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Aliases for PCP2 Gene

Aliases for PCP2 Gene

  • Purkinje Cell Protein 2 2 3
  • Purkinje Cell-Specific Protein L7 3
  • Purkinje Cell-Specific Protein 2 3
  • CTD-3214H19.6 3
  • GPSM4 3

External Ids for PCP2 Gene

Previous GeneCards Identifiers for PCP2 Gene

  • GC19M007602
  • GC19M007366
  • GC19M007696

Summaries for PCP2 Gene

GeneCards Summary for PCP2 Gene

PCP2 (Purkinje Cell Protein 2) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and GTPase regulator activity.

UniProtKB/Swiss-Prot for PCP2 Gene

  • May function as a cell-type specific modulator for G protein-mediated cell signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCP2 Gene

Genomics for PCP2 Gene

Regulatory Elements for PCP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCP2 Gene

Chromosome:
19
Start:
7,631,611 bp from pter
End:
7,636,967 bp from pter
Size:
5,357 bases
Orientation:
Minus strand

Genomic View for PCP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCP2 Gene

Proteins for PCP2 Gene

  • Protein details for PCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVA1-PCP2_HUMAN
    Recommended name:
    Purkinje cell protein 2 homolog
    Protein Accession:
    Q8IVA1
    Secondary Accessions:
    • M0R2R7
    • Q3KRG7

    Protein attributes for PCP2 Gene

    Size:
    136 amino acids
    Molecular mass:
    14547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCP2 Gene

Proteomics data for PCP2 Gene at MOPED

Post-translational modifications for PCP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PCP2 Gene

Domains & Families for PCP2 Gene

Protein Domains for PCP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVA1

UniProtKB/Swiss-Prot:

PCP2_HUMAN :
  • Contains 2 GoLoco domains.
Domain:
  • Contains 2 GoLoco domains.
genes like me logo Genes that share domains with PCP2: view

No data available for Gene Families for PCP2 Gene

Function for PCP2 Gene

Molecular function for PCP2 Gene

UniProtKB/Swiss-Prot Function:
May function as a cell-type specific modulator for G protein-mediated cell signaling.

Gene Ontology (GO) - Molecular Function for PCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0030695 GTPase regulator activity IEA --
genes like me logo Genes that share ontologies with PCP2: view

Phenotypes for PCP2 Gene

MGI mutant phenotypes for PCP2:
inferred from 4 alleles
GenomeRNAi human phenotypes for PCP2:
genes like me logo Genes that share phenotypes with PCP2: view

Animal Models for PCP2 Gene

MGI Knock Outs for PCP2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for PCP2 Gene

Localization for PCP2 Gene

Gene Ontology (GO) - Cellular Components for PCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with PCP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for PCP2 Gene

Pathways & Interactions for PCP2 Gene

SuperPathways for PCP2 Gene

No Data Available

Interacting Proteins for PCP2 Gene

Gene Ontology (GO) - Biological Process for PCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016056 rhodopsin mediated signaling pathway IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with PCP2: view

No data available for Pathways by source and SIGNOR curated interactions for PCP2 Gene

Drugs & Compounds for PCP2 Gene

No Compound Related Data Available

Transcripts for PCP2 Gene

mRNA/cDNA for PCP2 Gene

Unigene Clusters for PCP2 Gene

Purkinje cell protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for PCP2 Gene

GeneLoc Exon Structure for
PCP2
ECgene alternative splicing isoforms for
PCP2

Expression for PCP2 Gene

mRNA expression in normal human tissues for PCP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCP2 Gene

This gene is overexpressed in Testis (x21.9), Brain - Cerebellum (x7.8), and Brain - Cerebellar Hemisphere (x4.6).

Protein differential expression in normal tissues from HIPED for PCP2 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCP2 Gene



SOURCE GeneReport for Unigene cluster for PCP2 Gene Hs.591400

genes like me logo Genes that share expression patterns with PCP2: view

Protein tissue co-expression partners for PCP2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PCP2 Gene

Orthologs for PCP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCP2 35
  • 87.96 (n)
  • 85.71 (a)
PCP2 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCP2 35
  • 86.76 (n)
  • 86.03 (a)
PCP2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcp2 35
  • 80 (n)
  • 80.74 (a)
Pcp2 16
Pcp2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCP2 35
  • 98.53 (n)
  • 98.53 (a)
PCP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcp2 35
  • 82.91 (n)
  • 84.87 (a)
oppossum
(Monodelphis domestica)
Mammalia PCP2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCP2 36
  • 48 (a)
OneToOne
Species with no ortholog for PCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCP2 Gene

ENSEMBL:
Gene Tree for PCP2 (if available)
TreeFam:
Gene Tree for PCP2 (if available)

Paralogs for PCP2 Gene

(2) SIMAP similar genes for PCP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PCP2: view

No data available for Paralogs for PCP2 Gene

Variants for PCP2 Gene

Sequence variations from dbSNP and Humsavar for PCP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1862514 -- 7,633,434(+) TCCTC(C/T)GTCTT upstream-variant-2KB, synonymous-codon, reference, intron-variant
rs1862515 -- 7,633,767(+) GCAGC(A/G)TCCCC upstream-variant-2KB, intron-variant, utr-variant-5-prime
rs2279041 -- 7,632,200(+) GGTCT(G/T)ACACT intron-variant
rs2279042 -- 7,632,282(+) GGCAG(C/T)GGATG intron-variant
rs2305887 -- 7,632,686(+) CGCCC(C/T)ATGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCP2 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv833730 CNV Loss 17160897
nsv910970 CNV Loss 21882294
nsv833731 CNV Loss 17160897
nsv910979 CNV Loss 21882294

Variation tolerance for PCP2 Gene

Residual Variation Intolerance Score: 76.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCP2 Gene

HapMap Linkage Disequilibrium report
PCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCP2 Gene

Disorders for PCP2 Gene

Relevant External Links for PCP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCP2
genes like me logo Genes that share disorders with PCP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCP2 Gene

Publications for PCP2 Gene

  1. G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2). (PMID: 16298104) Willard F.S. … Siderovski D.P. (Cell. Signal. 2006) 23 67
  2. A Purkinje cell specific GoLoco domain protein, L7/Pcp-2, modulates receptor-mediated inhibition of Cav2.1 Ca2+ channels in a dose-dependent manner. (PMID: 15548431) Kinoshita-Kawada M. … Xi Zhu M. (Brain Res. Mol. Brain Res. 2004) 23 67
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  4. Transcriptional regulation of a Purkinje cell-specific gene through a functional interaction between ROR alpha and RAR. (PMID: 9224660) Matsui T. (Genes Cells 1997) 23 67
  5. Identification of natural monomeric response elements of the nuclear receptor RZR/ROR. They also bind COUP-TF homodimers. (PMID: 8702678) SchrAoder M. … Carlberg C. (J. Biol. Chem. 1996) 23 67

Products for PCP2 Gene

Sources for PCP2 Gene

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