Aliases for PCSK1N Gene
External Ids for PCSK1N Gene
Previous GeneCards Identifiers for PCSK1N Gene
The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]
GeneCards Summary for PCSK1N Gene
PCSK1N (Proprotein Convertase Subtilisin/Kexin Type 1 Inhibitor) is a Protein Coding gene. Diseases associated with PCSK1N include Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 and Frontotemporal Dementia. Gene Ontology (GO) annotations related to this gene include receptor binding and endopeptidase inhibitor activity.
UniProtKB/Swiss-Prot for PCSK1N Gene
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known (By similarity).