PCSK2 Gene

Aliases
for PCSK2 gene

Previous GC identifers: GC20P017195 GC20P017202 GC20P017155 GC20P017170

Summaries
for PCSK2 gene

Genomic Views
for PCSK2 gene

RefSeq DNA sequence:

NC_000020.10  NC_018931.1  NT_011387.8  

SwitchGear Promoter luciferase reporter plasmid: PCSK2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCSK2

PCSK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P017206:  view genomic region     (about GC identifiers)

Proteins
for PCSK2 gene

Explore the universe of human proteins at neXtProt for PCSK2: NX_P16519

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for PCSK2 (Proprotein Convertase 2/PCSK2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PCSK2 OriGene Protein Over-expression Lysate: PCSK2 OriGene Custom Protein Services for PCSK2
	GenScript Custom Purified and Recombinant Proteins Services for PCSK2
	Novus Biologicals PCSK2 Proteins Novus Biologicals PCSK2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PCSK2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PCSK2
	R&D Systems Antibodies for PCSK2 (Proprotein Convertase 2/PCSK2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for PCSK2
	GenScript Custom Superior Antibodies Services for PCSK2
	Novus Biologicals PCSK2 Antibodies
	Abcam antibodies for PCSK2
	Uscn Antibodies for PCSK2
	ThermoFisher Antibodies for PCSK2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PCSK2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PCSK2

Protein Domains /
Families
for PCSK2 gene

ProtoNet protein and cluster: P16519

Function
for PCSK2 gene

miRNA Products:		OriGene 3'-UTR Clone: PCSK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCSK2
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate PCSK2 (see all 55):
		hsa-miR-549 hsa-miR-582-3p hsa-miR-4307 hsa-miR-429 hsa-miR-300 hsa-miR-513a-5p hsa-miR-29b-1* hsa-miR-9
		SwitchGear 3'UTR luciferase reporter plasmid: PCSK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCSK2 (see all 7) OriGene shRNA RFP: PCSK2 OriGene siRNA: PCSK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCSK2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PCSK2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCSK2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCSK2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): PCSK2 (NM_002594)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCSK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCSK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PCSK2
		Search LifeMap BioReagents cell lines for PCSK2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCSK2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Pcsk2)

Pathways & Interactions
for PCSK2 gene

	Super-pathway	contained gene-specific pathways
1	Insulin Processing	Insulin Processing 1.00 Peptide hormone metabolism 0.39
2	Processing of Proinsulin to Insulin	Processing of Proinsulin to Insulin 1.00
3	Asparagine N-linked glycosylation	Metabolism of proteins 0.15

4        Reactome Pathways for PCSK2

	Processing of Proinsulin to Insulin
	Insulin Processing
	Metabolism of proteins
	Peptide hormone metabolism

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for PCSK2 gene

Transcripts
for PCSK2 gene

Expression
for PCSK2 gene

PCSK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTAAATTA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeInner Nuclear LayerType1 Off Cone Bipolar Cells			Bipolar, Retina
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCSK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PCSK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCSK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCSK2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCSK2

Orthologs
for PCSK2 gene

Paralogs
for PCSK2 gene

Paralogs for PCSK2 gene

PCSK4²  FURIN²  PCSK6²  PCSK1²  PCSK7²  PCSK5²  

6 SIMAP similar genes for PCSK2 using alignment to 1 protein entry:     NEC2_HUMAN:

PCSK1    PCSK4    FURIN    PCSK7    PCSK5    PCSK6

PCSK2 for paralogs           About GeneDecksing

Genomic Variants
for PCSK2 gene

10/5163 NCBI SNPs in PCSK2 are shown (see all 5163)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs23281731,2	C,F,A,	unknown	17318430(+)	TTAGCC/G/TAGGTA	3	--	int1		1		EA	120
rs1158874651,2	C,F,	--	17204816(+)	ACATCT/CGAGCC	1	--	us2k1		1		WA	118
rs1912054791,2		--	17204856(+)	GATACA/GAAAGT	1	--	us2k1		0	--	--	--	--
rs1509570721,2		--	17204990(+)	TTACAC/TAAAAA	1	--	us2k1		0	--	--	--	--
rs60806081,2	C,F,H,	--	17205071(+)	TGATGC/TTTCCT	1	--	us2k1		13		NS EA NA	1026
rs1117737081,2		--	17205086(+)	TACAGC/TGTATG	1	--	us2k1		2		CSA WA	120
rs749464861,2	C,F,	--	17205087(+)	ACAGCG/ATATGT	1	--	us2k1		1		WA	118
rs768495521,2	F,	--	17205202(+)	GGCCCA/GCAGCC	1	--	us2k1		1		WA	118
rs1836777261,2		--	17205218(+)	GTATAC/GATACC	1	--	us2k1		0	--	--	--	--
rs1885466221,2		--	17205249(+)	ATAGGA/GTCCCT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for PCSK2 (17206752 - 17456752 bp, first 250kb of PCSK2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for PCSK2
     3 CNVs: 6071 50625 3212
     1 Indel: 42682
Human Gene Mutation Database (HGMD): PCSK2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCSK2

DNA2.0 Custom Variant and Variant Library Synthesis for PCSK2

Disorders / Diseases
for PCSK2 gene

20/27 diseases for PCSK2

10/23 Novoseek disease relationships for PCSK2 gene (see all 23)    About this table

Publications
for PCSK2 gene

PubMed articles for PCSK2 gene, integrated from 9 sources (see all 267): (articles sorted by number of sources associating them with PCSK2)

Utopia: connect your pdf to the dynamic world of online information

1. Analysis of the gene encoding human PC2, a prohormone processing enzyme. (PubMed id 7983775)^{1, 2, 9} Ohagi S.... Nanjo K. (1994)
2. Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues. (PubMed id 1594602)^{1, 2, 9} Ohagi S.... Steiner D.F. (1992)
3. Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region). (PubMed id 1765368)^{1, 3, 9} Seidah N.G....Chretien M. (1991)
4. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. (PubMed id 2154467)^{1, 2, 9} Smeekens S.P. and Steiner D.F. (1990)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
8. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. (PubMed id 15585599)^{1, 9} Shen X....Friedman T.C. (2005)
9. Immunohistochemical expressions of prohormone convertase (PC)1/3 and PC2 in carcinoids of various organs. (PubMed id 10530621)^{1, 9} Kajiwara H....Osamura R.Y. (1999)
10. Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor. (PubMed id 10965896)^{1, 9} Li Q.L....Friedman T.C. (2000)

External Searches for PCSK2 gene

Genome Databases showing PCSK2 gene

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Specialized Databases showing PCSK2 gene

Products
for PCSK2 gene