PCNA Gene
protein-coding GIFtS : 68 GCID: GC20 M005095
proliferating cell nuclear antigen
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Aliasesfor PCNA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Proliferating Cell Nuclear Antigen 1 2 Cyclin3 DNA Polymerase Delta Auxiliary Protein2 Cyclin3
Export aliases for PCNA gene to outside databases Previous GC identifers: GC20M005083 GC20M005090 GC20M005043
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Summariesfor PCNA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PCNA : The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004 Function : Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication byincreasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion Gene Wiki entry for PCNA (Proliferating cell nuclear antigen)
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Genomic Viewsfor PCNA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000020.10 NC_018931.1 NT_011387.8 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PCNA gene promoter:PPAR-gamma1 LHX3b/Lhx3b AML1a LHX3a/Lhx3a SEF-1 (1) PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for PCNA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20pter-p12 Ensembl cytogenetic band: 20p12.3 HGNC cytogenetic band: 20pter-p12 PCNA Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M005095: view genomic region
(about GC identifiers )
Start: 5,095,599 bp from pter End:
5,107,272 bp from pter
Size: 11,674 bases Orientation:
minus strand
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Proteinsfor PCNA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004 See
protein sequence )Recommended Name: Size : 261 amino acids; 28769 DaSubunit : Homotrimer (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interactswith EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Forms a ternary complex with DNTTIP2 and core histone. Interacts with KCTD10 and PPP1R15A (By similarity). Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B; the interaction is direct. Interacts with HLTF and SHPRH. Interacts with NUDT15. Interaction is disrupted in response to UV irradiation and acetylation. Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. Interacts with DDX11. Interacts with EGFR; positively regulates PCNA. Interacts with PARPBP. Interacts (when ubiquitinated) with SPRTN; leading to enhance RAD18-mediated PCNA ubiquitination. Interacts (when polyubiquitinated) with ZRANB3. Interacts with SMARCAD1. Interacts with CDKN1C. Interacts with KIAA0101/PAF15 (via PIP-box)
Subcellular location : Nucleus. Note=Forms nuclear foci representing sites of ongoing DNA replication and vary inmorphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents
Miscellaneous : Antibodies against PCNA are present in sera from patients with systemic lupus erythematosus6/13 PDB 3D structures from (see all 13 ):1AXC (3D) 1U76 (3D) 1U7B (3D) 1UL1 (3D) 1VYJ (3D) 1VYM (3D) Secondary accessions : B2R897 D3DW02Explore the universe of human proteins at neXtProt for PCNA: NX_P12004 Post-translational modifications:
Following DNA damage, can be either monoubiquitinated to stimulate direct bypass of DNA lesions by specialized DNA polymerases or polyubiquitinated to promote recombination-dependent DNA synthesis across DNA lesions by template switching mechanisms. Following induction of replication stress, monoubiquitinated by the UBE2B-RAD18 complex on Lys-164, leading to recruit translesion (TLS) polymerases, which are able to synthesize across DNA lesions in a potentially error-prone manner. An error-free pathway also exists and requires non-canonical polyubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases, HLTF, RNF8 and SHPRH. This error-free pathway, also known as template switching, employs recombination mechanisms to synthesize across the lesion, using as a template the undamaged, newly synthesized strand of the sister chromatid. Monoubiquitination at Lys-164 also takes place in undamaged proliferating cells, and is mediated by the DCX(DTL) complex, leading to enhance PCNA-dependent translesion DNA synthesis. Sumoylated during S phase1
Acetylated in response to UV irradiation. Acetylation disrupts interaction with NUDT15 and promotes degradation1 Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P12004 PCNA Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_002583.1 NP_872590.1 ENSEMBL proteins: ENSP00000368438 ENSP00000368458 Reactome Protein details: P12004 Human Recombinant Protein Products: Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing PCNA Antibody Products: Assay Products for PCNA:
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Protein
Domains /for PCNA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P12004 ProtoNet protein and cluster: P12004
1 Blocks protein family : IPB000730 UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004 Similarity : Belongs to the PCNA family
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Functionfor PCNA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PCNA_HUMAN, P12004 Function : Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication byincreasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion
Genatlas biochemistry entry for PCNA cell-cycle regulated nuclear protein,proliferating cell nuclear antigen,complexing with RFCs to form a processivity factor (sliding clamp),for DNA polymerases delta and epsilon,also complexing with RFC,FEN1,GADD45,MSH2,MLH1,CDKN1A,LIG1,also involved in nucleotide mismatch repair (MM) and nucleotide excision repair (NER) Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): PCNA (NM_002592 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCNA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PCNA
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCNA
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing 5 GenomeRNAi human phenotypes for PCNA :Animal Models: Pcna tm1.1Mdsc for PCNA7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pcna) :About GeneDecksing
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Pathways & Interactionsfor PCNA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/25 super-pathways (see all 25 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Lagging Strand Synthesis 2 Resolution of Abasic Sites (AP sites) 3 G1/S-Specific Transcription 4 Cell cycle 5 Global Genomic NER (GG-NER)
Pathway sources See GeneCards unified pathways Show all pathways 5 5 1 5 5/9 (see all 9 ) 5/38 (see all 38 )5 (Kegg details for PCNA) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PCNA STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/526 Interacting proteins for PCNA (P12004 1 , 2 , 3 ENSP00000368438 4 via UniProtKB, MINT, STRING , and/or I2D (see all 526 )About this table Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000082 G1/S transition of mitotic cell cycle
TAS -- GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
TAS -- GO:0000084 S phase of mitotic cell cycle
TAS -- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
-- -- GO:0000278 mitotic cell cycle
TAS --
About GeneDecksing
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Drugs & Compoundsfor PCNA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for PCNA 10/133 Novoseek chemical compound relationships for PCNA gene (see all 133 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
paraffin
76.1
238
7684024 (4), 1354428 (4), 1355398 (3), 1359701 (3) (see all 99 )
bromodeoxyuridine
75.5
523
7855002 (6), 9332765 (5), 1363339 (5), 7735116 (5) (see all 99 )
dutp
66.5
50
9212738 (1), 9605486 (1), 16890762 (1), 17220163 (1) (see all 32 )
thymidine
61.3
161
10645230 (4), 8104445 (2), 7596173 (2), 10707869 (2) (see all 98 )
vegf
59.2
303
19549464 (7), 18324478 (6), 11930748 (4), 17636327 (4) (see all 99 )
hematoxylin
57
31
7907850 (1), 7535869 (1), 17725699 (1), 8214260 (1) (see all 24 )
norcantharidin
50.7
9
16784656 (3), 15312360 (2), 15832413 (2), 15567755 (1) (see all 5 )
aphidicolin
50.5
11
15661754 (2), 8532840 (2), 8695747 (1), 16959771 (1) (see all 8 )
estrogen
50.4
145
15565522 (4), 12378862 (3), 17636311 (3), 7831155 (3) (see all 77 )
progesterone
47.9
124
14967954 (3), 12378862 (2), 14680611 (2), 12515910 (2) (see all 76 )
PCNA
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Transcriptsfor PCNA gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PCNA gene (2 alternative transcripts): NM_002592.2 NM_182649.1 Unigene Cluster for PCNA:
Proliferating cell nuclear antigen Hs.147433 [show with all ESTs ] Unigene Representative Sequence: BM462208 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000379143 (uc002wlp.3 ) ENST00000379160 (uc002wlq.3 uc010zqs.1 )Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): PCNA (NM_002592 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCNA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PCNA
Additional cDNA sequence: AK300558.1 AK311014.1 AK313286.1 BC000491.2 BC062439.1 CR536501.1 CR541799.1 D28458.1 M15796.1 NR_028370.1
24/25 DOTS entries (see all 25 ): DT.91770921 DT.100759039
DT.95196529 DT.100860261 DT.100030957 DT.91711062 DT.91770931 DT.219602 DT.120809816 DT.100860263 DT.95369760 DT.120809613 DT.120809442 DT.120809640 DT.100860268 DT.40188445 DT.91804433 DT.92367074 DT.120809925 DT.219603 DT.95369779 DT.120809841 DT.91770924 DT.91811414 24/733 AceView cDNA sequences (see all 733 ):
BP357409 BP871205 CB529827 BG166783 CD364739 BM989257 BQ020619 BQ447329 BQ682146 BU624262 CB141467 CA443088 BM692698 BM979950 BP870487 BM464765 BM466077 CB116257 BP870563 CB150919 BM758843 BI767353 BP871502 BM781704 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for PCNA About this scheme ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 SP1 : - SP2 : - - - - SP3 : - SP4 : SP5 : -
ECgene alternative splicing isoforms for PCNA
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Expression for PCNA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PCNA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGCGTGAACC
About this image PCNA expression in embryonic tissues and stem cells About this table See PCNA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PCNA SOURCE GeneReport for Unigene cluster: Hs.147433 SABiosciences Expression via Pathway-Focused PCR Arrays including PCNA (see all 7 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCNA
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Orthologsfor PCNA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for PCNA gene from 10/39 species (see all 39 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Pcna1 5
proliferating cell nuclear antigen1, 5
88.38(n) 1 96.93(a) 1
2 (64.15 cM) 5 18538 1 NM_011045.2 1 NP_035175.1 1 132249162 5
chicken Aves PCNA1
proliferating cell nuclear antigen
83.14(n) 94.64(a)
373984 NM_204170.1 NP_989501.1
lizard Reptilia PCNA6
--
91(a)
1 ↔ 1
AAWZ02036634(13854-20122)
African clawed frog Amphibia pcna-A2
proliferating cell nuclear antigen
81.32(n)
BC057758.1
zebrafish Actinopterygii pcna2
proliferating cell nuclear antigen
79.82(n)
30678 BC049535.1
fruit fly Insecta mus2091 3
DNA replication3 1
71(a) 3 65.89(n) 1 71.04(a) 1
2 56F113 37290 1 NM_206182.2 1 NP_995904.1 1
worm Secernentea pcn-13
cyclin
48(a)
IV(4048321-4049633) --
baker's yeast Saccharomycetes POL30(YBR088C)4 1
Proliferating cell nuclear antigen (PCNA), functions more 4 1
47.29(n) 1 35.66(a) 1
2(425766-424990) 4 852385 1, 4 NP_009645.1 1, 4
thale cress eudicotyledons PCNA21
proliferating cell nuclear antigen 2
64.86(n) 66.02(a)
817506 NM_128510.2 NP_180517.1
rice Liliopsida Os.33762
Oryza sativa (japonica cultivar-group) cDNA cloneJ more
70.64(n)
AK071591.1
ENSEMBL Gene Tree for PCNA (if available)TreeFam Gene Tree for PCNA (if available)
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Paralogsfor PCNA gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PCNA gene About GeneDecksing 3 Pseudogenes.org Pseudogenes for PCNA PGOHUM00000242193 PGOHUM00000245632 PGOHUM00000241260
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Genomic Variantsfor PCNA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 20 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for PCNA (5095599 - 5107272 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for PCNA: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor PCNA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 176740
OMIM disorders : --20/322 (see all 322 ): About MalaCards polymorphous low-grade adenocarcinoma xeroderma pigmentosum, group a pigmented villonodular synovitis xeroderma pigmentosum smooth muscle tumor villonodular synovitis middle ear cholesteatoma syringocystadenoma papilliferum squamous cell carcinoma fibrillary astrocytoma nodular regenerative hyperplasia epithelial-myoepithelial carcinoma actinic keratosis mucinous cystadenocarcinoma maxillary sinus squamous cell carcinoma neural tube defect nevoid basal cell carcinoma syndrome spitz nevus dna topoisomerase ii portal vein thrombosis 10/98 Novoseek disease relationships for PCNA gene (see all 98 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tumors
78.5
2016
1281387 (7), 9159335 (6), 8105885 (6), 7606900 (5) (see all 99 )
carcinoma
72.8
370
7909154 (5), 9306559 (5), 8096556 (5), 12390713 (5) (see all 99 )
carcinoma squamous cell
69.5
238
7617390 (4), 8907001 (4), 9001344 (3), 19751907 (3) (see all 99 )
metastasis
66.7
319
15204422 (5), 14669354 (5), 12740649 (4), 9407990 (4) (see all 99 )
laryngeal squamous cell carcinoma
65.6
44
15844604 (3), 12740649 (2), 16995968 (2), 18607952 (2) (see all 19 )
hyperplasia
65.1
115
9066586 (4), 11748989 (3), 10349981 (3), 7927309 (2) (see all 66 )
dysplasia
64.9
196
7907076 (6), 9306559 (6), 8625229 (5), 8102179 (5) (see all 85 )
cancer
63.1
302
8099982 (4), 10370689 (3), 8917358 (3), 9350310 (3) (see all 99 )
hepatocellular carcinoma
60.5
122
7911731 (6), 11930748 (3), 8102592 (3), 18521065 (3) (see all 59 )
retinoblastoma
60.1
53
11835814 (2), 9396398 (2), 9109790 (1), 10212809 (1) (see all 36 )
Genetic Association Database (GAD): PCNA Human Genome Epidemiology (HuGE) Navigator: PCNA (30 documents) Tumor Gene Database (TGDB) : PCNA Export disorders for PCNA gene to outside databases
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Publicationsfor PCNA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PCNA gene, integrated from 9 sources (see all 3172 ):(articles sorted by number of sources associating them with PCNA) Utopia : connect your pdf to the dynamic
Structure of the human gene for the proliferating cell nuclear antigen. (PubMed id 2565339) 1 , 2 , 3(1989) Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2. (PubMed id 19419956) 1 , 2 , 9(2009) Structural basis for recruitment of human flap endonuclease 1 to PCNA. (PubMed id 15616578) 1 , 2 , 9(2005) PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. (PubMed id 18794347) 1 , 2 , 9(2008) A defined human system that supports bidirectional mismatch-provoked excision. (PubMed id 15225546) 1 , 2 , 9(2004) Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA. (PubMed id 11784855) 1 , 2 , 9(2002) Role of PCNA-dependent stimulation of 3'-phosphodiest erase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage. (PubMed id 19443450) 1 , 2 , 9(2009) Functional roles of p12, the fourth subunit of human DNA polymerase delta. (PubMed id 16510448) 1 , 2 , 9(2006) Tyrosine phosphorylation controls PCNA function through protein stability. (PubMed id 17115032) 1 , 2 , 9(2006) The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21. (PubMed id 9305916) 1 , 2 , 9(1997)
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External Searches for PCNA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing PCNA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing PCNA gene
(According to HUGE )
About This Section --
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Specialized Databases showing PCNA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for PCNA gene: PCNA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PCNA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for PCNA OriGene shRNA RFP for PCNA OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for PCNA Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PCNA OriGene 3'-UTR Clone for PCNA OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for PCNA OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PCNA OriGene Custom Protein Services for PCNA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCNA QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for PCNA
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCNA
ThermoFisher Antibody for PCNA
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PCNA
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and Proteopedia 
for PCNA (
GeneGo (Thomson Reuters) Pathways for PCNA
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
Microarrays
