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Aliases for PCOTH Gene

Aliases for PCOTH Gene

  • Pro-X-Gly Collagen Triple Helix Like Repeat Containing 2 3 5
  • C1QTNF9B Antisense RNA 1 2 3 4
  • C1QTNF9B Antisense Gene Protein 1 3 4
  • C1QTNF9B-AS1 3 4
  • C1QTNF9B Antisense RNA 1 (Non-Protein Coding) 2
  • Prostate Collagen Triple Helix Protein 3
  • Prostate Collagen Triple Helix 2

External Ids for PCOTH Gene

Previous HGNC Symbols for PCOTH Gene

  • C1QTNF9B-AS1

Previous GeneCards Identifiers for PCOTH Gene

  • GC13U900295
  • GC13P023361
  • GC13P024464
  • GC13P005274

Summaries for PCOTH Gene

GeneCards Summary for PCOTH Gene

PCOTH (Pro-X-Gly Collagen Triple Helix Like Repeat Containing) is a Protein Coding gene. An important paralog of this gene is PCOTHP1.

UniProtKB/Swiss-Prot for PCOTH Gene

  • May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCOTH Gene

Genomics for PCOTH Gene

Regulatory Elements for PCOTH Gene

Enhancers for PCOTH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G023866 1.3 FANTOM5 Ensembl ENCODE 12 -20.9 -20948 3.3 KLF1 CBX3 TAL1 TCF12 ZNF316 FOS NFE2 MAFK RNF2 L3MBTL2 C1QTNF9 MIPEP PCOTH C1QTNF9B TNFRSF19 MTCO3P2
GH13G023504 1.3 Ensembl ENCODE dbSUPER 11.3 -382.5 -382480 3.7 PKNOX1 ZBTB21 INSM2 FEZF1 CEBPG ZIC2 RARA HIC1 GLIS2 ZNF366 C1QTNF9B PCOTH MIPEP TNFRSF19 LINC00352 PIR60894
GH13G023608 1.3 Ensembl ENCODE 11.2 -279.4 -279368 3.0 HNRNPUL1 PKNOX1 FOXA2 ATF1 ARID4B FEZF1 ZNF48 YY1 JUNB REST MIPEP PCOTH C1QTNF9B TNFRSF19 LOC105370114
GH13G023372 1.2 Ensembl ENCODE 11.1 -512.7 -512720 8.3 PKNOX1 FOXA2 CREB3L1 SIN3A ZNF2 ZNF48 GLIS2 GATA2 CBX5 ZNF143 C1QTNF9B MIPEP PCOTH SACS RPLP1P13 SACS-AS1
GH13G023465 0.9 ENCODE 11.7 -421.9 -421900 2.0 PKNOX1 ARID4B SIN3A ZNF2 ZNF48 FOS ZNF263 MXD4 REST KAT8 C1QTNF9B MIPEP PCOTH TNFRSF19 LINC00327 LINC00352
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCOTH on UCSC Golden Path with GeneCards custom track

Promoters for PCOTH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059977 311 1601 FOXA2 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 FOS

Genomic Location for PCOTH Gene

Chromosome:
13
Start:
23,888,889 bp from pter
End:
23,897,263 bp from pter
Size:
8,375 bases
Orientation:
Plus strand

Genomic View for PCOTH Gene

Genes around PCOTH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCOTH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCOTH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCOTH Gene

Proteins for PCOTH Gene

  • Protein details for PCOTH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58A44-PCOTH_HUMAN
    Recommended name:
    Prostate collagen triple helix protein
    Protein Accession:
    Q58A44

    Protein attributes for PCOTH Gene

    Size:
    107 amino acids
    Molecular mass:
    10968 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PCOTH Gene

Post-translational modifications for PCOTH Gene

No Post-translational modifications

Other Protein References for PCOTH Gene

No data available for DME Specific Peptides for PCOTH Gene

Domains & Families for PCOTH Gene

Protein Domains for PCOTH Gene

ProtoNet:

Suggested Antigen Peptide Sequences for PCOTH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCOTH: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PCOTH Gene

Function for PCOTH Gene

Molecular function for PCOTH Gene

UniProtKB/Swiss-Prot Function:
May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.

Gene Ontology (GO) - Molecular Function for PCOTH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PCOTH: view

Phenotypes for PCOTH Gene

GenomeRNAi human phenotypes for PCOTH:
genes like me logo Genes that share phenotypes with PCOTH: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PCOTH Gene

Localization for PCOTH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCOTH Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCOTH gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PCOTH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PCOTH: view

Pathways & Interactions for PCOTH Gene

SuperPathways for PCOTH Gene

No Data Available

Interacting Proteins for PCOTH Gene

Selected Interacting proteins: Q58A44-PCOTH_HUMAN for PCOTH Gene via IID UniProtKB

Symbol External ID(s) Details
PSMA3

Gene Ontology (GO) - Biological Process for PCOTH Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCOTH Gene

Transcripts for PCOTH Gene

mRNA/cDNA for PCOTH Gene

(5) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PCOTH Gene

No ASD Table

Relevant External Links for PCOTH Gene

GeneLoc Exon Structure for
PCOTH
ECgene alternative splicing isoforms for
PCOTH

Expression for PCOTH Gene

mRNA Expression by UniProt/SwissProt for PCOTH Gene:

Q58A44-PCOTH_HUMAN
Tissue specificity: Expressed in prostate and testis. Weakly or not expressed in other tissues. Overexpressed in prostate cancers.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCOTH Gene

Orthologs for PCOTH Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PCOTH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF9B-AS1 34
  • 99.38 (n)
Species where no ortholog for PCOTH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCOTH Gene

ENSEMBL:
Gene Tree for PCOTH (if available)
TreeFam:
Gene Tree for PCOTH (if available)

Paralogs for PCOTH Gene

Paralogs for PCOTH Gene

(1) SIMAP similar genes for PCOTH Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PCOTH: view

Variants for PCOTH Gene

Sequence variations from dbSNP and Humsavar for PCOTH Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000481778 -- 23,889,366(+) GCCCT(A/C/G)CTGCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000670278 -- 23,890,839(+) AAAGA(A/C)AAAAT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000764810 -- 23,890,513(+) AACTG(G/T)GAGAA intron-variant, upstream-variant-2KB
rs1002983673 -- 23,891,034(+) AATGC(-/ACAG)ACAAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003897063 -- 23,889,865(+) GGGTT(C/T)CAGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PCOTH Gene

Variant ID Type Subtype PubMed ID
dgv1615n100 CNV gain 25217958
dgv3084n54 CNV gain 21841781
esv2422502 CNV duplication 17116639
esv2751136 CNV loss 17911159
esv3580576 CNV loss 25503493
esv3631536 CNV gain 21293372
esv3892311 CNV gain 25118596
esv5325 OTHER complex 18987735
nsv1041095 CNV loss 25217958
nsv1078303 OTHER inversion 25765185
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv455837 CNV gain 19166990
nsv525965 CNV gain 19592680
nsv561292 CNV loss 21841781
nsv832566 CNV gain 17160897
nsv983560 CNV duplication 23825009

Relevant External Links for PCOTH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCOTH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PCOTH Gene

Disorders for PCOTH Gene

Relevant External Links for PCOTH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCOTH

No disorders were found for PCOTH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCOTH Gene

Publications for PCOTH Gene

  1. PCOTH, a novel gene overexpressed in prostate cancers, promotes prostate cancer cell growth through phosphorylation of oncoprotein TAF-Ibeta/SET. (PMID: 15930275) Anazawa Y. … Nakamura Y. (Cancer Res. 2005) 2 3 4 22 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Genetic variants at 13q12.12 are associated with high myopia in the Han Chinese population. (PMID: 21640322) Shi Y. … Yang Z. (Am. J. Hum. Genet. 2011) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for PCOTH Gene

Sources for PCOTH Gene

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