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Aliases for PCNP Gene

Aliases for PCNP Gene

  • PEST Proteolytic Signal Containing Nuclear Protein 2 3 5
  • PEST-Containing Nuclear Protein 4

External Ids for PCNP Gene

Previous GeneCards Identifiers for PCNP Gene

  • GC03P097951
  • GC03P100722
  • GC03P102574
  • GC03P102613
  • GC03P102775
  • GC03P101292
  • GC03P098661

Summaries for PCNP Gene

GeneCards Summary for PCNP Gene

PCNP (PEST Proteolytic Signal Containing Nuclear Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PCNP Gene

  • May be involved in cell cycle regulation.

Additional gene information for PCNP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNP Gene

Genomics for PCNP Gene

GeneHancer (GH) Regulatory Elements for PCNP Gene

Promoters and enhancers for PCNP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I101572 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 561.6 +0.9 878 3.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 PCNP NXPE3 SENP7 ZBTB11-AS1 RPS18P5
GH03I101683 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 2.8 +112.3 112270 5.2 PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 YY1 RPL24 GC03P101686 LOC105374013 ZBTB11-AS1 SENP7 RPS18P5 ZNF90P1 ZBTB11 TFG PDCL3P4
GH03I101560 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.4 -11.5 -11472 2.3 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 TRMT10C SENP7 NXPE3 RPL24 ZBTB11-AS1 IMPG2 PDCL3P4 PCNP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PCNP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PCNP gene promoter:

Genomic Locations for PCNP Gene

Genomic Locations for PCNP Gene
chr3:101,573,534-101,594,437
(GRCh38/hg38)
Size:
20,904 bases
Orientation:
Plus strand
chr3:101,292,939-101,313,281
(GRCh37/hg19)

Genomic View for PCNP Gene

Genes around PCNP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCNP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNP Gene

Proteins for PCNP Gene

  • Protein details for PCNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW12-PCNP_HUMAN
    Recommended name:
    PEST proteolytic signal-containing nuclear protein
    Protein Accession:
    Q8WW12
    Secondary Accessions:
    • B2RBE7
    • D3DN52
    • Q53GF3
    • Q6AI44
    • Q96CU3
    • Q9NS81

    Protein attributes for PCNP Gene

    Size:
    178 amino acids
    Molecular mass:
    18925 Da
    Quaternary structure:
    • Interacts with UHRF2/NIRF.
    SequenceCaution:
    • Sequence=EAW79790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW79792.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCNP Gene

Post-translational modifications for PCNP Gene

  • N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.
  • Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.

No data available for DME Specific Peptides for PCNP Gene

Domains & Families for PCNP Gene

Gene Families for PCNP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PCNP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCNP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCNP: view

No data available for UniProtKB/Swiss-Prot for PCNP Gene

Function for PCNP Gene

Molecular function for PCNP Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell cycle regulation.

Gene Ontology (GO) - Molecular Function for PCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12176013
genes like me logo Genes that share ontologies with PCNP: view
genes like me logo Genes that share phenotypes with PCNP: view

Animal Model Products

miRNA for PCNP Gene

miRTarBase miRNAs that target PCNP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNP Gene

Localization for PCNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNP Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCNP gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12176013
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with PCNP: view

Pathways & Interactions for PCNP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IDA 14741369
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 14741369
genes like me logo Genes that share ontologies with PCNP: view

No data available for Pathways by source and SIGNOR curated interactions for PCNP Gene

Drugs & Compounds for PCNP Gene

No Compound Related Data Available

Transcripts for PCNP Gene

Unigene Clusters for PCNP Gene

PEST proteolytic signal containing nuclear protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNP Gene

No ASD Table

Relevant External Links for PCNP Gene

GeneLoc Exon Structure for
PCNP
ECgene alternative splicing isoforms for
PCNP

Expression for PCNP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCNP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCNP Gene

This gene is overexpressed in Tlymphocyte (12.8), Lavage (11.3), Amniocyte (8.3), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCNP Gene



Protein tissue co-expression partners for PCNP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCNP Gene:

PCNP

SOURCE GeneReport for Unigene cluster for PCNP Gene:

Hs.744968

Evidence on tissue expression from TISSUES for PCNP Gene

  • Nervous system(5)
  • Intestine(4.4)
  • Eye(2.9)
  • Kidney(2.8)
  • Lung(2.6)
  • Stomach(2.4)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PCNP: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCNP Gene

Orthologs for PCNP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCNP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCNP 33 34
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia PCNP 33 34
  • 97.19 (n)
dog
(Canis familiaris)
Mammalia PCNP 33 34
  • 97 (n)
mouse
(Mus musculus)
Mammalia Pcnp 33 16 34
  • 93.45 (n)
rat
(Rattus norvegicus)
Mammalia Pcnp 33
  • 93.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PCNP 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCNP 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCNP 33 34
  • 86.86 (n)
lizard
(Anolis carolinensis)
Reptilia PCNP 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcnp 33
  • 74.24 (n)
Str.7226 33
African clawed frog
(Xenopus laevis)
Amphibia pcnp-prov 33
zebrafish
(Danio rerio)
Actinopterygii pcnp 33 34
  • 72.73 (n)
Dr.15829 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.275 33
Species where no ortholog for PCNP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCNP Gene

ENSEMBL:
Gene Tree for PCNP (if available)
TreeFam:
Gene Tree for PCNP (if available)

Paralogs for PCNP Gene

genes like me logo Genes that share paralogs with PCNP: view

No data available for Paralogs for PCNP Gene

Variants for PCNP Gene

Sequence variations from dbSNP and Humsavar for PCNP Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000015362 -- 101,574,011(+) T/C upstream_transcript_variant
rs1000149284 -- 101,583,272(+) A/G intron_variant
rs1000298049 -- 101,586,056(+) A/G intron_variant
rs1000381104 -- 101,577,042(+) G/C intron_variant
rs1000480152 -- 101,592,359(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PCNP Gene

Variant ID Type Subtype PubMed ID
dgv294n21 CNV loss 19592680
nsv1109535 CNV deletion 24896259
nsv508944 CNV insertion 20534489
nsv963346 CNV duplication 23825009
nsv965193 CNV duplication 23825009

Variation tolerance for PCNP Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCNP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCNP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNP Gene

Disorders for PCNP Gene

Additional Disease Information for PCNP

No disorders were found for PCNP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNP Gene

Publications for PCNP Gene

  1. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. (PMID: 14741369) Mori T … Kochi H (FEBS letters 2004) 3 4 22 58
  2. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. (PMID: 12176013) Mori T … Kochi H (Biochemical and biophysical research communications 2002) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos EI … Reinberg D (Molecular cell 2015) 3 58

Products for PCNP Gene

Sources for PCNP Gene

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