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Aliases for PCNP Gene

Aliases for PCNP Gene

  • PEST Proteolytic Signal Containing Nuclear Protein 2 3
  • PEST-Containing Nuclear Protein 4

External Ids for PCNP Gene

Previous GeneCards Identifiers for PCNP Gene

  • GC03P097951
  • GC03P100722
  • GC03P102574
  • GC03P102613
  • GC03P102775
  • GC03P101292
  • GC03P098661

Summaries for PCNP Gene

GeneCards Summary for PCNP Gene

PCNP (PEST Proteolytic Signal Containing Nuclear Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PCNP Gene

  • May be involved in cell cycle regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCNP Gene

Genomics for PCNP Gene

Regulatory Elements for PCNP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCNP Gene

Chromosome:
3
Start:
101,573,534 bp from pter
End:
101,594,437 bp from pter
Size:
20,904 bases
Orientation:
Plus strand

Genomic View for PCNP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCNP Gene

Proteins for PCNP Gene

  • Protein details for PCNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW12-PCNP_HUMAN
    Recommended name:
    PEST proteolytic signal-containing nuclear protein
    Protein Accession:
    Q8WW12
    Secondary Accessions:
    • B2RBE7
    • D3DN52
    • Q53GF3
    • Q6AI44
    • Q96CU3
    • Q9NS81

    Protein attributes for PCNP Gene

    Size:
    178 amino acids
    Molecular mass:
    18925 Da
    Quaternary structure:
    • Interacts with UHRF2/NIRF.
    SequenceCaution:
    • Sequence=EAW79790.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW79792.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCNP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCNP Gene

Proteomics data for PCNP Gene at MOPED

Post-translational modifications for PCNP Gene

  • N-terminally acetylated in a HYPK-dependent manner by the NatA acetyltransferase complex which is composed of NAA10 and NAA15.
  • Ubiquitinated; mediated by UHRF2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCNP Gene

Antibody Products

No data available for DME Specific Peptides for PCNP Gene

Domains & Families for PCNP Gene

Protein Domains for PCNP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PCNP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCNP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PCNP Gene

Function for PCNP Gene

Molecular function for PCNP Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell cycle regulation

Gene Ontology (GO) - Molecular Function for PCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12176013
genes like me logo Genes that share ontologies with PCNP: view

Phenotypes for PCNP Gene

GenomeRNAi human phenotypes for PCNP:
genes like me logo Genes that share phenotypes with PCNP: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCNP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCNP Gene

Localization for PCNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCNP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCNP Gene COMPARTMENTS Subcellular localization image for PCNP gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for PCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12176013
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with PCNP: view

Pathways & Interactions for PCNP Gene

SuperPathways for PCNP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PCNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0016567 protein ubiquitination IDA 14741369
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 14741369
genes like me logo Genes that share ontologies with PCNP: view

No data available for Pathways by source and SIGNOR curated interactions for PCNP Gene

Drugs & Compounds for PCNP Gene

No Compound Related Data Available

Transcripts for PCNP Gene

Unigene Clusters for PCNP Gene

PEST proteolytic signal containing nuclear protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCNP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCNP Gene

No ASD Table

Relevant External Links for PCNP Gene

GeneLoc Exon Structure for
PCNP
ECgene alternative splicing isoforms for
PCNP

Expression for PCNP Gene

mRNA expression in normal human tissues for PCNP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCNP Gene

This gene is overexpressed in Tlymphocyte (12.8), Lavage (11.3), Amniocyte (8.3), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PCNP Gene



SOURCE GeneReport for Unigene cluster for PCNP Gene Hs.744968

genes like me logo Genes that share expression patterns with PCNP: view

Protein tissue co-expression partners for PCNP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCNP Gene

Orthologs for PCNP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCNP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCNP 35
  • 97.19 (n)
  • 96.63 (a)
PCNP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCNP 35
  • 97 (n)
  • 98.88 (a)
PCNP 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcnp 35
  • 93.45 (n)
  • 95.51 (a)
Pcnp 16
Pcnp 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCNP 35
  • 99.81 (n)
  • 99.44 (a)
PCNP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcnp 35
  • 93.42 (n)
  • 96.18 (a)
oppossum
(Monodelphis domestica)
Mammalia PCNP 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCNP 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCNP 35
  • 86.86 (n)
  • 86.29 (a)
PCNP 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCNP 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcnp 35
  • 74.24 (n)
  • 73.38 (a)
Str.7226 35
African clawed frog
(Xenopus laevis)
Amphibia pcnp-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15829 35
pcnp 35
  • 72.73 (n)
  • 73.74 (a)
pcnp 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.275 35
Species with no ortholog for PCNP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCNP Gene

ENSEMBL:
Gene Tree for PCNP (if available)
TreeFam:
Gene Tree for PCNP (if available)

Paralogs for PCNP Gene

genes like me logo Genes that share paralogs with PCNP: view

No data available for Paralogs for PCNP Gene

Variants for PCNP Gene

Sequence variations from dbSNP and Humsavar for PCNP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3584 -- 101,594,359(-) TAGGT(C/T)AATAT utr-variant-3-prime
rs890421 -- 101,591,628(-) acata(C/G)aaagg intron-variant
rs941310 -- 101,574,365(-) ATTCT(C/T)GCCCC intron-variant
rs1045675 -- 101,592,683(+) GTTTT(C/T)TGATA reference, missense
rs1045676 -- 101,592,699(+) AAGCT(A/G)TGGGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PCNP Gene

Variant ID Type Subtype PubMed ID
nsv508944 CNV Insertion 20534489
dgv294n21 CNV Loss 19592680

Variation tolerance for PCNP Gene

Residual Variation Intolerance Score: 49.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCNP Gene

HapMap Linkage Disequilibrium report
PCNP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCNP Gene

Disorders for PCNP Gene

Relevant External Links for PCNP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCNP
genes like me logo Genes that share disorders with PCNP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCNP Gene

Publications for PCNP Gene

  1. Serum proteomic approach for the identification of serum biomarkers contributed by oral squamous cell carcinoma and host tissue microenvironment. (PMID: 19284786) Bijian K. … Alaoui-Jamali M.A. (J. Proteome Res. 2009) 23 67
  2. Differentially expressed genes associated with human lung cancer. (PMID: 15944794) Xiao W. … Petersen I. (Oncol. Rep. 2005) 23 67
  3. NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. (PMID: 14741369) Mori T. … Kochi H. (FEBS Lett. 2004) 23 67
  4. NIRF, a novel RING finger protein, is involved in cell-cycle regulation. (PMID: 12176013) Mori T. … Kochi H. (Biochem. Biophys. Res. Commun. 2002) 2 67
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67

Products for PCNP Gene

Sources for PCNP Gene

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