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Aliases for PCMTD2 Gene

Aliases for PCMTD2 Gene

  • Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Domain Containing 2 2 3
  • C20orf36 3 4
  • Chromosome 20 Open Reading Frame 36 2

External Ids for PCMTD2 Gene

Previous HGNC Symbols for PCMTD2 Gene

  • C20orf36

Previous GeneCards Identifiers for PCMTD2 Gene

  • GC20P062358
  • GC20P062887
  • GC20P059616

Summaries for PCMTD2 Gene

GeneCards Summary for PCMTD2 Gene

PCMTD2 (Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. An important paralog of this gene is PCMTD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCMTD2 Gene

Genomics for PCMTD2 Gene

Regulatory Elements for PCMTD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PCMTD2 Gene

Chromosome:
20
Start:
64,255,695 bp from pter
End:
64,287,821 bp from pter
Size:
32,127 bases
Orientation:
Plus strand

Genomic View for PCMTD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCMTD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCMTD2 Gene

Proteins for PCMTD2 Gene

  • Protein details for PCMTD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV79-PCMD2_HUMAN
    Recommended name:
    Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
    Protein Accession:
    Q9NV79
    Secondary Accessions:
    • E1P5H3
    • Q8IW60
    • Q9H4K2

    Protein attributes for PCMTD2 Gene

    Size:
    361 amino acids
    Molecular mass:
    41072 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCMTD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCMTD2 Gene

Proteomics data for PCMTD2 Gene at MOPED

Post-translational modifications for PCMTD2 Gene

  • Ubiquitination at Lys 295
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PCMTD2 Gene

Domains & Families for PCMTD2 Gene

Protein Domains for PCMTD2 Gene

Suggested Antigen Peptide Sequences for PCMTD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NV79

UniProtKB/Swiss-Prot:

PCMD2_HUMAN :
  • Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
Family:
  • Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
genes like me logo Genes that share domains with PCMTD2: view

No data available for Gene Families for PCMTD2 Gene

Function for PCMTD2 Gene

Gene Ontology (GO) - Molecular Function for PCMTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with PCMTD2: view
genes like me logo Genes that share phenotypes with PCMTD2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCMTD2 Gene

Localization for PCMTD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCMTD2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCMTD2 Gene COMPARTMENTS Subcellular localization image for PCMTD2 gene
Compartment Confidence
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PCMTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PCMTD2: view

Pathways & Interactions for PCMTD2 Gene

SuperPathways for PCMTD2 Gene

No Data Available

Interacting Proteins for PCMTD2 Gene

Gene Ontology (GO) - Biological Process for PCMTD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process --
GO:0006479 protein methylation IEA --
genes like me logo Genes that share ontologies with PCMTD2: view

No data available for Pathways by source and SIGNOR curated interactions for PCMTD2 Gene

Drugs & Compounds for PCMTD2 Gene

No Compound Related Data Available

Transcripts for PCMTD2 Gene

Unigene Clusters for PCMTD2 Gene

Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCMTD2 Gene

No ASD Table

Relevant External Links for PCMTD2 Gene

GeneLoc Exon Structure for
PCMTD2
ECgene alternative splicing isoforms for
PCMTD2

Expression for PCMTD2 Gene

mRNA expression in normal human tissues for PCMTD2 Gene

Protein differential expression in normal tissues from HIPED for PCMTD2 Gene

This gene is overexpressed in Plasma (51.4) and Retina (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCMTD2 Gene



SOURCE GeneReport for Unigene cluster for PCMTD2 Gene Hs.744845

genes like me logo Genes that share expression patterns with PCMTD2: view

Protein tissue co-expression partners for PCMTD2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PCMTD2 Gene

Orthologs for PCMTD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PCMTD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC505807 35
  • 86.7 (n)
  • 95.29 (a)
PCMTD2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCMTD2 35
  • 87.13 (n)
  • 94.72 (a)
PCMTD2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcmtd2 35
  • 84.49 (n)
  • 91.36 (a)
Pcmtd2 16
Pcmtd2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PCMTD2 35
  • 99.82 (n)
  • 100 (a)
PCMTD2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcmtd2 35
  • 84.96 (n)
  • 90.81 (a)
oppossum
(Monodelphis domestica)
Mammalia PCMTD2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PCMTD2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCMTD2 35
  • 81.26 (n)
  • 94.46 (a)
PCMTD2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCMTD2 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcmtd2 35
  • 67.87 (n)
  • 75.56 (a)
Str.2977 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53341 35
zebrafish
(Danio rerio)
Actinopterygii LOC100536777 35
  • 73.23 (n)
  • 79.54 (a)
pcmtd2 36
  • 66 (a)
OneToMany
PCMTD2 (2 of 2) 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_R119.5 35
  • 42.64 (n)
  • 31.4 (a)
R119.5 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for PCMTD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PCMTD2 Gene

ENSEMBL:
Gene Tree for PCMTD2 (if available)
TreeFam:
Gene Tree for PCMTD2 (if available)

Paralogs for PCMTD2 Gene

Paralogs for PCMTD2 Gene

genes like me logo Genes that share paralogs with PCMTD2: view

Variants for PCMTD2 Gene

Sequence variations from dbSNP and Humsavar for PCMTD2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1060347 -- 64,276,168(+) TGACA(G/T)TCACA utr-variant-3-prime
rs6090097 -- 64,275,626(+) TTTAC(C/T)TTATG utr-variant-3-prime
rs10485816 -- 64,275,161(+) ATTGG(A/G)CAGTT utr-variant-3-prime
rs11907846 -- 64,275,080(+) TCTGC(C/T)TTTTT utr-variant-3-prime
rs62217988 -- 64,276,096(+) AAAAG(A/T)ACCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PCMTD2 Gene

Variant ID Type Subtype PubMed ID
nsv428381 CNV Gain+Loss 18775914
dgv1347e1 CNV Complex 17122850
nsv9834 CNV Gain 18304495
esv2447590 CNV Deletion 19546169
esv1549221 CNV Deletion 17803354
esv1694737 CNV Deletion 17803354

Variation tolerance for PCMTD2 Gene

Residual Variation Intolerance Score: 37.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCMTD2 Gene

HapMap Linkage Disequilibrium report
PCMTD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCMTD2 Gene

Disorders for PCMTD2 Gene

Relevant External Links for PCMTD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCMTD2
genes like me logo Genes that share disorders with PCMTD2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCMTD2 Gene

Publications for PCMTD2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 67
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67
  5. Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases. (PMID: 18187417) Mahrour N. … Conaway J.W. (J. Biol. Chem. 2008) 67

Products for PCMTD2 Gene

Sources for PCMTD2 Gene

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