PCMTD2 Gene
protein-coding GIFtS: 41
GCID: GC20P062887
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protein-L-isoaspartate (D-aspartate) O-methyltransferase...(Previous name: chromosome 20 open reading frame 36 )
(Previous symbol: C20orf36)
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Aliases
for PCMTD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Domain Containing21 2 | | C20orf361 2 3 | | FLJ108831 | | Chromosome 20 Open Reading Frame 361 | | Protein-L-Isoaspartate O-Methyltransferase Domain-Containing Protein 22 |
Export aliases for PCMTD2 gene to outside databasesPrevious GC identifers: GC20P062358 GC20P059616 |
Summaries
for PCMTD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PCMTD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011333.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PCMTD2 gene promoter:
AML1a POU3F1 FOXO3 CUTL1 GATA-2 Gfi-1 FOXO3b FOXO3a SEF-1 (1) LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PCMTD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCMTD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33PCMTD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P062887: view genomic region
(about GC identifiers)
Start:
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62,887,048 bp from pter |
End:
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62,926,855 bp from pter |
Size:
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39,808 bases |
Orientation:
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plus strand |
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Proteins
for PCMTD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PCMD2_HUMAN, Q9NV79 (See
protein sequence)Recommended Name: Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 Size: 361 amino acids; 41072 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: E1P5H3 Q8IW60 Q9H4K2Alternative splicing: 3 isoforms: Q9NV79-1 Q9NV79-2 Q9NV79-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PCMTD2: NX_Q9NV79
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NV79
PCMTD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001098395.1 NP_060727.2
ENSEMBL proteins: ENSP00000307854 ENSP00000299468 ENSP00000358773 ENSP00000266078
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
PCMTD2 for ontologies About GeneDecksing
PCMTD2 Antibody Products:
Assay Products for PCMTD2: |
Protein
Domains /
Families
for PCMTD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PCMTD2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NV79ProtoNet protein and cluster: Q9NV79 1 Blocks protein family: IPB000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
UniProtKB/Swiss-Prot: PCMD2_HUMAN, Q9NV79Similarity: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family |
Function
for PCMTD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCMTD2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCMTD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for PCMTD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCMTD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCMTD2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity |
IEA | -- |
PCMTD2 for ontologies About GeneDecksing
|
Pathways & Interactions
for PCMTD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCMTD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for PCMTD2 (ENSP000003078544) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for PCMTD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PCMTD2
Search CenterWatch for drugs/clinical trials and news about PCMTD2 / PCMD2
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Transcripts
for PCMTD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PCMTD2 gene (2 alternative transcripts): NM_001104925.1 NM_018257.2 Unigene Cluster for PCMTD2: Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Hs.279562 [show with all ESTs]Unigene Representative Sequence: NM_0045354 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308824(uc002yil.4) ENST00000299468 ENST00000369758(uc002yim.4)
ENST00000266078
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PCMTD2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PCMTD2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PCMTD2 (NM_018257) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PCMTD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCMTD2 |
Additional cDNA sequence: AB020642.1 AK001745.1 AK074436.1 AK126700.1 BC018917.2 BC032332.1 BC033665.2 BC040945.1 BC045775.1 BC053638.1 BC062313.1 BC118988.1 BC122537.1 M96980.1 NR_040415.1 24/25 DOTS entries (see all 25): DT.417715 DT.100817941 DT.100649035 DT.100817938 DT.310985 DT.100713679 DT.100811158 DT.106488 DT.91815702 DT.100817939 DT.120823508 DT.100652093 DT.101955105 DT.120823578 DT.75129887 DT.97823245 DT.120823546 DT.95075638 DT.100020123 DT.70104212 DT.95075614 DT.91681218 DT.92419813 DT.92433053 24/296 AceView cDNA sequences (see all 296): AI681678 AA741394 BX491817 BX464292 CA776650 N40581 AA150338 AI802053 BG675029 AI078224 BM668232 BU581182 BM822794 BC045775 BC062313 R98114 AK126700 BM996236 BC032332 BC018917 CA443672 BU509848 AI590756 AA477896
GeneLoc Exon Structure
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Expression
for PCMTD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PCMTD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PCMTD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PCMTD2
SOURCE GeneReport for Unigene cluster: Hs.279562
SABiosciences Custom PCR Arrays for PCMTD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PCMTD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PCMTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCMTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCMTD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCMTD2 |
Orthologs
for PCMTD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PCMTD2 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for PCMTD2 (if available)
TreeFam Gene Tree for PCMTD2 (if available) |
Paralogs
for PCMTD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PCMTD2 gene
- PCMTD12
2 SIMAP similar genes for PCMTD2 using alignment to 4 protein entries: PCMD2_HUMAN (see all proteins):PCMTD1 DKFZp666F248
PCMTD2 for paralogs About GeneDecksing
|
Genomic Variants
for PCMTD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PCMTD2 (62887048 - 62926855 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for PCMTD2
5 CNVs: 39296 4108 34483 103032 31050
3 Indels: 90666 79286 26919 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCMTD2 |
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Disorders
/ Diseases
for PCMTD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PCMTD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PCMTD2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with PCMTD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. (PubMed id 18187417)1 Mahrour N....Conaway J.W. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for PCMTD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PCMTD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PCMTD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PCMTD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PCMTD2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for PCMTD2 gene:
Search GeneIP for patents involving PCMTD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PCMTD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PCMTD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PCMTD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PCMTD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PCMTD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PCMTD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PCMTD2 |
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 | | | PCMTD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PCMTD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for PCMTD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PCMTD2 |
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