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Aliases for PCM1 Gene

Aliases for PCM1 Gene

  • Pericentriolar Material 1 2 3 5
  • HPCM-1 3 4
  • PCM-1 3 4
  • Pericentriolar Material 1 Protein 3
  • Pericentriolar Material 1, PCM1 3
  • RET/PCM-1 3
  • PTC4 3

External Ids for PCM1 Gene

Previous GeneCards Identifiers for PCM1 Gene

  • GC08P017656
  • GC08P017843
  • GC08P017790
  • GC08P017824
  • GC08P016324
  • GC08P017781

Summaries for PCM1 Gene

Entrez Gene Summary for PCM1 Gene

  • The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PCM1 Gene

PCM1 (Pericentriolar Material 1) is a Protein Coding gene. Diseases associated with PCM1 include Differentiated Thyroid Carcinoma and Atypical Chronic Myeloid Leukemia. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for PCM1 Gene

  • Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.

Gene Wiki entry for PCM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCM1 Gene

Genomics for PCM1 Gene

Regulatory Elements for PCM1 Gene

Enhancers for PCM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F017910 1.6 FANTOM5 Ensembl ENCODE 17.4 -8.7 -8740 6.2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 ZNF2 GLIS2 CBX5 FOS ENSG00000253671 PCM1 MTUS1 ASAH1 FGL1 NAT1
GH08F017921 1.2 ENCODE 17.7 +2.6 2583 8.1 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000253671 PCM1 MTUS1 ASAH1 FGL1 SLC7A2 LOC101929066
GH08F017962 0.7 ENCODE 24.3 +40.3 40306 1.3 SOX13 SOX5 SP5 CHD7 ZNF623 HDAC2 TCF7 BCL6 CREM TCF7L2 PCM1 ENSG00000253671 ASAH1 LOC101929066
GH08F017940 0.6 ENCODE 13 +18.4 18415 1.5 CHD1 MAFG CHD7 MAFF ZNF316 IRF1 MAFK ZNF652 EMSY ENSG00000253671 PCM1 MTUS1 LOC101929066
GH08F017846 1.5 FANTOM5 Ensembl ENCODE 4.7 -73.3 -73317 5.1 TBP ATF1 ARID4B FEZF1 ZSCAN9 RARA RFX5 ZNF121 ZNF366 EGR2 MTUS1 ENSG00000253671 ENSG00000253215 FGL1 ENSG00000253944 ASAH1 PCM1 MTMR7 GC08M017832 GC08P017880
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PCM1 on UCSC Golden Path with GeneCards custom track

Promoters for PCM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001386835 860 3401 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for PCM1 Gene

Chromosome:
8
Start:
17,922,840 bp from pter
End:
18,029,948 bp from pter
Size:
107,109 bases
Orientation:
Plus strand

Genomic View for PCM1 Gene

Genes around PCM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCM1 Gene

Proteins for PCM1 Gene

  • Protein details for PCM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15154-PCM1_HUMAN
    Recommended name:
    Pericentriolar material 1 protein
    Protein Accession:
    Q15154
    Secondary Accessions:
    • Q58F13
    • Q6P1K7
    • Q8NB85
    • Q9BWC1
    • Q9H4A2

    Protein attributes for PCM1 Gene

    Size:
    2024 amino acids
    Molecular mass:
    228533 Da
    Quaternary structure:
    • Self-associates. Interacts with C2CD3 (By similarity). Interacts with BBS4, BBS8, CETN3, HAP1, NDE1, NDEL1, MAP1LC3B, GABARAPAL2, and GABARAP. Interacts with CEP131; the interaction increases in response to ultraviolet light (UV) radiation. Associates with microtubule; association to microtubule is reduced in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling. Interacts with CCDC113. Interacts with SSX2IP (By similarity). Interacts with CCDC13 (PubMed:24816561). Interacts with CEP290 (By similarity). Interacts with PARD6A (PubMed:20719959).
    SequenceCaution:
    • Sequence=AAH27477.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH65022.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC03656.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC14882.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for PCM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCM1 Gene

Post-translational modifications for PCM1 Gene

  • Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation.
  • Ubiquitination at Lys 51, Lys 104, Lys 139, Lys 152, Lys 218, Lys 229, Lys 255, Lys 393, Lys 399, Lys 409, Lys 412, Lys 658, Lys 738, Lys 762, Lys 786, Lys 787, Lys 807, Lys 841, Lys 954, Lys 970, Lys 996, Lys 1076, Lys 1181, Lys 1197, Lys 1198, Lys 1221, Lys 1225, Lys 1234, Lys 1329, Lys 1345, Lys 1531, Lys 1602, Lys 1647, Lys 1659, and Lys 1701
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PCM1 (PCM-1)
  • Abcam antibodies for PCM1
  • Santa Cruz Biotechnology (SCBT) Antibodies for PCM1

No data available for DME Specific Peptides for PCM1 Gene

Domains & Families for PCM1 Gene

Protein Domains for PCM1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15154

UniProtKB/Swiss-Prot:

PCM1_HUMAN :
  • Belongs to the PCM1 family.
Family:
  • Belongs to the PCM1 family.
genes like me logo Genes that share domains with PCM1: view

No data available for Gene Families for PCM1 Gene

Function for PCM1 Gene

Molecular function for PCM1 Gene

GENATLAS Biochemistry:
pericentriolar material 1
UniProtKB/Swiss-Prot Function:
Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.
UniProtKB/Swiss-Prot Induction:
Expression is reduced in breast and ovarian cancer.

Gene Ontology (GO) - Molecular Function for PCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9361024
GO:0042802 identical protein binding ISS --
genes like me logo Genes that share ontologies with PCM1: view
genes like me logo Genes that share phenotypes with PCM1: view

Human Phenotype Ontology for PCM1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for PCM1

miRNA for PCM1 Gene

miRTarBase miRNAs that target PCM1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PCM1 Gene

Localization for PCM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCM1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, cilium basal body. Note=Recruitment to the centrosome requires microtubules and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to the cleavage site in telophase. Displaced from centriolar satellites and centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAP kinase signaling.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCM1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for PCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material ISS,TAS --
GO:0005737 cytoplasm ISS,IDA --
GO:0005813 centrosome IEA,ISS --
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with PCM1: view

Pathways & Interactions for PCM1 Gene

genes like me logo Genes that share pathways with PCM1: view

Pathways by source for PCM1 Gene

SIGNOR curated interactions for PCM1 Gene

Gene Ontology (GO) - Biological Process for PCM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0001764 neuron migration IEA --
GO:0022027 interkinetic nuclear migration IEA,ISS --
GO:0030030 cell projection organization IEA --
GO:0031122 cytoplasmic microtubule organization IMP 22797915
genes like me logo Genes that share ontologies with PCM1: view

Drugs & Compounds for PCM1 Gene

(1) Drugs for PCM1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PCM1: view

Transcripts for PCM1 Gene

Unigene Clusters for PCM1 Gene

Pericentriolar material 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCM1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - - - - - - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: - - -
SP22:
SP23:

ExUns: 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c · 25d ^ 26a · 26b ^
SP1: - -
SP2: - - - - - - - - - - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: -
SP19:
SP20: -
SP21:
SP22:
SP23:

ExUns: 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36a · 36b ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43
SP1: - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3:
SP4: - - -
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21:
SP22:
SP23:

Relevant External Links for PCM1 Gene

GeneLoc Exon Structure for
PCM1
ECgene alternative splicing isoforms for
PCM1

Expression for PCM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PCM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PCM1 Gene

This gene is overexpressed in Plasma (32.6) and Testis (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PCM1 Gene



Protein tissue co-expression partners for PCM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PCM1 Gene:

PCM1

SOURCE GeneReport for Unigene cluster for PCM1 Gene:

Hs.491148

mRNA Expression by UniProt/SwissProt for PCM1 Gene:

Q15154-PCM1_HUMAN
Tissue specificity: Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.
genes like me logo Genes that share expression patterns with PCM1: view

Primer Products

No data available for mRNA differential expression in normal tissues for PCM1 Gene

Orthologs for PCM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCM1 34 35
  • 99.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PCM1 34 35
  • 91.92 (n)
cow
(Bos Taurus)
Mammalia PCM1 34 35
  • 90.15 (n)
mouse
(Mus musculus)
Mammalia Pcm1 34 16 35
  • 88.94 (n)
rat
(Rattus norvegicus)
Mammalia Pcm1 34
  • 88.31 (n)
oppossum
(Monodelphis domestica)
Mammalia PCM1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCM1 34 35
  • 72.96 (n)
lizard
(Anolis carolinensis)
Reptilia PCM1 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcm1 34
  • 67.96 (n)
Str.18845 34
African clawed frog
(Xenopus laevis)
Amphibia pcm-1 34
zebrafish
(Danio rerio)
Actinopterygii pcm1 34 35
  • 59.54 (n)
Species where no ortholog for PCM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCM1 Gene

ENSEMBL:
Gene Tree for PCM1 (if available)
TreeFam:
Gene Tree for PCM1 (if available)

Paralogs for PCM1 Gene

No data available for Paralogs for PCM1 Gene

Variants for PCM1 Gene

Sequence variations from dbSNP and Humsavar for PCM1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10088513 -- 17,987,361(+) CAATA(A/C)TTTTA intron-variant
rs10091117 -- 17,940,249(+) TCCTT(A/T)ATGAA intron-variant
rs10096484 -- 17,924,341(+) TTTTT(A/T)AAATC intron-variant
rs10103879 -- 18,013,747(+) ATTAT(A/T)CTGTG intron-variant
rs10108545 -- 17,941,732(+) AGACA(C/T)TGACG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PCM1 Gene

Variant ID Type Subtype PubMed ID
nsv610701 CNV gain 21841781
nsv524215 CNV gain 19592680
nsv522647 CNV loss 19592680
nsv1116572 OTHER inversion 24896259
esv3891365 CNV gain 25118596
esv3616509 CNV loss 21293372
esv3616500 CNV gain 21293372
esv3572605 CNV loss 25503493
esv3543161 CNV deletion 23714750
esv2762735 CNV gain 21179565
esv2736700 CNV deletion 23290073
esv2676396 CNV deletion 23128226
dgv7123n100 CNV gain 25217958
dgv7121n100 CNV gain 25217958

Variation tolerance for PCM1 Gene

Residual Variation Intolerance Score: 92.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.17; 92.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCM1 Gene

Human Gene Mutation Database (HGMD)
PCM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCM1 Gene

Disorders for PCM1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PCM1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
atypical chronic myeloid leukemia
  • acml
occult macular dystrophy
  • ocmd
intracranial hypertension, idiopathic
  • pseudotumor cerebri
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association - COSMIC cancer census association via MalaCards
Search PCM1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PCM1_HUMAN
  • Note=A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma. Translocation t(8;9)(p22;p24) with JAK2 links the protein kinase domain of JAK2 to the major portion of PCM1.
  • Note=A chromosomal aberration involving PCM1 is found in papillary thyroid carcinomas (PTCs). Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1. {ECO:0000269 PubMed:10980597}.

Relevant External Links for PCM1

Genetic Association Database (GAD)
PCM1
Human Genome Epidemiology (HuGE) Navigator
PCM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCM1
genes like me logo Genes that share disorders with PCM1: view

No data available for Genatlas for PCM1 Gene

Publications for PCM1 Gene

  1. Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. (PMID: 15659651) Hames R.S. … Fry A.M. (Mol. Biol. Cell 2005) 2 3 4 22 64
  2. PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. (PMID: 8120099) Balczon R. … Zimmer W.E. (J. Cell Biol. 1994) 2 3 4 22 64
  3. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. (PMID: 16291865) Guo J. … Zhu X. (Mol. Biol. Cell 2006) 3 4 22 64
  4. Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. (PMID: 16943179) Srsen V. … Merdes A. (J. Cell Biol. 2006) 3 4 22 64
  5. The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. (PMID: 16091753) Bousquet M. … Brousset P. (Oncogene 2005) 3 4 22 64

Products for PCM1 Gene

Sources for PCM1 Gene

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