V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PCNA Gene

protein-coding GIFtS: 75

GC20M005043

proliferating cell nuclear antigen
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Cyclin ^³
MGC8367 ^²
OTTHUMP00000030189 ^²
OTTHUMP00000030190 ^²
cyclin ^²

Descriptions
DNA polymerase delta auxiliary protein ^²
proliferating cell nuclear antigen ^²

External Ids
HGNC: 8729¹
Entrez Gene: 5111²
UniProtKB: P12004³
Ensembl: ENSG00000132646⁷

Search outside databases for aliases for PCNA gene

Previous GC identifers: GC20M005083 GC20M005090

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PCNA:

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta.

The encoded protein acts as a homotrimer and helps increase the processivity of leading strand

synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is

involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same

protein have been found for this gene. Pseudogenes of this gene have been described on chromosome

4 and on the X chromosome. [provided by RefSeq]

UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004

Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the

control of eukaryotic DNA replication by increasing the polymerase's processibility during

elongation of the leading strand

Gene Wiki entry for PCNA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PCNA gene

Entrez Gene cytogenetic band: 20pter-p12 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20pter-p12

PCNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M005043: (about GC identifiers)

Start:	5,043,599 bp from pter
End:	5,055,268 bp from pter
Size:	11,670 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011387.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004 (See protein sequence)

Recommended Name: Proliferating cell nuclear antigen

Size: 261 amino acids; 28769 Da

Subunit: Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a

complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1,

ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex

with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF;

the interaction is direct

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1AXC (3D)

1U76 (3D)

1U7B (3D)

1UL1 (3D)

1VYJ (3D)

1VYM (3D)

1W60 (3D)

2ZVK (3D)

2ZVL (3D)

2ZVM (3D)

Post-translational modifications:

Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on

Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of

ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are

required for DNA repair¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002583.1 NP_872590.1

ENSEMBL proteins:

ENSP00000384027 ENSP00000368458 ENSP00000368438

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PCNA)
	Human Recombinant Proteins from Abnova (PCNA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA	--
GO:0005634	nucleus	IDA	15494374
GO:0005652	nuclear lamina	IEA	--
GO:0005654	nucleoplasm	EXP	9822671 11473323
GO:0005663	DNA replication factor C complex	TAS	2565339

About this table

Antibodies for PCNA:

	Invitrogen Antibodies for PCNA
	Millipore Mono- and Polyclonal Antibodies for the study of PCNA
	Sigma-Aldrich Antibody Arrays and Antibodies for PCNA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PCNA), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PCNA)
	Novus Biologicals Antibodies for PCNA

Assays for PCNA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P12004

ProtoNet protein and cluster: P12004

1 Blocks protein family: IPB000730 Proliferating cell nuclear antigen

UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004

Similarity: Belongs to the PCNA family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PCNA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PCNA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002592

Applied Biosystems Silencer® siRNAs for PCNA

Sigma-Aldrich siRNA and siRNA Panels for PCNA

Sigma-Aldrich shRNA Panels and shRNA for PCNA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PCNA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002592
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002592
untagged cDNA clones in CMV expression vector (see all 2): NM_002592

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002592

UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004

Function: This protein is an auxiliary protein of DNA polymerase delta and is involved in the

control of eukaryotic DNA replication by increasing the polymerase's processibility during

elongation of the leading strand

Genatlas biochemistry entry for PCNA:

cell-cycle regulated nuclear protein,proliferating cell nuclear antigen,complexing with RFCs to

form a processivity factor (sliding clamp),for DNA polymerases delta and epsilon,also complexing

with RFC,FEN1,GADD45,MSH2,MLH1,CDKN1A,LIG1,also involved in nucleotide mismatch repair (MM) and

nucleotide excision repair (NER)

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Pcna):

endocrine/exocrine gland	hematopoietic system	immune system	lethality-prenatal/perinatal	no phenotypic analysis
reproductive system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0005515	protein binding	IPI	9305916 15225546 15358233
GO:0030337	DNA polymerase processivity factor activity	IEA	--
GO:0032405	MutLalpha complex binding	IDA	11005803

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for PCNA (Your Favorite Gene powered by Ingenuity)

Role of CHK Proteins in Cell Cycle Checkpoint Control
p53 Signaling

GeneDecks PCNA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PCNA

5/428 Interacting proteins for PCNA (ENSP00000368438³ P12004^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 428 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BARD1	Q99728¹	STRING (score=.974) EBI-358311, EBI-473181
CDKN2A	P42771¹	STRING (score=.905) EBI-358311, EBI-375053
FEN1	P39748¹	STRING (score=.999) EBI-358311, EBI-707816
POLD1	P28340¹	STRING (score=.999) EBI-358311, EBI-716569
POLD2	P49005¹	STRING (score=.999) EBI-358311, EBI-372354

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006275	regulation of DNA replication	IEA	--
GO:0006281	DNA repair	NAS	15504738
GO:0006287	base-excision repair, gap-filling	IEA	--
GO:0006297	nucleotide-excision repair, DNA gap filling	EXP	9111189
GO:0006886	intracellular protein transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PCNA
10/35 Novoseek chemical compound relationships for PCNA gene (see all 35 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bromodeoxyuridine	75.44	502	7855002 (6), 9332765 (5), 1363339 (5), 7735116 (5) (see all 99)
dutp	66.03	48	9212738 (1), 9605486 (1), 16890762 (1), 17220163 (1) (see all 30)
thymidine	61.12	160	10645230 (4), 8104445 (2), 7596173 (2), 10707869 (2) (see all 98)
hematoxylin	54.92	31	7907850 (1), 7535869 (1), 17725699 (1), 8214260 (1) (see all 24)
norcantharidin	53.24	9	16784656 (3), 15312360 (2), 15832413 (2), 15567755 (1) (see all 5)
progesterone	47.74	120	14967954 (3), 12378862 (2), 14680611 (2), 12515910 (2) (see all 73)
biotin-11-dutp	42.53	2	2055960 (1), 1687687 (1)
3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2h-tetrazolium	39.26	3	15817666 (1), 14578678 (1)
gp-4,5	37.31	6	10698628 (3), 9078370 (2), 11266590 (1)
reticulin	36.18	4	8214260 (1), 11511789 (1), 9568727 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PCNA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PCNA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002592

Sigma-Aldrich siRNA and siRNA Panels for PCNA

Sigma-Aldrich shRNA Panels and shRNA for PCNA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002592 NM_182649

REFSEQ mRNAs for PCNA gene (2 alternative transcripts):

NM_002592.2 NM_182649.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002592 NM_182649

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002592
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002592
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002592

Additional cDNA sequence:

AK300558.1 AK311014.1 AK313286.1 BC000491.2 BC062439.1 CR536501.1 CR541799.1 CR617056.1

CR617091.1 CR619580.1 D28458.1 M15796.1

24/25 DOTS entries (see all 25 ):

DT.91770921 DT.100759039 DT.95196529 DT.100860261 DT.100030957 DT.91711062 DT.91770931 DT.219602

DT.120809816 DT.100860263 DT.95369760 DT.120809613 DT.120809442 DT.120809640 DT.100860268 DT.40188445

DT.91804433 DT.92367074 DT.120809925 DT.219603 DT.95369779 DT.120809841 DT.91770924 DT.91811414

24/733 AceView cDNA sequences (see all 733 ):

AA361459 BI831672 BM763985 BM770859 BM475636 BM685904 CB132811 BM692698

AU105826 BQ214140 BP870841 BU154500 CB108673 BP870671 W96444 BF794541

CD367010 BM841234 CB129877 BP870562 CB113248 BP354330 BP365286 BQ233597

highest scoring ESTs for PCNA:

AV761744 AV762528 AW610258 AW821162 BF685141 BF979036 BG533897 BG707111 BI048151 CB990423

Unigene Cluster for PCNA:

Proliferating cell nuclear antigen

Hs.147433 [show with all ESTs]

Unigene Representative Sequence: BM462208

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PCNA

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8
SP1:											-
SP2:			-		-		-				-
SP3:											-
SP4:
SP5:											-

About this scheme

ECgene alternative splicing isoforms for PCNA

3 Ensembl transcripts including schematic representations:

ENST00000404149 ENST00000379160 ENST00000379143

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PCNA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PCNA

¹ / ² / ³

4 probe-sets matching PCNA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1824_s_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.90	J05614	0.20	1.00	0.72	1
1884_s_at²^{, 3}	U95-A	2	1.00	0.88	0.96	1.10	M15796	0.80	1.00	0.91	1
201202_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002592	0.60	1.00	0.82	1
201202_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PCNA for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCGTGAACC

SOURCE GeneReport for Unigene cluster: Hs.147433
Expression variation in blood from EXPOLDB for PCNA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PCNA gene from 5/26 species (see all 26 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PCNA¹	--	proliferating cell nuclear antigen	92.21(n) 99.62(a)	477166 XM_534355.2 XP_534355.2
chimpanzee (Pan troglodytes)	PCNA¹	--	proliferating cell nuclear antigen	99.11(n) 100(a)	458081 XM_001165515.1 XP_001165515.1
cow (Bos taurus)	PCNA¹	--	proliferating cell nuclear antigen	92.46(n) 99.23(a)	515499 NM_001034494.1 NP_001029666.1
rat (Rattus norvegicus)	Pcna¹	--	proliferating cell nuclear antigen	89.14(n) 98.47(a)	25737 NM_022381.2 NP_071776.1
mouse (Mus musculus)	Pcna^{1, 5}	2 (75.00 cM)⁵	proliferating cell nuclear antigen^{1, 5}	88.38(n)¹ 96.93(a)¹	18538¹ NM_011045.2¹ NP_035175.1¹ AI327110⁵ AK012614⁵ (see all 21)

About this table Species with no ortholog for PCNA

ENSEMBL Gene Tree for PCNA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

3 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in PCNA are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3626^1,2	A,C,F,H	5043771(-)	`TCTCTG/CCAATT`	2	--	ut3¹ ese³		11		NS MN EU EA WA	836
--	rs8632^1,2	C,F,H	5043780(-)	`TTTCTC/TTATTC`	2	--	ut3¹ trp³		5		NS MN EU EA	624
	rs3730416^1,2	C,F,H	5049151(-)	`TACAAT/CGAACG`	2	--	int¹ ng3¹		9		NS EU WA	1052
--	rs3730415^1,2	A,C,F	5049610(-)	`CCGGGC/G/TGTGGT`	2	--	ng3¹ int¹		1		NS	174
--	rs6116655^1,2	A,C	5050345(+)	`tgactA/Gctcac`	2	--	ng3¹ int¹		0	--	--	--	--
--	rs3730414^1,2	C,F	5049649(-)	`tctacT/Caaaaa`	2	--	int¹ ng3¹		1		NS	180
--	rs3730417^1,2	F	5048991(-)	`ACTCTCT/-TCAGG`	2	--	ng3¹ int¹		1		NS	166
	rs1050525^1,2	H	5048328(-)	`CAGAGC/AATGGA`	2	R/S	mis¹ ese³		5		MN EU EA WA	588
--	rs6116656^1,2	C	5050631(+)	`tttttC/Tttttt`	2	--	int¹ ng3¹ trp³		0	--	--	--	--
--	rs34818603^1,2	C	5048995(+)	`AAGAG-/AGTACAG`	2	--	int¹ ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for PCNA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 176740

UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004

Antibodies are present in sera from patients with systemic lupus erythematosus

10/98 Novoseek disease relationships for PCNA gene (see all 98 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	78.36	1918	1281387 (7), 9159335 (6), 8105885 (6), 7606900 (5) (see all 99)
carcinoma	72.77	362	7909154 (5), 9306559 (5), 8096556 (5), 12390713 (5) (see all 99)
carcinoma squamous cell	69.58	230	7617390 (4), 8907001 (4), 9001344 (3), 8920767 (3) (see all 99)
metastasis	66.56	308	15204422 (5), 14669354 (5), 12740649 (4), 9407990 (4) (see all 99)
dysplasia	65.69	188	7907076 (6), 9306559 (6), 8625229 (5), 8102179 (5) (see all 82)
laryngeal squamous cell carcinoma	65.47	44	15844604 (3), 12740649 (2), 16995968 (2), 18607952 (2) (see all 19)
hyperplasia	65.06	112	9066586 (4), 11748989 (3), 10349981 (3), 7927309 (2) (see all 63)
cancer	61.92	287	8099982 (4), 10370689 (3), 8917358 (3), 9350310 (3) (see all 99)
adenoma	60.18	177	7717318 (8), 8099982 (5), 12174886 (4), 8892593 (4) (see all 75)
retinoblastoma	59.99	51	11835814 (2), 9396398 (2), 9109790 (1), 10212809 (1) (see all 35)

About this table

Genetic Association Database: PCNA
Human Genome Epidemiology Navigator: PCNA (13 documents)
Tumor Gene Database: PCNA

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/2637 PubMed articles for PCNA gene (see all 2637 ):

Structure of the human gene for the proliferating cell nuclear antigen. (PubMed id 2565339)^{2, 3, 4} Travali S....Calabretta B. (1989)
The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. (PubMed id 9305916)^{1, 3, 4} Gary R.... Park M.S. (1997)
Structural basis for recruitment of human flap endonuclease 1 to PCNA. (PubMed id 15616578)^{1, 3, 4} Sakurai S.... Hakoshima T. (2005)
A defined human system that supports bidirectional mismatch-provoked excision. (PubMed id 15225546)^{1, 3, 4} Dzantiev L....Modrich P. (2004)
Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. (PubMed id 11784855)^{1, 3, 4} Haracska L.... Prakash S. (2002)
PCNA is ubiquitinated by RNF8. (PubMed id 18948756)^{3, 4} Zhang S.... Lee M.Y.W.T. (2008)
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. (PubMed id 16195237)^{3, 6} Zienolddiny S....Haugen A. (2006)
Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. (PubMed id 17108083)^{3, 4} Unk I.... Haracska L. (2006)
Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448)^{3, 4} Li H....Lee M.Y. (2006)
The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. (PubMed id 15543136)^{3, 4} Poot R.A....Varga-Weisz P.D. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5111	HGNC: 8729	AceView: PCNA	Ensembl:ENSG00000132646	euGenes: HUgn5111
ECgene: PCNA	H-InvDB: PCNA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PCNA	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/pcna/
Wikipedia	http://en.wikipedia.org/wiki/PCNA

Licensable Technologies for PCNA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PCNA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PCNA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PCNA		Antibodies for PCNA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PCNA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PCNA)
	Antibodies (PCNA)
	Chimera RNAi (PCNA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PCNA)
	Antibodies (PCNA)

Search OriGene for PCNA

Search Tocris compounds for PCNA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PCNA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PCNA Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PCNA Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for PCNA

Summaries
for PCNA

Genomic Location
for PCNA

Proteins
for PCNA

Protein Domains/
Families
for PCNA

Gene Function
for PCNA

Pathways & Interactions
for PCNA

Drugs & Compounds
for PCNA

Transcripts
for PCNA

Expression
for PCNA

Orthologs
for PCNA

Paralogs
for PCNA

SNPs/Variants
for PCNA

Disorders & Mutations
for PCNA

Medical News
for PCNA

Publications
for PCNA

Search for PCNA

Genome Databases showing PCNA

Other Databases showing PCNA

Specialized Databases showing PCNA

Licensable Technologies
for PCNA

Services
for PCNA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PCNA Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor PCNA

Summariesfor PCNA

Genomic Locationfor PCNA

Proteinsfor PCNA

Protein Domains/Familiesfor PCNA

Gene Functionfor PCNA

Pathways & Interactionsfor PCNA

Drugs & Compoundsfor PCNA

Transcriptsfor PCNA

Expression for PCNA

Orthologsfor PCNA

Paralogsfor PCNA

SNPs/Variantsfor PCNA

Disorders & Mutationsfor PCNA

Medical Newsfor PCNA

Publicationsfor PCNA

Search for PCNA

Genome Databases showing PCNA

Other Databases showing PCNA

Specialized Databases showing PCNA

Licensable Technologiesfor PCNA

Servicesfor PCNA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PCNA

Summaries
for PCNA

Genomic Location
for PCNA

Proteins
for PCNA

Protein Domains/
Families
for PCNA

Gene Function
for PCNA

Pathways & Interactions
for PCNA

Drugs & Compounds
for PCNA

Transcripts
for PCNA

Expression
for PCNA

Orthologs
for PCNA

Paralogs
for PCNA

SNPs/Variants
for PCNA

Disorders & Mutations
for PCNA

Medical News
for PCNA

Publications
for PCNA

Licensable Technologies
for PCNA

Services
for PCNA