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Aliases for PCP4 Gene

Aliases for PCP4 Gene

  • Purkinje Cell Protein 4 2 3 5
  • Brain-Specific Polypeptide PEP-19 3 4
  • Brain-Specific Antigen PCP-4 3 4
  • Brain Specific Polypeptide PEP19 3
  • PEP-19 3
  • PEP19 4

External Ids for PCP4 Gene

Previous GeneCards Identifiers for PCP4 Gene

  • GC21P037813
  • GC21P037896
  • GC21P040160
  • GC21P040159
  • GC21P040121
  • GC21P040161
  • GC21P041239
  • GC21P026708

Summaries for PCP4 Gene

GeneCards Summary for PCP4 Gene

PCP4 (Purkinje Cell Protein 4) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for PCP4 Gene

  • Probable regulator of calmodulin signaling.

Gene Wiki entry for PCP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCP4 Gene

Genomics for PCP4 Gene

Regulatory Elements for PCP4 Gene

Genomic Location for PCP4 Gene

39,867,317 bp from pter
39,929,397 bp from pter
62,081 bases
Plus strand

Genomic View for PCP4 Gene

Genes around PCP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCP4 Gene

Proteins for PCP4 Gene

  • Protein details for PCP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Purkinje cell protein 4
    Protein Accession:
    Secondary Accessions:
    • A6NDJ9
    • Q6ICS4
    • Q93059

    Protein attributes for PCP4 Gene

    62 amino acids
    Molecular mass:
    6791 Da
    Quaternary structure:
    • Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater.

neXtProt entry for PCP4 Gene

Proteomics data for PCP4 Gene at MOPED

Post-translational modifications for PCP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCP4 Gene

Domains & Families for PCP4 Gene

Protein Domains for PCP4 Gene


Suggested Antigen Peptide Sequences for PCP4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Mostly intrisically disordered, with residual structure localized to the IQ motif.
  • Belongs to the PCP4 family.
  • Mostly intrisically disordered, with residual structure localized to the IQ motif.
  • Contains 1 IQ domain.
  • Belongs to the PCP4 family.
genes like me logo Genes that share domains with PCP4: view

No data available for Gene Families for PCP4 Gene

Function for PCP4 Gene

Molecular function for PCP4 Gene

GENATLAS Biochemistry:
Purkinje cell protein 4,rat PEP-19,neuron-specific polypeptide homolog gene,with homology to S100 calcium binding proteins,involved in the development of the central nervous system
UniProtKB/Swiss-Prot Function:
Probable regulator of calmodulin signaling.
genes like me logo Genes that share phenotypes with PCP4: view

Animal Models for PCP4 Gene

MGI Knock Outs for PCP4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PCP4 Gene

Localization for PCP4 Gene

Subcellular locations from

Jensen Localization Image for PCP4 Gene COMPARTMENTS Subcellular localization image for PCP4 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PCP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PCP4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PCP4 Gene

Pathways & Interactions for PCP4 Gene

SuperPathways for PCP4 Gene

No Data Available

Interacting Proteins for PCP4 Gene

Gene Ontology (GO) - Biological Process for PCP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development TAS 8914602
GO:0010976 positive regulation of neuron projection development IEA --
GO:0033603 positive regulation of dopamine secretion IEA --
GO:1904009 cellular response to monosodium glutamate IEA --
genes like me logo Genes that share ontologies with PCP4: view

No data available for Pathways by source and SIGNOR curated interactions for PCP4 Gene

Drugs & Compounds for PCP4 Gene

(1) Drugs for PCP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PCP4: view

Transcripts for PCP4 Gene

Unigene Clusters for PCP4 Gene

Purkinje cell protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCP4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for PCP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCP4 Gene

mRNA expression in normal human tissues for PCP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCP4 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x13.5), Brain - Caudate (basal ganglia) (x10.6), and Brain - Nucleus accumbens (basal ganglia) (x9.8).

Protein differential expression in normal tissues from HIPED for PCP4 Gene

This gene is overexpressed in Seminal vesicle (28.0) and Fetal Brain (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCP4 Gene

SOURCE GeneReport for Unigene cluster for PCP4 Gene Hs.80296

genes like me logo Genes that share expression patterns with PCP4: view

Protein tissue co-expression partners for PCP4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PCP4 Gene

Orthologs for PCP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCP4 36
  • 100 (a)
PCP4 35
  • 100 (n)
  • 100 (a)
(Bos Taurus)
Mammalia PCP4 35
  • 91.94 (n)
  • 96.77 (a)
(Canis familiaris)
Mammalia PCP4 35
  • 95.7 (n)
  • 100 (a)
PCP4 36
  • 100 (a)
(Mus musculus)
Mammalia Pcp4 16
Pcp4 36
  • 97 (a)
Pcp4 35
  • 89.25 (n)
  • 96.77 (a)
(Monodelphis domestica)
Mammalia PCP4 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Pcp4 35
  • 90.32 (n)
  • 96.77 (a)
(Gallus gallus)
Aves PCP4 35
  • 85.48 (n)
  • 98.39 (a)
PCP4 36
  • 81 (a)
(Danio rerio)
Actinopterygii pcp4a 36
  • 59 (a)
pcp4b 36
  • 65 (a)
Species with no ortholog for PCP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCP4 Gene

Gene Tree for PCP4 (if available)
Gene Tree for PCP4 (if available)

Paralogs for PCP4 Gene

(1) SIMAP similar genes for PCP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PCP4: view

No data available for Paralogs for PCP4 Gene

Variants for PCP4 Gene

Sequence variations from dbSNP and Humsavar for PCP4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs9152 -- 39,929,149(+) ACCAA(A/G)TTCAA utr-variant-3-prime
rs741791 -- 39,881,226(+) GAATG(C/T)TGGGG intron-variant
rs741792 -- 39,882,224(-) AAAGG(C/T)GTGAG intron-variant
rs928294 -- 39,911,683(+) AATGG(A/G)ATACT intron-variant
rs760149 -- 39,866,530(+) GACCC(G/T)CTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PCP4 Gene

Variant ID Type Subtype PubMed ID
nsv3523 CNV Insertion 18451855

Variation tolerance for PCP4 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCP4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCP4 Gene

Disorders for PCP4 Gene

Relevant External Links for PCP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCP4 Gene

Publications for PCP4 Gene

  1. Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3. (PMID: 8931698) Chen H.M. … Antonarakis S.E. (Hum. Genet. 1996) 2 3 4 23 67
  2. A new role for IQ motif proteins in regulating calmodulin function. (PMID: 14551202) Putkey J.A. … Waxham M.N. (J. Biol. Chem. 2003) 3 23
  3. Molecular genetic characterization and comparative mapping of the human PCP4 gene. (PMID: 8914602) Cabin D.E. … Reeves R.H. (Somat. Cell Mol. Genet. 1996) 2 3
  4. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. (PMID: 24403568) Felizola S.J. … Sasano H. (J. Mol. Endocrinol. 2014) 3
  5. Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: Implications for Down syndrome. (PMID: 24291518) Mouton-Liger F. … CrAcau N. (Neurobiol. Dis. 2014) 3

Products for PCP4 Gene

Sources for PCP4 Gene

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