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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PCNA Gene

protein-coding   GIFtS: 70
GCID: GC20M005095

Proliferating Cell Nuclear Antigen

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Proliferating Cell Nuclear Antigen1 2
cyclin2
DNA Polymerase Delta Auxiliary Protein2
Cyclin3

External Ids:    HGNC: 87291   Entrez Gene: 51112   Ensembl: ENSG000001326467   OMIM: 1767405   UniProtKB: P120043   

Export aliases for PCNA gene to outside databases

Previous GC identifers: GC20M005083 GC20M005090 GC20M005043


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCNA Gene:
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded
protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA
replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA
repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of
this gene have been described on chromosome 4 and on the X chromosome. (provided by RefSeq, Jul 2008)

GeneCards Summary for PCNA Gene: 
PCNA (proliferating cell nuclear antigen) is a protein-coding gene. Diseases associated with PCNA include large cell acanthoma, and renal cell carcinoma 4, and among its related super-pathways are Lagging Strand Synthesis and Global Genomic NER (GG-NER). GO annotations related to this gene include MutLalpha complex binding and identical protein binding.

UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004
Function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication
by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust
stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP)
endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key
role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA
replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins
that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated
PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is
involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion

Gene Wiki entry for PCNA (Proliferating cell nuclear antigen) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCNA gene promoter:
         PPAR-gamma1   LHX3b/Lhx3b   AML1a   LHX3a/Lhx3a   SEF-1 (1)   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PCNA promoter sequence
   Search SABiosciences Chromatin IP Primers for PCNA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20pter-p12   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p13-p12.3

PCNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCNA gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M005095:  view genomic region     (about GC identifiers)

Start:
5,095,599 bp from pter      End:
5,107,272 bp from pter
Size:
11,674 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004 (See protein sequence)
Recommended Name: Proliferating cell nuclear antigen  
Size: 261 amino acids; 28769 Da
Subunit: Homotrimer (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP.
Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Interacts with APEX2; this interaction is
triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Forms a ternary
complex with DNTTIP2 and core histone. Interacts with KCTD10 and PPP1R15A (By similarity). Interacts with POLD1,
POLD3 and POLD4. Interacts with BAZ1B; the interaction is direct. Interacts with HLTF and SHPRH. Interacts with
NUDT15. Interaction is disrupted in response to UV irradiation and acetylation. Interacts with CDKN1A/p21(CIP1)
and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. Interacts with DDX11. Interacts
with EGFR; positively regulates PCNA. Interacts with PARPBP. Interacts (when ubiquitinated) with SPRTN; leading
to enhance RAD18-mediated PCNA ubiquitination. Interacts (when polyubiquitinated) with ZRANB3. Interacts with
SMARCAD1. Interacts with CDKN1C. Interacts with KIAA0101/PAF15 (via PIP-box)
Subcellular location: Nucleus. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary in
morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence
of oxidative DNA damaging agents
Miscellaneous: Antibodies against PCNA are present in sera from patients with systemic lupus erythematosus
6/13 PDB 3D structures from and Proteopedia for PCNA (see all 13):
1AXC (3D)        1U76 (3D)        1U7B (3D)        1UL1 (3D)        1VYJ (3D)        1VYM (3D)    
Secondary accessions: B2R897 D3DW02

Explore the universe of human proteins at neXtProt for PCNA: NX_P12004

Explore proteomics data for PCNA at MOPED 

Post-translational modifications:

  • UniProtKB: Following DNA damage, can be either monoubiquitinated to stimulate direct bypass of DNA lesions by specialized DNA
    polymerases or polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template
    switching mechanisms. Following induction of replication stress, monoubiquitinated by the UBE2B-RAD18 complex on
    Lys-164, leading to recruit translesion (TLS) polymerases, which are able to synthesize across DNA lesions in a
    potentially error-prone manner. An error-free pathway also exists and requires non-canonical polyubiquitination
    on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases,
    HLTF, RNF8 and SHPRH. This error-free pathway, also known as template switching, employs recombination mechanisms
    to synthesize across the lesion, using as a template the undamaged, newly synthesized strand of the sister
    chromatid. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by
    the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis. Sumoylated during S phase
  • UniProtKB: Acetylated in response to UV irradiation. Acetylation disrupts interaction with NUDT15 and promotes degradation
  • UniProtKB: Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12004

  • PCNA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PCNA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002583.1  NP_872590.1  

    ENSEMBL proteins: 
     ENSP00000368438   ENSP00000368458  
    Reactome Protein details: P12004
    Human Recombinant Protein Products for PCNA: 
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    Enzo Life Sciences proteins for PCNA
    OriGene Purified Protein for PCNA
    OriGene Protein Over-expression Lysate for PCNA
    OriGene MassSpec for PCNA 
    OriGene Custom Protein Services for PCNA
    GenScript Custom Purified and Recombinant Proteins Services for PCNA
    Novus Biologicals PCNA Proteins
    Novus Biologicals PCNA Lysates
    Sino Biological Recombinant Protein for PCNA
    Sino Biological Cell Lysate for PCNA 
    ProSpec Recombinant Protein for PCNA
    Cloud-Clone Corp. Proteins for PCNA 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005663DNA replication factor C complex TAS2565339
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    PCNA for ontologies           About GeneDecksing



    PCNA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PCNA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PCNA 
    OriGene Antibodies for PCNA
    OriGene Custom Antibody Services for PCNA
    GenScript Superior Antibodies for PCNA
    Novus Biologicals PCNA Antibodies
    Abcam antibodies for PCNA
    Cloud-Clone Corp. Antibodies for PCNA 
    ThermoFisher Antibody for PCNA
    LSBio Antibodies in human, mouse, rat for PCNA 

    Assay Products for PCNA: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PCNA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCNA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PCNA 
    Cloud-Clone Corp. CLIAs for PCNA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000730 Pr_cel_nuc_antig
     IPR022659 Pr_cel_nuc_antig_CS
     IPR022648 Pr_cel_nuc_antig_N
     IPR022649 Pr_cel_nuc_antig_C

    Graphical View of Domain Structure for InterPro Entry P12004

    ProtoNet protein and cluster: P12004

    1 Blocks protein domain: IPB000730 Proliferating cell nuclear antigen

    UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004
    Similarity: Belongs to the PCNA family


    PCNA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCNA_HUMAN, P12004
    Function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication
    by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust
    stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP)
    endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key
    role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA
    replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins
    that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated
    PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is
    involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion

         Genatlas biochemistry entry for PCNA:
    cell-cycle regulated nuclear protein,proliferating cell nuclear antigen,complexing with RFCs to form a
    processivity factor (sliding clamp),for DNA polymerases delta and epsilon,also complexing with
    RFC,FEN1,GADD45,MSH2,MLH1,CDKN1A,LIG1,also involved in nucleotide mismatch repair (MM) and nucleotide excision
    repair (NER)

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity IDA11005803
    GO:0003677DNA binding ----
    GO:0005515protein binding IPI11005803
    GO:0030337DNA polymerase processivity factor activity IEA--
    GO:0030971receptor tyrosine kinase binding IPI17115032
         
    PCNA for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PCNA:
     Cell cycle / mitosis defect  Increased S DNA content  Increased cell death in DLD-1   Increased cell death in breast 
     S arrest 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Pcna):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     immune system  mortality/aging  no phenotypic analysis  reproductive system 

    PCNA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pcnatm1.1Mdsc for PCNA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PCNA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PCNA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PCNA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PCNA 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PCNA
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PCNA
    SwitchGear 3'UTR luciferase reporter plasmidPCNA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PCNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCNA

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PCNA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PCNA (see all 13)
    OriGene ORF clones in mouse, rat for PCNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCNA (NM_002592)
    Sino Biological Human cDNA Clone for PCNA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCNA
    Sirion Biotech Customized lentivirus for stable overexpression of PCNA 
                         Customized lentivirus expression plasmids for stable overexpression of PCNA 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PCNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCNA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PCNA About   (see all 28)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Lagging Strand Synthesis
    Gap-filling DNA repair synthesis and ligation in TC-NER0.94
    Processive synthesis on the C-strand of the telomere0.91
    Gap-filling DNA repair synthesis and ligation in GG-NER0.94
    Polymerase switching on the C-strand of the telomere0.70
    Repair synthesis for gap-filling by DNA polymerase in TC-NER0.94
    Leading Strand Synthesis0.70
    Repair synthesis of patch ~27-30 bases long by DNA polymerase0.94
    Polymerase switching0.70
    2Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.70
    Nucleotide Excision Repair Pathway0.49
    Nucleotide excision repair0.70
    3Resolution of Abasic Sites (AP sites)
    Resolution of Abasic Sites (AP sites)0.89
    Removal of DNA patch containing abasic residue0.89
    Base Excision Repair0.89
    Base excision repair0.53
    Resolution of AP sites via the multiple-nucleotide patch replacement pathway0.89
    4Mitotic G1-G1/S phases
    Mitotic G1-G1/S phases0.80
    G1 to S cell cycle control0.36
    G1/S Transition0.80
    5Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replacation0.95
    Cell cycle Transition and termination of DNA replication0.95

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for PCNA
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Signal transduction PTEN pathway
    Cell cycle Transition and termination of DNA replacation
    Signal transduction AKT signaling
    DNA damage Role of Brca1 and Brca2 in DNA repair

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PCNA
        Mismatch Repair in Eukaryotes
    DNA Repair Mechanisms
    Nucleotide Excision Repair Pathway
    GADD45 Pathway
    Chks in Checkpoint Regulation

    1 Cell Signaling Technology (CST) Pathway for PCNA
        Cell Cycle / Checkpoint Control

    5 GeneGo (Thomson Reuters) Pathways for PCNA
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Signal transduction AKT signaling
    Cell cycle Transition and termination of DNA replication
    Signal transduction PTEN pathway

    5/9 BioSystems Pathways for PCNA (see all 9)
        Senescence and Autophagy
    Cell cycle
    G1 to S cell cycle control
    Mismatch repair
    DNA Replication


    5/35        Reactome Pathways for PCNA (see all 35)
        Telomere Maintenance
    Leading Strand Synthesis
    G0 and Early G1
    G1/S-Specific Transcription
    S Phase


    5/7         Kegg Pathways  (Kegg details for PCNA) (see all 7):
        DNA replication
    Base excision repair
    Nucleotide excision repair
    Mismatch repair
    Cell cycle


    PCNA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PCNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/527 Interacting proteins for PCNA (P120041, 2, 3 ENSP000003684384) via UniProtKB, MINT, STRING, and/or I2D (see all 527)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint ----
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--

    PCNA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PCNA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCNA

    10/133 Novoseek inferred chemical compound relationships for PCNA gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paraffin 76.1 238 7684024 (4), 1354428 (4), 1355398 (3), 1359701 (3) (see all 99)
    bromodeoxyuridine 75.5 523 7855002 (6), 9332765 (5), 1363339 (5), 7735116 (5) (see all 99)
    dutp 66.5 50 9212738 (1), 9605486 (1), 16890762 (1), 17220163 (1) (see all 32)
    thymidine 61.3 161 10645230 (4), 8104445 (2), 7596173 (2), 10707869 (2) (see all 98)
    vegf 59.2 303 19549464 (7), 18324478 (6), 11930748 (4), 17636327 (4) (see all 99)
    hematoxylin 57 31 7907850 (1), 7535869 (1), 17725699 (1), 8214260 (1) (see all 24)
    norcantharidin 50.7 9 16784656 (3), 15312360 (2), 15832413 (2), 15567755 (1) (see all 5)
    aphidicolin 50.5 11 15661754 (2), 8532840 (2), 8695747 (1), 16959771 (1) (see all 8)
    estrogen 50.4 145 15565522 (4), 12378862 (3), 17636311 (3), 7831155 (3) (see all 77)
    progesterone 47.9 124 14967954 (3), 12378862 (2), 14680611 (2), 12515910 (2) (see all 76)

    Search CenterWatch for drugs/clinical trials and news about PCNA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PCNA gene (2 alternative transcripts): 
    NM_002592.2  NM_182649.1  

    Unigene Clusters for PCNA:

    Proliferating cell nuclear antigen
    Hs.147433  [show with all ESTs], Hs.744934  [show with all ESTs]
    Unigene Representative Sequences: BM462208, BU958871
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379143(uc002wlp.3) ENST00000379160(uc002wlq.3 uc010zqs.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    OriGene ORF clones in mouse, rat for PCNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PCNA (NM_002592)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PCNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCNA
    Sirion Biotech Customized lentivirus for stable overexpression of PCNA 
                         Customized lentivirus expression plasmids for stable overexpression of PCNA 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCNA

    Additional mRNA sequence: 

    D28458.1 NR_028370.1 

    24/25 DOTS entries (see all 25):

    DT.91770921  DT.100759039  DT.95196529  DT.100860261  DT.100030957  DT.91711062  DT.91770931  DT.219602 
    DT.120809816  DT.100860263  DT.95369760  DT.120809613  DT.120809442  DT.120809640  DT.100860268  DT.40188445 
    DT.91804433  DT.92367074  DT.120809925  DT.219603  DT.95369779  DT.120809841  DT.91770924  DT.91811414 

    24/733 AceView cDNA sequences (see all 733):

    AA191268 CA446890 BQ447329 BP870777 BU154500 BM979950 CB529409 BM475636 
    CR617056 AU105828 BM756259 BM741224 BP871502 CB141467 CD519986 BP870841 
    CB116815 AA953221 BM665369 CA444334 W96444 BM841234 BM763985 BP871243 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PCNA    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8
    SP1:                                -                                             
    SP2:        -     -     -           -                                             
    SP3:                                -                                             
    SP4:                                                                              
    SP5:                                -                                             


    ECgene alternative splicing isoforms for PCNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PCNA expression in normal human tissues (normalized intensities)      PCNA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGTGAACC
    PCNA Expression
    About this image


    PCNA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See PCNA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PCNA

    SOURCE GeneReport for Unigene clusters: Hs.147433 Hs.744934
        SABiosciences Expression via Pathway-Focused PCR Arrays including PCNA (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PCNA gene from 10/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pcna1 , 5 proliferating cell nuclear antigen1, 5 88.38(n)1
    96.93(a)1
      2 (64.15 cM)5
    185381  NM_011045.21  NP_035175.11 
     1322491625 
    chicken
    (Gallus gallus)
    Aves PCNA1 proliferating cell nuclear antigen 83.14(n)
    94.64(a)
      373984  NM_204170.1  NP_989501.1 
    lizard
    (Anolis carolinensis)
    Reptilia PCNA6
    Uncharacterized protein
    91(a)
    1 ↔ 1
    AAWZ02036634(13854-23015)
    African clawed frog
    (Xenopus laevis)
    Amphibia pcna-A2 proliferating cell nuclear antigen 81.32(n)    BC057758.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pcna2 proliferating cell nuclear antigen 79.82(n)   30678  BC049535.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mus2091 , 3 DNA replication3
    mutagen-sensitive 2091
    71(a)
    (best of 2)3
    65.89(n)1
    71.04(a)1
      2 56F113
    372901  NM_206182.21  NP_995904.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pcn-13 cyclin 48(a)   IV(4048321-4049633)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POL30(YBR088C)4
    POL301
    Proliferating cell nuclear antigen (PCNA), functions more4
    Pol30p1
    47.29(n)1
    35.66(a)1
      2(425766-424990)4
    8523851, 4  NP_009645.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PCNA21 proliferating cell nuclear antigen 2 64.86(n)
    66.02(a)
      817506  NM_128510.2  NP_180517.1 
    rice
    (Oryza sativa)
    Liliopsida Os.33762 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.64(n)    AK071591.1 


    ENSEMBL Gene Tree for PCNA (if available)
    TreeFam Gene Tree for PCNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PCNA gene

    PCNA for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PCNA
    PGOHUM00000242193 PGOHUM00000245632 PGOHUM00000241260


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/153 SNPs in PCNA are shown (see all 153)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114817691,2
    C--5055966(+) TTTCC-/TTTTTT 2 -- int1 us2k1 trp30--------
    rs36261,2
    C,F,A,H--5095771(-) TCTCTG/CCAATT 2 -- ut31 ese318Minor allele frequency- C:0.11NS MN EA NA WA CSA 848
    rs86321,2
    C,F,H--5095780(-) TTTCTC/TTATTC 2 -- ut31 trp39Minor allele frequency- T:0.04NS MN EA NA WA 748
    rs2007477991,2
    C--5095810(+) AAACAA/GTATCT 2 -- ut310--------
    rs1997160281,2
    --5095956(+) ATCTTA/GGGAGC 4 P syn10--------
    rs1477372151,2
    C,F--5095989(+) ATATCC/TGCAAT 4 A syn11Minor allele frequency- T:0.00NA 4546
    rs173531,2
    C,F--5096099(-) GTACCC/GCTTGG 4 P syn110Minor allele frequency- G:0.00EU NA NS MN 6561
    rs1405229671,2
    C,F--5096134(+) CGTTGA/GAGAGA 4 P S mis11Minor allele frequency- G:0.00NA 4548
    rs1403455431,2
    C,F--5096174(+) TACCTC/TAGTGC 4 L syn11Minor allele frequency- T:0.00NA 4548
    rs1883356611,2
    --5096259(+) AGAAAA/GTTGCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PCNA (5095599 - 5107272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PCNA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428375CNV Loss18775914
    nsv833902CNV Loss17160897
    nsv912629CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176740    OMIM disorders: --

    20/289 diseases for PCNA (see all 289):    About MalaCards
    large cell acanthoma    renal cell carcinoma 4    anthracosilicosis    image syndrome
    bizarre leiomyoma    fibrillary astrocytoma    lymphangiomatosis    urachal adenocarcinoma
    odontoma    cellular leiomyoma    partial hydatidiform mole    spitz nevus
    ovarian mucinous cystadenocarcinoma    lipodermatosclerosis    ovarian germ cell tumor    epithelial-myoepithelial carcinoma
    meigs syndrome    myoepithelial carcinoma    cerebellar medulloblastoma    actinic keratosis

    19 diseases from the University of Copenhagen DISEASES database for PCNA:
    Carcinoma     Adenoma     Hepatocellular carcinoma     Breast cancer
    Retinoblastoma     Colorectal cancer     Kidney disease     Lung cancer
    Vascular disease     Skin cancer     Liver disease     Malignant glioma
    Laryngeal carcinoma     Gastritis     Prostate cancer     Papilloma
    Urinary bladder cancer     Leiomyoma     Xeroderma pigmentosum

    PCNA for disorders           About GeneDecksing

    10/98 Novoseek inferred disease relationships for PCNA gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 78.5 2016 1281387 (7), 9159335 (6), 8105885 (6), 7606900 (5) (see all 99)
    carcinoma 72.8 370 7909154 (5), 9306559 (5), 8096556 (5), 12390713 (5) (see all 99)
    carcinoma squamous cell 69.5 238 7617390 (4), 8907001 (4), 9001344 (3), 19751907 (3) (see all 99)
    metastasis 66.7 319 15204422 (5), 14669354 (5), 12740649 (4), 9407990 (4) (see all 99)
    laryngeal squamous cell carcinoma 65.6 44 15844604 (3), 12740649 (2), 16995968 (2), 18607952 (2) (see all 19)
    hyperplasia 65.1 115 9066586 (4), 11748989 (3), 10349981 (3), 7927309 (2) (see all 66)
    dysplasia 64.9 196 7907076 (6), 9306559 (6), 8625229 (5), 8102179 (5) (see all 85)
    cancer 63.1 302 8099982 (4), 10370689 (3), 8917358 (3), 9350310 (3) (see all 99)
    hepatocellular carcinoma 60.5 122 7911731 (6), 11930748 (3), 8102592 (3), 18521065 (3) (see all 59)
    retinoblastoma 60.1 53 11835814 (2), 9396398 (2), 9109790 (1), 10212809 (1) (see all 36)

    Genetic Association Database (GAD): PCNA
    Human Genome Epidemiology (HuGE) Navigator: PCNA (30 documents)
    Tumor Gene Database (TGDB): PCNA

    Export disorders for PCNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PCNA gene, integrated from 9 sources (see all 3198):
    (articles sorted by number of sources associating them with PCNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human gene for the proliferating cell nuclear antigen. (PubMed id 2565339)1, 2, 3 Travali S....Calabretta B. (1989)
    2. Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. (PubMed id 19419956)1, 2, 9 Yu Y.... Zhu W.-G. (2009)
    3. Structural basis for recruitment of human flap endonuclease 1 to PCNA. (PubMed id 15616578)1, 2, 9 Sakurai S.... Hakoshima T. (2005)
    4. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. (PubMed id 18794347)1, 2, 9 Abbas T....Dutta A. (2008)
    5. A defined human system that supports bidirectional mismatch-provoked excision. (PubMed id 15225546)1, 2, 9 Dzantiev L....Modrich P. (2004)
    6. Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. (PubMed id 11784855)1, 2, 9 Haracska L.... Prakash S. (2002)
    7. Role of PCNA-dependent stimulation of 3'-phosphodiest erase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage. (PubMed id 19443450)1, 2, 9 Burkovics P....Haracska L. (2009)
    8. Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women. (PubMed id 18669164)1, 4, 9 Mitra A.K....Rath S.K. (2008)
    9. Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448)1, 2, 9 Li H.... Lee M.Y. (2006)
    10. Tyrosine phosphorylation controls PCNA function through protein stability. (PubMed id 17115032)1, 2, 9 Wang S.C....Hung M.C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5111 HGNC: 8729 AceView: PCNA Ensembl:ENSG00000132646 euGenes: HUgn5111
    ECgene: PCNA Kegg: 5111 H-InvDB: PCNA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PCNA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PCNA Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pcna/
    Wikipedia http://en.wikipedia.org/wiki/PCNA

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PCNA gene:
    Search GeneIP for patents involving PCNA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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