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PCSK5 Gene

protein-coding GIFtS: 56

GC09P077695

proprotein convertase subtilisin/kexin type 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 3.4.21.- ^³
OTTHUMP00000021497 ^²
OTTHUMP00000063532 ^²
PC5 ^¹, ², ³
PC6 ^¹, ², ³
PC6A ^²
SPC6 ^¹, ²
hPC6 ^³

Descriptions
Proprotein convertase PC5 ^², ³
Subtilisin/kexin-like protease PC5 ^², ³
prohormone convertase 5 ^²
proprotein convertase subtilisin/kexin type 5 ^²
protease PC6 ^²

External Ids
HGNC: 8747¹
Entrez Gene: 5125²
UniProtKB: Q92824³
Ensembl: ENSG00000099139⁷

Search outside databases for aliases for PCSK5 gene

Previous GC identifers: GC09P069549 GC09P070362 GC09P072075 GC09P073962 GC09P075735

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PCSK5:

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The

members of this family are proprotein convertases that process latent precursor proteins into

their biologically active products. This encoded protein mediates posttranslational

endoproteolytic processing for several integrin alpha subunits. It is thought to process prorenin,

pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Two alternatively

spliced transcripts are described for this gene but only one has its full length nature known.

[provided by RefSeq]

UniProtKB/Swiss-Prot: PCSK5_HUMAN, Q92824

Function: Likely to represent a widespread endoprotease activity within the constitutive and

regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif

Gene Wiki entry for PCSK5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PCSK5 gene

Entrez Gene cytogenetic band: 9q21.3 Ensembl cytogenetic band: 9q21.13 HGNC chromosome: 9

PCSK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P077695: (about GC identifiers)

Start:	77,695,406 bp from pter
End:	78,163,658 bp from pter
Size:	468,253 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PCSK5_HUMAN, Q92824 (See protein sequence)

Recommended Name: Proprotein convertase subtilisin/kexin type 5 precursor

Size: 913 amino acids; 101649 Da

Subcellular location: Secreted (By similarity)

Secondary accessions: Q13527 Q96EP4

Alternative splicing: 1 isoform: Q92824-1 (2 isoforms may be produced)

REFSEQ proteins: NP_006191.2

ENSEMBL proteins:

ENSP00000379415 ENSP00000365945 ENSP00000365958 ENSP00000365943

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PC6)
	Human Recombinant Proteins from Abnova (PCSK5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005796	Golgi lumen	EXP	8615794
GO:0030141	secretory granule	IEA	--

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Antibodies for PCSK5:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PC6), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for PCSK5

Assays for PCSK5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q92824

ProtoNet protein and cluster: Q92824

3 Blocks protein families:

IPB000209 Subtilisin serine protease family (S8) signature

IPB002884 Proprotein convertase

IPB006212 Furin-like repeat

UniProtKB/Swiss-Prot: PCSK5_HUMAN, Q92824

Domain: The propeptide domain acts as an intramolecular chaperone assisting the folding of the

zymogen within the endoplasmic reticulum

Similarity: Belongs to the peptidase S8 family

Similarity: Contains 1 homo B/P domain

Similarity: Contains 1 PLAC domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PCSK5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006200

Applied Biosystems Silencer® siRNAs for PCSK5

Sigma-Aldrich siRNA and siRNA Panels for PCSK5

Sigma-Aldrich shRNA for PCSK5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PCSK5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006200
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006200
untagged cDNA clones in CMV expression vector (see all 2): NM_006200

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006200

UniProtKB/Swiss-Prot: PCSK5_HUMAN, Q92824

Function: Likely to represent a widespread endoprotease activity within the constitutive and

regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif

Catalytic activity: Release of mature proteins from their proproteins by cleavage of

Arg-Xaa-Yaa-Arg- -Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys

Enzyme Number (IUBMB): EC 3.4.21.-

Genatlas biochemistry entry for PCSK5:

proprotein convertase subtilisin,kexin-like 5,exhibiting the presence of multiple alternative

forms,expressed in regulated and constitutively secreting cells

14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Pcsk5):

	craniofacial	digestive/alimentary	embryogenesis	growth/size
hematopoietic system	immune system	lethality-prenatal/perinatal	limbs/digits/tail	nervous system
no phenotypic analysis	renal/urinary system	respiratory system	skeleton

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--
GO:0042277	peptide binding	IEA	--

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for PCSK5

5/8 Interacting proteins for PCSK5 (ENSP00000365945³ Q92824²) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATN1	P54259²	MINT-2861631
NGF	ENSP00000358525³	STRING (score=.972)
FURIN	ENSP00000268171³	STRING (score=.916)
PCSK6	ENSP00000305056³	STRING (score=.911)
ANXA1	ENSP00000366109³	STRING (score=.77)

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5/15 Gene Ontology (GO) biological process terms (links to tree view) (see all 15 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	IEA	--
GO:0002001	renin secretion into blood stream	IEP	8901832
GO:0006465	signal peptide processing	IDA	16912035
GO:0007267	cell-cell signaling	TAS	8901832
GO:0007507	heart development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PCSK5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PCSK5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006200

Sigma-Aldrich siRNA and siRNA Panels for PCSK5

Sigma-Aldrich shRNA for PCSK5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006200

REFSEQ mRNAs for PCSK5 gene:

NM_006200.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006200

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006200
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006200
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006200

Additional cDNA sequence:

AK023096.1 AK056202.1 AK225773.1 AK310862.1 AL834522.1 BC012064.1 U49114.1 U56387.2

9 DOTS entries:

DT.312399 DT.311845 DT.121188067 DT.100644172 DT.91743071 DT.86846908 DT.100775705 DT.102826294

DT.121188127

24/130 AceView cDNA sequences (see all 130 ):

CD559043 AA399377 AI379031 AI146827 AI167576 AL138208 CD519399 AL138118

BC012064 CD622139 U49114 CD622141 AL834522 BM828796 AK056202 AX805784

AA401788 CF551985 AA317669 BU622566 AI435197 AW261870 BP346136 AW960690

highest scoring ESTs for PCSK5:

U56387 AA256399 AA256502 AA716104 AA779339 AI079572 AI093799 AI400544 AI567695 AI572500

Unigene Cluster for PCSK5:

Proprotein convertase subtilisin/kexin type 5

Hs.368542 [show with all ESTs]

Unigene Representative Sequence: NM_006200

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000396108 ENST00000376754 ENST00000376767 ENST00000376752

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PCSK5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PCSK5

¹ / ² / ³

8 probe-sets matching PCSK5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41032_at²^{, 3}	U95-A	1	0.31	1.00	0.97	0.66	U56387	1.00	1.00	1.00	1
60802_at*²^{, 3}	U95-C	1	1.00	1.00	0.95	1.37	AA778399	0.60	1.00	0.82	1
205559_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006200	0.60	1.00	0.82	1
205560_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006200	0.60	1.00	0.82	1
213652_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AU152579	0.40	1.00	0.76	1
205559_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205560_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213652_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PCSK5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TACATTTCAA

SOURCE GeneReport for Unigene cluster: Hs.368542
Expression variation in blood from EXPOLDB for PCSK5
UniProtKB/Swiss-Prot: PCSK5_HUMAN, Q92824
Tissue specificity: Expressed in T-lymphocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PCSK5 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PCSK5¹	--	proprotein convertase subtilisin/kexin type 5	91.14(n) 96(a)	484160 XM_541276.2 XP_541276.2
chimpanzee (Pan troglodytes)	PCSK5¹	--	proprotein convertase subtilisin/kexin type 5	97.53(n) 97.46(a)	464533 XM_520079.2 XP_520079.2
cow (Bos taurus)	PCSK5¹	--	proprotein convertase subtilisin/kexin type 5	89.92(n) 95.24(a)	528098 XM_606509.3 XP_606509.3
rat (Rattus norvegicus)	Pcsk5¹	--	proprotein convertase subtilisin/kexin type 5	87.7(n) 94.36(a)	116548 XM_342032.3 XP_342033.3
mouse (Mus musculus)	Pcsk5^{1, 5}	19 (18.00 cM)⁵	proprotein convertase subtilisin/kexin type 5^{1, 5}	88.43(n)¹ 94.96(a)¹	18552¹ XM_129214.6¹ XP_129214.5¹ AK032736⁵ AK143998⁵ (see all 12)

About this table Species with no ortholog for PCSK5

ENSEMBL Gene Tree for PCSK5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PCSK5 gene

PCSK4² PCSK6² FURIN²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1983 NCBI SNPs in PCSK5 are shown (see all 1983 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 721)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10869729^1,2	A,C,F,H	77998313(+)	`TTTTAT/CAACTG`	1	--	ng3¹ ese³		10		EU EA WA NA	1020
--	rs6560474^1,2	A,C,F,H	77693927(+)	`CTCTAC/GAGTAT`	1	--	ng5¹		4		EU EA WA	418
	rs3814115^1,2	A,C,F,H	77694549(+)	`GTGCAT/CGATAG`	1	--	ng5¹		12		EU EA WA	1254
	rs12005073^1,2	C,F	77695709(+)	`GTCCCG/TGCAGC`	1	--	ut5¹ ese³		2		NA	182
	rs7853608^1,2	A,C	77695286(+)	`TCGTCA/GGCGCC`	1	--	ng5¹		0	--	--	--	--
	rs3814117^1,2	C	77695423(+)	`AATCCC/TCGCGC`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs12551054^1,2	C	77693635(+)	`tgcgaC/Ggccaa`	1	--	ng5¹		0	--	--	--	--
--	rs7028015^1,2	A	77694531(+)	`CTGCCC/TGCTGC`	1	--	ng5¹		0	--	--	--	--
--	rs11144667^1,2	A	77693535(+)	`agcgaC/Gactcc`	1	--	ng5¹		0	--	--	--	--
	rs7040769^1,2	A,C,F	77696007(+)	`GTGTGT/CCGGAC`	1	C/C	syn¹ ese³		1		NA	72

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HapMap Linkage Disequilibrium images for PCSK5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600488

6 Novoseek disease relationships for PCSK5 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atherosclerosis	22.44	4	16244876 (2), 15911696 (1), 15756593 (1)
atherosclerotic plaque	19.63	1	15911696 (1)
restenosis	14.00	2	16244876 (2)
tumors	1.43	1	11457520 (1)
influenza	1.06	2	10074171 (1), 8057485 (1)
cancer	0.00	1	18664504 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/83 PubMed articles for PCSK5 gene (see all 83 ):

Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. (PubMed id 7782070)^{1, 2, 3} Mbikay M....Simpson E.M. (1995)
Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes. (PubMed id 8755538)^{1, 3, 4} Miranda L.... Franzusoff A. (1996)
Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility. (PubMed id 15601911)^{1, 3} Nie G....Salamonsen L.A. (2005)
Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family. (PubMed id 8620001)^{1, 3} Campan M....Haber E. (1996)
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis. (PubMed id 15911696)^{1, 3} Stawowy P....Graf K. (2005)
Single-nucleotide polymorphisms of the proprotein convertase subtilisin/ kexin type 5 (PCSK5) gene. (PubMed id 11776387)^{1, 3} Cao H....Hegele R.A. (2001)
Prohormone convertase PC5 is a candidate processing enzyme for prorenin in the human adrenal cortex. (PubMed id 8901832)^{1, 3} Mercure C....Reudelhuber T.L. (1996)
The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. (PubMed id 8947550)^{1, 3} De Bie I....Seidah N.G. (1996)
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2. (PubMed id 17242158)^{1, 3} McColl B.K....Achen M.G. (2007)
Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains. (PubMed id 11723118)^{1, 3} Fugere M....Day R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5125	HGNC: 8747	AceView: PCSK5	Ensembl:ENSG00000099139	euGenes: HUgn5125
ECgene: PCSK5	H-InvDB: PCSK5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for PCSK5
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PCSK5:

TaqMan ® Gene Expression Assays

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Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PCSK5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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PCSK5 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for PCSK5

Summaries
for PCSK5

Genomic Location
for PCSK5

Proteins
for PCSK5

Protein Domains/
Families
for PCSK5

Gene Function
for PCSK5

Pathways & Interactions
for PCSK5

Drugs & Compounds
for PCSK5

Transcripts
for PCSK5

Expression
for PCSK5

Orthologs
for PCSK5

Paralogs
for PCSK5

SNPs/Variants
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Disorders & Mutations
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Medical News
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for PCSK5

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Services
for PCSK5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PCSK5 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor PCSK5

Summariesfor PCSK5

Genomic Locationfor PCSK5

Proteinsfor PCSK5

Protein Domains/Familiesfor PCSK5

Gene Functionfor PCSK5

Pathways & Interactionsfor PCSK5

Drugs & Compoundsfor PCSK5

Transcriptsfor PCSK5

Expression for PCSK5

Orthologsfor PCSK5

Paralogsfor PCSK5

SNPs/Variantsfor PCSK5

Disorders & Mutationsfor PCSK5

Medical Newsfor PCSK5

Publicationsfor PCSK5

Search for PCSK5

Genome Databases showing PCSK5

Other Databases showing PCSK5

Specialized Databases showing PCSK5

Licensable Technologiesfor PCSK5

Servicesfor PCSK5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PCSK5

Summaries
for PCSK5

Genomic Location
for PCSK5

Proteins
for PCSK5

Protein Domains/
Families
for PCSK5

Gene Function
for PCSK5

Pathways & Interactions
for PCSK5

Drugs & Compounds
for PCSK5

Transcripts
for PCSK5

Expression
for PCSK5

Orthologs
for PCSK5

Paralogs
for PCSK5

SNPs/Variants
for PCSK5

Disorders & Mutations
for PCSK5

Medical News
for PCSK5

Publications
for PCSK5

Licensable Technologies
for PCSK5

Services
for PCSK5