PCP4L1 Gene
protein-coding GIFtS : 33
GCID: GC01 P161228
Purkinje cell protein 4 like 1 (Previous name: purkinje cell protein 4 like 1 )
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Aliasesfor PCP4L1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Purkinje Cell Protein 4 Like 1 1 2 IQM11 2 3 PCP4-Like Protein 12 3 Purkinje Cell Protein 4-Like Protein 12
Export aliases for PCP4L1 gene to outside databases Previous GC identifers: GC01P159496 GC01P132585
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Summariesfor PCP4L1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor PCP4L1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PCP4L1 gene promoter: FOXF2 RREB-1 MEF-2 MIF-1 YY1 PPAR-alpha MEF-2A PPAR-gamma1 PPAR-gamma2 aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for PCP4L1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCP4L1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q23.3 PCP4L1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P161228: view genomic region
(about GC identifiers )
Start:
161,228,517 bp from pter
End:
161,255,240 bp from pter
Size:
26,724 bases
Orientation:
plus strand
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Proteinsfor PCP4L1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PC4L1_HUMAN, A6NKN8 (See
protein sequence )Recommended Name: Purkinje cell protein 4-like protein 1 Size : 68 amino acids; 7476 Da
Secondary accessions : B2RV24 B9EJG4Explore the universe of human proteins at neXtProt for PCP4L1: NX_A6NKN8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A6NKN8 PCP4L1 Protein expression data from MOPED and PaxDb : --REFSEQ proteins: NP_001096036.1 ENSEMBL proteins: ENSP00000426296 Human Recombinant Protein Products: PCP4L1 Antibody Products: Assay Products for PCP4L1:
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Protein
Domains / Familiesfor PCP4L1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: A6NKN8
UniProtKB/Swiss-Prot: PC4L1_HUMAN, A6NKN8 Similarity : Belongs to the PCP4 familySimilarity : Contains 1 IQ domain
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Functionfor PCP4L1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PCP4L1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PCP4L1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PCP4L1 (NM_001102566 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCP4L1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PCP4L1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCP4L1
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Pathways & Interactionsfor PCP4L1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCP4L1
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Drugs & Compoundsfor PCP4L1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for PCP4L1 Search CenterWatch for drugs/clinical trials and news about PCP4L1 / PC4L1
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Transcriptsfor PCP4L1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
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QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PCP4L1 gene: NM_001102566.1 Unigene Cluster for PCP4L1:
Purkinje cell protein 4 like 1 Hs.433150 [show with all ESTs ] Unigene Representative Sequence: BC028905 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000504449 (uc001gad.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PCP4L1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PCP4L1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PCP4L1 (NM_001102566 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCP4L1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PCP4L1
Additional cDNA sequence: BC028905.2 BC067884.1 BC147003.1 BC147004.1
1 DOTS entry : DT.91975991
GeneLoc Exon Structure
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Expression for PCP4L1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PCP4L1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTAATCATT
About this image PCP4L1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Eye Inner Nuclear Layer Cholinergic Amacrine Cells Amacrine, Retina Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )
Genevestigator expression for PCP4L1 SOURCE GeneReport for Unigene cluster: Hs.433150 SABiosciences Custom PCR Arrays for PCP4L1 Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat PCP4L1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PCP4L1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PCP4L1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCP4L1
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Orthologsfor PCP4L1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for PCP4L1 gene from 2/7 species (see all 7 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Pcp4l11 , 5
Purkinje cell protein 4-like 11, 5
87.25(n) 1 86.76(a) 1
 
1 (79.11 cM) 5 66425 1 NM_025557.1 1 NP_079833.1 1 171173262 5
zebrafish (Danio rerio)
Actinopterygii
pcp4l16
Purkinje cell protein 4 like 1
51(a)
1 ↔ 1
2(37697938-37703032)
ENSEMBL Gene Tree for PCP4L1 (if available)TreeFam Gene Tree for PCP4L1 (if available)
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Paralogsfor PCP4L1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor PCP4L1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for PCP4L1 (161228517 - 161255240 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for PCP4L1: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor PCP4L1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor PCP4L1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PCP4L1 gene integrated from 9 sources : (articles sorted by number of sources associating them with PCP4L1) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738) 1 Fox C.S....Borecki I.B. (2012) Identification of candidate genes for human pituitary development by EST analysis. (PubMed id 19284880) 1 Ma Y....Hao X. (2009) Pcp4l1, a novel gene encoding a Pcp4-like polypeptide, is expressed in specific domains of the developing brain. (PubMed id 15053978) 1 Bulfone A....Banfi S. (2004) Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197) 1 Brandenberger R.... Stanton L.W. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PCP4L1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing PCP4L1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing PCP4L1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing PCP4L1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for PCP4L1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for PCP4L1 gene: Search GeneIP for patents involving PCP4L1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PCP4L1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for PCP4L1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for PCP4L1 Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PCP4L1 OriGene 3'-UTR Clone for PCP4L1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PCP4L1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PCP4L1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PCP4L1 OriGene Custom Protein Services for PCP4L1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCP4L1 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCP4L1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCP4L1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat PCP4L1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PCP4L1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PCP4L1
Search Tocris compounds for PCP4L1
PCP4L1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCP4L1
Search ThermoFisher Antibodies for PCP4L1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PCP4L1
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