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Aliases for PCSK5 Gene

Aliases for PCSK5 Gene

  • Proprotein Convertase Subtilisin/Kexin Type 5 2 3
  • Subtilisin/Kexin-Like Protease PC5 3 4
  • Proprotein Convertase 6 3 4
  • PC5 3 4
  • PC6 3 4
  • Prohormone Convertase 5 3
  • Proprotein Convertase 5 4
  • Protease PC6 3
  • EC 63
  • EC 63
  • EC 3.4.21.- 4
  • Subtilase 3
  • EC 3.4.21 63
  • PC6A 3
  • SPC6 3
  • HPC6 4

External Ids for PCSK5 Gene

Previous GeneCards Identifiers for PCSK5 Gene

  • GC09P069549
  • GC09P070362
  • GC09P072075
  • GC09P073962
  • GC09P075735
  • GC09P077695
  • GC09P078505
  • GC09P048336

Summaries for PCSK5 Gene

Entrez Gene Summary for PCSK5 Gene

  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]

GeneCards Summary for PCSK5 Gene

PCSK5 (Proprotein Convertase Subtilisin/Kexin Type 5) is a Protein Coding gene. Diseases associated with PCSK5 include currarino syndrome and nail disease. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include serine-type endopeptidase activity and peptide binding. An important paralog of this gene is PCSK1.

UniProtKB/Swiss-Prot for PCSK5 Gene

  • Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

Gene Wiki entry for PCSK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCSK5 Gene

Genomics for PCSK5 Gene

Regulatory Elements for PCSK5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCSK5 Gene

75,890,644 bp from pter
76,362,339 bp from pter
471,696 bases
Plus strand

Genomic View for PCSK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCSK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCSK5 Gene

Proteins for PCSK5 Gene

  • Protein details for PCSK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proprotein convertase subtilisin/kexin type 5
    Protein Accession:
    Secondary Accessions:
    • F5H2G7
    • Q13527
    • Q96EP4

    Protein attributes for PCSK5 Gene

    1860 amino acids
    Molecular mass:
    206942 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCSK5 Gene


neXtProt entry for PCSK5 Gene

Proteomics data for PCSK5 Gene at MOPED

Post-translational modifications for PCSK5 Gene

  • Ubiquitination at Lys56
  • Glycosylation at Asn225, Asn381, Asn665, Asn752, Asn802, Asn852, Asn1014, Asn1191, Asn1290, Asn1497, Asn1685, and Asn1707
  • Modification sites at PhosphoSitePlus

Other Protein References for PCSK5 Gene

Antibody Products

Domains for PCSK5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q92824
  • The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum
  • AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 (By similarity).
  • Contains 1 peptidase S8 domain.
  • Contains 1 PLAC domain.
  • Belongs to the peptidase S8 family.
  • Contains 22 FU (furin-like) repeats.
genes like me logo Genes that share domains with PCSK5: view

No data available for Gene Families for PCSK5 Gene

Function for PCSK5 Gene

Molecular function for PCSK5 Gene

GENATLAS Biochemistry:
proprotein convertase subtilisin,kexin-like 5,exhibiting the presence of multiple alternative forms,expressed in regulated and constitutively secreting cells
UniProtKB/Swiss-Prot CatalyticActivity:
Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg- -Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys
UniProtKB/Swiss-Prot Function:
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

Enzyme Numbers (IUBMB) for PCSK5 Gene

Gene Ontology (GO) - Molecular Function for PCSK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity --
GO:0004252 serine-type endopeptidase activity IDA 8901832
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IDA 15606899
GO:0042277 peptide binding ISS 8940009
genes like me logo Genes that share ontologies with PCSK5: view
genes like me logo Genes that share phenotypes with PCSK5: view

Animal Models for PCSK5 Gene

MGI Knock Outs for PCSK5:

Animal Model Products

miRNA for PCSK5 Gene

miRTarBase miRNAs that target PCSK5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCSK5

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PCSK5 Gene

Localization for PCSK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCSK5 Gene

Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.
Isoform PC6B: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PCSK5 Gene COMPARTMENTS Subcellular localization image for PCSK5 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PCSK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS 8940009
GO:0005794 Golgi apparatus ISS --
GO:0005796 Golgi lumen TAS --
GO:0016021 integral component of membrane IEA --
GO:0030141 secretory granule ISS --
genes like me logo Genes that share ontologies with PCSK5: view

Pathways for PCSK5 Gene

genes like me logo Genes that share pathways with PCSK5: view

Pathways by source for PCSK5 Gene

3 Reactome pathways for PCSK5 Gene

Gene Ontology (GO) - Biological Process for PCSK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS 8940009
GO:0002001 renin secretion into blood stream IEP 8901832
GO:0006465 signal peptide processing IDA 16912035
GO:0006508 proteolysis --
GO:0007267 cell-cell signaling TAS 8901832
genes like me logo Genes that share ontologies with PCSK5: view

Compounds for PCSK5 Gene

(1) Novoseek inferred chemical compound relationships for PCSK5 Gene

Compound -log(P) Hits PubMed IDs
serine 13.2 1
genes like me logo Genes that share compounds with PCSK5: view

Transcripts for PCSK5 Gene

Unigene Clusters for PCSK5 Gene

Proprotein convertase subtilisin/kexin type 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCSK5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCSK5 Gene

No ASD Table

Relevant External Links for PCSK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCSK5 Gene

mRNA expression in normal human tissues for PCSK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PCSK5 Gene

This gene is overexpressed in Lung (23.9), Peripheral blood mononuclear cells (19.7), Liver, secretome (14.1), and Pancreatic juice (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PCSK5 Gene

SOURCE GeneReport for Unigene cluster for PCSK5 Gene Hs.368542

mRNA Expression by UniProt/SwissProt for PCSK5 Gene

Tissue specificity: Expressed in T-lymphocytes
genes like me logo Genes that share expressions with PCSK5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for PCSK5 Gene

Orthologs for PCSK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCSK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCSK5 35
  • 82.62 (n)
  • 77.98 (a)
PCSK5 36
  • 79 (a)
(Canis familiaris)
Mammalia PCSK5 35
  • 86.85 (n)
  • 85.73 (a)
PCSK5 36
  • 84 (a)
(Mus musculus)
Mammalia Pcsk5 35
  • 82.82 (n)
  • 82.01 (a)
Pcsk5 16
Pcsk5 36
  • 81 (a)
(Pan troglodytes)
Mammalia PCSK5 35
  • 99.07 (n)
  • 98.82 (a)
PCSK5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pcsk5 35
  • 87.5 (n)
  • 94.14 (a)
(Monodelphis domestica)
Mammalia PCSK5 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
-- 36
  • 70 (a)
-- 36
  • 91 (a)
-- 36
  • 61 (a)
(Gallus gallus)
Aves PCSK5 35
  • 78.78 (n)
  • 82.68 (a)
PCSK5 36
  • 66 (a)
(Anolis carolinensis)
Reptilia PCSK5 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcsk5 35
  • 72.86 (n)
  • 78.75 (a)
(Danio rerio)
Actinopterygii pcsk5a 35
  • 57.91 (n)
  • 53.28 (a)
FP236851.1 36
  • 66 (a)
pcsk5b 36
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.902 35
fruit fly
(Drosophila melanogaster)
Insecta Fur1 37
  • 51 (a)
Fur2 37
  • 40 (a)
Fur2 35
  • 50.57 (n)
  • 43.72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002915 35
  • 50.75 (n)
  • 43.8 (a)
(Caenorhabditis elegans)
Secernentea aex-5 37
  • 36 (a)
bli-4 37
  • 45 (a)
kpc-1 37
  • 54 (a)
aex-5 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for PCSK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCSK5 Gene

Gene Tree for PCSK5 (if available)
Gene Tree for PCSK5 (if available)

Paralogs for PCSK5 Gene

Paralogs for PCSK5 Gene

Selected SIMAP similar genes for PCSK5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PCSK5: view

Variants for PCSK5 Gene

Sequence variations from dbSNP and Humsavar for PCSK5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs749836 -- 76,301,321(-) TTTAT(C/G)TCTAT intron-variant
rs756327 -- 76,350,972(-) GTTTC(C/T)CTCTA intron-variant
rs765468 -- 76,291,824(-) TACCC(A/C)AGAAT intron-variant
rs868968 -- 75,962,789(+) CTGGC(A/G)GAAAT intron-variant
rs868969 -- 75,962,904(+) GTTGG(A/T)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCSK5 Gene

Variant ID Type Subtype PubMed ID
nsv893472 CNV Gain 21882294
nsv893473 CNV Gain 21882294
esv988212 CNV Deletion 20482838
esv9306 CNV Gain 19470904
esv2676945 CNV Deletion 23128226
nsv831627 CNV Loss 17160897
esv2738574 CNV Deletion 23290073
esv33354 CNV Loss 17666407
esv1368287 CNV Deletion 17803354
esv2738575 CNV Deletion 23290073
esv2670080 CNV Deletion 23128226
esv2199133 CNV Deletion 18987734
esv2738576 CNV Deletion 23290073
esv1007851 CNV Deletion 20482838
esv2576493 CNV Deletion 19546169
esv1627785 CNV Deletion 17803354
esv28691 CNV Gain 19812545
nsv437647 CNV Loss 16327808
nsv6569 CNV Insertion 18451855
nsv893474 CNV Gain 21882294
nsv893475 CNV Gain 21882294
nsv893476 CNV Gain 21882294
esv2665184 CNV Deletion 23128226
esv2738577 CNV Deletion 23290073
nsv466422 CNV Loss 19166990
nsv508552 CNV Loss 20534489
esv2660720 CNV Deletion 23128226
nsv893477 CNV Gain 21882294
esv270678 CNV Insertion 20981092
nsv521139 CNV Gain 19592680
nsv523103 CNV Loss 19592680
esv1010025 CNV Deletion 20482838
esv2738578 CNV Deletion 23290073
nsv435888 CNV Deletion 17901297
nsv512104 CNV Loss 21212237
esv4993 CNV Deletion 18987735
esv995792 CNV Deletion 20482838
dgv1316e201 CNV Deletion 23290073
dgv1317e201 CNV Deletion 23290073
dgv1318e201 CNV Deletion 23290073
esv1007112 CNV Gain 20482838
esv24499 CNV Gain 19812545
nsv820404 CNV Deletion 20802225
esv1579961 CNV Deletion 17803354
esv2738595 CNV Deletion 23290073
esv2738597 CNV Deletion 23290073
nsv526457 CNV Loss 19592680
nsv893478 CNV Gain 21882294
nsv893479 CNV Gain 21882294

Relevant External Links for PCSK5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCSK5 Gene

Disorders for PCSK5 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PCSK5 Gene in MalaCards »

(5) Diseases for PCSK5 Gene including...

(3) University of Copenhagen DISEASES for PCSK5 Gene

(6) Novoseek inferred disease relationships for PCSK5 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 18.7 4
atherosclerotic plaque 15.9 1
restenosis 10.5 2
tumors 0 1
influenza 0 2

Relevant External Links for PCSK5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PCSK5: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for PCSK5 Gene

Publications for PCSK5 Gene

  1. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. (PMID: 7782070) Mbikay M. … Simpson E.M. (Genomics 1995) 2 3 23
  2. Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes. (PMID: 8755538) Miranda L. … Franzusoff A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  3. Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment. (PMID: 19764806) Kilpatrick L.M. … Nie G. (J. Proteome Res. 2009) 3 4 23
  4. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. (PMID: 20031622) Iatan I. … Genest J. (Circ Cardiovasc Genet 2009) 3 23 48
  5. Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases. (PMID: 18061232) Xiao Y. … Cohen E.A. (Virology 2008) 3 23

Products for PCSK5 Gene

Sources for PCSK5 Gene

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