genes that share ontologies with PCSK6: view

No data available for SIGNOR curated interactions for PCSK6 Gene

Drugs & Compounds for PCSK6 Gene

(3) Drugs for PCSK6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for PCSK6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCSK6: view

Transcripts for PCSK6 Gene

mRNA/cDNA for PCSK6 Gene

(9) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(21) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PCSK6 Gene

Proprotein convertase subtilisin/kexin type 6:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCSK6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: -
SP8: -
SP9:
SP10: -
SP11:

ExUns: 24 ^ 25a · 25b ^ 26a · 26b
SP1: - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:

Relevant External Links for PCSK6 Gene

GeneLoc Exon Structure for
PCSK6
ECgene alternative splicing isoforms for
PCSK6

Expression for PCSK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCSK6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCSK6 Gene

This gene is overexpressed in Liver (x12.5), Brain - Spinal cord (cervical c-1) (x8.5), Spleen (x4.8), and Brain - Substantia nigra (x4.1).

Protein differential expression in normal tissues from HIPED for PCSK6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (45.6) and Platelet (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PCSK6 Gene



Protein tissue co-expression partners for PCSK6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCSK6 Gene:

PCSK6

SOURCE GeneReport for Unigene cluster for PCSK6 Gene:

Hs.498494

mRNA Expression by UniProt/SwissProt for PCSK6 Gene:

P29122-PCSK6_HUMAN
Tissue specificity: Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.

Evidence on tissue expression from TISSUES for PCSK6 Gene

  • Nervous system(4.6)
  • Kidney(4.4)
  • Liver(2.5)
genes like me logo Genes that share expression patterns with PCSK6: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PCSK6 Gene

Orthologs for PCSK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCSK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCSK6 34 35
  • 98.18 (n)
dog
(Canis familiaris)
Mammalia PCSK6 34 35
  • 89.36 (n)
mouse
(Mus musculus)
Mammalia Pcsk6 34 16 35
  • 86.95 (n)
rat
(Rattus norvegicus)
Mammalia Pcsk6 34
  • 86.87 (n)
cow
(Bos Taurus)
Mammalia PCSK6 34 35
  • 85.59 (n)
oppossum
(Monodelphis domestica)
Mammalia PCSK6 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCSK6 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCSK6 34 35
  • 73.22 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 42 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia pcsk6 34
  • 69.83 (n)
zebrafish
(Danio rerio)
Actinopterygii PCSK6 35
  • 66 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea kpc-1 35
  • 43 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
Species where no ortholog for PCSK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCSK6 Gene

ENSEMBL:
Gene Tree for PCSK6 (if available)
TreeFam:
Gene Tree for PCSK6 (if available)

Paralogs for PCSK6 Gene

Paralogs for PCSK6 Gene

genes like me logo Genes that share paralogs with PCSK6: view

Variants for PCSK6 Gene

Sequence variations from dbSNP and Humsavar for PCSK6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000016290 -- 101,474,065(+) GTTAA(C/T)GAGCT intron-variant
rs1000020129 -- 101,407,914(+) GATAA(C/T)CGGGT intron-variant
rs1000072109 -- 101,441,894(+) TGCGT(C/T)GACCT intron-variant
rs1000094276 -- 101,370,944(+) CTGAG(A/T)CAATT intron-variant
rs1000098553 -- 101,470,061(+) TGCCA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCSK6 Gene

Variant ID Type Subtype PubMed ID
dgv1277n106 CNV deletion 24896259
dgv2673n100 CNV gain 25217958
dgv2674n100 CNV gain 25217958
dgv2675n100 CNV gain 25217958
dgv2676n100 CNV gain 25217958
dgv2677n100 CNV loss 25217958
dgv2678n100 CNV gain 25217958
dgv4791n54 CNV gain 21841781
dgv4792n54 CNV gain 21841781
dgv4793n54 CNV gain+loss 21841781
dgv4794n54 CNV gain 21841781
dgv4795n54 CNV gain+loss 21841781
dgv4796n54 CNV loss 21841781
dgv4797n54 CNV gain 21841781
dgv4798n54 CNV loss 21841781
dgv4799n54 CNV loss 21841781
esv1007750 CNV deletion 20482838
esv1370843 CNV insertion 17803354
esv1625622 CNV insertion 17803354
esv2244647 CNV deletion 18987734
esv22828 CNV loss 19812545
esv2343291 CNV deletion 18987734
esv2422359 CNV duplication 17116639
esv24793 CNV gain 19812545
esv2666943 CNV deletion 23128226
esv2750184 CNV deletion 23290073
esv2750186 CNV deletion 23290073
esv2750187 CNV deletion 23290073
esv2750188 CNV deletion 23290073
esv2750189 CNV deletion 23290073
esv2750190 CNV deletion 23290073
esv2750191 CNV deletion 23290073
esv2750192 CNV deletion 23290073
esv2750193 CNV deletion 23290073
esv2750194 CNV deletion 23290073
esv27538 CNV loss 19812545
esv2760063 CNV gain+loss 17122850
esv3387944 CNV insertion 20981092
esv34275 CNV gain 17911159
esv3581873 CNV loss 25503493
esv3581874 CNV loss 25503493
esv3581875 CNV loss 25503493
esv3637501 CNV gain 21293372
esv3637507 CNV gain 21293372
esv3637508 CNV loss 21293372
esv3637509 CNV loss 21293372
esv3637510 CNV loss 21293372
esv3637511 CNV gain 21293372
esv992073 CNV insertion 20482838
nsv1035599 CNV gain 25217958
nsv1044753 CNV gain 25217958
nsv1045675 CNV loss 25217958
nsv1046079 CNV gain 25217958
nsv1049577 CNV gain 25217958
nsv1050862 CNV gain 25217958
nsv1053507 CNV loss 25217958
nsv1070304 CNV deletion 25765185
nsv1071241 CNV deletion 25765185
nsv1078768 CNV insertion 25765185
nsv1078769 CNV insertion 25765185
nsv1115985 CNV insertion 24896259
nsv1126410 CNV deletion 24896259
nsv1136203 CNV deletion 24896259
nsv1142869 CNV tandem duplication 24896259
nsv1149056 CNV insertion 26484159
nsv1160324 CNV deletion 26073780
nsv428314 CNV loss 18775914
nsv457290 CNV loss 19166990
nsv457291 CNV gain 19166990
nsv469741 CNV gain 16826518
nsv471266 CNV gain 18288195
nsv475309 CNV novel sequence insertion 20440878
nsv477192 CNV novel sequence insertion 20440878
nsv523415 CNV gain 19592680
nsv570828 CNV gain 21841781
nsv570849 CNV loss 21841781
nsv570851 CNV loss 21841781
nsv570855 CNV loss 21841781
nsv570857 CNV loss 21841781
nsv570860 CNV gain+loss 21841781
nsv570875 CNV loss 21841781
nsv570887 CNV gain 21841781
nsv570890 CNV gain+loss 21841781
nsv570895 CNV loss 21841781
nsv833110 CNV gain+loss 17160897
nsv9310 CNV gain 18304495
nsv9311 CNV gain 18304495
nsv94947 CNV deletion 16902084
nsv952890 CNV deletion 24416366

Variation tolerance for PCSK6 Gene

Gene Damage Index Score: 7.66; 82.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCSK6 Gene

Human Gene Mutation Database (HGMD)
PCSK6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCSK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCSK6 Gene

Disorders for PCSK6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PCSK6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
avian influenza
  • avian flu
retinitis pigmentosa 31
  • rp31
anthrax disease
  • gas gangrene
malaria
  • malaria, severe
- elite association - COSMIC cancer census association via MalaCards
Search PCSK6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PCSK6

Genetic Association Database (GAD)
PCSK6
Human Genome Epidemiology (HuGE) Navigator
PCSK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCSK6
genes like me logo Genes that share disorders with PCSK6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCSK6 Gene

Publications for PCSK6 Gene

  1. Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. (PMID: 1741956) Kiefer M.C. … Barr P.J. (DNA Cell Biol. 1991) 2 3 4 22 64
  2. The association between paired basic amino acid cleaving enzyme 4 gene haplotype and diastolic blood pressure. (PMID: 15043778) Li J.P. … Huo Y. (Chin. Med. J. 2004) 3 22 46 64
  3. Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain. (PMID: 10215603) Sucic J.F. … Moehring T.J. (Biochem. J. 1999) 3 4 22 64
  4. Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4). (PMID: 9738469) Nagahama M. … Matsuda Y. (FEBS Lett. 1998) 3 4 22 64
  5. A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus. (PMID: 9192737) Mori K. … Matsuda Y. (J. Biochem. 1997) 3 4 22 64

Products for PCSK6 Gene

Sources for PCSK6 Gene

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