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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PCSK4 Gene

protein-coding   GIFtS: 54
GCID: GC19M001481

Proprotein Convertase Subtilisin/Kexin Type 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proprotein Convertase Subtilisin/Kexin Type 41 2     Proprotein Convertase 43
PC42 3     EC 3.4.218
SPC52     EC 3.4.21.758
EC 3.4.21.-3     EC 3.4.21.938

External Ids:    HGNC: 87461   Entrez Gene: 547602   Ensembl: ENSG000001152577   OMIM: 6004875   UniProtKB: Q6UW603   

Export aliases for PCSK4 gene to outside databases

Previous GC identifers: GC19U990073 GC19M001550 GC19M001421 GC19M001432 GC19M001256


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCSK4 Gene:
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent
precursor proteins into their biologically active products. The encoded protein plays a critical role in
reproduction and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein
(proPACAP) and pro-insulin-like growth factor II. (provided by RefSeq, Feb 2012)

GeneCards Summary for PCSK4 Gene: 
PCSK4 (proprotein convertase subtilisin/kexin type 4) is a protein-coding gene. Diseases associated with PCSK4 include thyroiditis. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PCSK2.

UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60
Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic
amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the
multiprotein transcription complex

Gene Wiki entry for PCSK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCSK4 gene promoter:
         AhR   Spz1   AML1a   Pax-5   SREBP-1c   LUN-1   SREBP-1b   Arnt   YY1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCSK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PCSK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCSK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PCSK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCSK4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001481:  view genomic region     (about GC identifiers)

Start:
1,481,427 bp from pter      End:
1,490,751 bp from pter
Size:
9,325 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60 (See protein sequence)
Recommended Name: Proprotein convertase subtilisin/kexin type 4 precursor  
Size: 755 amino acids; 82795 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Developmental stage: Localized predominantly in the cytotrophoblast layer of trophoblast cells during the first
trimester of pregnancy, and to the syncytiotrophoblast and stroma cells during the third trimester
Secondary accessions: Q8IY88 Q9UF79
Alternative splicing: 2 isoforms:  Q6UW60-1   Q6UW60-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCSK4: NX_Q6UW60

Explore proteomics data for PCSK4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UW60

  • 4/13 DME Specific Peptides for PCSK4 (Q6UW60) (see all 13)
     DGYTNSI  VTTDLHH  ASYDFND  WASGNGG 

    PCSK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PCSK4 Protein Expression
    REFSEQ proteins: NP_060043.2  
    ENSEMBL proteins: 
     ENSP00000465102   ENSP00000300954   ENSP00000466528   ENSP00000465649   ENSP00000466742  

    Human Recombinant Protein Products for PCSK4: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PCSK4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002080acrosomal membrane IEA--
    GO:0016021integral to membrane IEA--

    PCSK4 for ontologies           About GeneDecksing



    PCSK4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR006212 Furin_repeat
     IPR000209 Peptidase_S8/S53_dom
     IPR015500 Peptidase_S8_subtilisin-rel
     IPR022398 Peptidase_S8_His-AS
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q6UW60

    ProtoNet protein and cluster: Q6UW60

    3 Blocks protein domains:
    IPB000209 Subtilisin serine protease family (S8) signature
    IPB002884 Proprotein convertase
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60
    Similarity: Belongs to the peptidase S8 family. Furin subfamily
    Similarity: Contains 1 FU (furin-like) repeat


    PCSK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCSK4_HUMAN, Q6UW60
    Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic
    amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the
    multiprotein transcription complex

         Genatlas biochemistry entry for PCSK4:
    proprotein convertase subtilisin,kexin like 4,only expressed in testicular germ cells

         Enzyme Numbers (IUBMB): EC 3.4.21.932 EC 3.4.212 EC 3.4.21.752 EC 3.4.21.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IBA--
         
    PCSK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pcsk4):
     reproductive system 

    PCSK4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PCSK4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCSK4 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate PCSK4:
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    SwitchGear 3'UTR luciferase reporter plasmidPCSK4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PCSK4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for PCSK4 (Q6UW603 ENSP000003009544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOCS1O155243I2D: score=1 
    IGF2ENSP000003382974STRING: ENSP00000338297
    --C9JAF23I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0007340acrosome reaction IEA--
    GO:0009566fertilization ----
    GO:0048240sperm capacitation IEA--

    PCSK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PCSK4 for compounds           About GeneDecksing

    EMD Millipore small molecules for PCSK4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCSK4

    1 Novoseek inferred chemical compound relationship for PCSK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 41.6 3 17636173 (1), 7782070 (1)

    Search CenterWatch for drugs/clinical trials and news about PCSK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PCSK4 gene: 
    NM_017573.3  

    Unigene Cluster for PCSK4:

    Proprotein convertase subtilisin/kexin type 4
    Hs.46884  [show with all ESTs]
    Unigene Representative Sequence: NM_017573
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591201 ENST00000441747(uc002lta.2) ENST00000300954(uc002lsz.2 uc002ltb.1)
    ENST00000586616 ENST00000586074 ENST00000588195 ENST00000591303 ENST00000586002
    ENST00000587784 ENST00000588671 ENST00000590057 ENST00000591687
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCSK4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PCSK4:
    hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPCSK4 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: PCSK4 (NM_017573)
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    Sirion Biotech Customized lentivirus for stable overexpression of PCSK4 
                         Customized lentivirus expression plasmids for stable overexpression of PCSK4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCSK4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCSK4

    Additional mRNA sequence: 

    AL133566.1 AY358963.1 BC036354.1 

    5 DOTS entries:

    DT.108926  DT.86857418  DT.121472651  DT.95212240  DT.40261904 

    24/34 AceView cDNA sequences (see all 34):

    BM727965 NM_017573 BX282334 AA453604 BI830987 AA868344 AY358963 AL041695 
    AL133566 AK057235 AL041693 AI758731 AL043305 BM554228 BC036354 BI459546 
    BU742489 T19069 BG719638 BU634491 AW298335 BF062014 BM559874 AI479378 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PCSK4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                                                                -                           
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                          -     -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for PCSK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PCSK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCTCCCC
    PCSK4 Expression
    About this image


    See PCSK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PCSK4

    SOURCE GeneReport for Unigene cluster: Hs.46884

    UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60
    Tissue specificity: Placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PCSK4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcsk41 , 5 proprotein convertase subtilisin/kexin type 41, 5 81.05(n)1
    80.84(a)1
      10 (39.72 cM)5
    185511  NM_008793.21  NP_032819.11 
     803212835 
    chicken
    (Gallus gallus)
    Aves PCSK41 proprotein convertase subtilisin/kexin type 4 68.2(n)
    64.97(a)
      100859150  XM_003642877.1  XP_003642925.1 
    lizard
    (Anolis carolinensis)
    Reptilia PCSK46
    Uncharacterized protein
    66(a)
    1 ↔ 1
    AAWZ02039304(2305-7997)
    fruit fly
    (Drosophila melanogaster)
    Insecta Fur16
    Fur26
    Furin 2
    23(a)
    19(a)
    possible ortholog
    1 ↔ many
    3R(21173090-21298778)
    X(16267121-16275816)
    worm
    (Caenorhabditis elegans)
    Secernentea kpc-16
    aex-56
    (see all 3)
    Protein AEX-5
    (see all 3)
    38(a)
    31(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    I(11675941-11680967)
    I(14850070-14855827)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KEX26
    Subtilisin-like protease (proprotein convertase), ...
    24(a)
    1 → many
    XIV(202428-204872)


    ENSEMBL Gene Tree for PCSK4 (if available)
    TreeFam Gene Tree for PCSK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PCSK4 gene
    PCSK22  PCSK62  FURIN2  PCSK12  PCSK72  PCSK52  
    6 SIMAP similar genes for PCSK4 using alignment to 5 protein entries:     PCSK4_HUMAN (see all proteins):
    PCSK1    PCSK2    PCSK6    PCSK5    FURIN    PCSK7

    PCSK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/321 SNPs in PCSK4 are shown (see all 321)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853903921,2
    --1481318(+) TTCTCC/TGTGGC 1 -- int10--------
    rs118807591,2
    C,F,H--1481347(+) ACTGAT/CGTCCG 1 -- int18Minor allele frequency- C:0.14NS NA WA 728
    rs1173051721,2
    C,F--1481370(+) AGAAAC/TCACCT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1139064261,2
    C--1481426(+) ACTGAC/G/TCACCT 1 -- spd11CSA 1
    rs1868332931,2
    --1481468(+) TTGGAC/TGCGGT 1 -- ut310--------
    rs10478541,2
    C,F,A,H--1481481(-) GTCCGT/CCTCGG 1 -- ut31 ese326Minor allele frequency- C:0.45MN NS EA NA WA CSA 2537
    rs1912787901,2
    --1481483(+) GAGGCA/GGACAG 1 -- ut310--------
    rs10478521,2
    C,F,H--1481559(-) TGGGCG/AGGAGT 1 -- ut31 ese311Minor allele frequency- A:0.28MN NS EA NA WA 960
    rs3702588711,2
    C--1481587(+) GAGAC-/TCCTCTC 1 -- ut310--------
    rs1842476201,2
    --1481615(+) GCTTCA/GGGGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PCSK4 (1481427 - 1490751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for PCSK4 (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv470106CNV Loss18288195
    nsv910292CNV Loss21882294
    nsv910499CNV Loss21882294
    nsv910520CNV Loss21882294
    nsv910517CNV Loss21882294
    dgv3596n71CNV Loss21882294
    dgv3601n71CNV Loss21882294
    nsv910507CNV Loss21882294
    dgv3580n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600487    OMIM disorders: --

    2 diseases for PCSK4:    About MalaCards
    thyroiditis    


    PCSK4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PCSK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 6.99 2 15492278 (1), 10900462 (1)

    Genetic Association Database (GAD): PCSK4
    Human Genome Epidemiology (HuGE) Navigator: PCSK4 (3 documents)

    Export disorders for PCSK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PCSK4 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with PCSK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. (PubMed id 7782070)1, 3, 9 Mbikay M....Simpson E.M. (1995)
    2. Role of pro-IGF-II processing by proprotein convertase 4 in human placental development. (PubMed id 16040806)1, 2, 9 Qiu Q.... Gruslin A. (2005)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review. (PubMed id 19109312)1, 9 Gyamera-Acheampong C. and Mbikay M. (2009)
    7. The proprotein convertases furin and PACE4 play a significant role in tumor progression. (PubMed id 10900462)1, 9 Bassi D.E....Klein-Szanto A.J. (2000)
    8. The precursor to the germ cell-specific PCSK4 protein ase is inefficiently activated in transfected somatic cells: evidence of intera ction with the BiP chaperone. (PubMed id 21080038)1 Gyamera-Acheampong C....Mbikay M. (2011)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54760 HGNC: 8746 AceView: PCSK4 Ensembl:ENSG00000115257 euGenes: HUgn54760
    ECgene: PCSK4 H-InvDB: PCSK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PCSK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PCSK4 gene:
    Search GeneIP for patents involving PCSK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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