Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCNXL4 Gene

Aliases for PCNXL4 Gene

  • Pecanex-Like 4 (Drosophila) 2 3
  • Hepatitis C Virus F Protein-Binding Protein 2 3 4
  • HCV F Protein-Binding Protein 2 3 4
  • C14orf135 3 4
  • FBP2 3 4
  • Chromosome 14 Open Reading Frame 135 2
  • Pecanex-Like Protein C14orf135 3
  • HCV F-Interacting Protein 3

External Ids for PCNXL4 Gene

Previous HGNC Symbols for PCNXL4 Gene

  • C14orf135

Previous GeneCards Identifiers for PCNXL4 Gene

  • GC14P060559

Summaries for PCNXL4 Gene

GeneCards Summary for PCNXL4 Gene

PCNXL4 (Pecanex-Like 4 (Drosophila)) is a Protein Coding gene. Diseases associated with PCNXL4 include hepatitis c virus. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. An important paralog of this gene is PCNX.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNXL4 Gene

Genomics for PCNXL4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCNXL4 Gene

Chromosome:
14
Start:
60,091,827 bp from pter
End:
60,169,133 bp from pter
Size:
77,307 bases
Orientation:
Plus strand

Genomic View for PCNXL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCNXL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNXL4 Gene

No data available for Regulatory Elements for PCNXL4 Gene

Proteins for PCNXL4 Gene

  • Protein details for PCNXL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HM2-PCX4_HUMAN
    Recommended name:
    Pecanex-like protein 4
    Protein Accession:
    Q63HM2
    Secondary Accessions:
    • A8MXM2
    • Q9BQG8
    • Q9H9F2

    Protein attributes for PCNXL4 Gene

    Size:
    1172 amino acids
    Molecular mass:
    132702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33843.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14277.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66516.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PCNXL4 Gene

Proteomics data for PCNXL4 Gene at MOPED

Post-translational modifications for PCNXL4 Gene

  • Ubiquitination at Lys 734 and Lys 1165
  • Glycosylation at Asn 1120 and Asn 1147
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCNXL4 Gene

Domains & Families for PCNXL4 Gene

Protein Domains for PCNXL4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCNXL4 Gene

Graphical View of Domain Structure for InterPro Entry

Q63HM2

UniProtKB/Swiss-Prot:

PCX4_HUMAN :
  • Belongs to the pecanex family.
Family:
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNXL4: view

No data available for Gene Families for PCNXL4 Gene

Function for PCNXL4 Gene

Gene Ontology (GO) - Molecular Function for PCNXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16237761
genes like me logo Genes that share ontologies with PCNXL4: view
genes like me logo Genes that share phenotypes with PCNXL4: view

miRNA for PCNXL4 Gene

miRTarBase miRNAs that target PCNXL4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCNXL4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNXL4 Gene

Localization for PCNXL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNXL4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCNXL4 Gene COMPARTMENTS Subcellular localization image for PCNXL4 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for PCNXL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNXL4: view

Pathways & Interactions for PCNXL4 Gene

genes like me logo Genes that share pathways with PCNXL4: view

Pathways by source for PCNXL4 Gene

Gene Ontology (GO) - Biological Process for PCNXL4 Gene

None

No data available for SIGNOR curated interactions for PCNXL4 Gene

Drugs & Compounds for PCNXL4 Gene

No Compound Related Data Available

Transcripts for PCNXL4 Gene

Unigene Clusters for PCNXL4 Gene

Pecanex-like 4 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCNXL4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNXL4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: - - -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for PCNXL4 Gene

GeneLoc Exon Structure for
PCNXL4
ECgene alternative splicing isoforms for
PCNXL4

Expression for PCNXL4 Gene

mRNA expression in normal human tissues for PCNXL4 Gene

Protein differential expression in normal tissues from HIPED for PCNXL4 Gene

This gene is overexpressed in Fetal testis (51.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PCNXL4 Gene



SOURCE GeneReport for Unigene cluster for PCNXL4 Gene Hs.509499

genes like me logo Genes that share expression patterns with PCNXL4: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PCNXL4 Gene

Orthologs for PCNXL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNXL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCNXL4 35
  • 88.21 (n)
  • 83.49 (a)
PCNXL4 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCNXL4 35
  • 89.03 (n)
  • 84.83 (a)
PCNXL4 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcnxl4 35
  • 79.19 (n)
  • 76.1 (a)
Pcnxl4 16
Pcnxl4 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCNXL4 35
  • 99 (n)
  • 98.18 (a)
PCNXL4 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcnxl4 35
  • 77.62 (n)
  • 70.67 (a)
oppossum
(Monodelphis domestica)
Mammalia PCNXL4 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves C5H14ORF135 35
  • 70.41 (n)
  • 67.77 (a)
PCNXL4 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNXL4 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcnxl4 35
  • 63.92 (n)
  • 60.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398632 35
zebrafish
(Danio rerio)
Actinopterygii pcnxl4 35
  • 53.99 (n)
  • 50.49 (a)
pcnxl4 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pcx 36
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.12 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToOne
Species with no ortholog for PCNXL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCNXL4 Gene

ENSEMBL:
Gene Tree for PCNXL4 (if available)
TreeFam:
Gene Tree for PCNXL4 (if available)

Paralogs for PCNXL4 Gene

Paralogs for PCNXL4 Gene

genes like me logo Genes that share paralogs with PCNXL4: view

Variants for PCNXL4 Gene

Sequence variations from dbSNP and Humsavar for PCNXL4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs12465 -- 60,107,821(+) CTTTT(A/G)TACCA intron-variant, reference, synonymous-codon, nc-transcript-variant
rs150687 -- 60,115,217(-) AGCAA(A/C/G)CTAGT reference, missense, synonymous-codon, nc-transcript-variant
rs150688 -- 60,115,335(-) ATATA(C/T)GCTTT missense, reference, nc-transcript-variant
rs160222 -- 60,113,568(+) ttcac(C/T)atgtt intron-variant
rs160223 -- 60,113,280(-) TATAA(C/T)ATAGT intron-variant

Variation tolerance for PCNXL4 Gene

Gene Damage Index Score: 18.08; 98.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCNXL4 Gene

HapMap Linkage Disequilibrium report
PCNXL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PCNXL4 Gene

Disorders for PCNXL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCNXL4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association

Relevant External Links for PCNXL4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNXL4
genes like me logo Genes that share disorders with PCNXL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCNXL4 Gene

Publications for PCNXL4 Gene

  1. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev D.E. … Baranov P.V. (Elife 2015) 67
  2. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  3. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 67
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  5. Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system. (PMID: 16237761) Huang Y.P. … Shao Q. (World J. Gastroenterol. 2005) 67

Products for PCNXL4 Gene

Sources for PCNXL4 Gene

Back to Top

Content