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Aliases for PCNX1 Gene

Aliases for PCNX1 Gene

  • Pecanex Homolog 1 2 3 5
  • PCNXL1 3 4
  • PCNX 3 4
  • Pecanex Homolog 1 (Drosophila) 2
  • Pecanex Homolog (Drosophila) 2
  • Pecanex-Like 1 (Drosophila) 2
  • Pecanex Homolog Protein 1 4
  • Pecanex-Like Protein 1 3
  • KIAA0805 4
  • KIAA0995 4
  • Pecanex 3

External Ids for PCNX1 Gene

Previous HGNC Symbols for PCNX1 Gene

  • PCNXL1
  • PCNX

Summaries for PCNX1 Gene

Entrez Gene Summary for PCNX1 Gene

  • This gene encodes an evolutionarily conserved transmembrane protein similar to the pecanex protein in Drosophila. The fly protein is a component of the Notch signaling pathway, which functions in several developmental processes. [provided by RefSeq, Jul 2016]

GeneCards Summary for PCNX1 Gene

PCNX1 (Pecanex Homolog 1) is a Protein Coding gene. An important paralog of this gene is PCNX3.

Gene Wiki entry for PCNX1 Gene

Additional gene information for PCNX1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNX1 Gene

Genomics for PCNX1 Gene

Regulatory Elements for PCNX1 Gene

Enhancers for PCNX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H070885 1.8 FANTOM5 Ensembl ENCODE dbSUPER 50.7 -19.7 -19714 4 HDAC1 BATF TCF12 ZNF766 GATA2 ELK1 FOS ATF7 ETV6 RUNX3 PCNX1 MED6 ENSG00000274818 LOC100287335
GH14H070881 1.7 FANTOM5 Ensembl ENCODE dbSUPER 48.7 -24.4 -24405 2.8 PKNOX1 TBL1XR1 BATF ZNF366 ATF7 ETV6 RUNX3 CREM IKZF2 CBFB PCNX1 MED6 LOC100287335 ENSG00000274818
GH14H070904 1.5 Ensembl ENCODE dbSUPER 52.7 +1.9 1890 9.5 PKNOX1 ATF1 ARNT ARID4B SIN3A FEZF1 YY1 GLIS2 ZNF207 ZNF143 PCNX1 LOC105370557
GH14H071115 1.4 Ensembl ENCODE dbSUPER 43.5 +210.8 210771 4.4 ELF3 FOXA2 THRB RARA YY1 ATF7 CREM HMG20B CEBPB PPARG PCNX1 ENSG00000269927 GC14P071114
GH14H071129 1.4 Ensembl ENCODE dbSUPER 43 +223.7 223697 2.9 HDAC1 PKNOX1 ATF1 BMI1 TCF12 ELK1 IKZF2 NCOA1 NR2F2 MEF2D PCNX1 ENSG00000269927 GC14P071114
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCNX1 on UCSC Golden Path with GeneCards custom track

Promoters for PCNX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070364 695 2601 ARID4B SIN3A YY1 GLIS2 ZNF143 ZNF207 ATF7 MXD4 REST SMARCB1

Genomic Locations for PCNX1 Gene

Genomic Locations for PCNX1 Gene
207,978 bases
Plus strand

Genomic View for PCNX1 Gene

Genes around PCNX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX1 Gene

Proteins for PCNX1 Gene

  • Protein details for PCNX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pecanex-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RTR6
    • O94897
    • Q96AI7
    • Q9Y2J9

    Protein attributes for PCNX1 Gene

    2341 amino acids
    Molecular mass:
    258676 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA76839.1; Type=Frameshift; Positions=41; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNX1 Gene


neXtProt entry for PCNX1 Gene

Post-translational modifications for PCNX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCNX1 Gene

Domains & Families for PCNX1 Gene

Gene Families for PCNX1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PCNX1 Gene


Suggested Antigen Peptide Sequences for PCNX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pecanex family.
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX1: view

Function for PCNX1 Gene

Phenotypes From GWAS Catalog for PCNX1 Gene

Phenotypes for PCNX1 Gene

GenomeRNAi human phenotypes for PCNX1:
genes like me logo Genes that share phenotypes with PCNX1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX1 Gene

Localization for PCNX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNX1 gene
Compartment Confidence
plasma membrane 3
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX1: view

Pathways & Interactions for PCNX1 Gene

SuperPathways for PCNX1 Gene

No Data Available

Interacting Proteins for PCNX1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q96RV3-PCX1_HUMAN ENSP00000304192 for PCNX1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PCNX1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PCNX1 Gene

Drugs & Compounds for PCNX1 Gene

No Compound Related Data Available

Transcripts for PCNX1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX1 Gene

No ASD Table

Relevant External Links for PCNX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCNX1 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNX1 Gene

Orthologs for PCNX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PCNX 33 34
  • 99.28 (n)
(Canis familiaris)
Mammalia PCNX 33 34
  • 92.6 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
-- 34
  • 90 (a)
-- 34
  • 68 (a)
(Bos Taurus)
Mammalia PCNX 33 34
  • 90.16 (n)
(Monodelphis domestica)
Mammalia PCNX 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Pcnx 33
  • 86.27 (n)
(Mus musculus)
Mammalia Pcnx 33 16 34
  • 85.8 (n)
(Gallus gallus)
Aves PCNX 33 34
  • 81.11 (n)
(Anolis carolinensis)
Reptilia PCNX 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135121 33
  • 76.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7316 33
(Danio rerio)
Actinopterygii pcnx 33 34
  • 66.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta pcx 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea B0511.12 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13499 33
Species where no ortholog for PCNX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCNX1 Gene

Gene Tree for PCNX1 (if available)
Gene Tree for PCNX1 (if available)

Paralogs for PCNX1 Gene

Paralogs for PCNX1 Gene

genes like me logo Genes that share paralogs with PCNX1: view

Variants for PCNX1 Gene

Sequence variations from dbSNP and Humsavar for PCNX1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs193920949 Uncertain significance 71,019,061(+) TCGTG(G/T)CCTTT nc-transcript-variant, reference, missense
rs1000009196 -- 70,965,612(+) GAGCT(A/G)AGATG intron-variant, upstream-variant-2KB
rs1000011274 -- 70,943,657(+) CATAA(C/G)TAACG intron-variant, upstream-variant-2KB
rs1000014897 -- 71,090,170(+) TAGGA(C/T)AGACT intron-variant
rs1000016893 -- 70,913,201(+) TCATA(C/T)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCNX1 Gene

Variant ID Type Subtype PubMed ID
nsv957514 CNV deletion 24416366
nsv85150 CNV deletion 16902084
nsv826973 CNV loss 20364138
nsv565043 CNV gain 21841781
nsv471996 CNV novel sequence insertion 20440878
nsv1340 CNV insertion 18451855
nsv1153692 CNV duplication 26484159
nsv1134387 CNV deletion 24896259
nsv1053303 CNV gain 25217958
nsv1044090 CNV gain 25217958
nsv1038007 CNV gain 25217958
nsv1036929 CNV gain 25217958
esv7102 CNV loss 19470904
esv3634871 CNV loss 21293372
esv3581282 CNV loss 25503493
esv3551736 CNV deletion 23714750
esv3551734 CNV deletion 23714750
esv3551732 CNV deletion 23714750
esv3325758 CNV insertion 20981092
esv2748855 CNV deletion 23290073
esv2748854 CNV deletion 23290073
esv2748853 CNV deletion 23290073
esv2748851 CNV deletion 23290073
esv2675445 CNV deletion 23128226
esv2660325 CNV deletion 23128226
esv2590666 CNV deletion 19546169
esv2496217 CNV deletion 19546169
esv2392889 CNV deletion 18987734
esv2229536 CNV deletion 18987734
esv1181559 CNV deletion 17803354
esv1004840 CNV deletion 20482838

Variation tolerance for PCNX1 Gene

Residual Variation Intolerance Score: 0.482% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCNX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX1 Gene

Disorders for PCNX1 Gene

Relevant External Links for PCNX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PCNX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNX1 Gene

Publications for PCNX1 Gene

  1. The mammalian gene pecanex 1 is differentially expressed during spermatogenesis. (PMID: 15777640) Geisinger A … Wettstein R (Biochimica et biophysica acta 2005) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 60
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 60
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60

Products for PCNX1 Gene

Sources for PCNX1 Gene

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