Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCOLCE2 Gene

Aliases for PCOLCE2 Gene

  • Procollagen C-Endopeptidase Enhancer 2 2 3
  • Procollagen COOH-Terminal Proteinase Enhancer 2 3 4
  • Procollagen C-Proteinase Enhancer 2 3 4
  • PCPE2 3 4
  • PCPE-2 4

External Ids for PCOLCE2 Gene

Previous GeneCards Identifiers for PCOLCE2 Gene

  • GC03M139515
  • GC03M143365
  • GC03M143816
  • GC03M143857
  • GC03M144019
  • GC03M142534
  • GC03M139909

Summaries for PCOLCE2 Gene

GeneCards Summary for PCOLCE2 Gene

PCOLCE2 (Procollagen C-Endopeptidase Enhancer 2) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Collagen biosynthesis and modifying enzymes. GO annotations related to this gene include heparin binding and peptidase activator activity. An important paralog of this gene is TLL1.

UniProtKB/Swiss-Prot for PCOLCE2 Gene

  • Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.

Gene Wiki entry for PCOLCE2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCOLCE2 Gene

Genomics for PCOLCE2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCOLCE2 Gene

142,815,922 bp from pter
142,889,203 bp from pter
73,282 bases
Minus strand

Genomic View for PCOLCE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCOLCE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCOLCE2 Gene

No data available for Regulatory Elements for PCOLCE2 Gene

Proteins for PCOLCE2 Gene

  • Protein details for PCOLCE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Procollagen C-endopeptidase enhancer 2
    Protein Accession:
    Secondary Accessions:
    • B2RCH9
    • D3DNG4
    • Q9BRH3

    Protein attributes for PCOLCE2 Gene

    415 amino acids
    Molecular mass:
    45717 Da
    Quaternary structure:
    • Interacts with heparin with high affinity, and type I or II collagen.

neXtProt entry for PCOLCE2 Gene

Proteomics data for PCOLCE2 Gene at MOPED

Post-translational modifications for PCOLCE2 Gene

Other Protein References for PCOLCE2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PCOLCE2 Gene

Domains for PCOLCE2 Gene

Protein Domains for PCOLCE2 Gene

Suggested Antigen Peptide Sequences for PCOLCE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UKZ9
  • Contains 2 CUB domains.
  • Contains 1 NTR domain.
genes like me logo Genes that share domains with PCOLCE2: view

No data available for Gene Families for PCOLCE2 Gene

Function for PCOLCE2 Gene

Molecular function for PCOLCE2 Gene

UniProtKB/Swiss-Prot Function: Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.

Gene Ontology (GO) - Molecular Function for PCOLCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005518 collagen binding IDA 12393877
GO:0008191 metalloendopeptidase inhibitor activity --
GO:0008201 heparin binding IDA 12393877
GO:0016504 peptidase activator activity IDA 12393877
genes like me logo Genes that share ontologies with PCOLCE2: view

Phenotypes for PCOLCE2 Gene

genes like me logo Genes that share phenotypes with PCOLCE2: view

Animal Models for PCOLCE2 Gene

MGI Knock Outs for PCOLCE2:

Animal Model Products

CRISPR Products

miRNA for PCOLCE2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PCOLCE2 Gene

Localization for PCOLCE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCOLCE2 Gene


Subcellular locations from

Jensen Localization Image for PCOLCE2 Gene COMPARTMENTS Subcellular localization image for PCOLCE2 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCOLCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PCOLCE2: view

Pathways for PCOLCE2 Gene

genes like me logo Genes that share pathways with PCOLCE2: view

Pathways by source for PCOLCE2 Gene

Interacting Proteins for PCOLCE2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000295992 for PCOLCE2 Gene via STRING

Gene Ontology (GO) - Biological Process for PCOLCE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010952 positive regulation of peptidase activity IDA 12393877
genes like me logo Genes that share ontologies with PCOLCE2: view

Transcripts for PCOLCE2 Gene

Unigene Clusters for PCOLCE2 Gene

Procollagen C-endopeptidase enhancer 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCOLCE2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCOLCE2 Gene

No ASD Table

Relevant External Links for PCOLCE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCOLCE2 Gene

mRNA expression in normal human tissues for PCOLCE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCOLCE2 Gene

This gene is overexpressed in Heart - Atrial Appendage (8.4), Artery - Coronary (5.4), and Artery - Aorta (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PCOLCE2 Gene

SOURCE GeneReport for Unigene cluster for PCOLCE2 Gene Hs.8944

mRNA Expression by UniProt/SwissProt for PCOLCE2 Gene

Tissue specificity: Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland, trachea and placenta and weakly expressed in the brain. Expressed in cartilage.
genes like me logo Genes that share expressions with PCOLCE2: view

In Situ Assay Products

Orthologs for PCOLCE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCOLCE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCOLCE2 35
  • 99.52 (n)
  • 99.28 (a)
  • 99 (a)
(Bos Taurus)
Mammalia PCOLCE2 35
  • 89 (n)
  • 94.22 (a)
  • 94 (a)
(Canis familiaris)
Mammalia PCOLCE2 35
  • 92.95 (n)
  • 94.96 (a)
  • 79 (a)
(Mus musculus)
Mammalia Pcolce2 35
  • 85.57 (n)
  • 88.61 (a)
Pcolce2 16
Pcolce2 36
  • 87 (a)
(Monodelphis domestica)
Mammalia PCOLCE2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 5 (a)
(Rattus norvegicus)
Mammalia PCOLCE2 35
  • 85.99 (n)
  • 88.86 (a)
(Gallus gallus)
Aves PCOLCE2 35
  • 78.18 (n)
  • 84.79 (a)
  • 81 (a)
(Anolis carolinensis)
Reptilia PCOLCE2 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcolce2 35
  • 75.49 (n)
  • 81.93 (a)
(Danio rerio)
Actinopterygii pcolce2a 36
  • 62 (a)
pcolce2b 35
  • 69.71 (n)
  • 73.1 (a)
pcolce2b 36
  • 71 (a)
zgc63590 35
fruit fly
(Drosophila melanogaster)
Insecta CG32702 36
  • 2 (a)
CG42255 36
  • 3 (a)
(Caenorhabditis elegans)
Secernentea ZC116.3 36
  • 2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for PCOLCE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCOLCE2 Gene

Gene Tree for PCOLCE2 (if available)
Gene Tree for PCOLCE2 (if available)

Paralogs for PCOLCE2 Gene

Paralogs for PCOLCE2 Gene

Selected SIMAP similar genes for PCOLCE2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PCOLCE2: view

Variants for PCOLCE2 Gene

Sequence variations from dbSNP and Humsavar for PCOLCE2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7772 -- 142,818,229(+) GGAAT(C/G)CTCTT utr-variant-3-prime
rs12413 -- 142,818,175(-) GCCTC(C/T)GAGAT utr-variant-3-prime
rs728517 -- 142,831,958(-) GATGT(A/T)ACATG intron-variant
rs893883 -- 142,848,485(+) GAAAA(A/G)CGCCA intron-variant
rs893884 -- 142,848,741(+) ATTAG(A/G)TCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCOLCE2 Gene

Variant ID Type Subtype PubMed ID
esv2725999 CNV Deletion 23290073
nsv877562 CNV Gain 21882294
esv270805 CNV Insertion 20981092
dgv75n17 CNV Loss 16327808

Relevant External Links for PCOLCE2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCOLCE2 Gene

Disorders for PCOLCE2 Gene

(1) University of Copenhagen DISEASES for PCOLCE2 Gene

genes like me logo Genes that share disorders with PCOLCE2: view

No data available for UniProtKB/Swiss-Prot for PCOLCE2 Gene

Publications for PCOLCE2 Gene

  1. Identification and expression of a novel type I procollagen C- proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24. (PMID: 10873381) Xu H. … Wirtz M.K. (Genomics 2000) 2 3 4 23
  2. Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23. (PMID: 12063410) Steiglitz B.M. … Greenspan D.S. (Cytogenet. Cell Genet. 2001) 3 23
  3. Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. (PMID: 19237735) Zhu J. … Francone O.L. (J. Lipid Res. 2009) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for PCOLCE2 Gene

  • antibodies-online proteins for PCOLCE2
  • antibodies-online antibodies for PCOLCE2
  • antibodies-online kits for PCOLCE2

Sources for PCOLCE2 Gene

Back to Top