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Aliases for PCNX3 Gene

Aliases for PCNX3 Gene

  • Pecanex Homolog 3 (Drosophila) 2 3 5
  • Pecanex Homolog Protein 3 3 4
  • PCNXL3 3 4
  • Pecanex-Like 3 (Drosophila) 2
  • Pecanex-Like Protein 3 3
  • Pecanex-Like 3 3

External Ids for PCNX3 Gene

Previous HGNC Symbols for PCNX3 Gene

  • PCNXL3

Previous GeneCards Identifiers for PCNX3 Gene

  • GC11P065615

Summaries for PCNX3 Gene

GeneCards Summary for PCNX3 Gene

PCNX3 (Pecanex Homolog 3 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PCNX1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNX3 Gene

Genomics for PCNX3 Gene

Regulatory Elements for PCNX3 Gene

Enhancers for PCNX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 24.8 -124.2 -124239 40.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 LOC105369352 ZFPL1 KAT5 ENSG00000254461 EIF1AD NEAT1 FRMD8 EHBP1L1 POLA2 LOC101927789
GH11G065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 26.1 -190.1 -190141 18.8 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZFPL1 NEAT1 LOC105369352 KAT5 EIF1AD FRMD8 MUS81 PCNX3 POLA2 ENSG00000255320
GH11G065851 1.4 ENCODE dbSUPER 28.7 +243.2 243163 12.2 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SNX32 EIF1AD PCNX3 ZFPL1 ENSG00000258297 FRMD8 POLA2 KAT5 ENSG00000255320 CTSW
GH11G066342 1.8 FANTOM5 ENCODE dbSUPER 17.6 +734.2 734223 11.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 RIN1 EIF1AD ENSG00000258297 ACTN3 RAD9A RBM14 KAT5 ENSG00000255320 LOC105369352 CTSF
GH11G065650 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14.4 +38.4 38390 5.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 EIF1AD MAP3K11 ZFPL1 SIPA1 RNASEH2C LOC105369352 MRPL11 RBM14 KAT5 PCNX3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCNX3 on UCSC Golden Path with GeneCards custom track

Promoters for PCNX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040866 678 3201 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for PCNX3 Gene

Chromosome:
11
Start:
65,614,322 bp from pter
End:
65,637,439 bp from pter
Size:
23,118 bases
Orientation:
Plus strand

Genomic View for PCNX3 Gene

Genes around PCNX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX3 Gene

Proteins for PCNX3 Gene

  • Protein details for PCNX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6A9-PCX3_HUMAN
    Recommended name:
    Pecanex-like protein 3
    Protein Accession:
    Q9H6A9
    Secondary Accessions:
    • Q6MZN8

    Protein attributes for PCNX3 Gene

    Size:
    2034 amino acids
    Molecular mass:
    222039 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15353.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCNX3 Gene

Post-translational modifications for PCNX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCNX3 Gene

Domains & Families for PCNX3 Gene

Protein Domains for PCNX3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCNX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6A9

UniProtKB/Swiss-Prot:

PCX3_HUMAN :
  • Belongs to the pecanex family.
Family:
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX3: view

No data available for Gene Families for PCNX3 Gene

Function for PCNX3 Gene

genes like me logo Genes that share phenotypes with PCNX3: view

Animal Models for PCNX3 Gene

MGI Knock Outs for PCNX3:

Animal Model Products

CRISPR Products

miRNA for PCNX3 Gene

miRTarBase miRNAs that target PCNX3

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCNX3 Gene

Localization for PCNX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX3 gene
Compartment Confidence
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PCNX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX3: view

Pathways & Interactions for PCNX3 Gene

SuperPathways for PCNX3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNX3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCNX3 Gene

Drugs & Compounds for PCNX3 Gene

No Compound Related Data Available

Transcripts for PCNX3 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX3 Gene

No ASD Table

Relevant External Links for PCNX3 Gene

GeneLoc Exon Structure for
PCNX3
ECgene alternative splicing isoforms for
PCNX3

Expression for PCNX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCNX3 Gene:

PCNX3
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX3 Gene

Orthologs for PCNX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCNXL3 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia PCNXL3 34 35
  • 90.84 (n)
cow
(Bos Taurus)
Mammalia PCNXL3 34 35
  • 90.38 (n)
rat
(Rattus norvegicus)
Mammalia Pcnxl3 34
  • 88.61 (n)
mouse
(Mus musculus)
Mammalia Pcnxl3 34 35
  • 88.35 (n)
Pcnx3 16
oppossum
(Monodelphis domestica)
Mammalia PCNXL3 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCNXL3 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNXL3 35
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pcnxl3 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pcx 35
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.12 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
ManyToMany
Species where no ortholog for PCNX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PCNX3 Gene

ENSEMBL:
Gene Tree for PCNX3 (if available)
TreeFam:
Gene Tree for PCNX3 (if available)

Paralogs for PCNX3 Gene

Paralogs for PCNX3 Gene

genes like me logo Genes that share paralogs with PCNX3: view

Variants for PCNX3 Gene

Sequence variations from dbSNP and Humsavar for PCNX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000016935 -- 65,625,718(+) TCAGC(A/G)CCAGC downstream-variant-500B, reference, missense
rs1000204726 -- 65,620,146(+) GAGAT(C/T)TAAAG intron-variant
rs1000264077 -- 65,615,806(+) TCGCG(A/G)CTCCT upstream-variant-2KB, utr-variant-5-prime
rs1000302448 -- 65,630,709(+) TTTGT(C/G)CAAGG intron-variant
rs1000439950 -- 65,615,942(+) GAGCT(A/G)TCGCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PCNX3 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
esv2761680 CNV gain 21179565
nsv951018 CNV deletion 24416366

Variation tolerance for PCNX3 Gene

Residual Variation Intolerance Score: 4.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCNX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCNX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX3 Gene

Disorders for PCNX3 Gene

Relevant External Links for PCNX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNX3

No disorders were found for PCNX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNX3 Gene

Publications for PCNX3 Gene

  1. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for PCNX3 Gene

Sources for PCNX3 Gene

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