Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCNX4 Gene

Aliases for PCNX4 Gene

  • Pecanex Homolog 4 (Drosophila) 2 3 5
  • Hepatitis C Virus F Protein-Binding Protein 2 3 4
  • HCV F Protein-Binding Protein 2 3 4
  • Pecanex Homolog Protein 4 3 4
  • C14orf135 3 4
  • PCNXL4 3 4
  • FBP2 3 4
  • Chromosome 14 Open Reading Frame 135 2
  • Pecanex-Like Protein C14orf135 3
  • Pecanex-Like 4 (Drosophila) 2
  • HCV F-Interacting Protein 3
  • Pecanex-Like Protein 4 3
  • Pecanex-Like 4 3

External Ids for PCNX4 Gene

Previous HGNC Symbols for PCNX4 Gene

  • C14orf135
  • PCNXL4

Summaries for PCNX4 Gene

GeneCards Summary for PCNX4 Gene

PCNX4 (Pecanex Homolog 4 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PCNX2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNX4 Gene

Genomics for PCNX4 Gene

Regulatory Elements for PCNX4 Gene

Enhancers for PCNX4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G060090 1.6 Ensembl ENCODE dbSUPER 13.6 +1.9 1893 6.2 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DHRS7 L3HYPDH PCNX4 TRMT5 GC14P060140
GH14G060150 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12 +60.2 60176 2.4 USF1 PKNOX1 ZNF146 TAF1 JUN MAX SIN3A RARA CTBP1 GATA3 DHRS7 PCNX4 RTN1 PPM1A GC14P060159 SCOCP1 GC14P060140
GH14G060720 1.4 FANTOM5 ENCODE 12.5 +630.9 630904 4.6 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B MNAT1 PCNX4 TRMT5 RTN1 PPM1A SIX4 GC14M060376
GH14G060178 1.4 Ensembl ENCODE dbSUPER 10.8 +87.9 87925 1.6 PKNOX1 FOXA2 ZNF76 SIN3A ARID4B RAD21 YY1 ZNF335 ZNF263 ZBTB11 PPM1A RTN1 LOC101927702 PCNX4 C14orf39 GC14P060180 RPL17P2
GH14G060163 1.3 ENCODE dbSUPER 11.5 +73.6 73568 3.2 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF263 DHRS7 PCNX4 SCOCP1 GC14P060159
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCNX4 on UCSC Golden Path with GeneCards custom track

Promoters for PCNX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069212 673 3001 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9

Genomic Location for PCNX4 Gene

Chromosome:
14
Start:
60,091,827 bp from pter
End:
60,169,133 bp from pter
Size:
77,307 bases
Orientation:
Plus strand

Genomic View for PCNX4 Gene

Genes around PCNX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX4 Gene

Proteins for PCNX4 Gene

  • Protein details for PCNX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63HM2-PCX4_HUMAN
    Recommended name:
    Pecanex-like protein 4
    Protein Accession:
    Q63HM2
    Secondary Accessions:
    • A8MXM2
    • Q9BQG8
    • Q9H9F2

    Protein attributes for PCNX4 Gene

    Size:
    1172 amino acids
    Molecular mass:
    132702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH33843.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14277.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66516.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH56141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PCNX4 Gene

Post-translational modifications for PCNX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCNX4 Gene

Domains & Families for PCNX4 Gene

Protein Domains for PCNX4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCNX4 Gene

Graphical View of Domain Structure for InterPro Entry

Q63HM2

UniProtKB/Swiss-Prot:

PCX4_HUMAN :
  • Belongs to the pecanex family.
Family:
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX4: view

No data available for Gene Families for PCNX4 Gene

Function for PCNX4 Gene

Gene Ontology (GO) - Molecular Function for PCNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16237761
genes like me logo Genes that share ontologies with PCNX4: view
genes like me logo Genes that share phenotypes with PCNX4: view

Animal Model Products

miRNA for PCNX4 Gene

miRTarBase miRNAs that target PCNX4

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX4 Gene

Localization for PCNX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX4 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for PCNX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX4: view

Pathways & Interactions for PCNX4 Gene

SuperPathways for PCNX4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNX4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCNX4 Gene

Drugs & Compounds for PCNX4 Gene

No Compound Related Data Available

Transcripts for PCNX4 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX4 Gene

No ASD Table

Relevant External Links for PCNX4 Gene

GeneLoc Exon Structure for
PCNX4
ECgene alternative splicing isoforms for
PCNX4

Expression for PCNX4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCNX4 Gene:

PCNX4

Evidence on tissue expression from TISSUES for PCNX4 Gene

  • Nervous system(4.7)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX4 Gene

Orthologs for PCNX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCNXL4 34 35
  • 99 (n)
dog
(Canis familiaris)
Mammalia PCNXL4 34 35
  • 89.03 (n)
cow
(Bos Taurus)
Mammalia PCNXL4 34 35
  • 88.21 (n)
mouse
(Mus musculus)
Mammalia Pcnxl4 34 35
  • 79.19 (n)
Pcnx4 16
rat
(Rattus norvegicus)
Mammalia Pcnxl4 34
  • 77.62 (n)
oppossum
(Monodelphis domestica)
Mammalia PCNXL4 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
OneToMany
-- 35
  • 45 (a)
OneToMany
chicken
(Gallus gallus)
Aves C5H14ORF135 34
  • 70.41 (n)
PCNXL4 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNXL4 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcnxl4 34
  • 63.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398632 34
zebrafish
(Danio rerio)
Actinopterygii pcnxl4 34 35
  • 53.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta pcx 35
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.12 35
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToOne
Species where no ortholog for PCNX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCNX4 Gene

ENSEMBL:
Gene Tree for PCNX4 (if available)
TreeFam:
Gene Tree for PCNX4 (if available)

Paralogs for PCNX4 Gene

Paralogs for PCNX4 Gene

genes like me logo Genes that share paralogs with PCNX4: view

Variants for PCNX4 Gene

Sequence variations from dbSNP and Humsavar for PCNX4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000007676 -- 60,129,351(+) GAGTT(A/T)GAGAC intron-variant
rs1000061515 -- 60,110,469(+) TATGG(A/C)ACCAA intron-variant
rs1000158104 -- 60,104,111(+) GTCAG(C/G/T)AGTTC intron-variant
rs1000227231 -- 60,102,829(+) TTGTG(A/T)ATTTG intron-variant
rs1000262722 -- 60,104,768(+) ACCAC(C/G)CCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCNX4 Gene

Variant ID Type Subtype PubMed ID
esv1144667 CNV insertion 17803354
esv2759993 CNV loss 17122850
esv3422540 CNV insertion 20981092
nsv1044390 CNV loss 25217958
nsv1129376 OTHER inversion 24896259

Variation tolerance for PCNX4 Gene

Gene Damage Index Score: 18.08; 98.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCNX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCNX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX4 Gene

Disorders for PCNX4 Gene

Relevant External Links for PCNX4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNX4

No disorders were found for PCNX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNX4 Gene

Publications for PCNX4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  4. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev D.E. … Baranov P.V. (Elife 2015) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for PCNX4 Gene

Sources for PCNX4 Gene

Content
Loading form....