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Aliases for PCMTD2 Gene

Aliases for PCMTD2 Gene

  • Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Domain Containing 2 2 3
  • C20orf36 3 4
  • Protein-L-Isoaspartate O-Methyltransferase Domain-Containing Protein 2 3
  • Chromosome 20 Open Reading Frame 36 2

External Ids for PCMTD2 Gene

Previous HGNC Symbols for PCMTD2 Gene

  • C20orf36

Previous GeneCards Identifiers for PCMTD2 Gene

  • GC20P062358
  • GC20P062887
  • GC20P059616

Summaries for PCMTD2 Gene

GeneCards Summary for PCMTD2 Gene

PCMTD2 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. An important paralog of this gene is PCMTD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCMTD2 Gene

Genomics for PCMTD2 Gene

Regulatory Elements for PCMTD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCMTD2 Gene

Start:
64,255,695 bp from pter
End:
64,287,821 bp from pter
Size:
32,127 bases
Orientation:
Plus strand

Genomic View for PCMTD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCMTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCMTD2 Gene

Proteins for PCMTD2 Gene

  • Protein details for PCMTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV79-PCMD2_HUMAN
    Recommended name:
    Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
    Protein Accession:
    Q9NV79
    Secondary Accessions:
    • E1P5H3
    • Q8IW60
    • Q9H4K2

    Protein attributes for PCMTD2 Gene

    Size:
    361 amino acids
    Molecular mass:
    41072 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCMTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCMTD2 Gene

Proteomics data for PCMTD2 Gene at MOPED

Post-translational modifications for PCMTD2 Gene

  • Ubiquitination at Lys295
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCMTD2 Gene

Domains for PCMTD2 Gene

Protein Domains for PCMTD2 Gene

Suggested Antigen Peptide Sequences for PCMTD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NV79

UniProtKB/Swiss-Prot:

PCMD2_HUMAN :
  • Q9NV79
Family:
  • Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
genes like me logo Genes that share domains with PCMTD2: view

No data available for Gene Families for PCMTD2 Gene

Function for PCMTD2 Gene

Gene Ontology (GO) - Molecular Function for PCMTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with PCMTD2: view

Animal Model Products

miRNA for PCMTD2 Gene

miRTarBase miRNAs that target PCMTD2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PCMTD2 Gene

Localization for PCMTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCMTD2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCMTD2 Gene COMPARTMENTS Subcellular localization image for PCMTD2 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PCMTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PCMTD2: view

Pathways for PCMTD2 Gene

SuperPathways for PCMTD2 Gene

No Data Available

Interacting Proteins for PCMTD2 Gene

Gene Ontology (GO) - Biological Process for PCMTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0006479 protein methylation IEA --
genes like me logo Genes that share ontologies with PCMTD2: view

No data available for Pathways by source for PCMTD2 Gene

Transcripts for PCMTD2 Gene

Unigene Clusters for PCMTD2 Gene

Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCMTD2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCMTD2 Gene

No ASD Table

Relevant External Links for PCMTD2 Gene

GeneLoc Exon Structure for
PCMTD2
ECgene alternative splicing isoforms for
PCMTD2

Expression for PCMTD2 Gene

mRNA expression in normal human tissues for PCMTD2 Gene

Protein differential expression in normal tissues for PCMTD2 Gene

This gene is overexpressed in Plasma (51.4) and Retina (15.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCMTD2 Gene

SOURCE GeneReport for Unigene cluster for PCMTD2 Gene Hs.744845

genes like me logo Genes that share expressions with PCMTD2: view

Expression partners for PCMTD2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCMTD2 Gene

Orthologs for PCMTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCMTD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC505807 35
  • 86.7 (n)
  • 95.29 (a)
PCMTD2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCMTD2 35
  • 87.13 (n)
  • 94.72 (a)
PCMTD2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcmtd2 35
  • 84.49 (n)
  • 91.36 (a)
Pcmtd2 16
Pcmtd2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCMTD2 35
  • 99.82 (n)
  • 100 (a)
PCMTD2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcmtd2 35
  • 84.96 (n)
  • 90.81 (a)
oppossum
(Monodelphis domestica)
Mammalia PCMTD2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCMTD2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCMTD2 35
  • 81.26 (n)
  • 94.46 (a)
PCMTD2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCMTD2 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcmtd2 35
  • 67.87 (n)
  • 75.56 (a)
Str.2977 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53341 35
zebrafish
(Danio rerio)
Actinopterygii LOC100536777 35
  • 73.23 (n)
  • 79.54 (a)
pcmtd2 36
  • 66 (a)
OneToMany
PCMTD2 (2 of 2) 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_R119.5 35
  • 42.64 (n)
  • 31.4 (a)
R119.5 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for PCMTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCMTD2 Gene

ENSEMBL:
Gene Tree for PCMTD2 (if available)
TreeFam:
Gene Tree for PCMTD2 (if available)

Paralogs for PCMTD2 Gene

Paralogs for PCMTD2 Gene

Selected SIMAP similar genes for PCMTD2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PCMTD2: view

Variants for PCMTD2 Gene

Sequence variations from dbSNP and Humsavar for PCMTD2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1060285 -- 64,274,804(+) TAAAA(C/G)AACAA utr-variant-3-prime
rs1060347 -- 64,276,168(+) TGACA(G/T)TCACA utr-variant-3-prime
rs1808056 -- 64,259,579(+) gagac(A/G)gggtt intron-variant
rs1960299 -- 64,259,388(+) TCTCT(C/T)TTTTT intron-variant
rs1977171 -- 64,254,965(+) cagct(A/T)ggttt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PCMTD2 Gene

Variant ID Type Subtype PubMed ID
nsv428381 CNV Gain+Loss 18775914
dgv1347e1 CNV Complex 17122850
nsv9834 CNV Gain 18304495
esv2447590 CNV Deletion 19546169
esv1549221 CNV Deletion 17803354
esv1694737 CNV Deletion 17803354

Relevant External Links for PCMTD2 Gene

HapMap Linkage Disequilibrium report
PCMTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCMTD2 Gene

Disorders for PCMTD2 Gene

No disorders were found for PCMTD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PCMTD2 Gene

Publications for PCMTD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3

Products for PCMTD2 Gene

Sources for PCMTD2 Gene

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