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Aliases for PCNXL4 Gene

Aliases for PCNXL4 Gene

  • Pecanex-Like 4 (Drosophila) 2 3
  • Hepatitis C Virus F Protein-Binding Protein 2 3 4
  • HCV F Protein-Binding Protein 2 3 4
  • C14orf135 3 4
  • FBP2 3 4
  • Chromosome 14 Open Reading Frame 135 2
  • Pecanex-Like Protein C14orf135 3
  • HCV F-Interacting Protein 3
  • Pecanex-Like Protein 4 3

External Ids for PCNXL4 Gene

Previous HGNC Symbols for PCNXL4 Gene

  • C14orf135

Previous GeneCards Identifiers for PCNXL4 Gene

  • GC14P060559

Summaries for PCNXL4 Gene

GeneCards Summary for PCNXL4 Gene

PCNXL4 (Pecanex-Like 4 (Drosophila)) is a Protein Coding gene. Diseases associated with PCNXL4 include hepatitis c and hepatitis c virus. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is PCNX.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNXL4 Gene

Genomics for PCNXL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCNXL4 Gene

Start:
60,091,827 bp from pter
End:
60,169,133 bp from pter
Size:
77,307 bases
Orientation:
Plus strand

Genomic View for PCNXL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCNXL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNXL4 Gene

No data available for Regulatory Elements for PCNXL4 Gene

Proteins for PCNXL4 Gene

  • Protein details for PCNXL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HM2-PCX4_HUMAN
    Recommended name:
    Pecanex-like protein 4
    Protein Accession:
    Q63HM2
    Secondary Accessions:
    • A8MXM2
    • Q9BQG8
    • Q9H9F2

    Protein attributes for PCNXL4 Gene

    Size:
    1172 amino acids
    Molecular mass:
    132702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33843.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14277.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66516.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PCNXL4 Gene

Proteomics data for PCNXL4 Gene at MOPED

Post-translational modifications for PCNXL4 Gene

  • Ubiquitination at Lys734 and Lys1165
  • Glycosylation at Asn1120 and Asn1147
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCNXL4 Gene

Domains for PCNXL4 Gene

Protein Domains for PCNXL4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q63HM2

UniProtKB/Swiss-Prot:

PCX4_HUMAN :
  • Q63HM2
Family:
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNXL4: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for PCNXL4 Gene

Function for PCNXL4 Gene

Gene Ontology (GO) - Molecular Function for PCNXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16237761
genes like me logo Genes that share ontologies with PCNXL4: view

Phenotypes for PCNXL4 Gene

GenomeRNAi human phenotypes for PCNXL4:
genes like me logo Genes that share phenotypes with PCNXL4: view

Animal Model Products

CRISPR Products

miRNA for PCNXL4 Gene

miRTarBase miRNAs that target PCNXL4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCNXL4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PCNXL4 Gene

Localization for PCNXL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNXL4 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for PCNXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNXL4: view

No data available for Subcellular locations from COMPARTMENTS for PCNXL4 Gene

Pathways for PCNXL4 Gene

genes like me logo Genes that share pathways with PCNXL4: view

Pathways by source for PCNXL4 Gene

Interacting Proteins for PCNXL4 Gene

Gene Ontology (GO) - Biological Process for PCNXL4 Gene

None

Transcripts for PCNXL4 Gene

Unigene Clusters for PCNXL4 Gene

Pecanex-like 4 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCNXL4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PCNXL4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNXL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: - - -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for PCNXL4 Gene

GeneLoc Exon Structure for
PCNXL4
ECgene alternative splicing isoforms for
PCNXL4

Expression for PCNXL4 Gene

mRNA expression in normal human tissues for PCNXL4 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PCNXL4 Gene

SOURCE GeneReport for Unigene cluster for PCNXL4 Gene Hs.509499

genes like me logo Genes that share expressions with PCNXL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCNXL4 Gene

Orthologs for PCNXL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNXL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCNXL4 35
  • 99 (n)
  • 98.18 (a)
PCNXL4 36
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCNXL4 35
  • 88.21 (n)
  • 83.49 (a)
PCNXL4 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCNXL4 35
  • 89.03 (n)
  • 84.83 (a)
PCNXL4 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcnxl4 35
  • 79.19 (n)
  • 76.1 (a)
Pcnxl4 16
Pcnxl4 36
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCNXL4 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pcnxl4 35
  • 77.62 (n)
  • 70.67 (a)
chicken
(Gallus gallus)
Aves C5H14ORF135 35
  • 70.41 (n)
  • 67.77 (a)
PCNXL4 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNXL4 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398632 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pcnxl4 35
  • 63.92 (n)
  • 60.06 (a)
zebrafish
(Danio rerio)
Actinopterygii pcnxl4 35
  • 53.99 (n)
  • 50.49 (a)
pcnxl4 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pcx 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.12 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for PCNXL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCNXL4 Gene

ENSEMBL:
Gene Tree for PCNXL4 (if available)
TreeFam:
Gene Tree for PCNXL4 (if available)

Paralogs for PCNXL4 Gene

Paralogs for PCNXL4 Gene

genes like me logo Genes that share paralogs with PCNXL4: view

Variants for PCNXL4 Gene

Sequence variations from dbSNP and Humsavar for PCNXL4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs12465 -- 60,107,821(+) CTTTT(A/G)TACCA intron-variant, reference, synonymous-codon
rs150687 -- 60,115,217(-) AGCAA(A/G)CTAGT reference, synonymous-codon
rs150688 -- 60,115,335(-) ATATA(C/T)GCTTT missense, reference
rs160222 -- 60,113,568(+) ttcac(C/T)atgtt intron-variant
rs160223 -- 60,113,280(-) TATAA(C/T)ATAGT intron-variant

Relevant External Links for PCNXL4 Gene

HapMap Linkage Disequilibrium report
PCNXL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PCNXL4 Gene

Disorders for PCNXL4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PCNXL4 Gene including...

Search for PCNXL4 Gene in MalaCards »
genes like me logo Genes that share disorders with PCNXL4: view

No data available for UniProtKB/Swiss-Prot for PCNXL4 Gene

Publications for PCNXL4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for PCNXL4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PCNXL4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PCNXL4
    • Block miRNA regulation of PCNXL4 using miScript Target Protectors

    Sources for PCNXL4 Gene

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