Aliases for PCOLCE Gene
- Procollagen C-Endopeptidase Enhancer 2 3 5
- Procollagen C-Proteinase Enhancer 1 2 3 4
- Procollagen, Type 1, COOH-Terminal Proteinase Enhancer 2 3
- Type I Procollagen COOH-Terminal Proteinase Enhancer 3 4
- Type 1 Procollagen C-Proteinase Enhancer Protein 3 4
- Procollagen COOH-Terminal Proteinase Enhancer 1 3 4
External Ids for PCOLCE Gene
Previous GeneCards Identifiers for PCOLCE Gene
Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for PCOLCE Gene
PCOLCE (Procollagen C-Endopeptidase Enhancer) is a Protein Coding gene. Diseases associated with PCOLCE include Oculopharyngeal Muscular Dystrophy and Bone Fracture. Among its related pathways are Collagen biosynthesis and modifying enzymes and Degradation of the extracellular matrix. GO annotations related to this gene include heparin binding and peptidase activator activity. An important paralog of this gene is PCOLCE2.
UniProtKB/Swiss-Prot for PCOLCE Gene
Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.