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Aliases for PCNX3 Gene

Aliases for PCNX3 Gene

  • Pecanex Homolog 3 2 3 5
  • Pecanex Homolog Protein 3 3 4
  • PCNXL3 3 4
  • Pecanex Homolog 3 (Drosophila) 2
  • Pecanex-Like 3 (Drosophila) 2
  • Pecanex-Like Protein 3 3
  • Pecanex-Like 3 3

External Ids for PCNX3 Gene

Previous HGNC Symbols for PCNX3 Gene

  • PCNXL3

Previous GeneCards Identifiers for PCNX3 Gene

  • GC11P065615

Summaries for PCNX3 Gene

GeneCards Summary for PCNX3 Gene

PCNX3 (Pecanex Homolog 3) is a Protein Coding gene. An important paralog of this gene is PCNX1.

Additional gene information for PCNX3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNX3 Gene

Genomics for PCNX3 Gene

Regulatory Elements for PCNX3 Gene

Enhancers for PCNX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 131.1 -124.2 -124239 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 81.8 -190.1 -190141 18 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
GH11H065851 1.4 ENCODE dbSUPER 66.9 +243.2 243163 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC SART1 ENSG00000258297 RBM14 EIF1AD KAT5 POLA2 PCNX3 ZFPL1 SF3B2 SNX32
GH11H065567 1.7 FANTOM5 ENCODE dbSUPER 38.8 -40.6 -40648 11 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 PCNX3 SF1 POLA2 LOC105369352 EIF1AD SF3B2 EHBP1L1 ENSG00000254461 KAT5 SART1
GH11H065886 1.9 FANTOM5 ENCODE dbSUPER 30.7 +281.1 281137 18 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SNX32 RBM14 ENSG00000258297 ENSG00000254461 MUS81 SART1 CTSW KAT5 SF3B2 EIF1AD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCNX3 on UCSC Golden Path with GeneCards custom track

Promoters for PCNX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040866 678 3201 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for PCNX3 Gene

Chromosome:
11
Start:
65,614,322 bp from pter
End:
65,637,439 bp from pter
Size:
23,118 bases
Orientation:
Plus strand

Genomic View for PCNX3 Gene

Genes around PCNX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX3 Gene

Proteins for PCNX3 Gene

  • Protein details for PCNX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6A9-PCX3_HUMAN
    Recommended name:
    Pecanex-like protein 3
    Protein Accession:
    Q9H6A9
    Secondary Accessions:
    • Q6MZN8

    Protein attributes for PCNX3 Gene

    Size:
    2034 amino acids
    Molecular mass:
    222039 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15353.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCNX3 Gene

Post-translational modifications for PCNX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCNX3 Gene

Domains & Families for PCNX3 Gene

Gene Families for PCNX3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PCNX3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCNX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6A9

UniProtKB/Swiss-Prot:

PCX3_HUMAN :
  • Belongs to the pecanex family.
Family:
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX3: view

Function for PCNX3 Gene

Phenotypes From GWAS Catalog for PCNX3 Gene

genes like me logo Genes that share phenotypes with PCNX3: view

Animal Model Products

CRISPR Products

miRNA for PCNX3 Gene

miRTarBase miRNAs that target PCNX3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PCNX3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX3 Gene

Localization for PCNX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX3 gene
Compartment Confidence
plasma membrane 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCNX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX3: view

Pathways & Interactions for PCNX3 Gene

SuperPathways for PCNX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNX3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCNX3 Gene

Drugs & Compounds for PCNX3 Gene

No Compound Related Data Available

Transcripts for PCNX3 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PCNX3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX3 Gene

No ASD Table

Relevant External Links for PCNX3 Gene

GeneLoc Exon Structure for
PCNX3
ECgene alternative splicing isoforms for
PCNX3

Expression for PCNX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCNX3 Gene:

PCNX3
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX3 Gene

Orthologs for PCNX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCNXL3 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia PCNXL3 33 34
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia PCNXL3 33 34
  • 90.38 (n)
rat
(Rattus norvegicus)
Mammalia Pcnxl3 33
  • 88.61 (n)
mouse
(Mus musculus)
Mammalia Pcnxl3 33 34
  • 88.35 (n)
Pcnx3 16
oppossum
(Monodelphis domestica)
Mammalia PCNXL3 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCNXL3 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNXL3 34
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pcnxl3 34
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pcx 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.12 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
ManyToMany
Species where no ortholog for PCNX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PCNX3 Gene

ENSEMBL:
Gene Tree for PCNX3 (if available)
TreeFam:
Gene Tree for PCNX3 (if available)

Paralogs for PCNX3 Gene

Paralogs for PCNX3 Gene

genes like me logo Genes that share paralogs with PCNX3: view

Variants for PCNX3 Gene

Sequence variations from dbSNP and Humsavar for PCNX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000016935 -- 65,625,718(+) TCAGC(A/G)CCAGC downstream-variant-500B, reference, missense
rs1000204726 -- 65,620,146(+) GAGAT(C/T)TAAAG intron-variant
rs1000264077 -- 65,615,806(+) TCGCG(A/G)CTCCT upstream-variant-2KB, utr-variant-5-prime
rs1000302448 -- 65,630,709(+) TTTGT(C/G)CAAGG intron-variant
rs1000439950 -- 65,615,942(+) GAGCT(A/G)TCGCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PCNX3 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
esv2761680 CNV gain 21179565
nsv951018 CNV deletion 24416366

Variation tolerance for PCNX3 Gene

Residual Variation Intolerance Score: 4.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCNX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCNX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX3 Gene

Disorders for PCNX3 Gene

Relevant External Links for PCNX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNX3

No disorders were found for PCNX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNX3 Gene

Publications for PCNX3 Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) Global Lipids Genetics Consortium … Abecasis GR (Nature genetics 2013) 3 60

Products for PCNX3 Gene

Sources for PCNX3 Gene

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