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Aliases for PCSK2 Gene

Aliases for PCSK2 Gene

  • Proprotein Convertase Subtilisin/Kexin Type 2 2 3 5
  • KEX2-Like Endoprotease 2 2 3 4
  • Prohormone Convertase 2 3 4
  • EC 4 63
  • NEC 2 3 4
  • NEC2 3 4
  • PC2 3 4
  • Neuroendocrine Convertase 2 2
  • Proprotein Convertase 2 4
  • EC 3.4.21 63
  • NEC-2 3
  • SPC2 3

External Ids for PCSK2 Gene

Previous HGNC Symbols for PCSK2 Gene

  • NEC2

Previous GeneCards Identifiers for PCSK2 Gene

  • GC20P017195
  • GC20P017202
  • GC20P017155
  • GC20P017206
  • GC20P017170

Summaries for PCSK2 Gene

Entrez Gene Summary for PCSK2 Gene

  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]

GeneCards Summary for PCSK2 Gene

PCSK2 (Proprotein Convertase Subtilisin/Kexin Type 2) is a Protein Coding gene. Diseases associated with PCSK2 include Polycystic Kidney Disease, Autosomal Dominant and Hyperproinsulinemia. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Peptide hormone metabolism. GO annotations related to this gene include protein complex binding and endopeptidase activity. An important paralog of this gene is PCSK1.

UniProtKB/Swiss-Prot for PCSK2 Gene

  • Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Gene Wiki entry for PCSK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCSK2 Gene

Genomics for PCSK2 Gene

Regulatory Elements for PCSK2 Gene

Enhancers for PCSK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PCSK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCSK2 Gene

17,226,107 bp from pter
17,484,578 bp from pter
258,472 bases
Plus strand

Genomic View for PCSK2 Gene

Genes around PCSK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCSK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCSK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCSK2 Gene

Proteins for PCSK2 Gene

  • Protein details for PCSK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuroendocrine convertase 2
    Protein Accession:
    Secondary Accessions:
    • B1ANH9
    • B4DFQ3
    • Q14927
    • Q5JYQ1
    • Q8IWA8
    • Q9NQG3
    • Q9NUG1
    • Q9UJC6

    Protein attributes for PCSK2 Gene

    638 amino acids
    Molecular mass:
    70565 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA21069.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB89428.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB96732.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCSK2 Gene


neXtProt entry for PCSK2 Gene

Proteomics data for PCSK2 Gene at MOPED

Post-translational modifications for PCSK2 Gene

  • Glycosylation at Asn 375, Asn 514, and Asn 524
  • Modification sites at PhosphoSitePlus

Other Protein References for PCSK2 Gene

Antibody Products

  • R&D Systems Antibodies for PCSK2 (Proprotein Convertase 2/PCSK2)
  • Cell Signaling Technology (CST) Antibodies for PCSK2 (PCSK2)

Domains & Families for PCSK2 Gene

Gene Families for PCSK2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S8 domain.
  • Belongs to the peptidase S8 family. Furin subfamily.
  • Contains 1 peptidase S8 domain.
  • Belongs to the peptidase S8 family. Furin subfamily.
genes like me logo Genes that share domains with PCSK2: view

Function for PCSK2 Gene

Molecular function for PCSK2 Gene

GENATLAS Biochemistry:
proprotein convertase subtilisin,kexin like 2,primarily expressed in tissues and cells containing secretory granules
UniProtKB/Swiss-Prot CatalyticActivity:
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg- - bonds.
UniProtKB/Swiss-Prot Function:
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.

Enzyme Numbers (IUBMB) for PCSK2 Gene

genes like me logo Genes that share phenotypes with PCSK2: view

Animal Models for PCSK2 Gene

MGI Knock Outs for PCSK2:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCSK2 Gene

Localization for PCSK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCSK2 Gene

Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.

Subcellular locations from

Jensen Localization Image for PCSK2 Gene COMPARTMENTS Subcellular localization image for PCSK2 gene
Compartment Confidence
extracellular 5
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PCSK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030133 transport vesicle IEA --
GO:0030425 dendrite IEA --
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with PCSK2: view

Pathways & Interactions for PCSK2 Gene

genes like me logo Genes that share pathways with PCSK2: view

Pathways by source for PCSK2 Gene

1 Cell Signaling Technology pathway for PCSK2 Gene

Gene Ontology (GO) - Biological Process for PCSK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016486 peptide hormone processing IEA --
GO:0030070 insulin processing IDA 7626024
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PCSK2: view

No data available for SIGNOR curated interactions for PCSK2 Gene

Drugs & Compounds for PCSK2 Gene

(14) Drugs for PCSK2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Regular Approved, Experimental, Investigational Pharma Target 0
Insulin, porcine Approved Pharma Target 0

(14) Additional Compounds for PCSK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PCSK2: view

Transcripts for PCSK2 Gene

Unigene Clusters for PCSK2 Gene

Proprotein convertase subtilisin/kexin type 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCSK2 Gene

No ASD Table

Relevant External Links for PCSK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCSK2 Gene

mRNA expression in normal human tissues for PCSK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCSK2 Gene

This gene is overexpressed in Thyroid (x9.0), Brain - Frontal Cortex (BA9) (x5.1), and Brain - Anterior cingulate cortex (BA24) (x5.0).

Protein differential expression in normal tissues from HIPED for PCSK2 Gene

This gene is overexpressed in Adrenal (42.3), Vitreous humor (12.0), and Islet of Langerhans (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCSK2 Gene

SOURCE GeneReport for Unigene cluster for PCSK2 Gene Hs.315186

genes like me logo Genes that share expression patterns with PCSK2: view

Protein tissue co-expression partners for PCSK2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PCSK2 Gene

Orthologs for PCSK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCSK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PCSK2 35
  • 89.18 (n)
  • 96.08 (a)
PCSK2 36
  • 97 (a)
(Canis familiaris)
Mammalia PCSK2 35
  • 92.11 (n)
  • 98.43 (a)
PCSK2 36
  • 98 (a)
(Mus musculus)
Mammalia Pcsk2 35
  • 89.59 (n)
  • 96.86 (a)
Pcsk2 16
Pcsk2 36
  • 97 (a)
(Pan troglodytes)
Mammalia PCSK2 35
  • 99.63 (n)
  • 99.69 (a)
PCSK2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Pcsk2 35
  • 90.11 (n)
  • 96.39 (a)
(Monodelphis domestica)
Mammalia PCSK2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia PCSK2 36
  • 92 (a)
(Gallus gallus)
Aves PCSK2 35
  • 79.29 (n)
  • 90.85 (a)
PCSK2 36
  • 89 (a)
(Anolis carolinensis)
Reptilia PCSK2 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcsk2 35
  • 75.18 (n)
  • 87.62 (a)
Str.12201 35
African clawed frog
(Xenopus laevis)
Amphibia pcsk2-A 35
(Danio rerio)
Actinopterygii pcsk2 35
  • 75.96 (n)
  • 84.24 (a)
pcsk2 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta amon 37
  • 62 (a)
amon 35
  • 62.98 (n)
  • 65.25 (a)
amon 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002176 35
  • 62.91 (n)
  • 64.27 (a)
(Caenorhabditis elegans)
Secernentea aex-5 37
  • 34 (a)
bli-4 37
  • 43 (a)
egl-3 37
  • 59 (a)
egl-3 35
  • 59.57 (n)
  • 63.2 (a)
egl-3 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6212 36
  • 62 (a)
Species with no ortholog for PCSK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCSK2 Gene

Gene Tree for PCSK2 (if available)
Gene Tree for PCSK2 (if available)

Paralogs for PCSK2 Gene

Paralogs for PCSK2 Gene

(6) SIMAP similar genes for PCSK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PCSK2: view

Variants for PCSK2 Gene

Sequence variations from dbSNP and Humsavar for PCSK2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036548 A colorectal cancer sample
rs17854040 - 17,436,729(+) CCAGC(A/C)ATTCA reference, missense
rs17857236 - 17,481,603(+) CTGGC(A/G)AGTTG reference, missense
rs2104 -- 17,406,291(+) ATGGT(C/T)CCTCC intron-variant
rs140731 -- 17,340,301(+) CTAAC(-/TA)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCSK2 Gene

Variant ID Type Subtype PubMed ID
dgv4554n71 CNV Gain 21882294
nsv179945 CNV Loss 16902084
dgv4555n71 CNV Gain 21882294
nsv912798 CNV Gain 21882294
esv2722247 CNV Deletion 23290073
dgv21e197 CNV Deletion 19546169
esv2722248 CNV Deletion 23290073
dgv1315e1 CNV Complex 17122850
nsv3308 CNV Insertion 18451855
nsv517986 CNV Loss 19592680
nsv520899 CNV Loss 19592680
nsv3309 CNV Insertion 18451855
esv2722249 CNV Deletion 23290073
esv2722252 CNV Deletion 23290073
esv1992600 CNV Deletion 18987734
esv2722253 CNV Deletion 23290073
esv3535 CNV Deletion 18987735
esv2659718 CNV Deletion 23128226

Variation tolerance for PCSK2 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCSK2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCSK2 Gene

Disorders for PCSK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PCSK2 Gene - From: Novoseek and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PCSK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PCSK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PCSK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCSK2 Gene

Publications for PCSK2 Gene

  1. Analysis of the gene encoding human PC2, a prohormone processing enzyme. (PMID: 7983775) Ohagi S. … Nanjo K. (Nippon Rinsho 1994) 3 4 23 67
  2. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. (PMID: 15585599) Shen X. … Friedman T.C. (Am. J. Physiol. Endocrinol. Metab. 2005) 3 23
  3. Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases. (PMID: 16293189) Tzimas G.N. … Metrakos P. (BMC Cancer 2005) 3 23
  4. The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease. (PMID: 14614908) Winsky-Sommerer R. … Epelbaum J. (Neuroscience 2003) 3 23
  5. Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro. (PMID: 10931181) Higham C.E. … Clark A. (Eur. J. Biochem. 2000) 3 23

Products for PCSK2 Gene

Sources for PCSK2 Gene