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Aliases for PCNX1 Gene

Aliases for PCNX1 Gene

  • Pecanex Homolog 1 (Drosophila) 2 3 5
  • PCNXL1 3 4
  • PCNX 3 4
  • Pecanex Homolog (Drosophila) 2
  • Pecanex-Like 1 (Drosophila) 2
  • Pecanex Homolog Protein 1 4
  • Pecanex-Like Protein 1 3
  • KIAA0805 4
  • KIAA0995 4
  • Pecanex 3

External Ids for PCNX1 Gene

Previous HGNC Symbols for PCNX1 Gene

  • PCNXL1
  • PCNX

Summaries for PCNX1 Gene

Entrez Gene Summary for PCNX1 Gene

  • This gene encodes an evolutionarily conserved transmembrane protein similar to the pecanex protein in Drosophila. The fly protein is a component of the Notch signaling pathway, which functions in several developmental processes. [provided by RefSeq, Jul 2016]

GeneCards Summary for PCNX1 Gene

PCNX1 (Pecanex Homolog 1 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PCNX3.

Gene Wiki entry for PCNX1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNX1 Gene

Genomics for PCNX1 Gene

Regulatory Elements for PCNX1 Gene

Enhancers for PCNX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PCNX1 on UCSC Golden Path with GeneCards custom track

Promoters for PCNX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PCNX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PCNX1 Gene

Chromosome:
14
Start:
70,907,405 bp from pter
End:
71,115,382 bp from pter
Size:
207,978 bases
Orientation:
Plus strand

Genomic View for PCNX1 Gene

Genes around PCNX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNX1 Gene

Proteins for PCNX1 Gene

  • Protein details for PCNX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RV3-PCX1_HUMAN
    Recommended name:
    Pecanex-like protein 1
    Protein Accession:
    Q96RV3
    Secondary Accessions:
    • B2RTR6
    • O94897
    • Q96AI7
    • Q9Y2J9

    Protein attributes for PCNX1 Gene

    Size:
    2341 amino acids
    Molecular mass:
    258676 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76839.1; Type=Frameshift; Positions=41; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCNX1 Gene

Post-translational modifications for PCNX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCNX1 Gene

No data available for DME Specific Peptides for PCNX1 Gene

Domains & Families for PCNX1 Gene

Protein Domains for PCNX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCNX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96RV3

UniProtKB/Swiss-Prot:

PCX1_HUMAN :
  • Belongs to the pecanex family.
Family:
  • Belongs to the pecanex family.
genes like me logo Genes that share domains with PCNX1: view

No data available for Gene Families for PCNX1 Gene

Function for PCNX1 Gene

Phenotypes for PCNX1 Gene

GenomeRNAi human phenotypes for PCNX1:
genes like me logo Genes that share phenotypes with PCNX1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNX1 Gene

Localization for PCNX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNX1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for PCNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCNX1: view

No data available for Subcellular locations from COMPARTMENTS for PCNX1 Gene

Pathways & Interactions for PCNX1 Gene

SuperPathways for PCNX1 Gene

No Data Available

Interacting Proteins for PCNX1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304192%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000356234%0d%0a
Selected Interacting proteins: ENSP00000304192 Q96RV3-PCX1_HUMAN for PCNX1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PCNX1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PCNX1 Gene

Drugs & Compounds for PCNX1 Gene

No Compound Related Data Available

Transcripts for PCNX1 Gene

mRNA/cDNA for PCNX1 Gene

Unigene Clusters for PCNX1 Gene

Pecanex homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNX1 Gene

No ASD Table

Relevant External Links for PCNX1 Gene

GeneLoc Exon Structure for
PCNX1
ECgene alternative splicing isoforms for
PCNX1

Expression for PCNX1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PCNX1 Gene:

PCNX1

SOURCE GeneReport for Unigene cluster for PCNX1 Gene:

Hs.446559
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PCNX1 Gene

Orthologs for PCNX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCNX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCNX 34
  • 90.16 (n)
  • 93.64 (a)
PCNX 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCNX 34
  • 92.6 (n)
  • 96.05 (a)
PCNX 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcnx 34
  • 85.8 (n)
  • 91.03 (a)
Pcnx 16
Pcnx 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCNX 34
  • 99.28 (n)
  • 99.12 (a)
PCNX 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcnx 34
  • 86.27 (n)
  • 91.24 (a)
oppossum
(Monodelphis domestica)
Mammalia PCNX 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves PCNX 34
  • 81.11 (n)
  • 86.77 (a)
PCNX 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNX 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135121 34
  • 76.11 (n)
  • 82.47 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7316 34
zebrafish
(Danio rerio)
Actinopterygii pcnx 34
  • 66.83 (n)
  • 72.33 (a)
pcnx 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pcx 35
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0511.12 35
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13499 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
ManyToMany
Species where no ortholog for PCNX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCNX1 Gene

ENSEMBL:
Gene Tree for PCNX1 (if available)
TreeFam:
Gene Tree for PCNX1 (if available)

Paralogs for PCNX1 Gene

Paralogs for PCNX1 Gene

genes like me logo Genes that share paralogs with PCNX1: view

Variants for PCNX1 Gene

Sequence variations from dbSNP and Humsavar for PCNX1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs11625687 - 70,988,680(+) CATTG(A/C)TCATC intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11625690 - 70,988,695(+) CACCC(A/C/T)TAAGG intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs34222509 - 70,978,117(+) ACAGT(A/G)CTATA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1468469 -- 71,089,104(-) AATCA(C/T)CTGGG intron-variant
rs1468470 -- 71,088,814(-) TCCCC(A/G)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PCNX1 Gene

Variant ID Type Subtype PubMed ID
esv1004840 CNV deletion 20482838
esv1181559 CNV deletion 17803354
esv2229536 CNV deletion 18987734
esv2392889 CNV deletion 18987734
esv2496217 CNV deletion 19546169
esv2590666 CNV deletion 19546169
esv2660325 CNV deletion 23128226
esv2675445 CNV deletion 23128226
esv2748851 CNV deletion 23290073
esv2748853 CNV deletion 23290073
esv2748854 CNV deletion 23290073
esv2748855 CNV deletion 23290073
esv3325758 CNV insertion 20981092
esv3551732 CNV deletion 23714750
esv3551734 CNV deletion 23714750
esv3551736 CNV deletion 23714750
esv3581282 CNV loss 25503493
esv3634871 CNV loss 21293372
esv7102 CNV loss 19470904
nsv1036929 CNV gain 25217958
nsv1038007 CNV gain 25217958
nsv1044090 CNV gain 25217958
nsv1053303 CNV gain 25217958
nsv1134387 CNV deletion 24896259
nsv1153692 CNV duplication 26484159
nsv1340 CNV insertion 18451855
nsv471996 CNV novel sequence insertion 20440878
nsv565043 CNV gain 21841781
nsv826973 CNV loss 20364138
nsv85150 CNV deletion 16902084
nsv957514 CNV deletion 24416366

Variation tolerance for PCNX1 Gene

Residual Variation Intolerance Score: 0.482% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCNX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCNX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNX1 Gene

Disorders for PCNX1 Gene

Relevant External Links for PCNX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNX1

No disorders were found for PCNX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNX1 Gene

Publications for PCNX1 Gene

  1. The mammalian gene pecanex 1 is differentially expressed during spermatogenesis. (PMID: 15777640) Geisinger A. … Wettstein R. (Biochim. Biophys. Acta 2005) 2 3 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 65
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 65
  5. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4 65

Products for PCNX1 Gene

Sources for PCNX1 Gene

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