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PCSK4 Gene

protein-coding   GIFtS: 55
GCID: GC19M001481

Proprotein Convertase Subtilisin/Kexin Type 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Proprotein Convertase Subtilisin/Kexin Type 41 2     Proprotein Convertase 43
PC42 3     EC 3.4.218
SPC52     EC 3.4.21.758
EC 3.4.21.-3     EC 3.4.21.938

External Ids:    HGNC: 87461   Entrez Gene: 547602   Ensembl: ENSG000001152577   OMIM: 6004875   UniProtKB: Q6UW603   
ORGUL members:         

Export aliases for PCSK4 gene to outside databases

Previous GC identifers: GC19U990073 GC19M001550 GC19M001421 GC19M001432 GC19M001256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PCSK4 Gene:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that
process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory
pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a
heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes
place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific
members which cleave their substrates at single or paired basic residues. The protease is expressed only in the
testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic
development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and
pro-insulin-like growth factor II. (provided by RefSeq, Jan 2014)

GeneCards Summary for PCSK4 Gene:
PCSK4 (proprotein convertase subtilisin/kexin type 4) is a protein-coding gene. Diseases associated with PCSK4 include thyroiditis. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is PCSK2.

UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60
Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic
amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the
multiprotein transcription complex

Gene Wiki entry for PCSK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PCSK4 gene promoter:
         AhR   Spz1   AML1a   Pax-5   SREBP-1c   LUN-1   SREBP-1b   Arnt   YY1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCSK4 promoter sequence
   Search Chromatin IP Primers for PCSK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCSK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

PCSK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCSK4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001481:  view genomic region     (about GC identifiers)

Start:
1,481,427 bp from pter      End:
1,490,751 bp from pter
Size:
9,325 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60 (See protein sequence)
Recommended Name: Proprotein convertase subtilisin/kexin type 4 precursor  
Size: 755 amino acids; 82795 Da
Developmental stage: Localized predominantly in the cytotrophoblast layer of trophoblast cells during the first
trimester of pregnancy, and to the syncytiotrophoblast and stroma cells during the third trimester
Secondary accessions: Q8IY88 Q9UF79
Alternative splicing: 2 isoforms:  Q6UW60-1   Q6UW60-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PCSK4: NX_Q6UW60

Explore proteomics data for PCSK4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn475, Asn629
  • Selected DME Specific Peptides for PCSK4 (Q6UW60) (see all 13)
     DGYTNSI  VTTDLHH  ASYDFND  WASGNGG 


    See PCSK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060043.2  
    ENSEMBL proteins: 
     ENSP00000465102   ENSP00000300954   ENSP00000466528   ENSP00000465649   ENSP00000466742  

    PCSK4 Human Recombinant Protein Products:

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    Novus Biologicals PCSK4 Protein
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    Cloud-Clone Corp. Proteins for PCSK4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR006212 Furin_repeat
     IPR000209 Peptidase_S8/S53_dom
     IPR015500 Peptidase_S8_subtilisin-rel
     IPR022398 Peptidase_S8_His-AS
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry Q6UW60

    ProtoNet protein and cluster: Q6UW60

    3 Blocks protein domains:
    IPB000209 Subtilisin serine protease family (S8) signature
    IPB002884 Proprotein convertase
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60
    Similarity: Belongs to the peptidase S8 family. Furin subfamily
    Similarity: Contains 1 FU (furin-like) repeat


    PCSK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCSK4_HUMAN, Q6UW60
    Function: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic
    amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the
    multiprotein transcription complex

         Genatlas biochemistry entry for PCSK4:
    proprotein convertase subtilisin,kexin like 4,only expressed in testicular germ cells

         Enzyme Numbers (IUBMB): EC 3.4.21.932 EC 3.4.212 EC 3.4.21.752 EC 3.4.21.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IBA--
         
    PCSK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pcsk4):
     reproductive system 

    PCSK4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PCSK4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCSK4

    miRNA
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    miRTarBase miRNAs that target PCSK4:
    hsa-mir-335-5p (MIRT018385)

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    1 qRT-PCR Assays for microRNA that regulate PCSK4:
    hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPCSK4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: PCSK4 (NM_017573)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCSK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCSK4_HUMAN, Q6UW60: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus3
    extracellular2
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002080acrosomal membrane IEA--
    GO:0016021integral component of membrane IEA--

    PCSK4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCSK4
    Interactions:

        GeneGlobe Interaction Network for PCSK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PCSK4 (Q6UW603 ENSP000003009544) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOCS1O155243, ENSP000003294184I2D: score=1 STRING: ENSP00000329418
    DMXL2ENSP000002510764STRING: ENSP00000251076
    GSSENSP000002169514STRING: ENSP00000216951
    STX5ENSP000002941794STRING: ENSP00000294179
    TADA3ENSP000003076844STRING: ENSP00000307684
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IBA--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0007340acrosome reaction IEA--
    GO:0009566fertilization ----
    GO:0048240sperm capacitation IEA--

    PCSK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCSK4

    1 Novoseek inferred chemical compound relationship for PCSK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 41.6 3 17636173 (1), 7782070 (1)



    PCSK4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PCSK4 gene: 
    NM_017573.4  

    Unigene Cluster for PCSK4:

    Proprotein convertase subtilisin/kexin type 4
    Hs.46884  [show with all ESTs]
    Unigene Representative Sequence: NM_017573
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591201 ENST00000441747(uc002lta.2) ENST00000300954(uc002lsz.2 uc002ltb.1)
    ENST00000586616 ENST00000586074 ENST00000588195 ENST00000591303 ENST00000586002
    ENST00000587784 ENST00000588671 ENST00000590057 ENST00000591687
    miRNA
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    Block miRNA regulation of human, mouse, rat PCSK4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PCSK4:
    hsa-miR-450b-5p
    SwitchGear 3'UTR luciferase reporter plasmidPCSK4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PCSK4
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    GenScript: all cDNA clones in your preferred vector: PCSK4 (NM_017573)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCSK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCSK4
    Primer
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    OriGene qPCR primer pairs and template standards for PCSK4
    OriGene qSTAR qPCR primer pairs in human, mouse for PCSK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCSK4
      QuantiTect SYBR Green Assays in human, mouse, rat PCSK4
      QuantiFast Probe-based Assays in human, mouse, rat PCSK4

    Additional mRNA sequence: 

    AL133566.1 AY358963.1 BC036354.1 

    5 DOTS entries:

    DT.108926  DT.86857418  DT.121472651  DT.95212240  DT.40261904 

    Selected AceView cDNA sequences (see all 34):

    BI830987 NM_017573 BM727965 BX282334 AA453604 BM554228 AL133566 BU742489 
    AY358963 AK057235 AL041693 AA868344 BC036354 AI758731 AL041695 AL043305 
    BI459546 BF062014 BG719638 T19069 AW298335 BU634491 AA454137 N48818 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PCSK4 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                                                                -                           
    SP2:                                                                                                            
    SP3:                                                                                                            
    SP4:                                                                          -     -                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for PCSK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCSK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCTCCCC
    PCSK4 Expression
    About this image

    PCSK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCSK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46884

    UniProtKB/Swiss-Prot: PCSK4_HUMAN, Q6UW60
    Tissue specificity: Placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCSK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PCSK4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcsk41 , 5 proprotein convertase subtilisin/kexin type 41, 5 82.72(n)1
    84.11(a)1
      10 (39.72 cM)5
    185511  NM_008793.21  NP_032819.11 
     803212835 
    chicken
    (Gallus gallus)
    Aves PCSK41 proprotein convertase subtilisin/kexin type 4 68.09(n)
    64.97(a)
      100859150  XM_003642877.2  XP_003642925.2 
    lizard
    (Anolis carolinensis)
    Reptilia PCSK46
    proprotein convertase subtilisin/kexin type 4
    66(a)
    1 ↔ 1
    AAWZ02039304(2305-7997)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pcsk41 proprotein convertase subtilisin/kexin type 4 59.8(n)
    63.36(a)
      779814  NM_001078893.1  NP_001072361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pcsk5a6
    proprotein convertase subtilisin/kexin type 5a
    17(a)
    many ↔ many
    5(55857768-55941923) ENSDARG00000067537
    fruit fly
    (Drosophila melanogaster)
    Insecta Fur26
    Furin 2
    19(a)
    many ↔ many
    X(16267121-16275816)
    worm
    (Caenorhabditis elegans)
    Secernentea bli-46
    Protein BLI-4, isoform c
    31(a)
    many ↔ many
    I(6342231-6356678) WBGene00000254
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KEX21 KEX2 46.34(n)
    41.02(a)
      855483   NP_014161.1 


    ENSEMBL Gene Tree for PCSK4 (if available)
    TreeFam Gene Tree for PCSK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCSK4 gene
    PCSK22  PCSK62  FURIN2  PCSK12  PCSK72  PCSK52  
    6 SIMAP similar genes for PCSK4 using alignment to 5 protein entries:     PCSK4_HUMAN (see all proteins):
    PCSK1    PCSK2    PCSK6    PCSK5    FURIN    PCSK7

    PCSK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PCSK4 (see all 321)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1853903921,2
    --1481318(+) TTCTCC/TGTGGC 1 -- int10--------
    rs118807591,2
    C,F,H--1481347(+) ACTGAT/CGTCCG 1 -- int18Minor allele frequency- C:0.14NS NA WA 728
    rs1173051721,2
    C,F--1481370(+) AGAAAC/TCACCT 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1139064261,2
    C--1481426(+) ACTGAC/G/TCACCT 1 -- spd11CSA 1
    rs1868332931,2
    --1481468(+) TTGGAC/TGCGGT 1 -- ut310--------
    rs10478541,2
    C,F,A,H--1481481(-) GTCCGT/CCTCGG 1 -- ut31 ese326Minor allele frequency- C:0.45MN NS EA NA WA CSA 2537
    rs1912787901,2
    --1481483(+) GAGGCA/GGACAG 1 -- ut310--------
    rs10478521,2
    C,F,H--1481559(-) TGGGCG/AGGAGT 1 -- ut31 ese311Minor allele frequency- A:0.28MN NS EA NA WA 960
    rs3702588711,2
    C--1481587(+) GAGAC-/TCCTCTC 1 -- ut310--------
    rs1842476201,2
    --1481615(+) GCTTCA/GGGGTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PCSK4 (1481427 - 1490751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PCSK4 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv470106CNV Loss18288195
    nsv910292CNV Loss21882294
    nsv910499CNV Loss21882294
    nsv910520CNV Loss21882294
    nsv910517CNV Loss21882294
    dgv3596n71CNV Loss21882294
    dgv3601n71CNV Loss21882294
    nsv910507CNV Loss21882294
    dgv3580n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCSK4
    DNA2.0 Custom Variant and Variant Library Synthesis for PCSK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600487    OMIM disorders: --

    1 disease for PCSK4:    
    About MalaCards
    thyroiditis


    PCSK4 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PCSK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 6.99 2 15492278 (1), 10900462 (1)

    Genetic Association Database (GAD): PCSK4
    Human Genome Epidemiology (HuGE) Navigator: PCSK4 (3 documents)

    Export disorders for PCSK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCSK4 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with PCSK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human. (PubMed id 7782070)1, 3, 9 Mbikay M....Simpson E.M. (Genomics 1995)
    2. Role of pro-IGF-II processing by proprotein convertase 4 in human placental development. (PubMed id 16040806)1, 2, 9 Qiu Q.... Gruslin A. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review. (PubMed id 19109312)1, 9 Gyamera-Acheampong C. and Mbikay M. (Hum. Reprod. Update 2009)
    7. The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. (PubMed id 23775089)1 Seidah N.G....Mbikay M. (J. Biol. Chem. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. The biology and therapeutic targeting of the proprotein convertases. (PubMed id 22679642)1 Seidah N.G. and Prat A. (Nat Rev Drug Discov 2012)
    10. The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone. (PubMed id 21080038)1 Gyamera-Acheampong C....Mbikay M. (Mol. Cell. Biochem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 54760 HGNC: 8746 AceView: PCSK4 Ensembl:ENSG00000115257 euGenes: HUgn54760
    ECgene: PCSK4 H-InvDB: PCSK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PCSK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PCSK4 gene:
    Search GeneIP for patents involving PCSK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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