PCNT Gene
protein-coding GIFtS: 61
GCID: GC21P047744
|
|
pericentrin(Previous name: pericentrin 2 (kendrin) )
(Previous symbol: PCNT2)
| |
Aliases
for PCNT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
|
| Aliases |
|---|
| Pericentrin1 | | Pericentrin, Kendrin (KIAA0402)11 | | PCNT21 2 3 5 | | PCTN22 | | KEN1 2 5 | | Kendrin3 | | SCKL41 2 5 | | Pericentrin B2 | | PCN1 2 | | Pericentrin-21 | | PCNTB1 2 | | Pericentrin-3801 | | KIAA04021 3 | | Pericentrin-B3 | | MOPD22 5 | | Kendrin3 | | Pericentrin 2 (Kendrin)1 | | Pericentrin-B3 |
Export aliases for PCNT gene to outside databasesPrevious GC identifers: GC21P046569 GC21P033126 |
Summaries
for PCNT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PCNT:
The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component ofthe pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCMtargeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleationcomponent gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycleprogression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism typeII. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PCNT_HUMAN, O95613Function: Integral component of the filamentous matrix of the centrosome involved in the initial establishment oforganized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubulenetwork formation. Is an integral component of the pericentriolar material (PCM). May play an important role inpreventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome
Gene Wiki entry for PCNT
|
Genomic Views
for PCNT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics, Whole Chromsome Sequence According to
Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
|
| GC21P047744: |
GeneLoc |
Nature:405,311-319 |
Start:
|
47,744,036 bp from pter |
33,250,559 bp from centromere |
End:
|
47,865,682 bp from pter |
33,372,115 bp from centromere |
Size:
|
121,647 bases |
121,557 bases |
Orientation:
|
plus strand |
plus strand |
Proteins
for PCNT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PCNT_HUMAN, O95613 (See
protein sequence)Recommended Name: Pericentrin Size: 3336 amino acids; 378037 Da
Subunit: Interacts with CHD3. Interacts with CHD4; the interaction regulates centrosome integrity (By similarity).Interacts with DISC1 and PCM1. Binds calmodulin. Interacts with CDK5RAP2; the interaction is leading to centrosomallocalization of PCNT and CDK5RAP2. Interacts with isoform 1 of NEK2
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Note=Centrosomal at all stages of the cell cycle. Remainsassociated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome
Sequence caution: Sequence=AAD10838.1; Type=Frameshift; Positions=3320; Sequence=BAA23698.3; Type=Erroneous initiation;Note=Translation N-terminally shortened; Sequence=BAC04252.1; Type=Erroneous initiation; Note=Translation N-terminallyextended;
Secondary accessions: O43152 Q7Z7C9Alternative splicing: 2 isoforms: O95613-1 O95613-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PCNT: NX_O95613
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95613
PCNT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006022.3
ENSEMBL proteins: ENSP00000352572 ENSP00000404708 Reactome Protein details: O95613
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
PCNT for ontologies About GeneDecksing
PCNT Antibody Products:
Assay Products for PCNT: |
Protein
Domains /
Families
for PCNT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PCNT for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95613ProtoNet protein and cluster: O95613 UniProtKB/Swiss-Prot: PCNT_HUMAN, O95613Domain: Composed of a coiled-coil central region flanked by non-helical N- and C-terminals |
Function
for PCNT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PCNT_HUMAN, O95613Function: Integral component of the filamentous matrix of the centrosome involved in the initial establishment oforganized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubulenetwork formation. Is an integral component of the pericentriolar material (PCM). May play an important role inpreventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome Genatlas biochemistry entry for PCNT:murine pericentrin homolog (integral component of the filamentous matrix of the centrosome),>100kDa
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCNT (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCNT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PCNT (NM_006031) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCNT | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PCNT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCNT |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
PCNT for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PCNT:
Animal Models:
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Pcnt):
PCNT for phenotypes About GeneDecksing
|
Pathways & Interactions
for PCNT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for PCNT (see all 8)
PCNT for pathways About GeneDecksing
Interactions:
 SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PCNT
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/588 Interacting proteins for PCNT (O956131, 2, 3 ENSP000003525724) via UniProtKB, MINT, STRING, and/or I2D (see all 588)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
PCNT for ontologies About GeneDecksing
|
Drugs & Compounds
for PCNT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PCNT for compounds About GeneDecksing
 Browse Tocris compounds for PCNT
2 Novoseek chemical compound relationships for PCNT gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nocodazole |
60.3 |
1 |
14620743 (1) |
| aspartate |
0 |
1 |
17314514 (1) |
Search CenterWatch for drugs/clinical trials and news about PCNT
|
Transcripts
for PCNT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PCNT gene: NM_006031.5 Unigene Cluster for PCNT: Pericentrin Hs.474069 [show with all ESTs]Unigene Representative Sequence: NM_0060318 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359568(uc002zji.4) ENST00000490468(uc010gqk.1) ENST00000480896(uc002zjj.3)
ENST00000466474 ENST00000483844 ENST00000482575 ENST00000418394 ENST00000465356
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCNT (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCNT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PCNT (NM_006031) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCNT | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PCNT |
Additional cDNA sequence: AB007862.3 AF515282.1 AK024009.1 AK093923.1 AK296731.1 BC035913.1 U52962.1 20 DOTS entries: DT.444851 DT.100781365 DT.92429996 DT.91707801 DT.92429997 DT.100781362 DT.95364953 DT.95364954 DT.444852 DT.92429991 DT.95364955 DT.100781363 DT.40108700 DT.40230302 DT.40285789 DT.91794556 DT.91904409 DT.95113900 DT.97779100 DT.100024957 24/163 AceView cDNA sequences (see all 163): BQ433454 BM452021 BE350864 T07674 C21273 AF515282 BQ232886 AI580194 AI220041 AW452809 AL703675 BM977718 AL044798 AW004972 AW274704 N54774 BX504936 AA991614 AI332441 CR626553 AA306406 BF438100 CA976041 AA454507
GeneLoc Exon Structure
5/19 Alternative Splicing Database (ASD) splice patterns (SP) for PCNT (see all 19) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31a | · | 31b | · | 31c | · | 31d | ^ | 32a | · | 32b | · | 32c | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 36b | · | 36c | ^ | 37 | ^ | 38 | ^ | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43a | · | 43b | · | 43c | · | 43d | ^ | 44a | · | 44b | ^ | 45 | ^ | 46a | · | 46b | ^ | 47 | ^ | 48a | · | 48b | · | 48c | ^ | 49a | · | 49b | ^ | 50 | ^ | 51a | · |
|---|
|
| SP1: | - | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | |
| ExUns: | 51b | ^ | 52a | · | 52b | · | 52c | · |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | - | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for PCNT
|
Expression
for PCNT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PCNT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCCTGGCT
About this image
See PCNT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PCNT
SOURCE GeneReport for Unigene cluster: Hs.474069
UniProtKB/Swiss-Prot: PCNT_HUMAN, O95613Tissue specificity: Expressed in all tissues tested, including placenta, liver, kidney and thymus
SABiosciences Custom PCR Arrays for PCNT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCNT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PCNT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCNT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCNT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCNT |
Orthologs
for PCNT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PCNT gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for PCNT (if available)
TreeFam Gene Tree for PCNT (if available) |
Paralogs
for PCNT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PCNT gene
- GOLGA42 GCC22 CEP2502 AKAP92 LOC7287632 CROCC2 EEA12 NUMA12
- TRIP112 CENPF2 CNTRL2 GOLGB12
1 SIMAP similar gene for PCNT using alignment to 3 protein entries: PCNT_HUMAN (see all proteins):AKAP9
PCNT for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PCNT
PGOHUM00000239187
|
Genomic Variants
for PCNT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PCNT (47744036 - 47865682 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for PCNT
8 CNVs: 90833 67821 50792 79393 59581 50791 50790 73668
5 Indels: 46197 46196 40489 41457 103125
Human Gene Mutation Database (HGMD): PCNT
Locus Specific Mutation Databases (LSDB): PCNT
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCNT |
|
Disorders
/ Diseases
for PCNT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PCNT for disorders About GeneDecksing
OMIM gene information: 605925
OMIM disorders: 210720
UniProtKB/Swiss-Prot: PCNT_HUMAN, O95613
Defects in PCNT are the cause of microcephalic osteodysplastic primordial dwarfism type 2 (MOPD2)[MIM:210720]; also known as osteodysplastic primordial dwarfism type 2. Adults with this rare inherited condition havean average height of 100 centimeters and a brain size comparable to that of a 3-month-old baby, but are of near-normalintelligence
20/30  diseases for PCNT (see all 30): About MalaCardsmicrocephalic osteodysplastic primordial dwarfism type 2 seckel syndrome dwarfism seckel syndrome 4
adenomatous polyposis coli major depressive disorder mantle cell lymphoma myeloid leukemia
bipolar disorder cerebellar ataxia chronic myeloid leukemia acute myeloid leukemia
insulin resistance polyposis prostate cancer, progression of down syndrome
microcephaly prostate cancer vaccinia ataxia
2 diseases from the University of Copenhagen DISEASES database for PCNT:Seckel syndrome Microcephaly 10/11 Novoseek disease relationships for PCNT gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bipolar disorder |
32 |
11 |
17884020 (5), 19191256 (2), 19448849 (1) |
| schizophrenia |
16.5 |
14 |
19191256 (4), 17884020 (3), 20096683 (2), 19448849 (1) |
| chromosomal aberrations |
8.28 |
1 |
20062006 (1) |
| genetic disorder |
4.32 |
1 |
8812505 (1) |
| breast carcinoma |
0 |
2 |
10823944 (1), 14506732 (1) |
| psychiatric disorder |
0 |
2 |
17664024 (1), 17389905 (1) |
| shock |
0 |
5 |
8886893 (3), 8557693 (1) |
| glioma |
0 |
1 |
16251193 (1) |
| tumors |
0 |
6 |
18701509 (4), 15878869 (1) |
| carcinoma |
0 |
2 |
11864908 (1), 10613729 (1) |
Human Genome Epidemiology (HuGE) Navigator: PCNT (7 documents)
Export disorders for PCNT gene to outside databases
|
Publications
for PCNT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PCNT gene, integrated from 9 sources (see all 144):
(articles sorted by number of sources associating them with PCNT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2, 3 Ishikawa K....Ohara O. (1997)
- Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1. (PubMed id 11171385)1, 2, 9 Li Q.... Balczon R. (2001)
- Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin. (PubMed id 10823944)1, 2, 9 Flory M.R.... Davis T.N. (2000)
- Localization of a human homolog of the mouse pericentrin gene (PCNT) to chromosome 21qter. (PubMed id 8812505)1, 3, 9 Chen H....Antonarakis S.E. (1996)
- Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. (PubMed id 18157127)1, 2, 9 Griffith E....O'Driscoll M. (2008)
- Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. (PubMed id 18174396)1, 2, 9 Rauch A....Reis A. (2008)
- Involvement of a centrosomal protein kendrin in the m aintenance of centrosome cohesion by modulating Nek2A kinase activity. (PubMed id 20599736)1, 2 Matsuo K....Takahashi M. (2010)
- DISC1-kendrin interaction is involved in centrosomal microtubule network formation. (PubMed id 18955030)1, 2 Shimizu S....Tohyama M. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
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External Searches for PCNT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing PCNT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing PCNT gene
(According to HUGE)
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Specialized Databases showing PCNT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for PCNT | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PCNT gene:
Search GeneIP for patents involving PCNT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PCNT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PCNT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PCNT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCNT | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PCNT | | OriGene 3'-UTR Clone for PCNT | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCNT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCNT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PCNT | | OriGene Custom Protein Services for PCNT | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCNT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCNT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCNT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCNT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCNT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCNT |
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| | | | Search Tocris compounds for PCNT |
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 | | | PCNT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCNT |
|  |  |  | | | | Search ThermoFisher Antibodies for PCNT |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PCNT |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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