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Aliases for PCNX4 Gene

Aliases for PCNX4 Gene

  • Pecanex Homolog 4 2 3 5
  • Hepatitis C Virus F Protein-Binding Protein 2 3 4
  • HCV F Protein-Binding Protein 2 3 4
  • Pecanex Homolog Protein 4 3 4
  • C14orf135 3 4
  • PCNXL4 3 4
  • FBP2 3 4
  • Chromosome 14 Open Reading Frame 135 2
  • Pecanex Homolog 4 (Drosophila) 2
  • Pecanex-Like Protein C14orf135 3
  • Pecanex-Like 4 (Drosophila) 2
  • HCV F-Interacting Protein 3
  • Pecanex-Like Protein 4 3
  • Pecanex-Like 4 3

External Ids for PCNX4 Gene

Previous HGNC Symbols for PCNX4 Gene

  • C14orf135
  • PCNXL4

Summaries for PCNX4 Gene

GeneCards Summary for PCNX4 Gene

PCNX4 (Pecanex Homolog 4) is a Protein Coding gene. Diseases associated with PCNX4 include Hepatitis C Virus. An important paralog of this gene is PCNX3.

Additional gene information for PCNX4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNX4 Gene

Genomics for PCNX4 Gene

GeneHancer (GH) Regulatory Elements for PCNX4 Gene

Promoters and enhancers for PCNX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I060090 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 563.6 +1.9 1892 6.2 HDGF FOXA2 PKNOX1 MLX ARID4B NEUROD1 SIN3A DMAP1 IRF4 YY1 PCNX4 LOC105370524 DHRS7 L3HYPDH SCOCP1 TRMT5 GC14P060140
GH14I060640 Promoter/Enhancer 2.9 VISTA EPDnew Ensembl ENCODE dbSUPER 29.7 +558.4 558357 19.2 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SIX1 TRMT5 SLC38A6 PCNX4 C14orf39 LOC101927702 SIX4 TMEM30B MNAT1 SIX6
GH14I059481 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 -607.9 -607863 5.4 HDGF PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B L3HYPDH JKAMP GPR135 PCNX4 RBM8B ENSG00000258782
GH14I060163 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 +73.6 73567 3.2 ATF1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF207 DHRS7 PCNX4 GC14P060159 SCOCP1
GH14I060734 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 +643.9 643881 3.1 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 MNAT1 TRMT5 PCNX4 SLC38A6 RBM8B RNU6-398P MAD2L1P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCNX4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PCNX4 Gene

Genomic Locations for PCNX4 Gene
77,307 bases
Plus strand

Genomic View for PCNX4 Gene

Genes around PCNX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX4 Gene

Proteins for PCNX4 Gene

  • Protein details for PCNX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pecanex-like protein 4
    Protein Accession:
    Secondary Accessions:
    • A8MXM2
    • Q9BQG8
    • Q9H9F2

    Protein attributes for PCNX4 Gene

    1172 amino acids
    Molecular mass:
    132702 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH33843.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14277.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66516.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PCNX4 Gene

Post-translational modifications for PCNX4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PCNX4 Gene

Domains & Families for PCNX4 Gene

Gene Families for PCNX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PCNX4 Gene


Suggested Antigen Peptide Sequences for PCNX4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pecanex family.
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX4: view

Function for PCNX4 Gene

Phenotypes From GWAS Catalog for PCNX4 Gene

Gene Ontology (GO) - Molecular Function for PCNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16237761
genes like me logo Genes that share ontologies with PCNX4: view
genes like me logo Genes that share phenotypes with PCNX4: view

miRNA for PCNX4 Gene

miRTarBase miRNAs that target PCNX4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX4 Gene

Localization for PCNX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX4 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX4: view

Pathways & Interactions for PCNX4 Gene

SuperPathways for PCNX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PCNX4 Gene

Drugs & Compounds for PCNX4 Gene

No Compound Related Data Available

Transcripts for PCNX4 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX4 Gene

No ASD Table

Relevant External Links for PCNX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCNX4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCNX4 Gene:


Evidence on tissue expression from TISSUES for PCNX4 Gene

  • Nervous system(4.7)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX4 Gene

Orthologs for PCNX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCNXL4 33 34
  • 99 (n)
(Canis familiaris)
Mammalia PCNXL4 33 34
  • 89.03 (n)
(Bos Taurus)
Mammalia PCNXL4 33 34
  • 88.21 (n)
(Mus musculus)
Mammalia Pcnxl4 33 34
  • 79.19 (n)
Pcnx4 16
(Rattus norvegicus)
Mammalia Pcnxl4 33
  • 77.62 (n)
(Monodelphis domestica)
Mammalia PCNXL4 34
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
-- 34
  • 45 (a)
(Gallus gallus)
Aves C5H14ORF135 33
  • 70.41 (n)
  • 53 (a)
(Anolis carolinensis)
Reptilia PCNXL4 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcnxl4 33
  • 63.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398632 33
(Danio rerio)
Actinopterygii pcnxl4 33 34
  • 53.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta pcx 34
  • 5 (a)
(Caenorhabditis elegans)
Secernentea B0511.12 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for PCNX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCNX4 Gene

Gene Tree for PCNX4 (if available)
Gene Tree for PCNX4 (if available)

Paralogs for PCNX4 Gene

Paralogs for PCNX4 Gene

genes like me logo Genes that share paralogs with PCNX4: view

Variants for PCNX4 Gene

Sequence variations from dbSNP and Humsavar for PCNX4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000007676 -- 60,129,351(+) T/A intron_variant
rs1000061515 -- 60,110,469(+) A/C intron_variant
rs1000158104 -- 60,104,111(+) G/C/T intron_variant
rs1000227231 -- 60,102,829(+) A/T intron_variant
rs1000262722 -- 60,104,768(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PCNX4 Gene

Variant ID Type Subtype PubMed ID
esv1144667 CNV insertion 17803354
esv2759993 CNV loss 17122850
esv3422540 CNV insertion 20981092
nsv1044390 CNV loss 25217958
nsv1129376 OTHER inversion 24896259

Variation tolerance for PCNX4 Gene

Gene Damage Index Score: 18.08; 98.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCNX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX4 Gene

Disorders for PCNX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PCNX4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search PCNX4 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with PCNX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PCNX4 Gene

Publications for PCNX4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  4. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev DE … Baranov PV (eLife 2015) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for PCNX4 Gene

Sources for PCNX4 Gene

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