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Aliases for PCSK5 Gene

Aliases for PCSK5 Gene

  • Proprotein Convertase Subtilisin/Kexin Type 5 2 3 5
  • Subtilisin/Kexin-Like Protease PC5 3 4
  • Proprotein Convertase 6 3 4
  • PC5 3 4
  • PC6 3 4
  • Prohormone Convertase 5 3
  • Proprotein Convertase 5 4
  • Protease PC6 3
  • EC 61
  • EC 61
  • EC 3.4.21.- 4
  • Subtilase 3
  • EC 3.4.21 61
  • PC6A 3
  • SPC6 3
  • HPC6 4

External Ids for PCSK5 Gene

Previous GeneCards Identifiers for PCSK5 Gene

  • GC09P069549
  • GC09P070362
  • GC09P072075
  • GC09P073962
  • GC09P075735
  • GC09P077695
  • GC09P078505
  • GC09P048336

Summaries for PCSK5 Gene

Entrez Gene Summary for PCSK5 Gene

  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]

GeneCards Summary for PCSK5 Gene

PCSK5 (Proprotein Convertase Subtilisin/Kexin Type 5) is a Protein Coding gene. Diseases associated with PCSK5 include Currarino Syndrome and Avian Influenza. Among its related pathways are Metabolism and Signaling by GPCR. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is PCSK6.

UniProtKB/Swiss-Prot for PCSK5 Gene

  • Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

Gene Wiki entry for PCSK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCSK5 Gene

Genomics for PCSK5 Gene

Regulatory Elements for PCSK5 Gene

Enhancers for PCSK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F075909 0.6 ENCODE 22 +22.7 22703 7.1 ZNF362 ZNF680 SMARCA4 TEAD4 NFE2 MAFK NFE2L2 PCSK5 GC09P076099
GH09F075963 0.5 Ensembl ENCODE 20.1 +74.0 74003 1.6 PCSK5 GC09P076099
GH09F075992 1.2 Ensembl ENCODE 19.9 +103.0 103021 1.4 JUND JUN FOS NR3C1 PCSK5 GC09P076099
GH09F075950 0.5 ENCODE 19.5 +62.9 62850 6.3 L3MBTL2 CEBPB FEZF1 MNT RAD21 NR2F2 YY1 GATA3 ATF3 HNF4G PCSK5 GC09P076099
GH09F075988 1.1 ENCODE 18.4 +99.9 99915 3.7 PKNOX1 SMARCA4 PCSK5 GC09P076099
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PCSK5 on UCSC Golden Path with GeneCards custom track

Promoters for PCSK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001471386 699 3801 PKNOX1 ZNF76 KLF17 RAD21 ZNF2 YY1 GLIS2 ZNF366 ZNF143 KLF7

Genomic Location for PCSK5 Gene

75,890,601 bp from pter
76,362,339 bp from pter
471,739 bases
Plus strand

Genomic View for PCSK5 Gene

Genes around PCSK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCSK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCSK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCSK5 Gene

Proteins for PCSK5 Gene

  • Protein details for PCSK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proprotein convertase subtilisin/kexin type 5
    Protein Accession:
    Secondary Accessions:
    • F5H2G7
    • Q13527
    • Q96EP4

    Protein attributes for PCSK5 Gene

    1860 amino acids
    Molecular mass:
    206942 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCSK5 Gene


neXtProt entry for PCSK5 Gene

Selected DME Specific Peptides for PCSK5 Gene


Post-translational modifications for PCSK5 Gene

  • Ubiquitination at Lys 56
  • Glycosylation at Asn 225, Asn 381, Asn 665, Asn 752, Asn 802, Asn 852, Asn 1014, Asn 1191, Asn 1290, Asn 1497, Asn 1685, and Asn 1707
  • Modification sites at PhosphoSitePlus

Domains & Families for PCSK5 Gene

Gene Families for PCSK5 Gene

Graphical View of Domain Structure for InterPro Entry



  • The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
  • Belongs to the peptidase S8 family.
  • Contains 22 FU (furin-like) repeats.
  • The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
  • AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 (By similarity).
  • Contains 1 peptidase S8 domain.
  • Contains 1 PLAC domain.
  • Belongs to the peptidase S8 family.
  • Contains 22 FU (furin-like) repeats.
genes like me logo Genes that share domains with PCSK5: view

Function for PCSK5 Gene

Molecular function for PCSK5 Gene

GENATLAS Biochemistry:
proprotein convertase subtilisin,kexin-like 5,exhibiting the presence of multiple alternative forms,expressed in regulated and constitutively secreting cells
UniProtKB/Swiss-Prot CatalyticActivity:
Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg- -Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.
UniProtKB/Swiss-Prot Function:
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

Enzyme Numbers (IUBMB) for PCSK5 Gene

Gene Ontology (GO) - Molecular Function for PCSK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity IDA 8901832
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IDA 15606899
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with PCSK5: view
genes like me logo Genes that share phenotypes with PCSK5: view

Animal Models for PCSK5 Gene

MGI Knock Outs for PCSK5:

Animal Model Products

miRNA for PCSK5 Gene

miRTarBase miRNAs that target PCSK5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCSK5 Gene

Localization for PCSK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCSK5 Gene

Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.
Isoform PC6B: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PCSK5 Gene COMPARTMENTS Subcellular localization image for PCSK5 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PCSK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space ISS 8940009
GO:0005794 Golgi apparatus IEA,ISS --
GO:0005796 Golgi lumen TAS --
GO:0012505 endomembrane system IEA --
genes like me logo Genes that share ontologies with PCSK5: view

Pathways & Interactions for PCSK5 Gene

genes like me logo Genes that share pathways with PCSK5: view

Gene Ontology (GO) - Biological Process for PCSK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS 8940009
GO:0002001 renin secretion into blood stream IEP 8901832
GO:0003279 cardiac septum development IEA --
GO:0006465 signal peptide processing IDA 16912035
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with PCSK5: view

No data available for SIGNOR curated interactions for PCSK5 Gene

Drugs & Compounds for PCSK5 Gene

(1) Drugs for PCSK5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PCSK5: view

Transcripts for PCSK5 Gene

Unigene Clusters for PCSK5 Gene

Proprotein convertase subtilisin/kexin type 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCSK5 Gene

No ASD Table

Relevant External Links for PCSK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCSK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCSK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCSK5 Gene

This gene is overexpressed in Lung (23.9), Peripheral blood mononuclear cells (19.7), Liver, secretome (14.1), and Pancreatic juice (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCSK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCSK5 Gene:


SOURCE GeneReport for Unigene cluster for PCSK5 Gene:


mRNA Expression by UniProt/SwissProt for PCSK5 Gene:

Tissue specificity: Expressed in T-lymphocytes.
genes like me logo Genes that share expression patterns with PCSK5: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PCSK5 Gene

Orthologs for PCSK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCSK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCSK5 34 35
  • 99.07 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
-- 35
  • 91 (a)
-- 35
  • 70 (a)
-- 35
  • 61 (a)
(Rattus norvegicus)
Mammalia Pcsk5 34
  • 87.5 (n)
(Canis familiaris)
Mammalia PCSK5 34 35
  • 86.85 (n)
(Mus musculus)
Mammalia Pcsk5 34 16 35
  • 82.82 (n)
(Bos Taurus)
Mammalia PCSK5 34 35
  • 82.62 (n)
(Monodelphis domestica)
Mammalia PCSK5 35
  • 76 (a)
(Gallus gallus)
Aves PCSK5 34 35
  • 78.78 (n)
(Anolis carolinensis)
Reptilia PCSK5 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcsk5 34
  • 72.86 (n)
(Danio rerio)
Actinopterygii pcsk5b 35
  • 67 (a)
FP236851.1 35
  • 66 (a)
pcsk5a 34
  • 57.91 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.902 34
fruit fly
(Drosophila melanogaster)
Insecta Fur1 36
  • 51 (a)
Fur2 36 34
  • 50.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002915 34
  • 50.75 (n)
(Caenorhabditis elegans)
Secernentea kpc-1 36
  • 54 (a)
bli-4 36
  • 45 (a)
aex-5 36 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
Species where no ortholog for PCSK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCSK5 Gene

Gene Tree for PCSK5 (if available)
Gene Tree for PCSK5 (if available)

Paralogs for PCSK5 Gene

Paralogs for PCSK5 Gene

(6) SIMAP similar genes for PCSK5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PCSK5: view

Variants for PCSK5 Gene

Sequence variations from dbSNP and Humsavar for PCSK5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs61744763 Likely benign 76,328,030(+) CTTGA(C/T)CTGCT reference, missense
rs34417623 Uncertain significance 76,023,881(+) AACTA(C/T)GTGAG nc-transcript-variant, reference, synonymous-codon
rs1002420 -- 76,254,608(-) TCAAG(G/T)TCCTT intron-variant
rs10046791 -- 76,167,289(+) gaaaa(A/T)cactg intron-variant
rs1006279 -- 75,912,633(+) GTACT(A/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCSK5 Gene

Variant ID Type Subtype PubMed ID
dgv1258e201 CNV deletion 23290073
dgv1259e201 CNV deletion 23290073
dgv1260e201 CNV deletion 23290073
dgv12763n54 CNV loss 21841781
dgv12764n54 CNV loss 21841781
dgv4070n106 CNV deletion 24896259
esv1007112 CNV gain 20482838
esv1007851 CNV deletion 20482838
esv1010025 CNV deletion 20482838
esv1368287 CNV deletion 17803354
esv1579961 CNV deletion 17803354
esv1627785 CNV deletion 17803354
esv2199133 CNV deletion 18987734
esv24499 CNV gain 19812545
esv2576493 CNV deletion 19546169
esv2660720 CNV deletion 23128226
esv2665184 CNV deletion 23128226
esv2670080 CNV deletion 23128226
esv2676945 CNV deletion 23128226
esv2738574 CNV deletion 23290073
esv2738575 CNV deletion 23290073
esv2738576 CNV deletion 23290073
esv2738577 CNV deletion 23290073
esv2738578 CNV deletion 23290073
esv2738595 CNV deletion 23290073
esv2738597 CNV deletion 23290073
esv28691 CNV gain 19812545
esv3267717 CNV deletion 24192839
esv3306402 CNV mobile element insertion 20981092
esv33354 CNV loss 17666407
esv3451207 CNV insertion 20981092
esv3544950 CNV deletion 23714750
esv3544952 CNV deletion 23714750
esv3620732 CNV loss 21293372
esv3620735 CNV loss 21293372
esv3620736 CNV loss 21293372
esv3620738 CNV gain 21293372
esv3620739 CNV loss 21293372
esv4993 CNV loss 18987735
esv9306 CNV gain 19470904
esv988212 CNV deletion 20482838
esv995792 CNV deletion 20482838
nsv1075655 CNV deletion 25765185
nsv1075656 CNV deletion 25765185
nsv1126911 CNV deletion 24896259
nsv1152370 CNV duplication 26484159
nsv435888 CNV deletion 17901297
nsv437647 CNV loss 16327808
nsv466422 CNV loss 19166990
nsv508552 CNV deletion 20534489
nsv512104 CNV loss 21212237
nsv521139 CNV gain 19592680
nsv523103 CNV loss 19592680
nsv526457 CNV loss 19592680
nsv614691 CNV loss 21841781
nsv614692 CNV loss 21841781
nsv6569 CNV insertion 18451855
nsv820404 CNV deletion 20802225
nsv831627 CNV loss 17160897
nsv957713 CNV deletion 24416366

Variation tolerance for PCSK5 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 24.65; 99.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCSK5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCSK5 Gene

Disorders for PCSK5 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PCSK5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
currarino syndrome
  • currarino triad
avian influenza
  • avian flu
plasma cell neoplasm
  • plasma cell dyscrasia
mature b-cell neoplasm
  • mature b-cell lymphocytic neoplasm
neurotic disorder
  • depressive neurosis
- elite association - COSMIC cancer census association via MalaCards
Search PCSK5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PCSK5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PCSK5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCSK5 Gene

Publications for PCSK5 Gene

  1. Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment. (PMID: 19764806) Kilpatrick L.M. … Nie G. (J. Proteome Res. 2009) 3 4 22 64
  2. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. (PMID: 20031622) Iatan I. … Genest J. (Circ Cardiovasc Genet 2009) 3 22 46 64
  3. Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes. (PMID: 8755538) Miranda L. … Franzusoff A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  4. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. (PMID: 7782070) Mbikay M. … Simpson E.M. (Genomics 1995) 2 3 22 64
  5. Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6. (PMID: 22740495) Paule S. … Nie G. (Hum. Reprod. 2012) 3 4 64

Products for PCSK5 Gene

Sources for PCSK5 Gene

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