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PCOLCE2 Gene

protein-coding   GIFtS: 54
GCID: GC03M142534

Procollagen C-Endopeptidase Enhancer 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Procollagen C-Endopeptidase Enhancer 21 2
Procollagen C-Proteinase Enhancer 22 3
Procollagen COOH-Terminal Proteinase Enhancer 22 3
PCPE22 3
PCPE-23

External Ids:    HGNC: 87391   Entrez Gene: 265772   Ensembl: ENSG000001637107   OMIM: 6070645   UniProtKB: Q9UKZ93   

Export aliases for PCOLCE2 gene to outside databases

Previous GC identifers: GC03M139515 GC03M143365 GC03M143816 GC03M143857 GC03M144019 GC03M139909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PCOLCE2 Gene:
PCOLCE2 (procollagen C-endopeptidase enhancer 2) is a protein-coding gene. GO annotations related to this gene include peptidase activator activity and heparin binding. An important paralog of this gene is TLL2.

UniProtKB/Swiss-Prot: PCOC2_HUMAN, Q9UKZ9
Function: Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that
propeptide by BMP1

Gene Wiki entry for PCOLCE2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PCOLCE2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPCOLCE2 promoter sequence
   Search Chromatin IP Primers for PCOLCE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PCOLCE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21-q24   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q21-q24

PCOLCE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCOLCE2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M142534:  view genomic region     (about GC identifiers)

Start:
142,534,764 bp from pter      End:
142,608,045 bp from pter
Size:
73,282 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PCOC2_HUMAN, Q9UKZ9 (See protein sequence)
Recommended Name: Procollagen C-endopeptidase enhancer 2 precursor  
Size: 415 amino acids; 45717 Da
Subunit: Interacts with heparin with high affinity, and type I or II collagen
Secondary accessions: B2RCH9 D3DNG4 Q9BRH3

Explore the universe of human proteins at neXtProt for PCOLCE2: NX_Q9UKZ9

Explore proteomics data for PCOLCE2 at MOPED

Post-translational modifications: 

  • O-glycosylated; contains sialic acid1
  • Glycosylation2 at Asn355
  • Modification sites at PhosphoSitePlus

  • See PCOLCE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037495.1  
    ENSEMBL proteins: 
     ENSP00000419643   ENSP00000295992   ENSP00000419842   ENSP00000418782  
    Reactome Protein details: Q9UKZ9

    PCOLCE2 Human Recombinant Protein Products:

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    Novus Biologicals PCOLCE2 Proteins
    Novus Biologicals PCOLCE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for PCOLCE2 (10 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008993 TIMP-like_OB-fold
     IPR000859 CUB_dom
     IPR001134 Netrin_domain
     IPR018933 Netrin_module_non-TIMP

    Graphical View of Domain Structure for InterPro Entry Q9UKZ9

    ProtoNet protein and cluster: Q9UKZ9

    1 Blocks protein domain: IPB000859 CUB domain

    UniProtKB/Swiss-Prot: PCOC2_HUMAN, Q9UKZ9
    Similarity: Contains 2 CUB domains
    Similarity: Contains 1 NTR domain


    Find genes that share domains with PCOLCE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCOC2_HUMAN, Q9UKZ9
    Function: Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that
    propeptide by BMP1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IEA--
    GO:0005515protein binding ----
    GO:0005518collagen binding IDA12393877
    GO:0008191metalloendopeptidase inhibitor activity ----
    GO:0008201heparin binding IDA12393877
         
    Find genes that share ontologies with PCOLCE2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pcolce2):
     immune system  normal 

    Find genes that share phenotypes with PCOLCE2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pcolce2tm1Ccb for PCOLCE2

       genOway: Develop your customized and physiologically relevant rodent model for PCOLCE2

    miRNA
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    miRTarBase miRNAs that target PCOLCE2:
    hsa-mir-182-5p (MIRT047213), hsa-mir-192-5p (MIRT026916), hsa-mir-26b-5p (MIRT030184), hsa-mir-215-5p (MIRT024608)

    Block miRNA regulation of human, mouse, rat PCOLCE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCOLCE2 (see all 11):
    hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-3171 hsa-miR-2115 hsa-miR-4325 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidPCOLCE2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PCOC2_HUMAN, Q9UKZ9: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    mitochondrion2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016020membrane IEA--

    Find genes that share ontologies with PCOLCE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PCOLCE2 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Collagen formation0.75
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with PCOLCE2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PCOLCE2
        Collagen biosynthesis and modifying enzymes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PCOLCE2
    Interactions:

        Search GeneGlobe Interaction Network for PCOLCE2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PCOLCE2 (ENSP000002959924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP1ENSP000003057144STRING: ENSP00000305714
    ADAMTS14ENSP000003623044STRING: ENSP00000362304
    ADAMTS2ENSP000002515824STRING: ENSP00000251582
    ADAMTS3ENSP000002866574STRING: ENSP00000286657
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis IEA--
    GO:0010952positive regulation of peptidase activity IDA12393877

    Find genes that share ontologies with PCOLCE2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PCOLCE2 (PCOC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PCOLCE2 gene: 
    NM_013363.3  

    Unigene Cluster for PCOLCE2:

    Procollagen C-endopeptidase enhancer 2
    Hs.8944  [show with all ESTs]
    Unigene Representative Sequence: NM_013363
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470310 ENST00000295992(uc003evd.3) ENST00000470795 ENST00000485766
    ENST00000480473 ENST00000483986 ENST00000495732 ENST00000461818 ENST00000493733
    ENST00000483454
    miRNA
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    Block miRNA regulation of human, mouse, rat PCOLCE2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PCOLCE2 (see all 11):
    hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-3171 hsa-miR-2115 hsa-miR-4325 hsa-miR-363
    SwitchGear 3'UTR luciferase reporter plasmidPCOLCE2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PCOLCE2
    Predesigned siRNA for gene silencing in human, mouse, rat PCOLCE2
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    GenScript: all cDNA clones in your preferred vector: PCOLCE2 (NM_013363)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCOLCE2
    Primer
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    OriGene qPCR primer pairs and template standards for PCOLCE2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PCOLCE2
      QuantiTect SYBR Green Assays in human, mouse, rat PCOLCE2
      QuantiFast Probe-based Assays in human, mouse, rat PCOLCE2

    Additional mRNA sequence: 

    AF098269.1 AK075478.1 AK223633.1 AK315121.1 AY035400.1 AY358557.1 BC006265.2 CR536570.1 

    6 DOTS entries:

    DT.314867  DT.95161046  DT.100830661  DT.91697232  DT.100758601  DT.100845278 

    Selected AceView cDNA sequences (see all 154):

    CR608532 AI093329 CA428281 CB161420 AA043947 BQ949972 AA045459 BQ009836 
    BQ012799 AA133448 CD365355 BQ576221 CN480429 CB162347 AU279651 NM_013363 
    BQ008720 CR536570 CB529803 C02622 BM790280 CD251697 CN479764 AY035400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PCOLCE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAGGTAT
    PCOLCE2 Expression
    About this image


    PCOLCE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 10 entries
             Rostral Skull Membranous Bones
             HyStem+BMP4-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             Meckel's Cartilage
             HyStem+BMP4-induced 4D20.8 cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephric Mesenchyme
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    PCOLCE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PCOLCE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8944

    UniProtKB/Swiss-Prot: PCOC2_HUMAN, Q9UKZ9
    Tissue specificity: Highly expressed in the heart, trabecular meshwork, pituitary gland, bladder, mammary gland,
    trachea and placenta and weakly expressed in the brain. Expressed in cartilage

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PCOLCE2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcolce21 , 5 procollagen C-endopeptidase enhancer 21, 5 85.57(n)1
    88.61(a)1
      9 (50.18 cM)5
    764771  NM_029620.21  NP_083896.11 
     956376015 
    chicken
    (Gallus gallus)
    Aves PCOLCE21 procollagen C-endopeptidase enhancer 2 78.18(n)
    84.79(a)
      429124  XM_426680.4  XP_426680.4 
    lizard
    (Anolis carolinensis)
    Reptilia PCOLCE26
    procollagen C-endopeptidase enhancer 2
    71(a)
    1 ↔ 1
    3(21703746-21731169)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054276.12   -- 78.38(n)    BC054276.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc635902 hypothetical protein MGC63590 74.54(n)   393432  BC055153.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG422556
    CG327026
    --
    3(a)
    2(a)
    many ↔ many
    many ↔ many
    3L(11795051-11807855)
    X(9452698-9465341)
    worm
    (Caenorhabditis elegans)
    Secernentea ZC116.36
    Protein ZC116.3 (ZC116.3) mRNA, complete cds
    2(a)
    1 → many
    V(12611329-12628738) WBGene00013855


    ENSEMBL Gene Tree for PCOLCE2 (if available)
    TreeFam Gene Tree for PCOLCE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PCOLCE2 gene
    TLL22  CUBN2  CDCP22  PCOLCE2  BMP12  NETO22  MFRP2  NETO12  
    TLL12  
    8 SIMAP similar genes for PCOLCE2 using alignment to 5 protein entries:     PCOC2_HUMAN (see all proteins):
    PCOLCE    MASP1    NRP2    DKFZp686L21135    CUBN    C1S
    TLL1    NRP1

    Find genes that share paralogs with PCOLCE2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PCOLCE2 (see all 1609)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902830401,2
    --142536252(+) AAATAA/CTAGCC 1 -- int10--------
    rs1392275701,2
    --142536285(+) CACTCC/TTCAAA 1 -- int10--------
    rs1411537521,2
    --142536345(+) AGTGA-/GGGGCA 1 -- int10--------
    rs1808849841,2
    --142536388(+) TGTTTC/TGTCTC 1 -- int10--------
    rs1836294331,2
    --142536440(+) GCTTCC/TGTTTC 1 -- int10--------
    rs1499852291,2
    --142536441(+) CTTCCA/GTTTCA 1 -- int10--------
    rs76308171,2
    C,F,H--142536524(+) AGAGAG/AAAGAA 1 -- int16Minor allele frequency- A:0.14NS EA WA 538
    rs729926321,2
    C,F--142536692(+) TAAAAA/GGAAGT 1 -- int12Minor allele frequency- G:0.06WA 120
    rs2006227571,2
    C--142536712(+) GTTCTG/TTAATC 1 -- ut310--------
    rs1476903771,2
    --142536737(+) TATTAA/CGCATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PCOLCE2 (142534764 - 142608045 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PCOLCE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725999CNV Deletion23290073
    esv270805CNV Insertion20981092
    dgv75n17CNV Loss16327808
    nsv877562CNV Gain21882294

    Human Gene Mutation Database (HGMD): PCOLCE2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PCOLCE2
    DNA2.0 Custom Variant and Variant Library Synthesis for PCOLCE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607064    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PCOLCE2:
    Primary open angle glaucoma

    Find genes that share disorders with PCOLCE2           About GenesLikeMe


    Export disorders for PCOLCE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PCOLCE2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with PCOLCE2)
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    world of online information

    1. Identification and expression of a novel type I procollagen C- proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24. (PubMed id 10873381)1, 2, 3, 9 Xu H.... Wirtz M.K. (Genomics 2000)
    2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. (PubMed id 12393877)1, 2 Steiglitz B.M.... Greenspan D.S. (J. Biol. Chem. 2002)
    5. Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. (PubMed id 11597177)1, 2 Kumar S....Lark M.W. (Osteoarthritis Cartilage 2001)
    6. Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1. (PubMed id 19237735)1, 9 Zhu J....Francone O.L. (J. Lipid Res. 2009)
    7. Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23. (PubMed id 12063410)1, 9 Steiglitz B.M. and Greenspan D.S. (Cytogenet. Cell Genet. 2001)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26577 HGNC: 8739 AceView: PCOLCE2 Ensembl:ENSG00000163710 euGenes: HUgn26577
    ECgene: PCOLCE2 H-InvDB: PCOLCE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PCOLCE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PCOLCE2 gene:
    Search GeneIP for patents involving PCOLCE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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